FI105812B - Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmistamiseksi Download PDF

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Publication number
FI105812B
FI105812B FI931667A FI931667A FI105812B FI 105812 B FI105812 B FI 105812B FI 931667 A FI931667 A FI 931667A FI 931667 A FI931667 A FI 931667A FI 105812 B FI105812 B FI 105812B
Authority
FI
Finland
Prior art keywords
alkyl
indole
aryl
ylmethyl
hydrogen
Prior art date
Application number
FI931667A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI931667A (fi
FI931667A0 (fi
Inventor
Martin James Wythes
John Eugene Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24393510&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI105812(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of FI931667A publication Critical patent/FI931667A/fi
Publication of FI931667A0 publication Critical patent/FI931667A0/fi
Application granted granted Critical
Publication of FI105812B publication Critical patent/FI105812B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lasers (AREA)
  • Electroluminescent Light Sources (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI931667A 1990-10-15 1993-04-14 Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmistamiseksi FI105812B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US59792890A 1990-10-15 1990-10-15
US59792890 1990-10-15
PCT/US1991/007194 WO1992006973A1 (en) 1990-10-15 1991-10-08 Indole derivatives
US9107194 1991-10-08

Publications (3)

Publication Number Publication Date
FI931667A FI931667A (fi) 1993-04-14
FI931667A0 FI931667A0 (fi) 1993-04-14
FI105812B true FI105812B (fi) 2000-10-13

Family

ID=24393510

Family Applications (1)

Application Number Title Priority Date Filing Date
FI931667A FI105812B (fi) 1990-10-15 1993-04-14 Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmistamiseksi

Country Status (33)

Country Link
EP (1) EP0592438B1 (pl)
JP (2) JP2575272B2 (pl)
KR (1) KR0179053B1 (pl)
CN (1) CN1039322C (pl)
AT (1) ATE157361T1 (pl)
AU (1) AU651637B2 (pl)
BG (1) BG61975B1 (pl)
BR (2) BR9106978A (pl)
CA (1) CA2091562C (pl)
DE (3) DE9190141U1 (pl)
DK (1) DK0592438T5 (pl)
EG (1) EG20224A (pl)
ES (1) ES2104733T3 (pl)
FI (1) FI105812B (pl)
GR (1) GR3025087T3 (pl)
HU (2) HU225055B1 (pl)
IE (1) IE913555A1 (pl)
IL (3) IL115117A (pl)
LU (1) LU90902I2 (pl)
MX (1) MX9101606A (pl)
MY (1) MY111683A (pl)
NL (1) NL300070I2 (pl)
NO (3) NO305121B1 (pl)
NZ (2) NZ240217A (pl)
OA (1) OA09874A (pl)
PL (3) PL168919B1 (pl)
PT (1) PT99218B (pl)
RO (1) RO111767B1 (pl)
RU (1) RU2095360C1 (pl)
SG (1) SG54270A1 (pl)
WO (1) WO1992006973A1 (pl)
YU (1) YU48088B (pl)
ZA (1) ZA918156B (pl)

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* Cited by examiner, † Cited by third party
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US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
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US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
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TW288010B (pl) * 1992-03-05 1996-10-11 Pfizer
US5747501A (en) * 1992-04-07 1998-05-05 Pfizer, Inc. Indole derivatives
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UA34452C2 (uk) * 1992-04-10 2001-03-15 Пфайзер Інк. Похідні ациламіноіндолу, що проявляють серотонінову 5-нт1 агоністичну активність та похідні аміноіндолу як проміжні сполуки
GB9208161D0 (en) * 1992-04-14 1992-05-27 Pfizer Ltd Indoles
GB9210400D0 (en) * 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
TW251284B (pl) * 1992-11-02 1995-07-11 Pfizer
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1271352B (it) * 1993-04-08 1997-05-27 Boehringer Ingelheim Italia Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
CA2157397C (en) * 1993-04-22 1999-07-06 Martin James Wythes Indole derivatives as 5-ht1-like agonists for use in migraine
AP486A (en) * 1993-04-27 1996-04-16 Pfizer Indole derivatives.
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
CZ59996A3 (en) * 1993-08-31 1996-06-12 Pfizer 5-arylindole derivatives per se and for treating diseases, intermediates for their preparation and pharmaceutical compositions based thereon
CA2195850A1 (en) * 1994-08-03 1996-02-15 Guillaume Lebaut Substituted indoles
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
EP0804433B1 (en) * 1994-10-12 2002-09-18 Pfizer Limited Indole derivative for the treatment of migraine
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
AU726560B2 (en) * 1994-10-12 2000-11-09 Pfizer Research And Development Company, N.V./S.A. Use of indole derivatives for the treatment of various diseases
GB9424471D0 (en) * 1994-12-03 1995-01-18 Pfizer Ltd Treatment of emesis
JPH11502816A (ja) * 1995-03-20 1999-03-09 イーライ・リリー・アンド・カンパニー ５−置換−３−（１，２，３，６−テトラヒドロピリジン−４−イル）−および３−（ピペリジン−４−イル）−１ｈ−インドール類：新規５−ｈｔ▲下１ｆ▼アゴニスト
GB9510223D0 (en) * 1995-05-20 1995-07-19 Pfizer Ltd Therapeutic agent
US5945118A (en) * 1995-09-29 1999-08-31 Pfizer Inc Indole derivative for the treatment of migraine
GB9714383D0 (en) * 1997-07-08 1997-09-10 Pfizer Ltd Improved process
WO1999053956A1 (fr) * 1998-04-16 1999-10-28 Yamanouchi Pharmaceutical Co., Ltd. Remedes contre l'obesite
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US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
GB9825988D0 (en) 1998-11-27 1999-01-20 Pfizer Ltd Indole derivatives
GB9922963D0 (en) * 1999-09-28 1999-12-01 Pfizer Ltd Polymorphic salt
JP2000336074A (ja) 1999-03-24 2000-12-05 Sumitomo Chem Co Ltd ［２−（アリールスルホニル）エテニル］ベンゼン誘導体の製造方法
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
KR20020035857A (ko) * 1999-08-26 2002-05-15 후지야마 아키라 인돌 유도체 또는 그의 염의 제조방법
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FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
US20030166704A1 (en) 2000-12-20 2003-09-04 Pfizer Inc. New process
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US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
ES2453164T3 (es) 2001-08-15 2014-04-04 Pharmacia & Upjohn Company Llc Cristales que incluyen una sal de ácido málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida, procedimientos para su preparación y sus composiciones
US7132549B2 (en) 2003-05-30 2006-11-07 Pfizer Inc. Process
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US20070065463A1 (en) 2003-06-20 2007-03-22 Ronald Aung-Din Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
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US7645786B2 (en) 2005-06-15 2010-01-12 Pfizer Inc. Substituted arylpyrazoles
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JP2011526889A (ja) 2008-06-30 2011-10-20 アフギン ファーマ，エルエルシー 局所局部的神経作用療法
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US8754239B2 (en) 2010-01-19 2014-06-17 Sms Pharmaceuticals Limited Process for preparing eletriptan hydrobromide having α-form
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WO2014063752A1 (en) 2012-10-26 2014-05-01 Synthon Bv Process for making crystalline form alpha of eletriptan hydrobromide
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CN103408535B (zh) * 2013-08-13 2016-03-02 张家港威胜生物医药有限公司 一种依来曲普坦中间体-5-溴-3-(n-甲基吡咯啉-2-基甲基)-1h-吲哚合成工艺
BR112017018944A2 (pt) 2015-03-02 2018-05-15 Afgin Pharma Llc método de tratamento de um estado ou condição de doença em humanos com um medicamento carbinóide, e, método de tratamento de um estado ou condição de doença em um mamífero diferente de um humano com medicamento(s) carbinóide(s)
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
JP2019502761A (ja) 2016-01-21 2019-01-31 ラボラトリオス レヴィ エセエレ （（ｒ）−３−［（−１−メチルピロリジン−２−イル）メチル］−５−（２−フェニルスルホニルエチル）−１ｈ−インドールを作製する方法
CN106065008B (zh) * 2016-06-16 2018-06-05 黑龙江中医药大学 一种具有改善睡眠作用的吲哚-2-酰胺类化合物及其应用
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
TR201616365A1 (tr) 2016-11-14 2018-05-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Deksketoprofen ve eletri̇ptanin oral farmasöti̇k kompozi̇syonlari
TR201619983A2 (tr) 2016-12-29 2018-07-23 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Di̇klofenak ve eletri̇ptanin farmasöti̇k formülasyonlari
KR102129947B1 (ko) 2018-06-08 2020-07-03 김종창 콘크리트 타설을 위한 입체형 와이어 메쉬
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Also Published As

Publication number Publication date
RO111767B1 (ro) 1997-01-30
YU48088B (sh) 1997-01-08
BR1100080A (pt) 2000-06-06
DE10299004I1 (de) 2002-05-08
NO931378D0 (no) 1993-04-14
IL115117A (en) 1996-11-14
IL99701A0 (en) 1992-08-18
AU8950491A (en) 1992-05-20
EP0592438A1 (en) 1994-04-20
BG97632A (bg) 1994-03-31
DK0592438T5 (da) 1999-12-06
PT99218B (pt) 1999-04-30
DE10299004I2 (de) 2006-03-16
NO305121B1 (no) 1999-04-06
NL300070I1 (nl) 2002-02-01
PL169987B1 (en) 1996-09-30
HU9301098D0 (en) 1993-07-28
MX9101606A (es) 1992-06-05
SG54270A1 (en) 1998-11-16
CN1039322C (zh) 1998-07-29
IL115117A0 (en) 1995-12-08
DE69127468T2 (de) 1998-01-02
PL170330B1 (pl) 1996-11-29
WO1992006973A1 (en) 1992-04-30
JPH093063A (ja) 1997-01-07
IL99701A (en) 1996-10-31
CA2091562C (en) 2001-03-27
EP0592438B1 (en) 1997-08-27
CN1062529A (zh) 1992-07-08
YU165391A (sh) 1994-01-20
JP2575272B2 (ja) 1997-01-22
NO931378L (no) 1993-04-14
MY111683A (en) 2000-11-30
HU225055B1 (en) 2006-05-29
KR0179053B1 (ko) 1999-03-20
NO985607L (no) 1998-12-01
ATE157361T1 (de) 1997-09-15
DK0592438T3 (da) 1997-09-29
FI931667A (fi) 1993-04-14
AU651637B2 (en) 1994-07-28
DE69127468D1 (de) 1997-10-02
OA09874A (en) 1994-09-15
NO2001019I1 (no) 2001-12-03
BG61975B1 (bg) 1998-11-30
PL168919B1 (pl) 1996-05-31
LU90902I2 (fr) 2002-06-26
BR9106978A (pt) 1993-09-28
EG20224A (en) 1997-12-31
CA2091562A1 (en) 1992-04-16
ES2104733T3 (es) 1997-10-16
PT99218A (pt) 1992-09-30
NO985607D0 (no) 1998-12-01
NZ240217A (en) 1995-05-26
NL300070I2 (nl) 2002-03-01
NZ270675A (en) 1997-07-27
IE913555A1 (en) 1992-04-22
JPH05507288A (ja) 1993-10-21
DE9190141U1 (de) 1993-07-15
RU2095360C1 (ru) 1997-11-10
ZA918156B (en) 1993-04-14
FI931667A0 (fi) 1993-04-14
GR3025087T3 (en) 1998-01-30
HUT64326A (en) 1993-12-28
JP2677777B2 (ja) 1997-11-17

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