ES8200703A1 - Procedimiento para la preparacion de 1-hidroxi-esteroides - Google Patents

Procedimiento para la preparacion de 1-hidroxi-esteroides

Info

Publication number
ES8200703A1
ES8200703A1 ES498250A ES498250A ES8200703A1 ES 8200703 A1 ES8200703 A1 ES 8200703A1 ES 498250 A ES498250 A ES 498250A ES 498250 A ES498250 A ES 498250A ES 8200703 A1 ES8200703 A1 ES 8200703A1
Authority
ES
Spain
Prior art keywords
compounds
preparation
pharmaceutical compositions
compositions containing
hydroxy steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498250A
Other languages
English (en)
Other versions
ES498250A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES498250A0 publication Critical patent/ES498250A0/es
Publication of ES8200703A1 publication Critical patent/ES8200703A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE 1-HIDROXI-ESTEROIDES DE FORMULA (I), EN QUE R1 Y R2 SON HIDROGENO O GRUPOS ALCANOILO. SE BASA EN LA FERMENTACION DE UN COMPUESTO DE FORMULA (II) CON UN CULTIVO DE HONGOS DE CLASE "ASPERGILLUS", "CALONECTRIA", "MUCOR", "GLOMERELLA" O "SEPTOMYXA", CON 50-1.000 MG. DE SUSTRATO-LITRO DE MEDIO NUTRICIO, A TEMPERATURA DE 20-40 C Y PH DE 5-7. EL PRODUCTO SE AISLA POR EXTRACCION CON UN DISOLVENTE POLAR, SE CONCETRA POR EVAPORIZACION Y SE PURIFICA POR CROMATOGRAFIA Y-O CRISTALIZACION. OPCIONALMENTE, SE ESTERIFICAN LOS GRUPOS HIDROXI LIBRES POR REACCION CON ANHIDRIDOS DE ACIDOS O CLORUROS DE ACIDOS EN PRESENCIA DE CATALIZADORES BASICOS. SE USAN, COMO AGENTES DE EFECTO GESTAGENO, EN PRODUCTOS FARMACEUTICOS.
ES498250A 1980-01-23 1980-12-30 Procedimiento para la preparacion de 1-hidroxi-esteroides Expired ES8200703A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803002746 DE3002746A1 (de) 1980-01-23 1980-01-23 1-hydroxysteroide, verfahren zu ihrer herstellung und pharmazeutische praeparate, die diese verbindungen enthalten

Publications (2)

Publication Number Publication Date
ES498250A0 ES498250A0 (es) 1981-12-01
ES8200703A1 true ES8200703A1 (es) 1981-12-01

Family

ID=6092969

Family Applications (1)

Application Number Title Priority Date Filing Date
ES498250A Expired ES8200703A1 (es) 1980-01-23 1980-12-30 Procedimiento para la preparacion de 1-hidroxi-esteroides

Country Status (6)

Country Link
US (1) US4307088A (es)
EP (1) EP0033120B1 (es)
JP (1) JPS56110699A (es)
AT (1) ATE3982T1 (es)
DE (2) DE3002746A1 (es)
ES (1) ES8200703A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996015253A1 (de) * 1994-11-14 1996-05-23 Schering Aktiengesellschaft Verfahren zur herstellung von 1-hydroxymethyl-1.4-androstadien-3.17-dion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1517278A (en) * 1974-08-30 1978-07-12 Glaxo Lab Ltd Alkyl and haloalkyl androsta-1,4,15-triene and-4,15-diene-17beta-carboxylates
US4144334A (en) * 1974-10-18 1979-03-13 Schering Aktiengesellschaft Novel α-hydroxy steroids
DK136729C (da) * 1974-10-18 1978-05-01 Schering Ag Analogifremgangsmaade til fremstilling af 1alfa,17beta-dihydroxy-17beta-alkynyl-4-oestren-3-oner
DE2636405C2 (de) * 1976-08-12 1982-07-08 Schering Ag, 1000 Berlin Und 4619 Bergkamen Δ↑1↑↑5↑-17α-Chloräthinyl- und -Propinylsteroide der Östranreihe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Präparate
US4081537A (en) * 1975-10-10 1978-03-28 Schering Aktiengesellschaft Δ15 -Steroids and pharmaceutical compositions thereof
DE2614340A1 (de) * 1976-03-31 1977-10-27 Schering Ag Neue mittel und neue methoden zur ausloesung von aborten und zur therapie von genitalcarcinomen

Also Published As

Publication number Publication date
US4307088A (en) 1981-12-22
ES498250A0 (es) 1981-12-01
ATE3982T1 (de) 1983-07-15
JPS56110699A (en) 1981-09-01
DE3160492D1 (en) 1983-08-04
EP0033120B1 (de) 1983-06-29
JPH0121837B2 (es) 1989-04-24
DE3002746A1 (de) 1981-07-30
EP0033120A1 (de) 1981-08-05

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