ES2157920T3 - Procedimiento para recuperar un complejo factor viii/factor von willebrand inactivado de virus y de elevada pureza mediante cromatografia de intercambio anionico. - Google Patents

Procedimiento para recuperar un complejo factor viii/factor von willebrand inactivado de virus y de elevada pureza mediante cromatografia de intercambio anionico.

Info

Publication number
ES2157920T3
ES2157920T3 ES93902233T ES93902233T ES2157920T3 ES 2157920 T3 ES2157920 T3 ES 2157920T3 ES 93902233 T ES93902233 T ES 93902233T ES 93902233 T ES93902233 T ES 93902233T ES 2157920 T3 ES2157920 T3 ES 2157920T3
Authority
ES
Spain
Prior art keywords
pct
viruses
recovering
procedure
high purity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93902233T
Other languages
English (en)
Other versions
ES2157920T5 (es
Inventor
Monika Stadler
Horst Schwinn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Octapharma AG
Original Assignee
Octapharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6451895&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2157920(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Octapharma AG filed Critical Octapharma AG
Publication of ES2157920T3 publication Critical patent/ES2157920T3/es
Application granted granted Critical
Publication of ES2157920T5 publication Critical patent/ES2157920T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

SE DESCRIBE UN PROCESO ECONOMICO PARA LA RECUPERACION DEL FACTOR VIII DEL PLASMA SANGUINEO O CRIOPRECIPITADO. EN DICHO PROCESO, LA CROMATOGRAFIA INTERCAMBIADORA DE ANION SE REALIZA UTILIZANDO UN MATERIAL DE SEPARACION BASADO EN PORTADORES QUE CONTIENEN GRUPOS HIDROXIL, ESTANDO CUBIERTAS LAS SUPERFICIES DE TALES PORTADORES CON POLIMEROS LIGADOS COVALENTEMENTE, CONTENIENDO DICHOS POLIMEROS UNIDADES DE REPETICION REPRESENTADOS POR LA FORMULA (I) DONDE R1, R'' Y R", Y Y N ESTAN DEFINIDOS EN LA LLAMADA 1.
ES93902233T 1992-02-01 1993-01-20 Procedimiento para recuperar un complejo factor viii/factor von willebrand inactivado de virus y de elevada pureza mediante cromatografia de intercambio anionico. Expired - Lifetime ES2157920T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4204694 1992-02-01
DE4204694A DE4204694C3 (de) 1992-02-01 1992-02-01 Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie

Publications (2)

Publication Number Publication Date
ES2157920T3 true ES2157920T3 (es) 2001-09-01
ES2157920T5 ES2157920T5 (es) 2007-12-16

Family

ID=6451895

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93902233T Expired - Lifetime ES2157920T5 (es) 1992-02-01 1993-01-20 Procedimiento para recuperar un complejo factor viii/factor von willebrand inactivado de virus y de elevada pureza mediante cromatografia de intercambio anionico.

Country Status (16)

Country Link
US (1) US5714590A (es)
EP (1) EP0625161B9 (es)
JP (1) JP3556947B2 (es)
KR (1) KR100240310B1 (es)
AT (1) ATE203249T1 (es)
AU (1) AU670776B2 (es)
DE (2) DE4204694C3 (es)
DK (1) DK0625161T4 (es)
ES (1) ES2157920T5 (es)
FI (1) FI109908B (es)
GR (1) GR3036849T3 (es)
NO (1) NO315426B1 (es)
PT (1) PT625161E (es)
RU (1) RU2096414C1 (es)
TW (1) TW362099B (es)
WO (1) WO1993015105A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005067A1 (en) * 1991-09-05 1993-03-18 Baxter International, Inc. Topical fibrinogen complex
DE4342132C1 (de) * 1993-12-10 1994-11-03 Octapharma Ag Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie
DE4407837C1 (de) * 1994-03-09 1995-08-17 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie
AT403764B (de) 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
EP1148063A1 (de) * 2000-04-18 2001-10-24 Octapharma AG Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung
FR2874216B1 (fr) * 2004-08-16 2006-11-03 Lab Francais Du Fractionnement Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu
EP1739179A1 (en) 2005-06-30 2007-01-03 Octapharma AG Serum-free stable transfection and production of recombinant human proteins in human cell lines
MX2012005527A (es) * 2009-11-13 2012-08-08 Grifols Therapeutics Inc Preparaciones que contienen el factor de von willebrand (fvw) procedimientos, kits y aplicaciones relacionados con las mismas.
RU2445974C2 (ru) * 2010-04-26 2012-03-27 Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН Способ получения концентрата фактора viii из плазмы крови человека
EP2652491B1 (en) 2010-12-15 2017-11-29 Baxalta GmbH Eluate collection using conductivity gradient
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
DE3811042A1 (de) * 1988-03-31 1989-10-19 Merck Patent Gmbh Ionenaustauscher
ES2053619T3 (es) * 1988-05-27 1994-08-01 Centre Regional De Transfusion Procedimiento para la fabricacion de un factor antihemofilico de gran pureza y libre de virus mediante cromatografia.
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
ATE85221T1 (de) * 1988-11-05 1993-02-15 Octapharma Ag Verfahren zur herstellung eines hochreinen, nicht infektioesen antihaemophiliefaktors mittels chromatographie.
GB8913183D0 (en) * 1989-06-08 1989-07-26 Central Blood Lab Authority Chemical products
FR2651437A1 (fr) * 1989-09-05 1991-03-08 Lille Transfusion Sanguine Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total.

Also Published As

Publication number Publication date
AU670776B2 (en) 1996-08-01
JPH07503241A (ja) 1995-04-06
WO1993015105A1 (en) 1993-08-05
EP0625161B9 (en) 2007-09-19
DE69330458T3 (de) 2008-01-17
NO942832L (no) 1994-07-29
KR100240310B1 (ko) 2000-01-15
EP0625161B2 (en) 2007-05-16
ATE203249T1 (de) 2001-08-15
DE4204694A1 (de) 1993-08-12
EP0625161B1 (en) 2001-07-18
FI943545A (fi) 1994-07-28
US5714590A (en) 1998-02-03
DE69330458T2 (de) 2002-05-29
RU2096414C1 (ru) 1997-11-20
AU3351793A (en) 1993-09-01
DE69330458D1 (de) 2001-08-23
NO315426B1 (no) 2003-09-01
FI109908B (fi) 2002-10-31
FI943545A0 (fi) 1994-07-28
DE4204694C2 (de) 1994-02-10
PT625161E (pt) 2001-10-31
KR950700925A (ko) 1995-02-20
TW362099B (en) 1999-06-21
DK0625161T4 (da) 2007-09-03
DE4204694C3 (de) 1995-10-12
JP3556947B2 (ja) 2004-08-25
DK0625161T3 (da) 2001-09-24
EP0625161A1 (en) 1994-11-23
GR3036849T3 (en) 2002-01-31
ES2157920T5 (es) 2007-12-16
NO942832D0 (no) 1994-07-29

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