AR242223A1 - Procedimiento para la obtencion de nuevos 20-espiroxanos y compuestos analogos con anillo e abierto conteniendo oxigeno. - Google Patents
Procedimiento para la obtencion de nuevos 20-espiroxanos y compuestos analogos con anillo e abierto conteniendo oxigeno.Info
- Publication number
- AR242223A1 AR242223A1 AR86305012A AR30501286A AR242223A1 AR 242223 A1 AR242223 A1 AR 242223A1 AR 86305012 A AR86305012 A AR 86305012A AR 30501286 A AR30501286 A AR 30501286A AR 242223 A1 AR242223 A1 AR 242223A1
- Authority
- AR
- Argentina
- Prior art keywords
- spiroxanes
- analogues
- preparation
- pharmaceutical compositions
- open ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
- C07J21/003—Lactones at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/007—3 membered carbocyclic rings in position 6-7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH198183 | 1983-04-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR242223A1 true AR242223A1 (es) | 1993-03-31 |
Family
ID=4223123
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR84296305A AR241918A1 (es) | 1983-04-13 | 1984-04-13 | Procedimiento para obtener 20-spiroxanos y compuestos analogos de ciclo e abierto. |
AR86305012A AR242223A1 (es) | 1983-04-13 | 1986-08-01 | Procedimiento para la obtencion de nuevos 20-espiroxanos y compuestos analogos con anillo e abierto conteniendo oxigeno. |
AR86305011A AR242222A1 (es) | 1983-04-13 | 1986-08-21 | Procedimiento para la obtencion de nuevos 20-espiroxanos y compuestos analogos con anillo ''e'' abierto, conteniendo oxigeno |
AR86305013A AR242221A1 (es) | 1983-04-13 | 1986-08-21 | Procedimiento para la obtencion de nuevos 20-espiroxanos y compuestos analogos con anillo e abierto conteniendo oxigeno. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR84296305A AR241918A1 (es) | 1983-04-13 | 1984-04-13 | Procedimiento para obtener 20-spiroxanos y compuestos analogos de ciclo e abierto. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR86305011A AR242222A1 (es) | 1983-04-13 | 1986-08-21 | Procedimiento para la obtencion de nuevos 20-espiroxanos y compuestos analogos con anillo ''e'' abierto, conteniendo oxigeno |
AR86305013A AR242221A1 (es) | 1983-04-13 | 1986-08-21 | Procedimiento para la obtencion de nuevos 20-espiroxanos y compuestos analogos con anillo e abierto conteniendo oxigeno. |
Country Status (23)
Country | Link |
---|---|
US (1) | US4559332A (es) |
EP (1) | EP0122232B1 (es) |
JP (1) | JPS59231100A (es) |
AR (4) | AR241918A1 (es) |
AT (1) | ATE39256T1 (es) |
AU (1) | AU565017B2 (es) |
CA (1) | CA1220781A (es) |
DD (2) | DD251144A5 (es) |
DE (2) | DE3475622D1 (es) |
DK (1) | DK163988C (es) |
ES (4) | ES8602846A1 (es) |
FI (1) | FI77669C (es) |
GR (1) | GR81834B (es) |
HU (1) | HU191406B (es) |
IE (1) | IE57541B1 (es) |
IL (1) | IL71504A (es) |
LU (1) | LU91072I2 (es) |
NL (1) | NL300144I2 (es) |
NO (1) | NO159800C (es) |
NZ (1) | NZ207826A (es) |
PH (1) | PH19997A (es) |
PT (1) | PT78413B (es) |
ZA (1) | ZA842710B (es) |
Families Citing this family (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4670551A (en) * | 1984-06-21 | 1987-06-02 | Ciba-Geigy Corporation | Epoxy steroids |
ATE164588T1 (de) * | 1991-01-29 | 1998-04-15 | Shionogi & Co | Triterpenderivat |
US6245755B1 (en) | 1992-04-21 | 2001-06-12 | Curators Of The Unversity Of Missouri | Use of aldosterone antagonists to inhibit myocardial fibrosis |
US6150347A (en) * | 1992-04-21 | 2000-11-21 | The Curators Of The University Of Missouri | Use of aldosterone antagonists to inhibit myocardial fibrosis |
JPH05329410A (ja) * | 1992-05-29 | 1993-12-14 | Sekisui Plastics Co Ltd | マスキング材 |
US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
US6262277B1 (en) * | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
AU6039296A (en) * | 1995-06-07 | 1996-12-30 | G.D. Searle & Co. | Method to treat cardiofibrosis with a combination therapy of an angiotensin ii antagonist and an epoxy-steroidal aldoste rone antagonist |
CZ297975B6 (cs) * | 1995-06-07 | 2007-05-09 | G. D. Searle & Co. | Farmaceutická kombinace antagonisty receptoru proangiotensin II a epoxymexrenonu pro lécení kardiovaskulárních poruch |
US20050159594A1 (en) * | 1995-12-11 | 2005-07-21 | Pharmacia Corporation | Eplerenone crystal form exhibiting enhanced dissolution rate |
EP1167381A3 (en) * | 1995-12-11 | 2004-09-29 | G.D. Searle & Co. | Process for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and Intermediates useful therein |
WO1997021720A2 (en) * | 1995-12-11 | 1997-06-19 | G.D. Searle And Co. | Processes for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and intermediates useful therein and a general process for the epoxidation of olifinic double bonds |
US20020045746A1 (en) * | 1995-12-11 | 2002-04-18 | Barton Kathleen P. | Eplerenone crystalline form |
US20020038021A1 (en) * | 1995-12-11 | 2002-03-28 | Barton Kathleen P. | Eplerenone crystalline form exhibiting enhanced dissolution rate |
AU747959B2 (en) * | 1995-12-11 | 2002-05-30 | G.D. Searle & Co. | Processes and intermediates for the preparation of 9, 11-epoxy steroids |
US20050267302A1 (en) * | 1995-12-11 | 2005-12-01 | G.D. Searle & Co. | Eplerenone crystalline form exhibiting enhanced dissolution rate |
CN100369927C (zh) | 1996-12-11 | 2008-02-20 | G·D·瑟尔公司 | 9,11-环氧甾族化合物和其中有用的中间体的制备方法 |
US6887991B1 (en) * | 1996-12-11 | 2005-05-03 | G. D. Searle & Company | Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein |
EP1223174A3 (en) * | 1996-12-11 | 2005-03-16 | G.D. Searle & Co. | Processes for preparation of 3-keto-7alpha-alkoxycarbonyl-delta-4,5- steroids and intermediates useful therein |
WO1999062347A1 (fr) * | 1998-05-29 | 1999-12-09 | Kyowa Hakko Kogyo Co., Ltd. | Procede de production d'assaisonnements liquides ayant la saveur de legumes marines dans une pate de son de riz salee |
CN1330556A (zh) * | 1998-11-06 | 2002-01-09 | G·D·西尔公司 | 血管紧张肽-转化酶抑制剂和醛固酮拮抗剂用于降低心血管疾病的发病率和死亡率的联合疗法 |
UA74141C2 (uk) * | 1998-12-09 | 2005-11-15 | Дж.Д. Сірл Енд Ко. | Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти) |
EA005815B1 (ru) * | 1998-12-23 | 2005-06-30 | Джи.Ди.Сирл Ллс | Комбинация ингибиторов транспорта желчных кислот в подвздошной кишке и ингибиторов белка, переносящего эфиры холестерина, для сердечно-сосудистых показаний |
EP1140187B1 (en) * | 1998-12-23 | 2003-09-03 | G.D. Searle LLC. | Combinations of an ibat inhibitor and a mtp inhibitor for cardiovascular indications |
PL348609A1 (en) | 1998-12-23 | 2002-06-03 | Searle Llc | Combinations of ileal bile acid transport inhibitors and bile acid sequestring agents for cardiovascular indications |
US6462091B1 (en) | 1998-12-23 | 2002-10-08 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications |
DK1140189T3 (da) * | 1998-12-23 | 2003-09-15 | Searle Llc | Kombinationer af ileal galdesyre-transportinhibitorer og fibrinsyrederivater til cardiovaskulære indikationer |
ES2203239T3 (es) | 1998-12-23 | 2004-04-01 | G.D. Searle Llc | Combinaciones de inhibidores de la proteina de transferencia de ester de colesterilo y de agentes secuestrantes de acidos biliares para indicaciones cardiovasculares. |
CA2356157C (en) | 1998-12-23 | 2008-04-01 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
US6489366B1 (en) | 1998-12-23 | 2002-12-03 | G. D. Searle, Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
US20030096798A1 (en) * | 1999-11-09 | 2003-05-22 | Williams Gordon H. | Methods for the treatment or prophylaxis of aldosterone-mediated pathogenic effects in a subject using an epoxy-steroidal aldosterone antagonist |
US20030203884A1 (en) * | 1999-11-09 | 2003-10-30 | Pharmacia Corporation | Methods for the treatment or prophylaxis of aldosterone-mediated pathogenic effects in a subject using an epoxy-steroidal aldosterone antagonist |
NZ513962A (en) * | 1999-12-08 | 2004-08-27 | Pharmacia Corp | Eplerenone crystalline form |
US20030083493A1 (en) * | 1999-12-08 | 2003-05-01 | Barton Kathleen P. | Eplerenone drug substance having high phase purity |
KR100607923B1 (ko) * | 1999-12-08 | 2006-08-04 | 파마시아 코포레이션 | 증가된 용해 속도를 나타내는 결정형 에플레레논 |
ES2240209T3 (es) * | 1999-12-08 | 2005-10-16 | Pharmacia Corporation | Composiciones de eplerenona nanoparticulada. |
EP1505072A3 (en) * | 1999-12-08 | 2006-06-21 | Pharmacia Corporation | Eplerenone crystalline form exhiniting enhanced dissolution rate |
EP1527782A1 (en) * | 1999-12-08 | 2005-05-04 | Pharmacia Corporation | Nanoparticulate eplerenone compositions |
WO2001068096A2 (en) * | 2000-03-10 | 2001-09-20 | Pharmacia Corporation | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
AU2001240115A1 (en) | 2000-03-10 | 2001-09-24 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
EP1280533A2 (en) * | 2000-05-11 | 2003-02-05 | Pharmacia Corporation | Aldosterone antagonist composition for release during aldosterone acrophase |
AU1604001A (en) * | 2000-06-13 | 2001-12-24 | Pharmacia Corp | Use of an aldosterone antagonist for the treatment or prohpylaxis of aldosterone-mediated pathogenic effects |
US20020123485A1 (en) * | 2000-07-27 | 2002-09-05 | Alexander John C. | Epoxy steroidal aldosterone antagonist and beta-adrenergic antagonist combination therapy for treatment of congestive heart failure |
US6716829B2 (en) | 2000-07-27 | 2004-04-06 | Pharmacia Corporation | Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders |
ATE306272T1 (de) * | 2000-08-28 | 2005-10-15 | Pharmacia Corp | Verwendung von einem aldosteron-rezeptor- antagonisten zur verbesserung der kognitiven funktion |
AU2002241768A1 (en) * | 2000-10-30 | 2002-06-18 | Pharmacia Corporation | Aspergillus ochraceus 11 alpha hydroxylase and oxidoreductase |
CN100408099C (zh) * | 2000-11-09 | 2008-08-06 | 阿斯特拉曾尼卡有限公司 | 含有嵌段共聚物的口服药物组合物 |
US8168616B1 (en) | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
US20040077625A1 (en) * | 2001-07-25 | 2004-04-22 | Tremont Samuel J. | Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake |
US20030220310A1 (en) * | 2001-07-27 | 2003-11-27 | Schuh Joseph R. | Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure |
CA2464685A1 (en) * | 2001-11-02 | 2003-05-15 | G.D. Searle Llc | Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake |
AU2002346721A1 (en) * | 2001-12-12 | 2003-06-23 | Pharmacia Corporation | Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists |
MXPA04006255A (es) | 2002-01-17 | 2004-09-27 | Pharmacia Corp | Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato. |
WO2003080068A1 (en) * | 2002-03-18 | 2003-10-02 | Pharmacia Corporation | Combination of an aldosterone receptor antagonist and nicotinic acid or a nicotinic acid derivative |
CA2479259A1 (en) * | 2002-03-18 | 2003-10-02 | Pharmacia Corporation | Combination of an aldosterone receptor antagonist and a bile acid sequestering agent |
BR0308475A (pt) * | 2002-03-20 | 2005-01-11 | Pharmacia Corp | Formulação de eplerenona estável na armazenagem |
US7235655B2 (en) * | 2002-03-22 | 2007-06-26 | Pharmacia & Upjohn Company | Processes to prepare eplerenone |
JP2005523306A (ja) * | 2002-03-22 | 2005-08-04 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | エプレレノンの製法 |
JP2006507369A (ja) * | 2002-08-16 | 2006-03-02 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 5−アンドロステン−3β−オールステロイド中間体およびそれらの製法 |
US20070066579A1 (en) * | 2002-08-16 | 2007-03-22 | White Michael J | 5-androsten-3beta-ol steroid intermediates and processs for their preparation |
EP1560841A1 (en) * | 2002-11-06 | 2005-08-10 | Pharmacia & Upjohn Company LLC | Processes for preparing 7-carboxy substituted steroids |
RU2289586C2 (ru) * | 2002-11-07 | 2006-12-20 | Фармация Энд Апджон Компани Ллс | Способ получения 7-замещенных стероидных соединений, соединения, способы получения эплеренона, продукт |
CL2004000545A1 (es) * | 2003-03-18 | 2005-01-28 | Pharmacia Corp Sa Organizada B | Uso de un antagonista de los receptores de aldosterona y un antagonista de receptores de endotelina para el tratamiento o profilaxis de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopatia y enfermedades cardiovascul |
CL2004000544A1 (es) * | 2003-03-18 | 2005-01-28 | Pharmacia Corp Sa Organizada B | Uso de una combinacion farmaceutica, de un antagonista del receptor de aldosterona y un inhibidor de endopeptidasa neutral, util para el tratamiento y prevencion de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopati |
CL2004000574A1 (es) * | 2003-03-21 | 2005-02-11 | Pharmacia Corp Sa Organizada B | Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion. |
US20040266743A1 (en) * | 2003-05-09 | 2004-12-30 | Pharmacia Corporation | Combination of an aldosterone receptor antagonist and a renin inhibitor |
US20040265948A1 (en) * | 2003-06-27 | 2004-12-30 | White Michael Jon | Microbial method for hydrolysis and oxidation of androst-5-ene and pregn-5-ene steroid esters |
GB0327839D0 (en) | 2003-12-01 | 2003-12-31 | Novartis Ag | Organic compounds |
EP1730164A1 (en) * | 2004-03-22 | 2006-12-13 | Pharmacia & Upjohn Company LLC | Improved process for the preparation of 9,11 epoxy steroids |
US20070196471A1 (en) * | 2004-04-02 | 2007-08-23 | Thosar Shilpa S | Micronized Eplerenone Compositions |
US20050232957A1 (en) * | 2004-04-14 | 2005-10-20 | Katz Kenneth A | Compositions and methods for moisturizing skin |
CN1321128C (zh) * | 2005-07-15 | 2007-06-13 | 浙江医药股份有限公司新昌制药厂 | 孕甾-4-烯-7,21-二甲酸,9,11-环氧-17-羟基-3-氧代,γ-内酯,甲酯,(7α,11α,17α)-的制备方法 |
WO2007025780A2 (en) * | 2005-09-02 | 2007-03-08 | Recordati Ireland Limited | Aldosterone receptor antagonists |
EP1842543A1 (en) | 2006-04-05 | 2007-10-10 | Speedel Pharma AG | Pharmaceutical composition coprising an aldosterone synthase inhibitor and a mineralcorticoid receptor antagonist |
US20070248665A1 (en) * | 2006-04-24 | 2007-10-25 | Sherman Bernard C | Compositions comprising co-precipitate of eplerenone and a water-soluble excipient |
DE102006028032A1 (de) * | 2006-06-14 | 2007-12-20 | Henkel Kgaa | Aufhell- und/oder Färbemittel mit Nitrilen |
EP2124959A4 (en) * | 2006-12-21 | 2011-09-14 | Alphapharm Pty Ltd | PHARMACEUTICAL COMPOSITION |
CA2582496A1 (en) * | 2007-03-20 | 2008-09-20 | Apotex Pharmachem Inc. | Improved process for the preparation and purification of eplerenone |
FR2917975B1 (fr) | 2007-06-26 | 2009-10-16 | Ceva Sante Animale Sa | Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains |
DE102008026793A1 (de) * | 2008-06-02 | 2009-12-03 | Bayer Schering Pharma Aktiengesellschaft | C-Ring-substituierte Pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate |
CN101863951B (zh) * | 2009-04-15 | 2012-06-06 | 浙江省天台县奥锐特药业有限公司 | 依普利酮的制备方法 |
MA33364B1 (fr) | 2009-05-28 | 2012-06-01 | Novartis Ag | Dérivés aminobutyriques substitués en tant qu'inhibiteurs de néprilysine |
ES2602826T3 (es) | 2009-05-28 | 2017-02-22 | Novartis Ag | Derivados aminobutíricos sustituidos como inhibidores de neprilisina |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
JP5913136B2 (ja) * | 2010-02-08 | 2016-04-27 | プレーリー ファーマシューティカルズ、エルエルシー | 糖質コルチコイド感作物質としてのプロゲストーゲンの使用方法 |
CA2796307A1 (en) | 2010-05-10 | 2011-11-17 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for the treatment of fluid accumulation in and/ or under the retina |
JP6180930B2 (ja) | 2010-06-16 | 2017-08-16 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 創傷治癒過程における再上皮化を刺激するための方法及び組成物 |
TR201007653A2 (tr) | 2010-09-20 | 2012-04-24 | Bi̇lgi̇ç Mahmut | Eplerenon içeren farmasötik kompozisyon |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
WO2012107513A1 (en) * | 2011-02-10 | 2012-08-16 | Crystal Pharma, S.A.U. | Process for obtaining drospirenone |
ITMI20121037A1 (it) * | 2012-06-14 | 2013-12-15 | Ind Chimica Srl | Processo per la preparazione di nitrili utili come intermedi per la sintesi di molecole ad attivita' farmacologica |
AP2015008621A0 (en) | 2013-02-14 | 2015-07-31 | Novartis Ag | Substituted bisphenyl butanoic nep 'neutral endopeptidase' inhibitors |
CN104262450A (zh) * | 2014-09-19 | 2015-01-07 | 江苏嘉逸医药有限公司 | 依普利酮的制备及精制方法 |
US9562068B2 (en) | 2014-10-17 | 2017-02-07 | Industriale Chimica, S.R.L. | Process for the preparation of 7 α-(methoxycarbonyl)-3-OXO-17alpha-pregn-4,9(11)-dien-21,17-carbolactone, a useful intermediate for the synthesis of molecules with pharmacological activity |
WO2017055248A1 (en) | 2015-09-28 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of heart failure |
WO2017064121A1 (en) | 2015-10-13 | 2017-04-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation |
CN105753930A (zh) * | 2016-03-30 | 2016-07-13 | 北京万全德众医药生物技术有限公司 | 依普利酮的一种合成方法 |
US20190262363A1 (en) | 2016-07-26 | 2019-08-29 | INSERM (Institut National de la Santé et de la Recherche Médicale | Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis |
JOP20190086A1 (ar) | 2016-10-21 | 2019-04-18 | Novartis Ag | مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
WO2023031277A1 (en) | 2021-08-31 | 2023-03-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of ocular rosacea |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3095412A (en) * | 1961-12-19 | 1963-06-25 | Searle & Co | 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs |
GB1041534A (en) * | 1963-04-24 | 1966-09-07 | Merck & Co Inc | 20-spiroxane compounds |
US3729491A (en) * | 1970-06-15 | 1973-04-24 | Searle & Co | 3,5-dioxo-a-nor-b-homo steroidal spirolactones |
GB1368006A (en) * | 1972-08-24 | 1974-09-25 | Searle & Co | 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone |
US3849404A (en) * | 1973-03-09 | 1974-11-19 | Searle & Co | Purification of 6,7-dihydro-17-hydroxy-3-oxo-3'h-cyclopropa(6,7)-17alpha-pregna-4,6-diene-21-carboxylic acid gamma-lactones |
DE2652761C2 (de) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
DE2922500A1 (de) * | 1979-05-31 | 1980-12-04 | Schering Ag | 6 beta .7 beta |
DE3111951A1 (de) * | 1981-03-23 | 1982-09-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel |
-
1984
- 1984-04-09 US US06/598,109 patent/US4559332A/en not_active Expired - Lifetime
- 1984-04-09 FI FI841400A patent/FI77669C/fi not_active IP Right Cessation
- 1984-04-10 EP EP84810179A patent/EP0122232B1/de not_active Expired
- 1984-04-10 DE DE8484810179T patent/DE3475622D1/de not_active Expired
- 1984-04-10 LU LU91072C patent/LU91072I2/fr unknown
- 1984-04-10 AT AT84810179T patent/ATE39256T1/de not_active IP Right Cessation
- 1984-04-11 GR GR74371A patent/GR81834B/el unknown
- 1984-04-11 DD DD84261867A patent/DD251144A5/de not_active IP Right Cessation
- 1984-04-11 CA CA000451691A patent/CA1220781A/en not_active Expired
- 1984-04-11 ES ES531517A patent/ES8602846A1/es not_active Expired
- 1984-04-11 IL IL71504A patent/IL71504A/xx not_active IP Right Cessation
- 1984-04-11 DD DD84276211A patent/DD233375A5/de not_active IP Right Cessation
- 1984-04-12 AU AU26853/84A patent/AU565017B2/en not_active Expired
- 1984-04-12 ZA ZA842710A patent/ZA842710B/xx unknown
- 1984-04-12 NO NO841465A patent/NO159800C/no not_active IP Right Cessation
- 1984-04-12 HU HU841435A patent/HU191406B/hu unknown
- 1984-04-12 PH PH30539A patent/PH19997A/en unknown
- 1984-04-12 PT PT78413A patent/PT78413B/pt unknown
- 1984-04-12 NZ NZ207826A patent/NZ207826A/en unknown
- 1984-04-12 IE IE906/84A patent/IE57541B1/en active Protection Beyond IP Right Term
- 1984-04-12 DK DK189484A patent/DK163988C/da active Protection Beyond IP Right Term
- 1984-04-12 JP JP59071900A patent/JPS59231100A/ja active Granted
- 1984-04-13 AR AR84296305A patent/AR241918A1/es active
-
1985
- 1985-07-01 ES ES544769A patent/ES8705460A1/es not_active Expired
- 1985-07-01 ES ES544770A patent/ES8705461A1/es not_active Expired
- 1985-07-01 ES ES544768A patent/ES8705459A1/es not_active Expired
-
1986
- 1986-08-01 AR AR86305012A patent/AR242223A1/es active
- 1986-08-21 AR AR86305011A patent/AR242222A1/es active
- 1986-08-21 AR AR86305013A patent/AR242221A1/es active
-
2004
- 2004-03-25 NL NL300144C patent/NL300144I2/nl unknown
- 2004-04-08 DE DE200412000012 patent/DE122004000012I1/de active Granted
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3475622D1 (en) | 20-spiroxanes and analogues with open ring e, process for their preparation and pharmaceutical compositions | |
DE3461090D1 (en) | 11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them | |
IL72085A (en) | 13alpha-alkylgonanes,processes for their preparation and pharmaceutical compositions containing them | |
GB2140412B (en) | Thiazolidine derivatives, process for the preparation and pharmaceutical compositions thereof | |
IL70756A (en) | 3-amino-pyridazine derivatives,their preparation and pharmaceutical compositions containing them | |
IL73951A0 (en) | 2-phenyl-imidazoles,their preparation and pharmaceutical compositions containing them | |
IL71475A (en) | N-aryl-alpha-amino-carboxamides,their preparation and pharmaceutical compositions containing them | |
IL72151A (en) | Tetrahydropyridazinone derivatives,their preparation and pharmaceutical compositions containing them | |
IL73427A0 (en) | Oxazolidine derivatives,their preparation and pharmaceutical compositions containing them | |
EP0145121A3 (en) | Pyrazoloquinolines, process for their preparation, and pharmaceutical compositions containing them | |
IL70755A (en) | 3-amino-4-cyano-pyridazine derivatives,their preparation and pharmaceutical compositions containing them | |
IL73222A0 (en) | Benzenesulfonyl-lactam derivatives,their preparation and pharmaceutical compositions containing them | |
IL71419A0 (en) | Phenylaminobenzenealkanols,their preparation and pharmaceutical compositions containing them | |
IL72307A (en) | Pyridinyl-2-pyrimidinamines,their preparation and pharmaceutical compositions containing them | |
IL71110A0 (en) | Azolylmethylcycloalkanes,their preparation and pharmaceutical compositions containing them | |
GB2138817B (en) | 4-pheny-tetrahydro-furano-pyridines, process for their preparation, and pharmaceutical compositions containing them | |
IL73776A (en) | N-phenyl-1h-tetrazole-5-carboxamide derivatives,their preparation and pharmaceutical compositions containing them | |
IL73231A0 (en) | 1-acetylaminophenyl-2-amino-propanone derivatives,their preparation and pharmaceutical compositions containing them | |
GB2138422B (en) | Diphenylazomethines, their preparation and pharmaceutical compositions containing them | |
IL73586A0 (en) | Pyrimidoisoquinoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same | |
EP0269298A3 (en) | Cephalosporins, process for their preparation and pharmaceutical compositions | |
IL67332A (en) | Inter-m-phenylene-prostacyclin analogues,process for the preparation thereof and pharmaceutical compositions containing them | |
IL72008A0 (en) | 1-phenoxy-3-hydroxyindolyl-alkylamino-3-propanols,their preparation and pharmaceutical compositions containing them | |
ZA845491B (en) | 1-phenylimidazolidin-2-ones,process for their preparation and pharmaceutical compositions containing them | |
IL72408A0 (en) | 9-anthryloxyaminoalkanes,their preparation and pharmaceutical compositions containing them |