FI103043B1 - Process for the preparation of novel therapeutically useful 8-vinyl and 8-ethynylquinolone carboxylic acid derivatives and intermediates useful in the process - Google Patents

Process for the preparation of novel therapeutically useful 8-vinyl and 8-ethynylquinolone carboxylic acid derivatives and intermediates useful in the process

Info

Publication number
FI103043B1
FI103043B1 FI923268A FI923268A FI103043B1 FI 103043 B1 FI103043 B1 FI 103043B1 FI 923268 A FI923268 A FI 923268A FI 923268 A FI923268 A FI 923268A FI 103043 B1 FI103043 B1 FI 103043B1
Authority
FI
Finland
Prior art keywords
vinyl
preparation
useful
ethynylquinolone
carboxylic acid
Prior art date
Application number
FI923268A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI923268A0 (en
FI103043B (en
FI923268A (en
Inventor
Uwe Petersen
Thomas Himmler
Thomas Schenke
Andreas Krebs
Klaus Grohe
Klaus-Dieter Bremm
Karl Georg Metzger
Rainer Endermann
Hans-Joachim Zeiler
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI923268A0 publication Critical patent/FI923268A0/en
Publication of FI923268A publication Critical patent/FI923268A/en
Priority to FI970312A priority Critical patent/FI970312A0/en
Application granted granted Critical
Publication of FI103043B1 publication Critical patent/FI103043B1/en
Publication of FI103043B publication Critical patent/FI103043B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paints Or Removers (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)

Abstract

The invention relates to novel 8-vinyl- and 8-ethynyl- quinolonecarboxylic acids, a process for their preparation and antibacterial agents and feed additives containing them.
FI923268A 1991-07-19 1992-07-16 Process for the preparation of novel therapeutically useful 8-vinyl and 8-ethynylquinolone carboxylic acid derivatives and intermediates useful in the process FI103043B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI970312A FI970312A0 (en) 1991-07-19 1997-01-24 8-halogenkinolinkarboxylsyraderivat

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4123918A DE4123918A1 (en) 1991-07-19 1991-07-19 8-VINYL AND 8-ETHINYL-CHINOLON CARBONIC ACIDS
DE4123918 1991-07-19

Publications (4)

Publication Number Publication Date
FI923268A0 FI923268A0 (en) 1992-07-16
FI923268A FI923268A (en) 1993-01-20
FI103043B1 true FI103043B1 (en) 1999-04-15
FI103043B FI103043B (en) 1999-04-15

Family

ID=6436512

Family Applications (1)

Application Number Title Priority Date Filing Date
FI923268A FI103043B (en) 1991-07-19 1992-07-16 Process for the preparation of novel therapeutically useful 8-vinyl and 8-ethynylquinolone carboxylic acid derivatives and intermediates useful in the process

Country Status (22)

Country Link
EP (1) EP0523512B1 (en)
JP (1) JP3174405B2 (en)
KR (1) KR100240608B1 (en)
AT (1) ATE147733T1 (en)
AU (1) AU658901B2 (en)
CA (1) CA2073993A1 (en)
CZ (1) CZ282037B6 (en)
DE (2) DE4123918A1 (en)
DK (1) DK0523512T3 (en)
ES (1) ES2097835T3 (en)
FI (1) FI103043B (en)
GR (1) GR3022305T3 (en)
HU (1) HU219910B (en)
IE (1) IE80557B1 (en)
IL (1) IL102520A (en)
MX (1) MX9204110A (en)
NO (1) NO302886B1 (en)
PL (1) PL171910B1 (en)
RU (1) RU2077533C1 (en)
SK (1) SK219192A3 (en)
TW (1) TW201309B (en)
ZA (1) ZA925351B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121214A1 (en) * 1991-06-27 1993-01-14 Bayer Ag 7-AZAISOINDOLINYL CHINOLONE AND NAPHTHYRIDONE CARBONIC ACID DERIVATIVES
DE4230804A1 (en) * 1992-09-15 1994-03-17 Bayer Ag 7-isoindolinyl quinolone and naphthyridone derivatives
DE4303657A1 (en) * 1993-02-09 1994-08-11 Bayer Ag New quinolone and naphthyridonecarboxylic acid derivatives
KR950018003A (en) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 Novel quinolone derivatives and methods for their preparation
DE4418510A1 (en) * 1994-05-27 1995-11-30 Bayer Ag 1,9-bridged thiazolol [3,4-a] quinoline derivatives
DE4425659A1 (en) * 1994-07-20 1996-01-25 Bayer Ag New N1-diverse 6-fluoro-8-difluoromethoxy substituted quinolonecarboxylic acids
DE4427530A1 (en) * 1994-08-04 1996-02-08 Bayer Ag New 7-tri:cyclic amino-quinolone or naphthyridone derivs
ATE269320T1 (en) * 1996-04-19 2004-07-15 Wakunaga Pharma Co Ltd NEW PYRIDONE CARBOXYLIC ACID DERIVATIVES OR SALTS OF THESE DERIVATIVES AND ANTIBACTERIAL AGENTS CONTAINING THEM AS THE ACTIVE INGREDIENTS
AU1040597A (en) * 1996-12-04 1998-06-29 Daiichi Pharmaceutical Co., Ltd. Substituted aminomethylpyrrolidine derivatives
TR200001435T2 (en) 1997-09-15 2000-08-21 The Procter & Gamble Company Antimicrobial quinolones, their combinations and uses
US7514451B2 (en) 2003-09-10 2009-04-07 Kyorin Pharmaceutical Co., Ltd. 7-(4-Substituted-3-cyclopropylaminomethyl-1 pyrrolidinyl) quinolonecarboxylic acid derivative
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
WO2007037303A1 (en) * 2005-09-28 2007-04-05 Daiichi Sankyo Company, Limited Process for preparation of tetrasubstituted 5-azaspiro[2.4]- heptane derivatives and optically active intermediates thereof
JP5097967B2 (en) 2006-03-28 2012-12-12 タイゲン バイオテクノロジー カンパニー，リミテッド Malates and (3S, 5S) -7- [3-amino-5-methyl-piperidinyl] -1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid Polymorphs of
KR20110082635A (en) 2006-03-28 2011-07-19 워너 칠콧 컴퍼니 엘엘씨 A coupling process for preparing quinolone intermediates
US8222407B2 (en) 2007-05-24 2012-07-17 Kyorin Pharmaceutical Co., Ltd. Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
SG11202010024UA (en) * 2018-05-09 2020-11-27 Bayer Animal Health Gmbh New quinoline derivatives
RU2757741C1 (en) * 2021-03-01 2021-10-21 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Ciprofloxacin derivative with antibacterial activity against antibiotic-resistant strains of microorganisms

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123536A (en) * 1977-12-14 1978-10-31 Warner-Lambert Company Dialkyl ({[3-(alkoxycarbonyl)-1,4-dihydro-4-oxo-8-quinolinyl]amino}methylene)propanedioates
DE3705621C2 (en) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclic substituted quinolonecarboxylic acid derivatives
JPS62215572A (en) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd Quinolone carboxylic acid derivative
US5047538A (en) * 1990-04-12 1991-09-10 Warner-Lambert Company Quinolinecarboxylic acid antibacterial agents

Also Published As

Publication number Publication date
RU2077533C1 (en) 1997-04-20
KR930002320A (en) 1993-02-22
SK279221B6 (en) 1998-08-05
TW201309B (en) 1993-03-01
HU9202349D0 (en) 1992-10-28
MX9204110A (en) 1993-08-01
AU1966392A (en) 1993-01-21
NO302886B1 (en) 1998-05-04
HUT61741A (en) 1993-03-01
ATE147733T1 (en) 1997-02-15
CZ219192A3 (en) 1993-02-17
DE4123918A1 (en) 1993-01-21
CA2073993A1 (en) 1993-01-20
ZA925351B (en) 1993-04-28
PL295331A1 (en) 1993-07-12
IE922348A1 (en) 1993-01-27
NO922639L (en) 1993-01-20
DE59207880D1 (en) 1997-02-27
ES2097835T3 (en) 1997-04-16
FI923268A0 (en) 1992-07-16
CZ282037B6 (en) 1997-04-16
EP0523512B1 (en) 1997-01-15
PL171910B1 (en) 1997-06-30
GR3022305T3 (en) 1997-04-30
SK219192A3 (en) 1998-08-05
IL102520A0 (en) 1993-01-14
HU219910B (en) 2001-09-28
JP3174405B2 (en) 2001-06-11
FI103043B (en) 1999-04-15
IE80557B1 (en) 1998-09-23
EP0523512A1 (en) 1993-01-20
KR100240608B1 (en) 2000-03-02
FI923268A (en) 1993-01-20
JPH05262738A (en) 1993-10-12
DK0523512T3 (en) 1997-06-30
AU658901B2 (en) 1995-05-04
IL102520A (en) 1997-07-13
NO922639D0 (en) 1992-07-03

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Owner name: BAYER AKTIENGESELLSCHAFT