FI103043B1 - Menetelmä uusien, terapeuttisesti käyttökelpoisten 8-vinyyli- ja 8-etynyylikinolonikarboksyylihappojohdannaisten valmistamiseksi sekä menetelmässä käyttökelpoiset välituotteet - Google Patents
Menetelmä uusien, terapeuttisesti käyttökelpoisten 8-vinyyli- ja 8-etynyylikinolonikarboksyylihappojohdannaisten valmistamiseksi sekä menetelmässä käyttökelpoiset välituotteetInfo
- Publication number
- FI103043B1 FI103043B1 FI923268A FI923268A FI103043B1 FI 103043 B1 FI103043 B1 FI 103043B1 FI 923268 A FI923268 A FI 923268A FI 923268 A FI923268 A FI 923268A FI 103043 B1 FI103043 B1 FI 103043B1
- Authority
- FI
- Finland
- Prior art keywords
- vinyl
- preparation
- useful
- ethynylquinolone
- carboxylic acid
- Prior art date
Links
- BWKNVUWKBKUASR-UHFFFAOYSA-N 8-ethynyl-2-oxo-1h-quinoline-3-carboxylic acid Chemical class C1=CC(C#C)=C2NC(=O)C(C(=O)O)=CC2=C1 BWKNVUWKBKUASR-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 229920002554 vinyl polymer Polymers 0.000 title 1
- 239000003674 animal food additive Substances 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Paints Or Removers (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI970312A FI970312A7 (fi) | 1991-07-19 | 1992-07-16 | 8-halogeenikinoliinikarboksyylihappojohdannaiset |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4123918 | 1991-07-19 | ||
| DE4123918A DE4123918A1 (de) | 1991-07-19 | 1991-07-19 | 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI923268A0 FI923268A0 (fi) | 1992-07-16 |
| FI923268L FI923268L (fi) | 1993-01-20 |
| FI103043B FI103043B (fi) | 1999-04-15 |
| FI103043B1 true FI103043B1 (fi) | 1999-04-15 |
Family
ID=6436512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI923268A FI103043B1 (fi) | 1991-07-19 | 1992-07-16 | Menetelmä uusien, terapeuttisesti käyttökelpoisten 8-vinyyli- ja 8-etynyylikinolonikarboksyylihappojohdannaisten valmistamiseksi sekä menetelmässä käyttökelpoiset välituotteet |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0523512B1 (cs) |
| JP (1) | JP3174405B2 (cs) |
| KR (1) | KR100240608B1 (cs) |
| AT (1) | ATE147733T1 (cs) |
| AU (1) | AU658901B2 (cs) |
| CA (1) | CA2073993A1 (cs) |
| CZ (1) | CZ282037B6 (cs) |
| DE (2) | DE4123918A1 (cs) |
| DK (1) | DK0523512T3 (cs) |
| ES (1) | ES2097835T3 (cs) |
| FI (1) | FI103043B1 (cs) |
| GR (1) | GR3022305T3 (cs) |
| HU (1) | HU219910B (cs) |
| IE (1) | IE80557B1 (cs) |
| IL (1) | IL102520A (cs) |
| MX (1) | MX9204110A (cs) |
| NO (1) | NO302886B1 (cs) |
| PL (1) | PL171910B1 (cs) |
| RU (1) | RU2077533C1 (cs) |
| SK (1) | SK219192A3 (cs) |
| TW (1) | TW201309B (cs) |
| ZA (1) | ZA925351B (cs) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4121214A1 (de) * | 1991-06-27 | 1993-01-14 | Bayer Ag | 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate |
| DE4230804A1 (de) * | 1992-09-15 | 1994-03-17 | Bayer Ag | 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate |
| DE4303657A1 (de) * | 1993-02-09 | 1994-08-11 | Bayer Ag | Neue Chinolon- und Naphthyridoncarbonsäurederivate |
| KR950018003A (ko) * | 1993-12-09 | 1995-07-22 | 스미스클라인 비참 피엘씨 | 신규한 퀴놀론 유도체 및 그의 제조 방법 |
| DE4418510A1 (de) * | 1994-05-27 | 1995-11-30 | Bayer Ag | 1,9-überbrückte Thiazolol[3,4-a]chinolinderivate |
| DE4425659A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Neue N1-diverse 6-Fluor-8-difluormethoxy substituierte Chinoloncarbonsäuren |
| DE4427530A1 (de) * | 1994-08-04 | 1996-02-08 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäure-Derivate |
| EP0882049B1 (de) * | 1996-02-23 | 2002-11-20 | Bayer Ag | Gegebenenfalls substituierte 8-cyan-1-cyclopropyl-7-(2,8-diazabicyclo- 4.3.0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäuren und ihre derivate |
| PT897919E (pt) | 1996-04-19 | 2004-11-30 | Wakunaga Pharma Co Ltd | Novos derivados do acido piridonacarboxilico ou seus sais e agentes anti-bacterianos contendo-os como ingrediente activo |
| AU1040597A (en) * | 1996-12-04 | 1998-06-29 | Daiichi Pharmaceutical Co., Ltd. | Substituted aminomethylpyrrolidine derivatives |
| NZ503740A (en) | 1997-09-15 | 2002-09-27 | Procter & Gamble | Antimicrobial quinolones, their compositions and uses |
| JP4639149B2 (ja) | 2003-09-10 | 2011-02-23 | 杏林製薬株式会社 | ７−（４−置換−３−シクロプロピルアミノメチル−１−ピロリジニル）キノロンカルボン酸誘導体 |
| US7563805B2 (en) * | 2005-05-19 | 2009-07-21 | Daiichi Pharmaceutical Co., Ltd. | Tri-, tetra-substituted-3-aminopyrrolidine derivative |
| RU2420524C2 (ru) * | 2005-05-19 | 2011-06-10 | Дайити Санкио Компани, Лимитед | Производные три- или тетра-замещенного-3-аминопирролидина |
| WO2007037303A1 (ja) * | 2005-09-28 | 2007-04-05 | Daiichi Sankyo Company, Limited | テトラ置換－５－アザスピロ[２．４]へプタン誘導体の製法およびその光学活性中間体 |
| EP1999125A2 (en) | 2006-03-28 | 2008-12-10 | The Procter and Gamble Company | A coupling process for preparing quinolone intermediates |
| NZ570494A (en) | 2006-03-28 | 2011-09-30 | Warner Chilcott Co Llc | Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid |
| JP5322927B2 (ja) | 2007-05-24 | 2013-10-23 | 杏林製薬株式会社 | １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 |
| CA3099610A1 (en) * | 2018-05-09 | 2019-11-14 | Bayer Animal Health Gmbh | New quinoline derivatives |
| RU2757741C1 (ru) * | 2021-03-01 | 2021-10-21 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | Производное ципрофлоксацина, обладающее антибактериальной активностью в отношении антибиотикоустойчивых штаммов микроорганизмов |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4123536A (en) * | 1977-12-14 | 1978-10-31 | Warner-Lambert Company | Dialkyl ({[3-(alkoxycarbonyl)-1,4-dihydro-4-oxo-8-quinolinyl]amino}methylene)propanedioates |
| DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
| JPS62215572A (ja) * | 1986-03-17 | 1987-09-22 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
| US5047538A (en) * | 1990-04-12 | 1991-09-10 | Warner-Lambert Company | Quinolinecarboxylic acid antibacterial agents |
-
1991
- 1991-07-19 DE DE4123918A patent/DE4123918A1/de not_active Withdrawn
-
1992
- 1992-06-26 TW TW081105031A patent/TW201309B/zh active
- 1992-07-03 NO NO922639A patent/NO302886B1/no not_active IP Right Cessation
- 1992-07-06 DK DK92111454.2T patent/DK0523512T3/da active
- 1992-07-06 ES ES92111454T patent/ES2097835T3/es not_active Expired - Lifetime
- 1992-07-06 DE DE59207880T patent/DE59207880D1/de not_active Expired - Fee Related
- 1992-07-06 EP EP92111454A patent/EP0523512B1/de not_active Expired - Lifetime
- 1992-07-06 AT AT92111454T patent/ATE147733T1/de not_active IP Right Cessation
- 1992-07-13 SK SK2191-92A patent/SK219192A3/sk unknown
- 1992-07-13 CZ CS922191A patent/CZ282037B6/cs not_active IP Right Cessation
- 1992-07-14 MX MX9204110A patent/MX9204110A/es not_active IP Right Cessation
- 1992-07-14 AU AU19663/92A patent/AU658901B2/en not_active Ceased
- 1992-07-16 CA CA002073993A patent/CA2073993A1/en not_active Abandoned
- 1992-07-16 IL IL102520A patent/IL102520A/xx not_active IP Right Cessation
- 1992-07-16 FI FI923268A patent/FI103043B1/fi active IP Right Grant
- 1992-07-17 JP JP21245092A patent/JP3174405B2/ja not_active Expired - Fee Related
- 1992-07-17 HU HU9202349A patent/HU219910B/hu not_active IP Right Cessation
- 1992-07-17 PL PL92295331A patent/PL171910B1/pl unknown
- 1992-07-17 RU SU925052410A patent/RU2077533C1/ru active
- 1992-07-17 IE IE922348A patent/IE80557B1/en not_active IP Right Cessation
- 1992-07-17 ZA ZA925351A patent/ZA925351B/xx unknown
- 1992-07-18 KR KR1019920012826A patent/KR100240608B1/ko not_active Expired - Fee Related
-
1997
- 1997-01-16 GR GR970400065T patent/GR3022305T3/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Owner name: BAYER AKTIENGESELLSCHAFT |