FI109908B - Menetelmä erittäin puhtaan, virusinaktivoidun tekijän VIII ja von Willebrand -tekijän kompleksin saamiseksi talteen anioninvaihtokromatografian avulla - Google Patents

Menetelmä erittäin puhtaan, virusinaktivoidun tekijän VIII ja von Willebrand -tekijän kompleksin saamiseksi talteen anioninvaihtokromatografian avulla Download PDF

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Publication number
FI109908B
FI109908B FI943545A FI943545A FI109908B FI 109908 B FI109908 B FI 109908B FI 943545 A FI943545 A FI 943545A FI 943545 A FI943545 A FI 943545A FI 109908 B FI109908 B FI 109908B
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FI
Finland
Prior art keywords
groups
mono
factor viii
carbon atoms
anion exchange
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FI943545A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI943545A (fi
FI943545A0 (fi
Inventor
Horst Schwinn
Monika Stadler
Original Assignee
Octapharma Ag
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Application filed by Octapharma Ag filed Critical Octapharma Ag
Publication of FI943545A publication Critical patent/FI943545A/fi
Publication of FI943545A0 publication Critical patent/FI943545A0/fi
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Publication of FI109908B publication Critical patent/FI109908B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
FI943545A 1992-02-01 1994-07-28 Menetelmä erittäin puhtaan, virusinaktivoidun tekijän VIII ja von Willebrand -tekijän kompleksin saamiseksi talteen anioninvaihtokromatografian avulla FI109908B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4204694 1992-02-01
DE4204694A DE4204694C3 (de) 1992-02-01 1992-02-01 Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie
PCT/EP1993/000114 WO1993015105A1 (en) 1992-02-01 1993-01-20 Process for recovering a high-purity virus-inactivated factor viii by anion exchanger chromatography
EP9300114 1993-01-20

Publications (3)

Publication Number Publication Date
FI943545A FI943545A (fi) 1994-07-28
FI943545A0 FI943545A0 (fi) 1994-07-28
FI109908B true FI109908B (fi) 2002-10-31

Family

ID=6451895

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943545A FI109908B (fi) 1992-02-01 1994-07-28 Menetelmä erittäin puhtaan, virusinaktivoidun tekijän VIII ja von Willebrand -tekijän kompleksin saamiseksi talteen anioninvaihtokromatografian avulla

Country Status (16)

Country Link
US (1) US5714590A (no)
EP (1) EP0625161B9 (no)
JP (1) JP3556947B2 (no)
KR (1) KR100240310B1 (no)
AT (1) ATE203249T1 (no)
AU (1) AU670776B2 (no)
DE (2) DE4204694C3 (no)
DK (1) DK0625161T4 (no)
ES (1) ES2157920T5 (no)
FI (1) FI109908B (no)
GR (1) GR3036849T3 (no)
NO (1) NO315426B1 (no)
PT (1) PT625161E (no)
RU (1) RU2096414C1 (no)
TW (1) TW362099B (no)
WO (1) WO1993015105A1 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005067A1 (en) * 1991-09-05 1993-03-18 Baxter International, Inc. Topical fibrinogen complex
DE4342132C1 (de) * 1993-12-10 1994-11-03 Octapharma Ag Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie
DE4407837C1 (de) * 1994-03-09 1995-08-17 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie
AT403764B (de) 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
EP1148063A1 (de) * 2000-04-18 2001-10-24 Octapharma AG Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung
FR2874216B1 (fr) * 2004-08-16 2006-11-03 Lab Francais Du Fractionnement Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu
EP1739179A1 (en) 2005-06-30 2007-01-03 Octapharma AG Serum-free stable transfection and production of recombinant human proteins in human cell lines
MX2012005527A (es) * 2009-11-13 2012-08-08 Grifols Therapeutics Inc Preparaciones que contienen el factor de von willebrand (fvw) procedimientos, kits y aplicaciones relacionados con las mismas.
RU2445974C2 (ru) * 2010-04-26 2012-03-27 Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН Способ получения концентрата фактора viii из плазмы крови человека
EP2652491B1 (en) 2010-12-15 2017-11-29 Baxalta GmbH Eluate collection using conductivity gradient
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
DE3811042A1 (de) * 1988-03-31 1989-10-19 Merck Patent Gmbh Ionenaustauscher
ES2053619T3 (es) * 1988-05-27 1994-08-01 Centre Regional De Transfusion Procedimiento para la fabricacion de un factor antihemofilico de gran pureza y libre de virus mediante cromatografia.
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
ATE85221T1 (de) * 1988-11-05 1993-02-15 Octapharma Ag Verfahren zur herstellung eines hochreinen, nicht infektioesen antihaemophiliefaktors mittels chromatographie.
GB8913183D0 (en) * 1989-06-08 1989-07-26 Central Blood Lab Authority Chemical products
FR2651437A1 (fr) * 1989-09-05 1991-03-08 Lille Transfusion Sanguine Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total.

Also Published As

Publication number Publication date
AU670776B2 (en) 1996-08-01
JPH07503241A (ja) 1995-04-06
WO1993015105A1 (en) 1993-08-05
EP0625161B9 (en) 2007-09-19
DE69330458T3 (de) 2008-01-17
NO942832L (no) 1994-07-29
KR100240310B1 (ko) 2000-01-15
EP0625161B2 (en) 2007-05-16
ATE203249T1 (de) 2001-08-15
DE4204694A1 (de) 1993-08-12
EP0625161B1 (en) 2001-07-18
FI943545A (fi) 1994-07-28
US5714590A (en) 1998-02-03
DE69330458T2 (de) 2002-05-29
RU2096414C1 (ru) 1997-11-20
AU3351793A (en) 1993-09-01
ES2157920T3 (es) 2001-09-01
DE69330458D1 (de) 2001-08-23
NO315426B1 (no) 2003-09-01
FI943545A0 (fi) 1994-07-28
DE4204694C2 (de) 1994-02-10
PT625161E (pt) 2001-10-31
KR950700925A (ko) 1995-02-20
TW362099B (en) 1999-06-21
DK0625161T4 (da) 2007-09-03
DE4204694C3 (de) 1995-10-12
JP3556947B2 (ja) 2004-08-25
DK0625161T3 (da) 2001-09-24
EP0625161A1 (en) 1994-11-23
GR3036849T3 (en) 2002-01-31
ES2157920T5 (es) 2007-12-16
NO942832D0 (no) 1994-07-29

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