DE69330458D1 - Verfahren zur gewinnung eines hochreinen factor viii/von willebrand faktor komplexes durch anionenaustauschchromatographie - Google Patents

Verfahren zur gewinnung eines hochreinen factor viii/von willebrand faktor komplexes durch anionenaustauschchromatographie

Info

Publication number
DE69330458D1
DE69330458D1 DE69330458T DE69330458T DE69330458D1 DE 69330458 D1 DE69330458 D1 DE 69330458D1 DE 69330458 T DE69330458 T DE 69330458T DE 69330458 T DE69330458 T DE 69330458T DE 69330458 D1 DE69330458 D1 DE 69330458D1
Authority
DE
Germany
Prior art keywords
pct
obtaining
high purity
anion exchange
exchange chromatography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69330458T
Other languages
English (en)
Other versions
DE69330458T2 (de
DE69330458T3 (de
Inventor
Monika Stadler
Horst Schwinn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Octapharma AG
Original Assignee
Octapharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6451895&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69330458(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Octapharma AG filed Critical Octapharma AG
Priority to DE69330458T priority Critical patent/DE69330458T3/de
Application granted granted Critical
Publication of DE69330458D1 publication Critical patent/DE69330458D1/de
Publication of DE69330458T2 publication Critical patent/DE69330458T2/de
Publication of DE69330458T3 publication Critical patent/DE69330458T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE69330458T 1992-02-01 1993-01-20 Verfahren zur gewinnung eines hochreinen factor viii/von willebrand faktor komplexes durch anionenaustauschchromatographie Expired - Lifetime DE69330458T3 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69330458T DE69330458T3 (de) 1992-02-01 1993-01-20 Verfahren zur gewinnung eines hochreinen factor viii/von willebrand faktor komplexes durch anionenaustauschchromatographie

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4204694 1992-02-01
DE4204694A DE4204694C3 (de) 1992-02-01 1992-02-01 Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie
PCT/EP1993/000114 WO1993015105A1 (en) 1992-02-01 1993-01-20 Process for recovering a high-purity virus-inactivated factor viii by anion exchanger chromatography
DE69330458T DE69330458T3 (de) 1992-02-01 1993-01-20 Verfahren zur gewinnung eines hochreinen factor viii/von willebrand faktor komplexes durch anionenaustauschchromatographie

Publications (3)

Publication Number Publication Date
DE69330458D1 true DE69330458D1 (de) 2001-08-23
DE69330458T2 DE69330458T2 (de) 2002-05-29
DE69330458T3 DE69330458T3 (de) 2008-01-17

Family

ID=6451895

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4204694A Expired - Lifetime DE4204694C3 (de) 1992-02-01 1992-02-01 Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie
DE69330458T Expired - Lifetime DE69330458T3 (de) 1992-02-01 1993-01-20 Verfahren zur gewinnung eines hochreinen factor viii/von willebrand faktor komplexes durch anionenaustauschchromatographie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE4204694A Expired - Lifetime DE4204694C3 (de) 1992-02-01 1992-02-01 Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie

Country Status (16)

Country Link
US (1) US5714590A (de)
EP (1) EP0625161B9 (de)
JP (1) JP3556947B2 (de)
KR (1) KR100240310B1 (de)
AT (1) ATE203249T1 (de)
AU (1) AU670776B2 (de)
DE (2) DE4204694C3 (de)
DK (1) DK0625161T4 (de)
ES (1) ES2157920T5 (de)
FI (1) FI109908B (de)
GR (1) GR3036849T3 (de)
NO (1) NO315426B1 (de)
PT (1) PT625161E (de)
RU (1) RU2096414C1 (de)
TW (1) TW362099B (de)
WO (1) WO1993015105A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2887329B2 (ja) * 1991-09-05 1999-04-26 バクスター インターナショナル インク 局所用フィブリノーゲン複合体
DE4342132C1 (de) * 1993-12-10 1994-11-03 Octapharma Ag Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie
DE4407837C1 (de) * 1994-03-09 1995-08-17 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie
AT403764B (de) 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
EP1148063A1 (de) * 2000-04-18 2001-10-24 Octapharma AG Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung
FR2874216B1 (fr) * 2004-08-16 2006-11-03 Lab Francais Du Fractionnement Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu
EP1739179A1 (de) 2005-06-30 2007-01-03 Octapharma AG Serumfreie stabile Transfektion und Produktion von rekombinanten humanen Proteinen in humanen Zelllinien
PL2499165T3 (pl) * 2009-11-13 2017-04-28 Grifols Therapeutics Inc. Preparaty zawierające czynnik von willenbranda (vwf) oraz sposoby, zestawy i zastosowania z nim powiązane
RU2445974C2 (ru) * 2010-04-26 2012-03-27 Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН Способ получения концентрата фактора viii из плазмы крови человека
SG191186A1 (en) 2010-12-15 2013-07-31 Baxter Int Eluate collection using conductivity gradient
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
DE3811042A1 (de) * 1988-03-31 1989-10-19 Merck Patent Gmbh Ionenaustauscher
DE3878227D1 (de) * 1988-05-27 1993-03-18 Centre Regional De Transfusion Verfahren zur herstellung eines hochreinen, virusfreien antihaemophiliefaktors mittels chromatographie.
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
ES2053684T3 (es) * 1988-11-05 1994-08-01 Octapharma Ag Procedimiento para preparar un factor antihemofilico, altamente puro, no infeccioso, mediante cromatografia.
GB8913183D0 (en) * 1989-06-08 1989-07-26 Central Blood Lab Authority Chemical products
FR2651437A1 (fr) * 1989-09-05 1991-03-08 Lille Transfusion Sanguine Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total.

Also Published As

Publication number Publication date
JP3556947B2 (ja) 2004-08-25
DE4204694A1 (de) 1993-08-12
DK0625161T4 (da) 2007-09-03
ES2157920T5 (es) 2007-12-16
DE69330458T2 (de) 2002-05-29
DE69330458T3 (de) 2008-01-17
FI943545A0 (fi) 1994-07-28
GR3036849T3 (en) 2002-01-31
EP0625161B2 (de) 2007-05-16
AU670776B2 (en) 1996-08-01
ATE203249T1 (de) 2001-08-15
NO942832D0 (no) 1994-07-29
AU3351793A (en) 1993-09-01
ES2157920T3 (es) 2001-09-01
KR950700925A (ko) 1995-02-20
DE4204694C2 (de) 1994-02-10
DE4204694C3 (de) 1995-10-12
NO942832L (no) 1994-07-29
PT625161E (pt) 2001-10-31
EP0625161B9 (de) 2007-09-19
EP0625161A1 (de) 1994-11-23
WO1993015105A1 (en) 1993-08-05
TW362099B (en) 1999-06-21
FI109908B (fi) 2002-10-31
KR100240310B1 (ko) 2000-01-15
DK0625161T3 (da) 2001-09-24
NO315426B1 (no) 2003-09-01
US5714590A (en) 1998-02-03
RU2096414C1 (ru) 1997-11-20
EP0625161B1 (de) 2001-07-18
JPH07503241A (ja) 1995-04-06
FI943545A (fi) 1994-07-28

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