FI108637B - Förfarande för framställning av som läkemedel användbar trometaminsalter av (+)-(S)-2-(3-benzoylfenyl)propansyra - Google Patents

Förfarande för framställning av som läkemedel användbar trometaminsalter av (+)-(S)-2-(3-benzoylfenyl)propansyra Download PDF

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Publication number
FI108637B
FI108637B FI952230A FI952230A FI108637B FI 108637 B FI108637 B FI 108637B FI 952230 A FI952230 A FI 952230A FI 952230 A FI952230 A FI 952230A FI 108637 B FI108637 B FI 108637B
Authority
FI
Finland
Prior art keywords
ketoprofen
salt
benzoylphenyl
propanoic acid
compound
Prior art date
Application number
FI952230A
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English (en)
Finnish (fi)
Other versions
FI952230A0 (sv
FI952230A (sv
Inventor
Germano Garganico
Casellas David Mauleon
Perez M Luisa Garcia
Original Assignee
Menarini Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Lab filed Critical Menarini Lab
Publication of FI952230A0 publication Critical patent/FI952230A0/sv
Publication of FI952230A publication Critical patent/FI952230A/sv
Application granted granted Critical
Publication of FI108637B publication Critical patent/FI108637B/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Claims (5)

1 O 8 6 ό 7
1, Förfarande för framställning av som läkemedel användbar trometaminsalt av (+) - (S) - 2 - (3 - benzoylfeny l)propansyra, ; 5
9. CHj Il H3N—CfCHjOOj 0 10 (I) kännetecknat därav, att förfarandet innefattar att man later 15 (+)-(S)-2~(3-benzoylfenyl)propansyra (III) j? H CH, ;20 Kj IjT dll) • * » » * · I I I 25 reagera med trometamin, t^NCXCt^OH^, i ekvimolära mängder.
.*·. 2. Förfarande enligt patentkrav 1, kännetecknat därav, att reaktionen utförs * · · i ett polärt lösningsmedel eller i en blandning av polära lösningsmedel. * 1 « · ’·’ 30
3. Förfarande enligt patentkrav 2, kännetecknat därav, att reaktionen utförs * ” i en blandning av vatten och metanol eller etanol. , I
4. Förfarande enligt patentkrav 1, kännetecknat därav, att reaktionen utförs vid en temperatur mellan 0 °C och lösningsmedlets äterloppstemperatur över en period pä 1—24 timmar.
5 5. Förfarande enligt patentkrav 4, kännetecknat därav, att reaktionstempera- turen är 15-40 °C.
FI952230A 1992-11-10 1995-05-09 Förfarande för framställning av som läkemedel användbar trometaminsalter av (+)-(S)-2-(3-benzoylfenyl)propansyra FI108637B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ES9202260 1992-11-10
ES09202260A ES2058024B1 (es) 1992-11-10 1992-11-10 Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.
EP9303127 1993-11-09
PCT/EP1993/003127 WO1994011332A1 (en) 1992-11-10 1993-11-09 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent

Publications (3)

Publication Number Publication Date
FI952230A0 FI952230A0 (sv) 1995-05-09
FI952230A FI952230A (sv) 1995-05-09
FI108637B true FI108637B (sv) 2002-02-28

Family

ID=8278730

Family Applications (1)

Application Number Title Priority Date Filing Date
FI952230A FI108637B (sv) 1992-11-10 1995-05-09 Förfarande för framställning av som läkemedel användbar trometaminsalter av (+)-(S)-2-(3-benzoylfenyl)propansyra

Country Status (27)

Country Link
US (1) US5554789A (sv)
EP (1) EP0668851B1 (sv)
JP (1) JP3778516B2 (sv)
KR (1) KR100284838B1 (sv)
AT (1) ATE153649T1 (sv)
AU (1) AU674040B2 (sv)
BG (1) BG61723B1 (sv)
BR (1) BR9307408A (sv)
CA (1) CA2149013C (sv)
CZ (1) CZ286621B6 (sv)
DE (2) DE668851T1 (sv)
DK (1) DK0668851T3 (sv)
ES (2) ES2058024B1 (sv)
FI (1) FI108637B (sv)
GR (2) GR960300012T1 (sv)
HK (1) HK1006306A1 (sv)
HU (2) HU217973B (sv)
MD (1) MD921G2 (sv)
NO (2) NO304306B1 (sv)
NZ (1) NZ257557A (sv)
PL (1) PL175265B1 (sv)
RO (1) RO118712B1 (sv)
RU (1) RU2128160C1 (sv)
SK (1) SK280550B6 (sv)
UA (1) UA44233C2 (sv)
UY (1) UY24179A1 (sv)
WO (1) WO1994011332A1 (sv)

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EP2147679B1 (en) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions for blood-brain barrier transport
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EP1739072A1 (en) * 2005-06-15 2007-01-03 Laboratorios Menarini S.A. Polymorphic forms of dexketoprofen trometamol, preparation and pharmaceutical compositions thereof
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
TWI364413B (en) * 2008-07-25 2012-05-21 Univ Nat Central Racemic ibuprofen amine salt and synthesis method thereof
PL2350082T3 (pl) * 2008-10-31 2015-08-31 C A I R Biosciences Gmbh Sól likofelonu z choliną i trometaminą
JP5564517B2 (ja) 2009-02-20 2014-07-30 ティーオー − ビービービー ホールディング ベスローテン フェンノートシャップ グルタチオンをベースとする薬物送達システム
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
ES2350670B1 (es) * 2009-06-10 2011-12-07 Polichem, S.L. Composicion veterinaria de ketoprofeno
CN101928214B (zh) * 2009-06-19 2012-12-19 黄石世星药业有限责任公司 右旋酮洛芬氨丁三醇的一种合成方法
EP2475636A1 (en) * 2009-06-30 2012-07-18 Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi A process for preparing dexketoprofen trometamol form a and form b crystals
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102557976B (zh) * 2010-12-15 2015-06-10 辽宁盛京制药有限公司 溴芬酸有机盐及其制备方法、其组合物及用途
TR201104864A2 (tr) 2011-05-18 2012-12-21 Bi̇lgi̇ç Mahmut Deksketoprofen içeren suda çözünebilir formülasyonlar.
TR201205317A2 (tr) 2011-05-18 2012-12-21 B�Lg�� Mahmut Deksketoprofen içeren efervesan formülasyonlar.
CN102381986A (zh) * 2011-07-25 2012-03-21 南京特丰药业股份有限公司 一种右旋布洛芬氨丁三醇盐及其口服溶液的制备方法
WO2013022410A2 (en) * 2011-08-08 2013-02-14 Mahmut Bilgic Production method for effervescent formulations comprising dexketoprofen
WO2013095315A1 (en) 2011-12-19 2013-06-27 Mahmut Bilgic Formulations comprising dexketoprofen (particle size 300-2500 micrometer)
WO2013100877A1 (en) 2011-12-27 2013-07-04 Mahmut Bilgic Dexketoprofen formulations
EP2671569B1 (en) 2012-06-06 2015-09-16 Galenicum Health S.L. Stable pharmaceutical compositions with fast onset
EP2759293A1 (en) 2013-01-25 2014-07-30 Laboratorios Lesvi, S.L. Pharmaceutical compositions of (+)-(s)-2-(3-benzoylphenyl)propionic acid tromethamine salt
EP2764875A1 (en) 2013-02-06 2014-08-13 Galenicum Health S.L. Process for preparing a stable pharmaceutical composition comprising dexketoprofen trometamol
ITMI20130210A1 (it) 2013-02-14 2014-08-15 Menarini Lab Composizioni farmaceutiche contenenti dexketoprofene e tramadolo
TR201616365A1 (tr) 2016-11-14 2018-05-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Deksketoprofen ve eletri̇ptanin oral farmasöti̇k kompozi̇syonlari
US10927067B2 (en) 2016-11-28 2021-02-23 Sarin Parayil Organic crystalline salt of haloacetic acid
TR201618765A2 (tr) 2016-12-16 2018-07-23 Imuneks Farma Ilac Sanayi Ve Ticaret Anonim Sirketi Ağrı ve enflamasyonun tedavisi için steroid olmayan anti-enflamatuvar ilaçlar ve H2 reseptörü antagonisti kombinasyonları.
KR102462607B1 (ko) * 2020-11-11 2022-11-03 대원제약주식회사 펠루비프로펜 신규 염을 주성분으로 하는 안정성이 증가된 약학적 조성물
KR102552315B1 (ko) * 2020-11-11 2023-07-06 대원제약주식회사 펠루비프로펜 신규 염을 주성분으로 하며 위장장애 부작용이 저감된 약학적 조성물
WO2023182869A1 (en) * 2022-03-25 2023-09-28 Ildong Pharmaceutical Co., Ltd. Novel salt of glp-1 receptor agonist compound, preparation method thereof and pharmaceutical composition comprising thereof

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Also Published As

Publication number Publication date
RU95112575A (ru) 1997-06-20
CA2149013A1 (en) 1994-05-26
KR100284838B1 (ko) 2001-04-02
ES2081780T3 (es) 1997-07-01
PL308466A1 (en) 1995-07-24
CZ286621B6 (cs) 2000-05-17
ATE153649T1 (de) 1997-06-15
CA2149013C (en) 2004-08-10
CZ114995A3 (en) 1995-10-18
RU2128160C1 (ru) 1999-03-27
DE69311130D1 (de) 1997-07-03
SK280550B6 (sk) 2000-03-13
GR3024344T3 (en) 1997-10-31
ES2058024A1 (es) 1994-10-16
DE668851T1 (de) 1996-10-10
NO304306B1 (no) 1998-11-30
HU219975B (hu) 2001-10-28
NO951790L (no) 1995-07-06
PL175265B1 (pl) 1998-12-31
NZ257557A (en) 1996-01-26
HU217973B (hu) 2000-05-28
JPH08503203A (ja) 1996-04-09
UA44233C2 (uk) 2002-02-15
EP0668851B1 (en) 1997-05-28
JP3778516B2 (ja) 2006-05-24
HK1006306A1 (en) 1999-02-19
NO951790D0 (no) 1995-05-08
UY24179A1 (es) 1996-09-03
BG61723B1 (bg) 1998-04-30
SK60395A3 (en) 1995-09-13
DE69311130T2 (de) 1997-09-18
EP0668851A1 (en) 1995-08-30
NO2006007I1 (no) 2006-08-14
RO118712B1 (ro) 2003-09-30
DK0668851T3 (da) 1997-12-22
HUT71903A (en) 1996-02-28
BG99609A (bg) 1996-01-31
MD921G2 (ro) 1998-10-31
WO1994011332A1 (en) 1994-05-26
HU9802850D0 (en) 1999-02-01
AU5421094A (en) 1994-06-08
ES2058024B1 (es) 1995-05-01
US5554789A (en) 1996-09-10
FI952230A0 (sv) 1995-05-09
AU674040B2 (en) 1996-12-05
ES2081780T1 (es) 1996-03-16
GR960300012T1 (en) 1996-03-31
BR9307408A (pt) 1999-08-24
HU9501375D0 (en) 1995-06-28
FI952230A (sv) 1995-05-09

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