FI943545A - Menetelmä tekijän VIII, jonka puhtausaste on korkea ja josta virukset on inaktivoitu, saamiseksi talteen anioninvaihtokromatografian avulla - Google Patents
Menetelmä tekijän VIII, jonka puhtausaste on korkea ja josta virukset on inaktivoitu, saamiseksi talteen anioninvaihtokromatografian avulla Download PDFInfo
- Publication number
- FI943545A FI943545A FI943545A FI943545A FI943545A FI 943545 A FI943545 A FI 943545A FI 943545 A FI943545 A FI 943545A FI 943545 A FI943545 A FI 943545A FI 943545 A FI943545 A FI 943545A
- Authority
- FI
- Finland
- Prior art keywords
- pct
- factor viii
- high purity
- anion exchange
- recovering high
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 102000001690 Factor VIII Human genes 0.000 title abstract 2
- 108010054218 Factor VIII Proteins 0.000 title abstract 2
- 229960000301 factor viii Drugs 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 238000005349 anion exchange Methods 0.000 title 1
- 239000000969 carrier Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 238000005571 anion exchange chromatography Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4204694 | 1992-02-01 | ||
DE4204694A DE4204694C3 (de) | 1992-02-01 | 1992-02-01 | Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie |
PCT/EP1993/000114 WO1993015105A1 (en) | 1992-02-01 | 1993-01-20 | Process for recovering a high-purity virus-inactivated factor viii by anion exchanger chromatography |
EP9300114 | 1993-01-20 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI943545A0 FI943545A0 (fi) | 1994-07-28 |
FI943545A true FI943545A (fi) | 1994-07-28 |
FI109908B FI109908B (fi) | 2002-10-31 |
Family
ID=6451895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI943545A FI109908B (fi) | 1992-02-01 | 1994-07-28 | Menetelmä erittäin puhtaan, virusinaktivoidun tekijän VIII ja von Willebrand -tekijän kompleksin saamiseksi talteen anioninvaihtokromatografian avulla |
Country Status (16)
Country | Link |
---|---|
US (1) | US5714590A (fi) |
EP (1) | EP0625161B9 (fi) |
JP (1) | JP3556947B2 (fi) |
KR (1) | KR100240310B1 (fi) |
AT (1) | ATE203249T1 (fi) |
AU (1) | AU670776B2 (fi) |
DE (2) | DE4204694C3 (fi) |
DK (1) | DK0625161T4 (fi) |
ES (1) | ES2157920T5 (fi) |
FI (1) | FI109908B (fi) |
GR (1) | GR3036849T3 (fi) |
NO (1) | NO315426B1 (fi) |
PT (1) | PT625161E (fi) |
RU (1) | RU2096414C1 (fi) |
TW (1) | TW362099B (fi) |
WO (1) | WO1993015105A1 (fi) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69229272T2 (de) * | 1991-09-05 | 2000-02-03 | Baxter International Inc., Deerfield | Topischer fibrinogenkomplex |
DE4342132C1 (de) * | 1993-12-10 | 1994-11-03 | Octapharma Ag | Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie |
DE4407837C1 (de) * | 1994-03-09 | 1995-08-17 | Octapharma Ag | Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie |
AT403764B (de) | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
EP1148063A1 (de) | 2000-04-18 | 2001-10-24 | Octapharma AG | Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung |
FR2874216B1 (fr) * | 2004-08-16 | 2006-11-03 | Lab Francais Du Fractionnement | Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu |
EP1739179A1 (en) | 2005-06-30 | 2007-01-03 | Octapharma AG | Serum-free stable transfection and production of recombinant human proteins in human cell lines |
CA2780542C (en) * | 2009-11-13 | 2020-03-24 | Grifols Therapeutics Inc. | Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto |
RU2445974C2 (ru) * | 2010-04-26 | 2012-03-27 | Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН | Способ получения концентрата фактора viii из плазмы крови человека |
AU2011343813B2 (en) | 2010-12-15 | 2015-05-21 | Takeda Pharmaceutical Company Limited | Eluate collection using conductivity gradient |
BRPI1105317A2 (pt) | 2011-01-24 | 2013-04-30 | Fundacco Hemoct De Ribeirco Preto | produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4876241A (en) * | 1987-05-22 | 1989-10-24 | Armour Pharmaceutical Company | Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants |
DE3811042A1 (de) * | 1988-03-31 | 1989-10-19 | Merck Patent Gmbh | Ionenaustauscher |
DE3878227D1 (de) * | 1988-05-27 | 1993-03-18 | Centre Regional De Transfusion | Verfahren zur herstellung eines hochreinen, virusfreien antihaemophiliefaktors mittels chromatographie. |
FR2632309B1 (fr) * | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
DE3878245D1 (de) * | 1988-11-05 | 1993-03-18 | Octapharma Ag | Verfahren zur herstellung eines hochreinen, nicht infektioesen antihaemophiliefaktors mittels chromatographie. |
GB8913183D0 (en) * | 1989-06-08 | 1989-07-26 | Central Blood Lab Authority | Chemical products |
FR2651437A1 (fr) * | 1989-09-05 | 1991-03-08 | Lille Transfusion Sanguine | Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. |
-
1992
- 1992-02-01 DE DE4204694A patent/DE4204694C3/de not_active Expired - Lifetime
-
1993
- 1993-01-20 DE DE69330458T patent/DE69330458T3/de not_active Expired - Lifetime
- 1993-01-20 RU RU9394035758A patent/RU2096414C1/ru not_active IP Right Cessation
- 1993-01-20 ES ES93902233T patent/ES2157920T5/es not_active Expired - Lifetime
- 1993-01-20 JP JP51290293A patent/JP3556947B2/ja not_active Expired - Lifetime
- 1993-01-20 AU AU33517/93A patent/AU670776B2/en not_active Expired
- 1993-01-20 AT AT93902233T patent/ATE203249T1/de active
- 1993-01-20 PT PT93902233T patent/PT625161E/pt unknown
- 1993-01-20 WO PCT/EP1993/000114 patent/WO1993015105A1/en active IP Right Grant
- 1993-01-20 US US08/284,403 patent/US5714590A/en not_active Expired - Lifetime
- 1993-01-20 KR KR1019940702645A patent/KR100240310B1/ko not_active IP Right Cessation
- 1993-01-20 DK DK93902233T patent/DK0625161T4/da active
- 1993-01-20 EP EP93902233A patent/EP0625161B9/en not_active Expired - Lifetime
- 1993-01-28 TW TW082100487A patent/TW362099B/zh not_active IP Right Cessation
-
1994
- 1994-07-28 FI FI943545A patent/FI109908B/fi not_active IP Right Cessation
- 1994-07-29 NO NO19942832A patent/NO315426B1/no not_active IP Right Cessation
-
2001
- 2001-10-09 GR GR20010401713T patent/GR3036849T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NO942832D0 (no) | 1994-07-29 |
DE4204694C2 (de) | 1994-02-10 |
FI943545A0 (fi) | 1994-07-28 |
RU2096414C1 (ru) | 1997-11-20 |
JPH07503241A (ja) | 1995-04-06 |
DE69330458T3 (de) | 2008-01-17 |
GR3036849T3 (en) | 2002-01-31 |
AU3351793A (en) | 1993-09-01 |
DE4204694C3 (de) | 1995-10-12 |
US5714590A (en) | 1998-02-03 |
EP0625161B1 (en) | 2001-07-18 |
EP0625161B2 (en) | 2007-05-16 |
ES2157920T3 (es) | 2001-09-01 |
NO942832L (no) | 1994-07-29 |
TW362099B (en) | 1999-06-21 |
EP0625161A1 (en) | 1994-11-23 |
JP3556947B2 (ja) | 2004-08-25 |
EP0625161B9 (en) | 2007-09-19 |
FI109908B (fi) | 2002-10-31 |
NO315426B1 (no) | 2003-09-01 |
AU670776B2 (en) | 1996-08-01 |
KR100240310B1 (ko) | 2000-01-15 |
ES2157920T5 (es) | 2007-12-16 |
KR950700925A (ko) | 1995-02-20 |
PT625161E (pt) | 2001-10-31 |
WO1993015105A1 (en) | 1993-08-05 |
DE4204694A1 (de) | 1993-08-12 |
ATE203249T1 (de) | 2001-08-15 |
DK0625161T3 (da) | 2001-09-24 |
DE69330458D1 (de) | 2001-08-23 |
DK0625161T4 (da) | 2007-09-03 |
DE69330458T2 (de) | 2002-05-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |