ES8204741A1 - Procedimiento para la preparacion de 3-desoxi-a15-esteroides - Google Patents
Procedimiento para la preparacion de 3-desoxi-a15-esteroidesInfo
- Publication number
- ES8204741A1 ES8204741A1 ES499209A ES499209A ES8204741A1 ES 8204741 A1 ES8204741 A1 ES 8204741A1 ES 499209 A ES499209 A ES 499209A ES 499209 A ES499209 A ES 499209A ES 8204741 A1 ES8204741 A1 ES 8204741A1
- Authority
- ES
- Spain
- Prior art keywords
- steroids
- delta
- desoxy
- preparation
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
- C07J33/007—Cyclic thioketals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 3-DESOXI-DELTA 15-ESTEROIDES DE FORMULA (I), EN LA QUE R1 ES HIDROGENO O ACILO Y R2 ES ETINILO, CLOROETINILO O PROPINILO. CONSISTE EN LA REACCION DE UN 17-OXO-ESTEROIDE DE FORMULA (II) CON UN COMPUESTO ORGANOMETALICO DE FORMULA RI-M, EN LA QUE M ES UN METAL ALCALINO, CUANDO R2 ES ETINILO,CLOROETINILO O PROPINILO, O ES HALURO DE MAGNESIO O DE CINC, CUANDO R2 ES UN GRUPO ETINILO O PROPINILO. LA REACCION SE LLEVA A CABO EN PRESENCIA DE UN DISOLVENTE ORGANICO Y A UNA TEMPERATURA ENTRE -78 Y 50 GRADOS CENTIGRADOS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO GESTAGENOS PARA LA FABRICACION DE ANTICONCEPTIVOS, ASI COMO EL TRATAMIENTO DE PERTURBACIONES GINECOLOGICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803005374 DE3005374A1 (de) | 1980-02-11 | 1980-02-11 | 3-desoxy-delta hoch 15 -steroide, verfahren zu ihrer herstellung sowie diese enthaltende pharmazeutische praeparate |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8204741A1 true ES8204741A1 (es) | 1982-06-01 |
ES499209A0 ES499209A0 (es) | 1982-06-01 |
Family
ID=6094509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES499209A Granted ES499209A0 (es) | 1980-02-11 | 1981-02-06 | Procedimiento para la preparacion de 3-desoxi-a15-esteroides |
Country Status (5)
Country | Link |
---|---|
US (1) | US4390530A (es) |
EP (1) | EP0034114B1 (es) |
JP (1) | JPS56127396A (es) |
DE (2) | DE3005374A1 (es) |
ES (1) | ES499209A0 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3005374A1 (de) * | 1980-02-11 | 1981-08-20 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | 3-desoxy-delta hoch 15 -steroide, verfahren zu ihrer herstellung sowie diese enthaltende pharmazeutische praeparate |
WO1986000814A1 (en) * | 1984-07-24 | 1986-02-13 | Key Pharmaceuticals, Inc. | Adhesive transdermal dosage layer |
DE3909770A1 (de) * | 1989-03-21 | 1990-09-27 | Schering Ag | Verfahren zur herstellung von 3-desoxy-4-en-steroiden |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3503959A (en) * | 1962-03-30 | 1970-03-31 | Sterling Drug Inc | 3-amino steroids |
GB1070943A (en) * | 1964-03-03 | 1967-06-07 | Herchel Smith | 13-alkylgonanes and 13-alkyl-d-homogonanes |
DE1934272A1 (de) * | 1969-07-02 | 1971-01-14 | Schering Ag | d-18-Methyl-17 alpha-alkinyl-4-oestren-17 beta-ole |
US4081537A (en) * | 1975-10-10 | 1978-03-28 | Schering Aktiengesellschaft | Δ15 -Steroids and pharmaceutical compositions thereof |
DE3005374A1 (de) * | 1980-02-11 | 1981-08-20 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | 3-desoxy-delta hoch 15 -steroide, verfahren zu ihrer herstellung sowie diese enthaltende pharmazeutische praeparate |
-
1980
- 1980-02-11 DE DE19803005374 patent/DE3005374A1/de not_active Withdrawn
-
1981
- 1981-02-02 EP EP81730010A patent/EP0034114B1/de not_active Expired
- 1981-02-02 DE DE8181730010T patent/DE3160050D1/de not_active Expired
- 1981-02-06 ES ES499209A patent/ES499209A0/es active Granted
- 1981-02-11 US US06/233,350 patent/US4390530A/en not_active Expired - Fee Related
- 1981-02-12 JP JP1820781A patent/JPS56127396A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS56127396A (en) | 1981-10-06 |
ES499209A0 (es) | 1982-06-01 |
JPS6361958B2 (es) | 1988-11-30 |
EP0034114A1 (de) | 1981-08-19 |
DE3005374A1 (de) | 1981-08-20 |
EP0034114B1 (de) | 1983-02-09 |
DE3160050D1 (en) | 1983-03-17 |
US4390530A (en) | 1983-06-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19990401 |