LU91072I2 - Eplerenone et ses sels pharmaceutiquement acceptables - INSPRA - Google Patents

Eplerenone et ses sels pharmaceutiquement acceptables - INSPRA

Info

Publication number
LU91072I2
LU91072I2 LU91072C LU91072C LU91072I2 LU 91072 I2 LU91072 I2 LU 91072I2 LU 91072 C LU91072 C LU 91072C LU 91072 C LU91072 C LU 91072C LU 91072 I2 LU91072 I2 LU 91072I2
Authority
LU
Luxembourg
Prior art keywords
inspra
eplerenone
pharmaceutically acceptable
acceptable salts
salts
Prior art date
Application number
LU91072C
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of LU91072I2 publication Critical patent/LU91072I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/007—3 membered carbocyclic rings in position 6-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
LU91072C 1983-04-13 1984-04-10 Eplerenone et ses sels pharmaceutiquement acceptables - INSPRA LU91072I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH198183 1983-04-13

Publications (1)

Publication Number Publication Date
LU91072I2 true LU91072I2 (fr) 2004-04-07

Family

ID=4223123

Family Applications (1)

Application Number Title Priority Date Filing Date
LU91072C LU91072I2 (fr) 1983-04-13 1984-04-10 Eplerenone et ses sels pharmaceutiquement acceptables - INSPRA

Country Status (23)

Country Link
US (1) US4559332A (fr)
EP (1) EP0122232B1 (fr)
JP (1) JPS59231100A (fr)
AR (4) AR241918A1 (fr)
AT (1) ATE39256T1 (fr)
AU (1) AU565017B2 (fr)
CA (1) CA1220781A (fr)
DD (2) DD251144A5 (fr)
DE (2) DE3475622D1 (fr)
DK (1) DK163988C (fr)
ES (4) ES531517A0 (fr)
FI (1) FI77669C (fr)
GR (1) GR81834B (fr)
HU (1) HU191406B (fr)
IE (1) IE57541B1 (fr)
IL (1) IL71504A (fr)
LU (1) LU91072I2 (fr)
NL (1) NL300144I1 (fr)
NO (1) NO159800C (fr)
NZ (1) NZ207826A (fr)
PH (1) PH19997A (fr)
PT (1) PT78413B (fr)
ZA (1) ZA842710B (fr)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4670551A (en) * 1984-06-21 1987-06-02 Ciba-Geigy Corporation Epoxy steroids
EP0526642B1 (fr) * 1991-01-29 1998-04-01 Shionogi Seiyaku Kabushiki Kaisha Derive de triterpene
US6150347A (en) * 1992-04-21 2000-11-21 The Curators Of The University Of Missouri Use of aldosterone antagonists to inhibit myocardial fibrosis
US6245755B1 (en) 1992-04-21 2001-06-12 Curators Of The Unversity Of Missouri Use of aldosterone antagonists to inhibit myocardial fibrosis
JPH05329410A (ja) * 1992-05-29 1993-12-14 Sekisui Plastics Co Ltd マスキング材
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
RU2166330C2 (ru) * 1995-06-07 2001-05-10 Джи. Ди. Сирл Энд Ко. Комбинация, содержащая антагонист рецептора ангиотензина ii и эпоксистероидный антагонист рецептора альдостерона
AU6039296A (en) * 1995-06-07 1996-12-30 G.D. Searle & Co. Method to treat cardiofibrosis with a combination therapy of an angiotensin ii antagonist and an epoxy-steroidal aldoste rone antagonist
US20050159594A1 (en) * 1995-12-11 2005-07-21 Pharmacia Corporation Eplerenone crystal form exhibiting enhanced dissolution rate
EP1167381A3 (fr) * 1995-12-11 2004-09-29 G.D. Searle & Co. Procédés de préparation de steroides 7.alpha.-carboxylyl 9,11-epoxy et Intermediaires utiles dans ces procédés
US20050267302A1 (en) * 1995-12-11 2005-12-01 G.D. Searle & Co. Eplerenone crystalline form exhibiting enhanced dissolution rate
AU747959B2 (en) * 1995-12-11 2002-05-30 G.D. Searle & Co. Processes and intermediates for the preparation of 9, 11-epoxy steroids
US20020045746A1 (en) * 1995-12-11 2002-04-18 Barton Kathleen P. Eplerenone crystalline form
US20020038021A1 (en) * 1995-12-11 2002-03-28 Barton Kathleen P. Eplerenone crystalline form exhibiting enhanced dissolution rate
DE69637140T2 (de) 1995-12-11 2008-04-10 G.D. Searle Llc, Chicago Verfahren zur herstellung einer epoxy-verbindung
KR100523409B1 (ko) * 1996-12-11 2005-10-24 지.디. 썰 엘엘씨 9,11-에폭시 스테로이드의 제조방법 및 이 제조방법에유용한 중간체
US6887991B1 (en) * 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
ZA9711038B (en) * 1996-12-11 1999-01-25 Searle & Co Spr process for preparation of 9,11-Epoxy steroids and intermediates useful therein
EP1148061B1 (fr) * 1996-12-11 2007-10-17 G.D. Searle LLC. Procédé d'époxydation
JP4334144B2 (ja) * 1998-05-29 2009-09-30 キリン協和フーズ株式会社 糠漬け風味液の製造方法
HK1040056A1 (zh) * 1998-11-06 2002-05-24 G.D. Searle & Co. 血管紧张肽转换酶抑制剂及醛甾䣳对抗物的综合治疗以减低心血管疾病的发病率及死亡率
UA74141C2 (uk) 1998-12-09 2005-11-15 Дж.Д. Сірл Енд Ко. Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти)
WO2000038722A1 (fr) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINAISONS D'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE L'ESTER DE CHOLESTERYLE ET D'INHIBITEURS DE LA HMG CoA-REDUCTASE UTILISEES DANS LE CADRE DE TROUBLES CARDIO-VASCULAIRES
ATE242007T1 (de) * 1998-12-23 2003-06-15 Searle Llc Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen
WO2000038728A1 (fr) 1998-12-23 2000-07-06 G.D. Searle Llc Combinaisons d'inhibiteurs du transport ileal des acides biliaires et d'agents sequestrant les acides biliaires utilisees dans le cadre de troubles cardio-vasculaires
ATE240120T1 (de) 1998-12-23 2003-05-15 Searle Llc Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen
WO2000038724A1 (fr) * 1998-12-23 2000-07-06 G.D. Searle Llc Combinaisons d'inhibiteurs de la proteine de transfert de l'ester de cholesteryle et de derives de l'acide fibrique utilisees dans le cadre de troubles cardio-vasculaires
EA005815B1 (ru) * 1998-12-23 2005-06-30 Джи.Ди.Сирл Ллс Комбинация ингибиторов транспорта желчных кислот в подвздошной кишке и ингибиторов белка, переносящего эфиры холестерина, для сердечно-сосудистых показаний
AU779264B2 (en) * 1998-12-23 2005-01-13 G.D. Searle Llc Combinations for cardiovascular indications
ATE242008T1 (de) 1998-12-23 2003-06-15 Searle Llc Kombnationen von cholesteryl ester transfer protein inhibitoren und gallensäure sequestriermitteln für kardiovaskuläre indikationen
US20030203884A1 (en) * 1999-11-09 2003-10-30 Pharmacia Corporation Methods for the treatment or prophylaxis of aldosterone-mediated pathogenic effects in a subject using an epoxy-steroidal aldosterone antagonist
US20030096798A1 (en) * 1999-11-09 2003-05-22 Williams Gordon H. Methods for the treatment or prophylaxis of aldosterone-mediated pathogenic effects in a subject using an epoxy-steroidal aldosterone antagonist
US20030083493A1 (en) * 1999-12-08 2003-05-01 Barton Kathleen P. Eplerenone drug substance having high phase purity
IL144764A0 (en) * 1999-12-08 2002-06-30 Pharmacia Corp Eplerenone crystalline form exhibiting enhanced dissolution rate
EP1505072A3 (fr) * 1999-12-08 2006-06-21 Pharmacia Corporation Forme cristalline d'eplerenone possédant une vitesse de dissolution accrue
EP1527782A1 (fr) * 1999-12-08 2005-05-04 Pharmacia Corporation Compositions nanoparticulaires d'eplérenone
DE60019741T2 (de) * 1999-12-08 2006-03-02 Pharmacia Corp., Chicago Nanopartikelzusammensetzungen enthaltend eplerenon
KR100584104B1 (ko) * 1999-12-08 2006-05-30 파마시아 코포레이션 결정형 에플레레논
EP1286984A2 (fr) 2000-03-10 2003-03-05 Pharmacia Corporation Procede de preparation de tetrahydrobenzothiepines
WO2001068096A2 (fr) * 2000-03-10 2001-09-20 Pharmacia Corporation Polytherapie pour la prophylaxie et le traitement d'etats et de troubles hyperlipidemiques
CA2409437A1 (fr) * 2000-05-11 2001-11-22 Pharmacia Corporation Composition antagoniste de l'aldosterone destinee a etre liberee durant l'acrophase de l'aldosterone
AU1604001A (en) * 2000-06-13 2001-12-24 Pharmacia Corp Use of an aldosterone antagonist for the treatment or prohpylaxis of aldosterone-mediated pathogenic effects
US6716829B2 (en) 2000-07-27 2004-04-06 Pharmacia Corporation Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
CA2415789A1 (fr) * 2000-07-27 2002-02-07 Pharmacia Corporation Polytherapie par antagoniste d'aldosterone epoxy-steroidien et antagoniste beta-adrenergique pour le traitement de l'insuffisance cardiaque congestive
AU2001285318A1 (en) * 2000-08-28 2002-03-13 Pharmacia Corporation Use of an aldosterone receptor antagonist to improve cognitive function
EP1352054A2 (fr) * 2000-10-30 2003-10-15 Pharmacia Corporation 11 alpha hydroxylase et oxydoreductase d'aspergillus ochraceus
PT1343530E (pt) * 2000-11-09 2007-09-25 Astrazeneca Ab Composição farmacêutica oral contendo um copolímero de blocos
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US20040077625A1 (en) * 2001-07-25 2004-04-22 Tremont Samuel J. Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake
US20030220310A1 (en) * 2001-07-27 2003-11-27 Schuh Joseph R. Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure
BR0213501A (pt) * 2001-11-02 2004-08-24 Searle Llc Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato
WO2003049745A1 (fr) * 2001-12-12 2003-06-19 Pharmacia Corporation Methode de traitement de troubles ophtalmiques a l'aide d'antagonistes epoxy-steroidiens des recepteurs de l'aldosterone
WO2003061604A2 (fr) 2002-01-17 2003-07-31 Pharmacia Corporation Nouveaux composes d'alkyl/aryl hydroxy ou cetothiepine servant d'inhibiteurs du transport des acides biliaires de type ileal et de l'absorption de taurocholate
CN1642556A (zh) * 2002-03-18 2005-07-20 法玛西雅公司 醛固酮受体拮抗剂与胆汁酸多价螯合剂的联合
KR20040091141A (ko) * 2002-03-18 2004-10-27 파마시아 코포레이션 알도스테론 수용체 길항물질 및 니코틴산 또는 니코틴산유도체의 혼합물
AU2003225871A1 (en) * 2002-03-20 2003-10-08 Pharmacia Corporation Storage stable eplerenone formulation
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
DK1487859T3 (da) * 2002-03-22 2008-10-06 Pharmacia & Upjohn Co Llc Fremstillingsmetoder til at fremstille Eplerenon
EP1534732B1 (fr) * 2002-08-16 2006-09-13 Pharmacia & Upjohn Company LLC Intermediaires de 5 androstene-3-ol steroides et leurs procedes de preparation
US20070066579A1 (en) * 2002-08-16 2007-03-22 White Michael J 5-androsten-3beta-ol steroid intermediates and processs for their preparation
US7196208B2 (en) * 2002-11-06 2007-03-27 Peter Guillaume Marie Wuts Processes for preparing 7-carboxy substituted steroids
CA2500580A1 (fr) * 2002-11-07 2004-05-27 Pharmacia & Upjohn Company Llc Procedes de preparation de 5-androstenes substitues en c-7
CL2004000545A1 (es) * 2003-03-18 2005-01-28 Pharmacia Corp Sa Organizada B Uso de un antagonista de los receptores de aldosterona y un antagonista de receptores de endotelina para el tratamiento o profilaxis de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopatia y enfermedades cardiovascul
CL2004000544A1 (es) * 2003-03-18 2005-01-28 Pharmacia Corp Sa Organizada B Uso de una combinacion farmaceutica, de un antagonista del receptor de aldosterona y un inhibidor de endopeptidasa neutral, util para el tratamiento y prevencion de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopati
CL2004000574A1 (es) * 2003-03-21 2005-02-11 Pharmacia Corp Sa Organizada B Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.
WO2004100871A2 (fr) * 2003-05-09 2004-11-25 Pharmacia Corporation Combinaison d'un antagoniste du recepteur de l'aldosterone et d'un inhibiteur de renine
US20040265948A1 (en) * 2003-06-27 2004-12-30 White Michael Jon Microbial method for hydrolysis and oxidation of androst-5-ene and pregn-5-ene steroid esters
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
CA2560389A1 (fr) * 2004-03-22 2005-10-06 Pharmacia & Upjohn Company Llc Procede ameliore de preparation de 9,11 epoxy steroides
US20070196471A1 (en) * 2004-04-02 2007-08-23 Thosar Shilpa S Micronized Eplerenone Compositions
US20050232957A1 (en) * 2004-04-14 2005-10-20 Katz Kenneth A Compositions and methods for moisturizing skin
CN1321128C (zh) * 2005-07-15 2007-06-13 浙江医药股份有限公司新昌制药厂 孕甾－4－烯－7，21－二甲酸，9，11－环氧－17－羟基－3－氧代，γ－内酯，甲酯，(7α,11α,17α)－的制备方法
WO2007025780A2 (fr) * 2005-09-02 2007-03-08 Recordati Ireland Limited Antagonistes des recepteurs de l'aldosterone
EP1842543A1 (fr) 2006-04-05 2007-10-10 Speedel Pharma AG Composition pharmaceutique comprennant un inhibiteur de l'aldosteron synthase et un antagoniste de recepteur mineralcorticoide
US20070248665A1 (en) * 2006-04-24 2007-10-25 Sherman Bernard C Compositions comprising co-precipitate of eplerenone and a water-soluble excipient
DE102006028032A1 (de) * 2006-06-14 2007-12-20 Henkel Kgaa Aufhell- und/oder Färbemittel mit Nitrilen
CA2673419A1 (fr) * 2006-12-21 2008-06-26 Alphapharm Pty Ltd Composition pharmaceutique
CA2582496A1 (fr) * 2007-03-20 2008-09-20 Apotex Pharmachem Inc. Procede ameliore permettant la preparation et la purification de l'eplerenone
FR2917975B1 (fr) 2007-06-26 2009-10-16 Ceva Sante Animale Sa Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
DE102008026793A1 (de) * 2008-06-02 2009-12-03 Bayer Schering Pharma Aktiengesellschaft C-Ring-substituierte Pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate
CN101863951B (zh) * 2009-04-15 2012-06-06 浙江省天台县奥锐特药业有限公司 依普利酮的制备方法
KR20120041702A (ko) 2009-05-28 2012-05-02 노파르티스 아게 네프릴리신 억제제로서의 치환된 아미노부티르산 유도체
JP5420761B2 (ja) 2009-05-28 2014-02-19 ノバルティス アーゲー ネプリリシン阻害剤としての置換アミノプロピオン酸誘導体
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
EP2533799B8 (fr) * 2010-02-08 2019-12-25 Shenzhen Evergreen Therapeutics Co., Ltd. Procédé pour l'utilisation de progestogène comme sensibilisateur aux glucocorticoïdes
JP6148175B2 (ja) 2010-05-10 2017-06-14 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 網膜中および／または網膜下における液体貯留の処置のための方法および組成物
EP2582365B1 (fr) 2010-06-16 2019-03-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Compositions pour stimuler la réépithélialisation durant la cicatrisation d'une blessure
TR201007653A2 (tr) 2010-09-20 2012-04-24 Bi̇lgi̇ç Mahmut Eplerenon içeren farmasötik kompozisyon
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
WO2012107513A1 (fr) * 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Procédé d'obtention de la drospirénone
ITMI20121037A1 (it) * 2012-06-14 2013-12-15 Ind Chimica Srl Processo per la preparazione di nitrili utili come intermedi per la sintesi di molecole ad attivita' farmacologica
WO2014126979A1 (fr) 2013-02-14 2014-08-21 Novartis Ag Dérivés d'acide phosphonique butanoïque de bisphénol substitués en qualité d'inhibiteurs de nep (endopeptidase neutre)
CN104262450A (zh) * 2014-09-19 2015-01-07 江苏嘉逸医药有限公司 依普利酮的制备及精制方法
ES2699923T3 (es) 2014-10-17 2019-02-13 Ind Chimica Srl Proceso para la preparación de 7alfa-(metoxicarbonil)-3-oxo-17alfa-pregn-4,9(11)-dien-21,17-carbolactona, un intermedio útil para la síntesis de moléculas con actividad farmacológica
WO2017055248A1 (fr) 2015-09-28 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement d'une insuffisance cardiaque
EP3362095B1 (fr) 2015-10-13 2020-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et préparations pharmaceutiques pour le traitement de la neovascularisation choroidienne
CN105753930A (zh) * 2016-03-30 2016-07-13 北京万全德众医药生物技术有限公司 依普利酮的一种合成方法
US20190262363A1 (en) 2016-07-26 2019-08-29 INSERM (Institut National de la Santé et de la Recherche Médicale Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis
JOP20190086A1 (ar) 2016-10-21 2019-04-18 Novartis Ag مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
US20240366632A1 (en) 2021-08-31 2024-11-07 Institut National de la Santé et de la Recherche Médicale Methods for the treatment of ocular rosacea

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3095412A (en) * 1961-12-19 1963-06-25 Searle & Co 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs
GB1041534A (en) * 1963-04-24 1966-09-07 Merck & Co Inc 20-spiroxane compounds
US3729491A (en) * 1970-06-15 1973-04-24 Searle & Co 3,5-dioxo-a-nor-b-homo steroidal spirolactones
GB1368006A (en) * 1972-08-24 1974-09-25 Searle & Co 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone
US3849404A (en) * 1973-03-09 1974-11-19 Searle & Co Purification of 6,7-dihydro-17-hydroxy-3-oxo-3'h-cyclopropa(6,7)-17alpha-pregna-4,6-diene-21-carboxylic acid gamma-lactones
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2922500A1 (de) * 1979-05-31 1980-12-04 Schering Ag 6 beta .7 beta
DE3111951A1 (de) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel

Also Published As

Publication number Publication date
JPS59231100A (ja) 1984-12-25
DE122004000012I1 (de) 2012-05-16
PT78413B (en) 1986-08-22
ES544770A0 (es) 1987-05-01
ES8602846A1 (es) 1985-12-01
CA1220781A (fr) 1987-04-21
FI841400L (fi) 1984-10-14
NL300144I2 (nl) 2004-06-01
NO159800B (no) 1988-10-31
DE3475622D1 (en) 1989-01-19
ES8705460A1 (es) 1987-05-01
DD251144A5 (de) 1987-11-04
IL71504A0 (en) 1984-07-31
DD233375A5 (de) 1986-02-26
ES8705459A1 (es) 1987-05-01
ES8705461A1 (es) 1987-05-01
AR242221A1 (es) 1993-03-31
US4559332A (en) 1985-12-17
NO841465L (no) 1984-10-15
HU191406B (en) 1987-02-27
NL300144I1 (nl) 2004-06-01
EP0122232A1 (fr) 1984-10-17
PH19997A (en) 1986-08-28
DK189484D0 (da) 1984-04-12
AR241918A1 (es) 1993-01-29
DK163988C (da) 1992-09-21
JPH0212479B2 (fr) 1990-03-20
FI841400A0 (fi) 1984-04-09
AR242223A1 (es) 1993-03-31
DE122004000012I2 (de) 2006-06-08
IL71504A (en) 1987-07-31
AU2685384A (en) 1984-10-18
ZA842710B (en) 1984-11-28
ES544768A0 (es) 1987-05-01
NZ207826A (en) 1986-07-11
NO159800C (no) 1989-02-08
PT78413A (en) 1984-05-01
AR242222A1 (es) 1993-03-31
IE57541B1 (en) 1992-10-07
ATE39256T1 (de) 1988-12-15
GR81834B (fr) 1984-12-12
FI77669B (fi) 1988-12-30
DK189484A (da) 1984-10-14
IE840906L (en) 1984-10-13
FI77669C (fi) 1989-04-10
ES544769A0 (es) 1987-05-01
EP0122232B1 (fr) 1988-12-14
DK163988B (da) 1992-04-27
ES531517A0 (es) 1985-12-01
AU565017B2 (en) 1987-09-03

Similar Documents

Publication Publication Date Title
LU91072I2 (fr) Eplerenone et ses sels pharmaceutiquement acceptables - INSPRA
LU90829I2 (fr) Tepoxalin-zubrin et ses d-riv-s pharmaceutiquement acceptables
DE3464100D1 (en) Electric-cable structure and its application
IT1205010B (it) Tetraidronaftalin-derivati e indan-derivati
ES542657A0 (es) Perfeccionamientos en los aparatos de fermentacion y proce- dimiento de fermentacion correspondiente
DK41484A (da) Beta-phenethanolaminer og deres anvendelse
DK165463C (da) Taetnings- og afstrygningsindretning
DK551187D0 (da) Terapeutisk praeparat og dettes fremstilling
DK412787A (da) Medicinsk-kirurgisk pose og dennes fremstilling
DK254488D0 (da) Azaindol- og indolizinderivater
DK210689D0 (da) Steroidderivater
DK150784D0 (da) Lege-og instruktionsorgan
DK553782A (da) Cyclohexyl- og phenylsubstituerede enkephaliner og deres fremstilling
DK413187A (da) Semicarbazoner og thiosemicarbazoner
DK406384A (da) Imidazobenzodiazepinderivater og disses anvendelse
DK488185A (da) N6-benzopyrano- og benzothiopyranoadenosiner
PT89072A (pt) Estojo estanque e impermeavel
DK422984D0 (da) Aminocyklopentaner og farmaceutiske praeparater deraf
DK501989A (da) Mikrobiocidt praeparat og dettes fremstilling
DK162607C (da) Azopigmentpraeparater og deres anvendelse
FR2588259B1 (fr) Bis-acridiniques monopontes et bis-acridiniques bipontes
DE3475192D1 (de) Pyrrolizidinones and indolizidones
FR2633963B1 (fr) Sas d'isolation adaptable et amovible
SE8304181D0 (sv) Energiforfaranden och -anordningar
DK428987D0 (da) En fallelaas