LU91072I2 - Eplerenone et ses sels pharmaceutiquement acceptables - INSPRA - Google Patents

Eplerenone et ses sels pharmaceutiquement acceptables - INSPRA

Info

Publication number
LU91072I2
LU91072I2 LU91072C LU91072C LU91072I2 LU 91072 I2 LU91072 I2 LU 91072I2 LU 91072 C LU91072 C LU 91072C LU 91072 C LU91072 C LU 91072C LU 91072 I2 LU91072 I2 LU 91072I2
Authority
LU
Luxembourg
Prior art keywords
inspra
eplerenone
pharmaceutically acceptable
acceptable salts
salts
Prior art date
Application number
LU91072C
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of LU91072I2 publication Critical patent/LU91072I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/007—3 membered carbocyclic rings in position 6-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
LU91072C 1983-04-13 1984-04-10 Eplerenone et ses sels pharmaceutiquement acceptables - INSPRA LU91072I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH198183 1983-04-13

Publications (1)

Publication Number Publication Date
LU91072I2 true LU91072I2 (fr) 2004-04-07

Family

ID=4223123

Family Applications (1)

Application Number Title Priority Date Filing Date
LU91072C LU91072I2 (fr) 1983-04-13 1984-04-10 Eplerenone et ses sels pharmaceutiquement acceptables - INSPRA

Country Status (23)

Country Link
US (1) US4559332A (fr)
EP (1) EP0122232B1 (fr)
JP (1) JPS59231100A (fr)
AR (4) AR241918A1 (fr)
AT (1) ATE39256T1 (fr)
AU (1) AU565017B2 (fr)
CA (1) CA1220781A (fr)
DD (2) DD233375A5 (fr)
DE (2) DE3475622D1 (fr)
DK (1) DK163988C (fr)
ES (4) ES8602846A1 (fr)
FI (1) FI77669C (fr)
GR (1) GR81834B (fr)
HU (1) HU191406B (fr)
IE (1) IE57541B1 (fr)
IL (1) IL71504A (fr)
LU (1) LU91072I2 (fr)
NL (1) NL300144I2 (fr)
NO (1) NO159800C (fr)
NZ (1) NZ207826A (fr)
PH (1) PH19997A (fr)
PT (1) PT78413B (fr)
ZA (1) ZA842710B (fr)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
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CN102811730B (zh) * 2010-02-08 2014-07-09 杜涛 孕激素作为糖皮质激素增敏剂的使用
EP2977084B1 (fr) 2010-05-10 2017-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Procedes et compositions pour le traitement de l'accumulation de fluides dans et/ou sous la retine
JP6180930B2 (ja) 2010-06-16 2017-08-16 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 創傷治癒過程における再上皮化を刺激するための方法及び組成物
TR201007653A2 (tr) 2010-09-20 2012-04-24 Bi̇lgi̇ç Mahmut Eplerenon içeren farmasötik kompozisyon
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
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CN104262450A (zh) * 2014-09-19 2015-01-07 江苏嘉逸医药有限公司 依普利酮的制备及精制方法
ES2699923T3 (es) 2014-10-17 2019-02-13 Ind Chimica Srl Proceso para la preparación de 7alfa-(metoxicarbonil)-3-oxo-17alfa-pregn-4,9(11)-dien-21,17-carbolactona, un intermedio útil para la síntesis de moléculas con actividad farmacológica
WO2017055248A1 (fr) 2015-09-28 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement d'une insuffisance cardiaque
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CN105753930A (zh) * 2016-03-30 2016-07-13 北京万全德众医药生物技术有限公司 依普利酮的一种合成方法
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JOP20190086A1 (ar) 2016-10-21 2019-04-18 Novartis Ag مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
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EP0122232A1 (fr) 1984-10-17
NL300144I1 (nl) 2004-06-01
PH19997A (en) 1986-08-28
JPS59231100A (ja) 1984-12-25
NL300144I2 (nl) 2004-06-01
IE840906L (en) 1984-10-13
US4559332A (en) 1985-12-17
PT78413B (en) 1986-08-22
DK189484A (da) 1984-10-14
DD233375A5 (de) 1986-02-26
FI77669B (fi) 1988-12-30
EP0122232B1 (fr) 1988-12-14
DD251144A5 (de) 1987-11-04
GR81834B (fr) 1984-12-12
DK163988B (da) 1992-04-27
AR242223A1 (es) 1993-03-31
DE122004000012I2 (de) 2006-06-08
PT78413A (en) 1984-05-01
ATE39256T1 (de) 1988-12-15
ES8705461A1 (es) 1987-05-01
DK163988C (da) 1992-09-21
ES544769A0 (es) 1987-05-01
DE3475622D1 (en) 1989-01-19
AR241918A1 (es) 1993-01-29
ES8705460A1 (es) 1987-05-01
AR242222A1 (es) 1993-03-31
ZA842710B (en) 1984-11-28
FI841400A0 (fi) 1984-04-09
IL71504A0 (en) 1984-07-31
ES8705459A1 (es) 1987-05-01
CA1220781A (fr) 1987-04-21
ES544768A0 (es) 1987-05-01
AU565017B2 (en) 1987-09-03
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FI841400A (fi) 1984-10-14
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HU191406B (en) 1987-02-27
NO159800B (no) 1988-10-31
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IL71504A (en) 1987-07-31
ES8602846A1 (es) 1985-12-01
DE122004000012I1 (de) 2012-05-16
AU2685384A (en) 1984-10-18
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NO159800C (no) 1989-02-08
FI77669C (fi) 1989-04-10
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JPH0212479B2 (fr) 1990-03-20
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