ATE66453T1 - Herstellung von zwischenverbindungen fuer leukotrien-antagonisten. - Google Patents

Herstellung von zwischenverbindungen fuer leukotrien-antagonisten.

Info

Publication number
ATE66453T1
ATE66453T1 AT88305444T AT88305444T ATE66453T1 AT E66453 T1 ATE66453 T1 AT E66453T1 AT 88305444 T AT88305444 T AT 88305444T AT 88305444 T AT88305444 T AT 88305444T AT E66453 T1 ATE66453 T1 AT E66453T1
Authority
AT
Austria
Prior art keywords
antagonists
leukotrian
production
intermediate compounds
dihydroxyphenones
Prior art date
Application number
AT88305444T
Other languages
English (en)
Inventor
Winston Stanley Marshall
Sandra Kay Sigmund
Celia Ann Whitesitt
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE66453T1 publication Critical patent/ATE66453T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT88305444T 1987-06-19 1988-06-15 Herstellung von zwischenverbindungen fuer leukotrien-antagonisten. ATE66453T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6490087A 1987-06-19 1987-06-19
EP88305444A EP0295882B1 (de) 1987-06-19 1988-06-15 Herstellung von Zwischenverbindungen für Leukotrien-Antagonisten

Publications (1)

Publication Number Publication Date
ATE66453T1 true ATE66453T1 (de) 1991-09-15

Family

ID=22058969

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88305444T ATE66453T1 (de) 1987-06-19 1988-06-15 Herstellung von zwischenverbindungen fuer leukotrien-antagonisten.

Country Status (10)

Country Link
EP (1) EP0295882B1 (de)
JP (1) JPS6416740A (de)
KR (1) KR960002601B1 (de)
AT (1) ATE66453T1 (de)
CA (1) CA1300170C (de)
DE (1) DE3864324D1 (de)
ES (1) ES2029019T3 (de)
GR (1) GR3002593T3 (de)
HU (1) HU202814B (de)
IL (1) IL86748A (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100383215B1 (ko) * 2000-09-25 2003-05-12 한국생명공학연구원 신균주 ｍｔ90049(ｋｃｔｃ 18043ｐ)와 이 균주로부터생산된 신규 화합물과 신규 화합물의 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661505A (en) * 1982-11-03 1987-04-28 Eli Lilly And Company Leukotriene antagonists
EP0167286A1 (de) * 1984-06-04 1986-01-08 Celanese Corporation Verfahren zur Herstellung von 4-Hydroxyacetophenon

Also Published As

Publication number Publication date
IL86748A0 (en) 1988-11-30
HU202814B (en) 1991-04-29
ES2029019T3 (es) 1992-07-16
CA1300170C (en) 1992-05-05
EP0295882A1 (de) 1988-12-21
JPS6416740A (en) 1989-01-20
EP0295882B1 (de) 1991-08-21
KR890000390A (ko) 1989-03-14
KR960002601B1 (ko) 1996-02-23
HUT47235A (en) 1989-02-28
GR3002593T3 (en) 1993-01-25
IL86748A (en) 1992-06-21
DE3864324D1 (de) 1991-09-26

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee