ES2053684T3 - Procedimiento para preparar un factor antihemofilico, altamente puro, no infeccioso, mediante cromatografia. - Google Patents

Procedimiento para preparar un factor antihemofilico, altamente puro, no infeccioso, mediante cromatografia.

Info

Publication number
ES2053684T3
ES2053684T3 ES88118478T ES88118478T ES2053684T3 ES 2053684 T3 ES2053684 T3 ES 2053684T3 ES 88118478 T ES88118478 T ES 88118478T ES 88118478 T ES88118478 T ES 88118478T ES 2053684 T3 ES2053684 T3 ES 2053684T3
Authority
ES
Spain
Prior art keywords
infectious
chromatography
prepare
procedure
highly pure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88118478T
Other languages
English (en)
Inventor
Andrew Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Octapharma AG
Original Assignee
Octapharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8199529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2053684(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Octapharma AG filed Critical Octapharma AG
Application granted granted Critical
Publication of ES2053684T3 publication Critical patent/ES2053684T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Chemical Vapour Deposition (AREA)
  • Intermediate Stations On Conveyors (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA PRODUCCION DE UNOS FACTORES ANTIHEMOFILICOS (AHF O FACTOR VIII) DE PLASMA SANGUINEO NO INFECCIOSOS Y MUY PUROS A TRAVES DEL TRATAMIENTO DE UNA FRACCION ENRIQUECIDA EN FACTOR VIII CON DISOLVENTES ORGANICOS BIOCOMPATIBLES Y PURIFICACION DE LA FRACCION ENRIQUECIDA CON DISOLVENTES ORGANICOS. EL PROCEDIMIENTO SE CARACTERIZA PORQUE LA FRACCION ENRIQUECIDA EN EL FACTOR VIII SE OBTIENE A TRAVES DE UN PROCEDIMIENTO CROMTAOGRAFICO. LA FRACCION ENRIQUECIDA EN FACTOR VIII SE SOMETE A UNA CROMATOGRAFIA PERMEABLE DE GEL CON MATERIAL INTERCAMBIADOR DE IONES DESPUES DE UN PROCEDIMIENTO PREVIO DE ELIMINACION DE VIRUS.
ES88118478T 1988-11-05 1988-11-05 Procedimiento para preparar un factor antihemofilico, altamente puro, no infeccioso, mediante cromatografia. Expired - Lifetime ES2053684T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88118478A EP0367840B1 (de) 1988-11-05 1988-11-05 Verfahren zur Herstellung eines hochreinen, nicht infektiösen Antihämophiliefaktors mittels Chromatographie

Publications (1)

Publication Number Publication Date
ES2053684T3 true ES2053684T3 (es) 1994-08-01

Family

ID=8199529

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88118478T Expired - Lifetime ES2053684T3 (es) 1988-11-05 1988-11-05 Procedimiento para preparar un factor antihemofilico, altamente puro, no infeccioso, mediante cromatografia.

Country Status (8)

Country Link
EP (1) EP0367840B1 (es)
JP (1) JPH03502200A (es)
AT (1) ATE85221T1 (es)
DE (1) DE3878245D1 (es)
DK (1) DK161590D0 (es)
ES (1) ES2053684T3 (es)
FI (1) FI903366A0 (es)
WO (1) WO1990005140A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4008852A1 (de) * 1990-03-20 1991-09-26 Octapharma Ag Verfahren zur herstellung von nicht-infektioesem blutplasma
IT1248723B (it) * 1990-06-12 1995-01-26 Scalvo S P A Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo
FR2681867B1 (fr) * 1991-09-26 1993-12-31 Pasteur Merieux Serums Vaccins Procede de purification du facteur viii et preparations obtenues.
DE4204694C3 (de) * 1992-02-01 1995-10-12 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie
AT399818B (de) * 1992-04-24 1995-07-25 Immuno Ag Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation
IT1256622B (it) * 1992-12-04 1995-12-12 Sclavo Spa Processo per l'estrazione del complesso fattore viii-fattore von willebrand (fviii:c-fvw) da plasma umano totale.
JPH08506498A (ja) * 1993-02-09 1996-07-16 オクタファルマ・アクチエンゲセルシャフト 非脂質被覆ウイルスの失活方法
SE9301582D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Purification of plasma proteins
DE4337573C1 (de) * 1993-11-04 1995-05-18 Octapharma Ag Verfahren zur Herstellung einer virusinaktivierten Faktor VIII enthaltenden Fraktion mittels chromatographischer Methoden
AT407159B (de) † 1997-06-13 2001-01-25 Immuno Ag Verfahren zur abreicherung von viralen und molekularen pathogenen aus einem biologischen material
WO2000074733A1 (en) * 1999-06-08 2000-12-14 Octapharma Ag Process for removing viruses from biological samples
EP1148063A1 (de) 2000-04-18 2001-10-24 Octapharma AG Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE713764A (es) 1967-05-01 1968-09-16 Baxter Travenol Lab
JPS52125609A (en) 1976-04-09 1977-10-21 Green Cross Corp:The Purification of agglutination factor viii
DE2635894A1 (de) * 1976-08-10 1978-02-16 Biotest Serum Institut Gmbh Verfahren zur herstellung eines antihaemophiles globulin a enthaltenden konzentrats
US4386068A (en) * 1980-02-26 1983-05-31 Cutter Laboratories, Inc. Antihemophilic factor concentrate and method for preparation
US4495175A (en) 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US4478825A (en) * 1983-10-14 1984-10-23 Armour Pharmaceutical Company Warm ethanol method for preparation of low fibrinogen antihemophilic factor
US4508709A (en) * 1983-12-05 1985-04-02 Armour Pharmaceutical Company Process for purifying factor VIII:C
DE3432083A1 (de) 1984-08-31 1986-03-06 Behringwerke Ag, 3550 Marburg Pasteurisierte, isoagglutininfreie faktor viii-praeparation und verfahren zu ihrer herstellung
US4743680A (en) 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
EP0238701B1 (de) * 1986-03-27 1992-03-18 Octapharma AG Verfahren zur Herstellung eines hochgereinigten Antihämophilie-Faktors
US4789545A (en) 1986-03-31 1988-12-06 New York Blood Center, Inc. Removal of lipid soluble process chemicals from biological materials by extraction with naturally occurring oils or synthetic substitutes thereof
JPS63108000A (ja) * 1986-05-15 1988-05-12 Green Cross Corp:The 第８因子の精製方法
DE3878227D1 (de) 1988-05-27 1993-03-18 Centre Regional De Transfusion Verfahren zur herstellung eines hochreinen, virusfreien antihaemophiliefaktors mittels chromatographie.

Also Published As

Publication number Publication date
WO1990005140A1 (de) 1990-05-17
EP0367840B1 (de) 1993-02-03
EP0367840A1 (de) 1990-05-16
DK161590A (da) 1990-07-04
ATE85221T1 (de) 1993-02-15
DE3878245D1 (de) 1993-03-18
FI903366A0 (fi) 1990-07-04
DK161590D0 (da) 1990-07-04
JPH03502200A (ja) 1991-05-23

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