ES8705461A1 - Procedimiento para la obtencion de nuevos compuestos este- roides - Google Patents
Procedimiento para la obtencion de nuevos compuestos este- roidesInfo
- Publication number
- ES8705461A1 ES8705461A1 ES544770A ES544770A ES8705461A1 ES 8705461 A1 ES8705461 A1 ES 8705461A1 ES 544770 A ES544770 A ES 544770A ES 544770 A ES544770 A ES 544770A ES 8705461 A1 ES8705461 A1 ES 8705461A1
- Authority
- ES
- Spain
- Prior art keywords
- analogues
- alpha
- group
- oriented
- open ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
- C07J21/003—Lactones at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/007—3 membered carbocyclic rings in position 6-7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA OBTENER NUEVOS COMPUESTOS DE ESTEROIDES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON METILURO DE DIMETILSULFONIO, EN BENCENO, A PRESION NORMAL Y ENTRE 0J Y EL PUNTO DE EBULLICION DE LA MEZCLA DE REACCION, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDO, SIENDO: A-A, EL GRUPO CH2-CH2 O CHFCH; R1 Y R2 SON UN RESTO A O B; B-B, EL GRUPO CH2-CH2 O A O B ORIENTADO; X ES DOS ATOMOS DE H U OXO; E Y1 E Y2 FORMAN UN PUENTE OXIGENO, HIDROXILO O ALCOXI. TIENEN UTILIDAD COMO DIURETICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH198183 | 1983-04-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8705461A1 true ES8705461A1 (es) | 1987-05-01 |
ES544770A0 ES544770A0 (es) | 1987-05-01 |
Family
ID=4223123
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES531517A Granted ES531517A0 (es) | 1983-04-13 | 1984-04-11 | Procedimiento para la obtencion de nuevos compuestos esteroides |
ES544770A Expired ES8705461A1 (es) | 1983-04-13 | 1985-07-01 | Procedimiento para la obtencion de nuevos compuestos este- roides |
ES544768A Expired ES8705459A1 (es) | 1983-04-13 | 1985-07-01 | Procedimiento para la obtencion de nuevos compuestos este- roides |
ES544769A Expired ES8705460A1 (es) | 1983-04-13 | 1985-07-01 | Procedimiento para la obtencion de nuevos compuestos este- roides |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES531517A Granted ES531517A0 (es) | 1983-04-13 | 1984-04-11 | Procedimiento para la obtencion de nuevos compuestos esteroides |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES544768A Expired ES8705459A1 (es) | 1983-04-13 | 1985-07-01 | Procedimiento para la obtencion de nuevos compuestos este- roides |
ES544769A Expired ES8705460A1 (es) | 1983-04-13 | 1985-07-01 | Procedimiento para la obtencion de nuevos compuestos este- roides |
Country Status (23)
Country | Link |
---|---|
US (1) | US4559332A (es) |
EP (1) | EP0122232B1 (es) |
JP (1) | JPS59231100A (es) |
AR (4) | AR241918A1 (es) |
AT (1) | ATE39256T1 (es) |
AU (1) | AU565017B2 (es) |
CA (1) | CA1220781A (es) |
DD (2) | DD233375A5 (es) |
DE (2) | DE3475622D1 (es) |
DK (1) | DK163988C (es) |
ES (4) | ES531517A0 (es) |
FI (1) | FI77669C (es) |
GR (1) | GR81834B (es) |
HU (1) | HU191406B (es) |
IE (1) | IE57541B1 (es) |
IL (1) | IL71504A (es) |
LU (1) | LU91072I2 (es) |
NL (1) | NL300144I2 (es) |
NO (1) | NO159800C (es) |
NZ (1) | NZ207826A (es) |
PH (1) | PH19997A (es) |
PT (1) | PT78413B (es) |
ZA (1) | ZA842710B (es) |
Families Citing this family (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4670551A (en) * | 1984-06-21 | 1987-06-02 | Ciba-Geigy Corporation | Epoxy steroids |
US5248807A (en) * | 1991-01-29 | 1993-09-28 | Shionogi & Co., Ltd. | Triterpene derivatives |
US6150347A (en) * | 1992-04-21 | 2000-11-21 | The Curators Of The University Of Missouri | Use of aldosterone antagonists to inhibit myocardial fibrosis |
US6245755B1 (en) | 1992-04-21 | 2001-06-12 | Curators Of The Unversity Of Missouri | Use of aldosterone antagonists to inhibit myocardial fibrosis |
JPH05329410A (ja) * | 1992-05-29 | 1993-12-14 | Sekisui Plastics Co Ltd | マスキング材 |
US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
US6262277B1 (en) * | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
PT831910E (pt) * | 1995-06-07 | 2002-05-31 | Searle & Co | Terapia de combinacao a base de um antagonista epoxi-esteroidal de aldosterona e um antagonista de angiotensina ii para o tratamento de ataque cardiaco congestivo |
AU6039296A (en) * | 1995-06-07 | 1996-12-30 | G.D. Searle & Co. | Method to treat cardiofibrosis with a combination therapy of an angiotensin ii antagonist and an epoxy-steroidal aldoste rone antagonist |
US20020038021A1 (en) * | 1995-12-11 | 2002-03-28 | Barton Kathleen P. | Eplerenone crystalline form exhibiting enhanced dissolution rate |
US20020045746A1 (en) * | 1995-12-11 | 2002-04-18 | Barton Kathleen P. | Eplerenone crystalline form |
US20050159594A1 (en) * | 1995-12-11 | 2005-07-21 | Pharmacia Corporation | Eplerenone crystal form exhibiting enhanced dissolution rate |
EP1170299A3 (en) * | 1995-12-11 | 2004-11-10 | G.D. Searle & Co. | Intermediates useful in the preparation of 9,11-epoxy steroids and methods for their production |
AU747959B2 (en) * | 1995-12-11 | 2002-05-30 | G.D. Searle & Co. | Processes and intermediates for the preparation of 9, 11-epoxy steroids |
US20050267302A1 (en) * | 1995-12-11 | 2005-12-01 | G.D. Searle & Co. | Eplerenone crystalline form exhibiting enhanced dissolution rate |
DE69637140T2 (de) | 1995-12-11 | 2008-04-10 | G.D. Searle Llc, Chicago | Verfahren zur herstellung einer epoxy-verbindung |
DE69716116T2 (de) | 1996-12-11 | 2003-09-04 | Searle & Co | VERFAHREN ZUR HERSTELLUNG VON 3-KETO-7alpha-ALKOXYCARBONYL- delta4,5-STEROIDEN SOWIE ZWISCHENPRODUKTE |
US6887991B1 (en) | 1996-12-11 | 2005-05-03 | G. D. Searle & Company | Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein |
EP1223174A3 (en) * | 1996-12-11 | 2005-03-16 | G.D. Searle & Co. | Processes for preparation of 3-keto-7alpha-alkoxycarbonyl-delta-4,5- steroids and intermediates useful therein |
US6368835B1 (en) * | 1998-05-29 | 2002-04-09 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing a lactone using corynebacterium sp. NK-1 (FERM BP-6329) |
CZ20011590A3 (cs) * | 1998-11-06 | 2003-01-15 | G. D. Searle & Co. | Léčivo pro léčení kardiovaskulárních poruch a kompozice s obsahem inhibitoru enzymu konvertujícího angiotensin, antagonisty aldosteronu, kličkového diuretika a digoxinu |
UA74141C2 (uk) * | 1998-12-09 | 2005-11-15 | Дж.Д. Сірл Енд Ко. | Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти) |
US6489366B1 (en) | 1998-12-23 | 2002-12-03 | G. D. Searle, Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
WO2000038725A1 (en) * | 1998-12-23 | 2000-07-06 | G.D. Searle Llc | Combinations for cardiovascular indications |
ES2203239T3 (es) | 1998-12-23 | 2004-04-01 | G.D. Searle Llc | Combinaciones de inhibidores de la proteina de transferencia de ester de colesterilo y de agentes secuestrantes de acidos biliares para indicaciones cardiovasculares. |
IL143947A0 (en) * | 1998-12-23 | 2002-04-21 | Searle Llc | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications |
JP2002533414A (ja) * | 1998-12-23 | 2002-10-08 | ジー.ディー.サール エルエルシー | 心臓血管に適用するための回腸胆汁酸輸送阻害剤および胆汁酸隔離剤の組み合わせ |
NZ512536A (en) | 1998-12-23 | 2003-11-28 | G | Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications |
US6462091B1 (en) | 1998-12-23 | 2002-10-08 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications |
AU776664B2 (en) | 1998-12-23 | 2004-09-16 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
US20030096798A1 (en) * | 1999-11-09 | 2003-05-22 | Williams Gordon H. | Methods for the treatment or prophylaxis of aldosterone-mediated pathogenic effects in a subject using an epoxy-steroidal aldosterone antagonist |
US20030203884A1 (en) * | 1999-11-09 | 2003-10-30 | Pharmacia Corporation | Methods for the treatment or prophylaxis of aldosterone-mediated pathogenic effects in a subject using an epoxy-steroidal aldosterone antagonist |
EP1527782A1 (en) * | 1999-12-08 | 2005-05-04 | Pharmacia Corporation | Nanoparticulate eplerenone compositions |
JP2003516414A (ja) * | 1999-12-08 | 2003-05-13 | ファルマシア コーポレイション | より高い溶解速度を示すエプレレノン結晶形 |
DE60019741T2 (de) * | 1999-12-08 | 2006-03-02 | Pharmacia Corp., Chicago | Nanopartikelzusammensetzungen enthaltend eplerenon |
EP1505072A3 (en) * | 1999-12-08 | 2006-06-21 | Pharmacia Corporation | Eplerenone crystalline form exhiniting enhanced dissolution rate |
US20030083493A1 (en) * | 1999-12-08 | 2003-05-01 | Barton Kathleen P. | Eplerenone drug substance having high phase purity |
EP1175434A2 (en) * | 1999-12-08 | 2002-01-30 | Pharmacia Corporation | Eplerenone crystalline form |
US6794544B2 (en) | 2000-03-10 | 2004-09-21 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
US20020061888A1 (en) * | 2000-03-10 | 2002-05-23 | Keller Bradley T. | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
CA2409437A1 (en) * | 2000-05-11 | 2001-11-22 | Pharmacia Corporation | Aldosterone antagonist composition for release during aldosterone acrophase |
AU1604001A (en) * | 2000-06-13 | 2001-12-24 | Pharmacia Corp | Use of an aldosterone antagonist for the treatment or prohpylaxis of aldosterone-mediated pathogenic effects |
US20020123485A1 (en) * | 2000-07-27 | 2002-09-05 | Alexander John C. | Epoxy steroidal aldosterone antagonist and beta-adrenergic antagonist combination therapy for treatment of congestive heart failure |
US6716829B2 (en) | 2000-07-27 | 2004-04-06 | Pharmacia Corporation | Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders |
AU2001285318A1 (en) * | 2000-08-28 | 2002-03-13 | Pharmacia Corporation | Use of an aldosterone receptor antagonist to improve cognitive function |
WO2002046386A2 (en) * | 2000-10-30 | 2002-06-13 | Pharmacia Corporation | Aspergillus ochraceus 11 alpha hydroxylase and oxidoreductase |
CN100408099C (zh) * | 2000-11-09 | 2008-08-06 | 阿斯特拉曾尼卡有限公司 | 含有嵌段共聚物的口服药物组合物 |
US8168616B1 (en) | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
US20040077625A1 (en) * | 2001-07-25 | 2004-04-22 | Tremont Samuel J. | Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake |
US20030220310A1 (en) * | 2001-07-27 | 2003-11-27 | Schuh Joseph R. | Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure |
JP2005518347A (ja) * | 2001-11-02 | 2005-06-23 | ジー.ディー. サール エルエルシー | 頂端ナトリウム共依存性胆汁酸輸送(asbt)およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物 |
IL162475A0 (en) | 2001-12-12 | 2005-11-20 | Pharmacia Corp | Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists |
MXPA04006255A (es) | 2002-01-17 | 2004-09-27 | Pharmacia Corp | Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato. |
KR20040091141A (ko) * | 2002-03-18 | 2004-10-27 | 파마시아 코포레이션 | 알도스테론 수용체 길항물질 및 니코틴산 또는 니코틴산유도체의 혼합물 |
MXPA04009039A (es) * | 2002-03-18 | 2005-01-25 | Pharmacia Corp | Combinacion de un antagonista de los receptores de la aldosterona y un agente secuestrante de los acidos biliares. |
MXPA04009037A (es) * | 2002-03-20 | 2005-01-25 | Pharmacia Corp | Formulacion de eplerenona de almacenamiento estable. |
EP1490390A2 (en) * | 2002-03-22 | 2004-12-29 | Pharmacia Corporation | C-17 spirolactonization and 6,7 oxidation of steroids |
US7235655B2 (en) * | 2002-03-22 | 2007-06-26 | Pharmacia & Upjohn Company | Processes to prepare eplerenone |
US20070066579A1 (en) * | 2002-08-16 | 2007-03-22 | White Michael J | 5-androsten-3beta-ol steroid intermediates and processs for their preparation |
DE60308388T2 (de) * | 2002-08-16 | 2007-09-20 | Pharmacia & Upjohn Co. Llc, Kalamazoo | 5-Androsten-3beta-ol-Steroide und Verfahren für ihre Herstellung |
TW200407150A (en) * | 2002-11-06 | 2004-05-16 | Upjohn Co | Processes for preparing 7- carboxy substituted steroids |
EP1562974B1 (en) * | 2002-11-07 | 2007-02-21 | Pharmacia & Upjohn Company LLC | Processes for preparing c-7 substituted 5-androstenes |
CL2004000545A1 (es) * | 2003-03-18 | 2005-01-28 | Pharmacia Corp Sa Organizada B | Uso de un antagonista de los receptores de aldosterona y un antagonista de receptores de endotelina para el tratamiento o profilaxis de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopatia y enfermedades cardiovascul |
CL2004000544A1 (es) * | 2003-03-18 | 2005-01-28 | Pharmacia Corp Sa Organizada B | Uso de una combinacion farmaceutica, de un antagonista del receptor de aldosterona y un inhibidor de endopeptidasa neutral, util para el tratamiento y prevencion de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopati |
CL2004000574A1 (es) * | 2003-03-21 | 2005-02-11 | Pharmacia Corp Sa Organizada B | Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion. |
US20040266743A1 (en) * | 2003-05-09 | 2004-12-30 | Pharmacia Corporation | Combination of an aldosterone receptor antagonist and a renin inhibitor |
US20040265948A1 (en) * | 2003-06-27 | 2004-12-30 | White Michael Jon | Microbial method for hydrolysis and oxidation of androst-5-ene and pregn-5-ene steroid esters |
GB0327839D0 (en) | 2003-12-01 | 2003-12-31 | Novartis Ag | Organic compounds |
AR049479A1 (es) * | 2004-03-22 | 2006-08-09 | Pharmacia & Upjohn Co Llc | Proceso mejorado para la preparacion de 9,11-epoxi esteroides |
US20070196471A1 (en) * | 2004-04-02 | 2007-08-23 | Thosar Shilpa S | Micronized Eplerenone Compositions |
US20050232957A1 (en) * | 2004-04-14 | 2005-10-20 | Katz Kenneth A | Compositions and methods for moisturizing skin |
CN1321128C (zh) * | 2005-07-15 | 2007-06-13 | 浙江医药股份有限公司新昌制药厂 | 孕甾-4-烯-7,21-二甲酸,9,11-环氧-17-羟基-3-氧代,γ-内酯,甲酯,(7α,11α,17α)-的制备方法 |
WO2007025780A2 (en) * | 2005-09-02 | 2007-03-08 | Recordati Ireland Limited | Aldosterone receptor antagonists |
EP1842543A1 (en) | 2006-04-05 | 2007-10-10 | Speedel Pharma AG | Pharmaceutical composition coprising an aldosterone synthase inhibitor and a mineralcorticoid receptor antagonist |
US20070248665A1 (en) * | 2006-04-24 | 2007-10-25 | Sherman Bernard C | Compositions comprising co-precipitate of eplerenone and a water-soluble excipient |
DE102006028032A1 (de) * | 2006-06-14 | 2007-12-20 | Henkel Kgaa | Aufhell- und/oder Färbemittel mit Nitrilen |
US20100086586A1 (en) * | 2006-12-21 | 2010-04-08 | Brett Antony Mooney | Pharmaceutical Composition |
CA2582496A1 (en) * | 2007-03-20 | 2008-09-20 | Apotex Pharmachem Inc. | Improved process for the preparation and purification of eplerenone |
FR2917975B1 (fr) | 2007-06-26 | 2009-10-16 | Ceva Sante Animale Sa | Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains |
DE102008026793A1 (de) * | 2008-06-02 | 2009-12-03 | Bayer Schering Pharma Aktiengesellschaft | C-Ring-substituierte Pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate |
CN101863951B (zh) * | 2009-04-15 | 2012-06-06 | 浙江省天台县奥锐特药业有限公司 | 依普利酮的制备方法 |
MX2011012627A (es) | 2009-05-28 | 2011-12-14 | Novartis Ag | Derivados aminobutiricos sustituidos como inhibidores de nepralisina. |
EP2594557B1 (en) | 2009-05-28 | 2016-08-10 | Novartis AG | Substituted aminopropionic derivatives as neprilysin inhibitors |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
EP2533799B8 (en) * | 2010-02-08 | 2019-12-25 | Shenzhen Evergreen Therapeutics Co., Ltd. | Methods for the use of progestogen as a glucocorticoid sensitizer |
US8957052B2 (en) | 2010-05-10 | 2015-02-17 | Universite Paris Descartes | Methods and compositions for the treatment of fluid accumulation in and/or under the retina |
JP6180930B2 (ja) | 2010-06-16 | 2017-08-16 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 創傷治癒過程における再上皮化を刺激するための方法及び組成物 |
TR201007653A2 (tr) | 2010-09-20 | 2012-04-24 | Bi̇lgi̇ç Mahmut | Eplerenon içeren farmasötik kompozisyon |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
WO2012107513A1 (en) * | 2011-02-10 | 2012-08-16 | Crystal Pharma, S.A.U. | Process for obtaining drospirenone |
ITMI20121037A1 (it) * | 2012-06-14 | 2013-12-15 | Ind Chimica Srl | Processo per la preparazione di nitrili utili come intermedi per la sintesi di molecole ad attivita' farmacologica |
CN105073762B (zh) | 2013-02-14 | 2017-03-08 | 诺华股份有限公司 | 作为nep(中性内肽酶)抑制剂的取代的联苯丁酰膦酸衍生物 |
CN104262450A (zh) * | 2014-09-19 | 2015-01-07 | 江苏嘉逸医药有限公司 | 依普利酮的制备及精制方法 |
US9562068B2 (en) | 2014-10-17 | 2017-02-07 | Industriale Chimica, S.R.L. | Process for the preparation of 7 α-(methoxycarbonyl)-3-OXO-17alpha-pregn-4,9(11)-dien-21,17-carbolactone, a useful intermediate for the synthesis of molecules with pharmacological activity |
WO2017055248A1 (en) | 2015-09-28 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of heart failure |
ES2846835T3 (es) | 2015-10-13 | 2021-07-29 | Inst Nat Sante Rech Med | Métodos y composiciones farmacéuticas para el tratamiento de la neovascularización coroidea |
CN105753930A (zh) * | 2016-03-30 | 2016-07-13 | 北京万全德众医药生物技术有限公司 | 依普利酮的一种合成方法 |
EP3490606B8 (en) | 2016-07-26 | 2024-04-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis |
JOP20190086A1 (ar) | 2016-10-21 | 2019-04-18 | Novartis Ag | مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
WO2023031277A1 (en) | 2021-08-31 | 2023-03-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of ocular rosacea |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3095412A (en) * | 1961-12-19 | 1963-06-25 | Searle & Co | 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs |
GB1041534A (en) * | 1963-04-24 | 1966-09-07 | Merck & Co Inc | 20-spiroxane compounds |
US3729491A (en) * | 1970-06-15 | 1973-04-24 | Searle & Co | 3,5-dioxo-a-nor-b-homo steroidal spirolactones |
GB1368006A (en) * | 1972-08-24 | 1974-09-25 | Searle & Co | 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone |
US3849404A (en) * | 1973-03-09 | 1974-11-19 | Searle & Co | Purification of 6,7-dihydro-17-hydroxy-3-oxo-3'h-cyclopropa(6,7)-17alpha-pregna-4,6-diene-21-carboxylic acid gamma-lactones |
DE2652761C2 (de) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
DE2922500A1 (de) * | 1979-05-31 | 1980-12-04 | Schering Ag | 6 beta .7 beta |
DE3111951A1 (de) * | 1981-03-23 | 1982-09-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel |
-
1984
- 1984-04-09 FI FI841400A patent/FI77669C/fi not_active IP Right Cessation
- 1984-04-09 US US06/598,109 patent/US4559332A/en not_active Expired - Lifetime
- 1984-04-10 LU LU91072C patent/LU91072I2/fr unknown
- 1984-04-10 DE DE8484810179T patent/DE3475622D1/de not_active Expired
- 1984-04-10 EP EP84810179A patent/EP0122232B1/de not_active Expired
- 1984-04-10 AT AT84810179T patent/ATE39256T1/de not_active IP Right Cessation
- 1984-04-11 ES ES531517A patent/ES531517A0/es active Granted
- 1984-04-11 GR GR74371A patent/GR81834B/el unknown
- 1984-04-11 DD DD84276211A patent/DD233375A5/de not_active IP Right Cessation
- 1984-04-11 DD DD84261867A patent/DD251144A5/de not_active IP Right Cessation
- 1984-04-11 IL IL71504A patent/IL71504A/xx not_active IP Right Cessation
- 1984-04-11 CA CA000451691A patent/CA1220781A/en not_active Expired
- 1984-04-12 IE IE906/84A patent/IE57541B1/en active Protection Beyond IP Right Term
- 1984-04-12 PT PT78413A patent/PT78413B/pt unknown
- 1984-04-12 PH PH30539A patent/PH19997A/en unknown
- 1984-04-12 HU HU841435A patent/HU191406B/hu unknown
- 1984-04-12 ZA ZA842710A patent/ZA842710B/xx unknown
- 1984-04-12 NZ NZ207826A patent/NZ207826A/en unknown
- 1984-04-12 DK DK189484A patent/DK163988C/da active Protection Beyond IP Right Term
- 1984-04-12 AU AU26853/84A patent/AU565017B2/en not_active Expired
- 1984-04-12 NO NO841465A patent/NO159800C/no not_active IP Right Cessation
- 1984-04-12 JP JP59071900A patent/JPS59231100A/ja active Granted
- 1984-04-13 AR AR84296305A patent/AR241918A1/es active
-
1985
- 1985-07-01 ES ES544770A patent/ES8705461A1/es not_active Expired
- 1985-07-01 ES ES544768A patent/ES8705459A1/es not_active Expired
- 1985-07-01 ES ES544769A patent/ES8705460A1/es not_active Expired
-
1986
- 1986-08-01 AR AR86305012A patent/AR242223A1/es active
- 1986-08-21 AR AR86305013A patent/AR242221A1/es active
- 1986-08-21 AR AR86305011A patent/AR242222A1/es active
-
2004
- 2004-03-25 NL NL300144C patent/NL300144I2/nl unknown
- 2004-04-08 DE DE200412000012 patent/DE122004000012I1/de active Granted
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8705460A1 (es) | Procedimiento para la obtencion de nuevos compuestos este- roides | |
HU9202615D0 (en) | Method for producing new 1-acyl-piperidine derivatives | |
ES8401498A1 (es) | Procedimiento de preparacion de nuevos derivados esteroides sustituidos en 11b. | |
MY103365A (en) | 4-demethoxy-4-amino-anthracyclines | |
NZ312303A (en) | Novel nor-pregnanes for inducing hypothalamic effects | |
KR910004653A (ko) | 스테로이드 5-α-환원효소의 억제제로서의 7-케토 또는 히드록시 3,5-디엔 스테로이드 | |
ES2003200A6 (es) | Un procedimiento para la preparacion de esteroides aminoglicosidicos. | |
ES8605535A1 (es) | Procedimiento para la preparacion de 6,6-etilen-15,16-meti- len-3-oxo-17&-pregn-4-en-21,17-carbolactonas | |
MY100512A (en) | New 6-or 7-methlenandrosta-1, 4-diene-3, 17-dione derivatives and process for their preparation. | |
ES8707737A1 (es) | Procedimiento para la obtencion de una 9 l 11 l epoxiesteroide | |
ES2003201A6 (es) | Un procedimiento para la preparacion de esteroides aminoglicosidicos. | |
ES8106914A1 (es) | Procedimiento para la preparacion de nuevos derivados de amino-14 esteroides. | |
ES2003198A6 (es) | Un procedimiento para la preparacion de esteroides aminoglicosidicos. | |
DK420985A (da) | Fremgangsmaade til fremstilling af pregnanderivater | |
IL154828A0 (en) | 17alpha FLUOROALKYL STEROIDS, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS | |
BG99313A (en) | 117-alkylketonesteroids as 5- -reductase inhibitors | |
GB1498239A (en) | Quaternary salts of d-homosteroids | |
WILKINS et al. | Jr., ROSEMBERG, E., and MIGEON, CJ (1951). J. clin. Endocrin., 11, 1. ZAFFARONI, A., HECHTER, O., and PINCUS, G.(1951). J. Amer. chem. | |
IE850128L (en) | Guanidine derivatives | |
ES8200703A1 (es) | Procedimiento para la preparacion de 1-hidroxi-esteroides | |
GB1469223A (en) | Azidocarbonic acid esters of steroids | |
TW343976B (en) | 17-substituted steroids useful in cancer treatment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC1A | Transfer granted | ||
FD1A | Patent lapsed |
Effective date: 20070122 |