GB1498239A - Quaternary salts of d-homosteroids - Google Patents
Quaternary salts of d-homosteroidsInfo
- Publication number
- GB1498239A GB1498239A GB44288/75A GB4428875A GB1498239A GB 1498239 A GB1498239 A GB 1498239A GB 44288/75 A GB44288/75 A GB 44288/75A GB 4428875 A GB4428875 A GB 4428875A GB 1498239 A GB1498239 A GB 1498239A
- Authority
- GB
- United Kingdom
- Prior art keywords
- homo
- androstane
- dipiperidino
- hydroxy
- androstan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1498239 D-homo steroid amine salts F HOFFMANN-LA ROCHE & CO AG 28 Oct 1975 [29 Oct 1974] 44288/75 Heading C2U The invention comprises the mono and bis quaternary salts of diamines of Formula I and also the acid addition salts of the monoquaternary salts (R<SP>1</SP>, R<SP>2</SP>, R<SP>4</SP> and R<SP>5</SP> are each H, C 1-10 alkyl or C 7-10 aralkyl, or NR<SP>1</SP>R<SP>2</SP> or NR<SP>4</SP>R<SP>5</SP> is a heterocyclic group; R<SP>3</SP> is H or acyl; R<SP>6</SP> is oxo (H, α-OR<SP>7</SP>) or (H, #-OR<SP>7</SP>) where R<SP>7</SP> is H or acyl); and their preparation by salification of the diamines (e.g. with an alkyl halide) and if desired reducing a 17a-oxo group or acylating a 3- or 17ahydroxy group. 3# - Hydroxy - D - homo - 5α - androstan- 17a - one#3# - hydroxy - 17a,17a - ethylenedioxy- D - homo - 5α - androstane#3# - tosyloxy- 17a,17a - ethylenedioxy - D - homo - 5α - androstane#17a,17a - ethylenedixoy - D - homo - 5α- androst - 2 - ene#D - homo - 5α - androst - 2- en - 17a - one#17a - acetoxy - D - homo - 5α androsta - 2,17(17a) - diene#17α# - acetoxy- 2α,3α; 17a,17aα - diepoxy - D - homo - 5α- androstane#(i) 3α - hydroxy - 2#,17# - bis- (dimethylamino) - D - homo - 5α - androstan - 17aone or (ii) 3α - hydroxy - 2#.17# - dipiperidino- D - homo - 5α - androstan - 17a - one; then (ii)# 3α,17α# - dihydroxy - 2#,17# - dipiperidino - D- homo - 5α - androstane#3α,17a# - diacetoxy- 2#,17#-dipiperidino-D-homo-5α-androstane. 3#,17α# - Dihydroxy - D - homo - 5α - androstane - 3#,17α# - ditosyloxy - D - homo - 5α- androstane#D - homo - 5α - androsta - 2,17(17a)- diene#(i) 2α,3α; 17α,17aα - diepoxy - D- homo - 5α - androstane and (ii) its 17#,17a#- isomer; then (i) #3α,17aα - dihydroxy- 2#,17# - dipiperidino - D - homo - 5α - androstane#3α,17aα - diacetoxy - 2#,17# - dipiperidino-D-homo-5α-androstane. Anaesthetic parenteral compositions comprise a carrier and a compound of the invention.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1446974A CH602794A5 (en) | 1974-10-29 | 1974-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1498239A true GB1498239A (en) | 1978-01-18 |
Family
ID=4401103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB44288/75A Expired GB1498239A (en) | 1974-10-29 | 1975-10-28 | Quaternary salts of d-homosteroids |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS51125267A (en) |
| AR (1) | AR212436A1 (en) |
| AT (1) | AT349161B (en) |
| BE (1) | BE834925A (en) |
| CA (1) | CA1050009A (en) |
| CH (1) | CH602794A5 (en) |
| DD (1) | DD123332A5 (en) |
| DE (1) | DE2547739A1 (en) |
| DK (1) | DK135316B (en) |
| ES (1) | ES442142A1 (en) |
| FI (1) | FI53711C (en) |
| FR (1) | FR2289175A1 (en) |
| GB (1) | GB1498239A (en) |
| HU (1) | HU174161B (en) |
| IE (1) | IE42058B1 (en) |
| IL (1) | IL48219A (en) |
| LU (1) | LU73655A1 (en) |
| NL (1) | NL7512661A (en) |
| NO (1) | NO139736C (en) |
| NZ (1) | NZ178817A (en) |
| PL (1) | PL100305B1 (en) |
| SE (1) | SE413248B (en) |
| ZA (1) | ZA756169B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2362648A (en) * | 2000-05-23 | 2001-11-28 | Univerzita Palackeho V Olomouc | Triterpenoid derivatives |
| WO2003062260A1 (en) * | 2002-01-18 | 2003-07-31 | Regents Of The University Of Minnesota | Triterpene quaternary salts as biologically active surfactants |
-
1974
- 1974-10-29 CH CH1446974A patent/CH602794A5/xx not_active IP Right Cessation
-
1975
- 1975-09-29 ZA ZA00756169A patent/ZA756169B/en unknown
- 1975-09-30 NZ NZ178817A patent/NZ178817A/en unknown
- 1975-09-30 IL IL48219A patent/IL48219A/en unknown
- 1975-10-10 FI FI752825A patent/FI53711C/en not_active IP Right Cessation
- 1975-10-21 AR AR260869A patent/AR212436A1/en active
- 1975-10-23 CA CA238,187A patent/CA1050009A/en not_active Expired
- 1975-10-24 DE DE19752547739 patent/DE2547739A1/en not_active Withdrawn
- 1975-10-27 LU LU73655A patent/LU73655A1/xx unknown
- 1975-10-27 JP JP50128445A patent/JPS51125267A/en active Pending
- 1975-10-27 SE SE7512006A patent/SE413248B/en unknown
- 1975-10-27 FR FR7532779A patent/FR2289175A1/en active Granted
- 1975-10-28 DD DD189086A patent/DD123332A5/xx unknown
- 1975-10-28 GB GB44288/75A patent/GB1498239A/en not_active Expired
- 1975-10-28 BE BE161295A patent/BE834925A/en unknown
- 1975-10-28 DK DK485975AA patent/DK135316B/en not_active IP Right Cessation
- 1975-10-28 AT AT819375A patent/AT349161B/en not_active IP Right Cessation
- 1975-10-28 NO NO753616A patent/NO139736C/en unknown
- 1975-10-28 PL PL1975184292A patent/PL100305B1/en unknown
- 1975-10-28 ES ES442142A patent/ES442142A1/en not_active Expired
- 1975-10-28 IE IE2344/75A patent/IE42058B1/en unknown
- 1975-10-28 HU HU75HO1849A patent/HU174161B/en unknown
- 1975-10-29 NL NL7512661A patent/NL7512661A/en not_active Application Discontinuation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2362648A (en) * | 2000-05-23 | 2001-11-28 | Univerzita Palackeho V Olomouc | Triterpenoid derivatives |
| WO2003062260A1 (en) * | 2002-01-18 | 2003-07-31 | Regents Of The University Of Minnesota | Triterpene quaternary salts as biologically active surfactants |
| US7199114B2 (en) | 2002-01-18 | 2007-04-03 | The Regents Of The University Of Minnesota | Triterpene quaternary salts as biologically active surfactants |
| US7410958B2 (en) | 2002-01-18 | 2008-08-12 | Regents Of The University Of Minnesota | Triterpene quaternary salts as biologically active surfactants |
Also Published As
| Publication number | Publication date |
|---|---|
| AR212436A1 (en) | 1978-07-14 |
| SE413248B (en) | 1980-05-12 |
| FI53711B (en) | 1978-03-31 |
| IE42058L (en) | 1976-04-29 |
| JPS51125267A (en) | 1976-11-01 |
| DE2547739A1 (en) | 1976-05-06 |
| FI752825A (en) | 1976-04-30 |
| ATA819375A (en) | 1978-08-15 |
| FI53711C (en) | 1978-07-10 |
| FR2289175B1 (en) | 1980-05-30 |
| NO139736C (en) | 1979-05-09 |
| NO753616L (en) | 1976-04-30 |
| AT349161B (en) | 1979-03-26 |
| ZA756169B (en) | 1976-09-29 |
| SE7512006L (en) | 1976-04-30 |
| DK135316C (en) | 1977-08-22 |
| NL7512661A (en) | 1976-05-04 |
| DD123332A5 (en) | 1976-12-12 |
| AU8541875A (en) | 1977-04-07 |
| ES442142A1 (en) | 1977-04-01 |
| CA1050009A (en) | 1979-03-06 |
| NZ178817A (en) | 1978-06-02 |
| NO139736B (en) | 1979-01-22 |
| CH602794A5 (en) | 1978-08-15 |
| HU174161B (en) | 1979-11-28 |
| IL48219A (en) | 1979-01-31 |
| LU73655A1 (en) | 1977-05-31 |
| IE42058B1 (en) | 1980-05-21 |
| DK135316B (en) | 1977-04-04 |
| DK485975A (en) | 1976-04-30 |
| FR2289175A1 (en) | 1976-05-28 |
| PL100305B1 (en) | 1978-09-30 |
| IL48219A0 (en) | 1975-11-25 |
| BE834925A (en) | 1976-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |