ES8600934A1 - Procedimiento para preparar derivados de 4-oxo-1, 4-dihidroquinoleina - Google Patents

Procedimiento para preparar derivados de 4-oxo-1, 4-dihidroquinoleina

Info

Publication number
ES8600934A1
ES8600934A1 ES529933A ES529933A ES8600934A1 ES 8600934 A1 ES8600934 A1 ES 8600934A1 ES 529933 A ES529933 A ES 529933A ES 529933 A ES529933 A ES 529933A ES 8600934 A1 ES8600934 A1 ES 8600934A1
Authority
ES
Spain
Prior art keywords
antibacterial agents
manufacture
specified
agents
benzoxazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529933A
Other languages
English (en)
Other versions
ES529933A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES8600934A1 publication Critical patent/ES8600934A1/es
Publication of ES529933A0 publication Critical patent/ES529933A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 4-OXO-14-DIHIDROQUINOLEINA DE FORMULA GENERAL (I) EN LA QUE X ES CH CF O C-OH; Y ES HIDROGENO O FLUOR; Y N ES 0 1 O 2 Y SUS SALES DE ADICION DE ACIDO O BASE FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) CON UNA AMIDINA DE FORMULA GENERAL (III). DE APLICACION EN TERAPEUTICA EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS.
ES529933A 1982-09-09 1984-02-22 Procedimiento para preparar derivados de 4-oxo-1, 4-dihidroquinoleina Granted ES529933A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41640682A 1982-09-09 1982-09-09
US52227583A 1983-08-12 1983-08-12

Publications (2)

Publication Number Publication Date
ES8600934A1 true ES8600934A1 (es) 1985-10-16
ES529933A0 ES529933A0 (es) 1985-10-16

Family

ID=27023343

Family Applications (6)

Application Number Title Priority Date Filing Date
ES525493A Granted ES525493A0 (es) 1982-09-09 1983-09-08 Procedimiento para preparar derivados de 4-oxo-1,4-dihidroquinoleina.
ES529934A Expired ES8505673A1 (es) 1982-09-09 1984-02-22 Procedimiento para preparar derivados de 4-oxo-1, 4-dihidroquinoleina
ES529935A Granted ES529935A0 (es) 1982-09-09 1984-02-22 Procedimiento para preparar derivados de 4-oxo-1, 4-dihidroquinoleina
ES529937A Granted ES529937A0 (es) 1982-09-09 1984-02-22 Procedimiento para preparar derivados de 4-oxo-1, 4-dihidroquinoleina
ES529936A Granted ES529936A0 (es) 1982-09-09 1984-02-22 Procedimiento para preparar derivados de 4-oxo-1, 4-dihidroquinoleina
ES529933A Granted ES529933A0 (es) 1982-09-09 1984-02-22 Procedimiento para preparar derivados de 4-oxo-1, 4-dihidroquinoleina

Family Applications Before (5)

Application Number Title Priority Date Filing Date
ES525493A Granted ES525493A0 (es) 1982-09-09 1983-09-08 Procedimiento para preparar derivados de 4-oxo-1,4-dihidroquinoleina.
ES529934A Expired ES8505673A1 (es) 1982-09-09 1984-02-22 Procedimiento para preparar derivados de 4-oxo-1, 4-dihidroquinoleina
ES529935A Granted ES529935A0 (es) 1982-09-09 1984-02-22 Procedimiento para preparar derivados de 4-oxo-1, 4-dihidroquinoleina
ES529937A Granted ES529937A0 (es) 1982-09-09 1984-02-22 Procedimiento para preparar derivados de 4-oxo-1, 4-dihidroquinoleina
ES529936A Granted ES529936A0 (es) 1982-09-09 1984-02-22 Procedimiento para preparar derivados de 4-oxo-1, 4-dihidroquinoleina

Country Status (21)

Country Link
EP (1) EP0106489B1 (es)
JP (5) JPH0742284B2 (es)
KR (1) KR890001424B1 (es)
AU (1) AU562286B2 (es)
CA (1) CA1340721C (es)
CS (1) CS246065B2 (es)
DD (1) DD216010A5 (es)
DE (1) DE3377493D1 (es)
DK (2) DK171098B1 (es)
ES (6) ES525493A0 (es)
FI (1) FI83513C (es)
GR (1) GR79059B (es)
HU (1) HU196986B (es)
IE (1) IE55898B1 (es)
IL (1) IL69601A (es)
NO (1) NO164418C (es)
NZ (1) NZ205529A (es)
OA (1) OA07527A (es)
PH (1) PH21530A (es)
PT (1) PT77308B (es)
ZA (1) ZA836357B (es)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
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US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US5281612A (en) * 1982-09-09 1994-01-25 Warner-Lambert Company Naphthyridine antibacterial agents
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CS274601B2 (en) * 1983-07-27 1991-09-15 Dainippon Pharmaceutical Co Method of 1,8-naphthyridine derivative production
JPS60260577A (ja) * 1984-06-06 1985-12-23 Dainippon Pharmaceut Co Ltd １，８−ナフチリジン誘導体
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids
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US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
JPS60228479A (ja) * 1984-04-26 1985-11-13 Toyama Chem Co Ltd １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩
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US4604401A (en) * 1984-07-20 1986-08-05 Warner-Lambert Company Antibacterial agents III
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
IN162769B (es) * 1984-11-13 1988-07-09 Kyorin Seiyaku Kk
AU576272B2 (en) * 1984-11-13 1988-08-18 Kyorin Pharmaceutical Co. Ltd. Quinolone carboxylic acid derivates
DE3508816A1 (de) * 1985-01-10 1986-07-10 Bayer Ag, 5090 Leverkusen 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren
US4851535A (en) * 1985-01-23 1989-07-25 Toyama Chemical Co., Ltd. Nicotinic acid derivatives
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AU578793B2 (en) * 1985-02-15 1988-11-03 Dainippon Pharmaceutical Co. Ltd. Novel 1,8-naphthyridine derivatives and processes for preparation thereof
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AU5427286A (en) * 1985-03-08 1986-09-11 Kyorin Pharmaceutical Co. Ltd. 7-(1-pyrrolidinyl)-3-quinolinecarboxylic acid derivatives
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IL77846A (en) * 1985-03-25 1989-08-15 Warner Lambert Co Process for the preparation of 7-amino-quinolin-4-oxy-3-carboxylic acid derivatives
US4578473A (en) * 1985-04-15 1986-03-25 Warner-Lambert Company Process for quinoline-3-carboxylic acid antibacterial agents
US4657913A (en) * 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
DE3685157D1 (de) * 1985-06-26 1992-06-11 Daiichi Seiyaku Co Pyridoncarbonsaeurederivate.
JPH0635457B2 (ja) * 1985-06-28 1994-05-11 杏林製薬株式会社 ピリドンカルボン酸誘導体およびその製造方法
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US4767762A (en) * 1985-12-23 1988-08-30 Abbott Laboratories Tricyclic quinoline and naphthyride antibacterials
JPS62228063A (ja) * 1985-12-27 1987-10-06 Sankyo Co Ltd キノリンカルボン酸誘導体
US4772706A (en) * 1986-01-13 1988-09-20 Warner-Lambert Company Process for quinoline-3-carboxylic acid antibacterial agents
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JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
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US4771055A (en) * 1986-07-28 1988-09-13 Warner-Lambert Company 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
JPS6416767A (en) * 1987-07-09 1989-01-20 Dainippon Pharmaceutical Co 8-halogenoquinoline derivative, its ester and salt
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
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FR2625200A1 (en) * 1987-12-29 1989-06-30 Esteve Labor Dr 7-(1-Azetidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their application as medicaments
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
KR910003630B1 (ko) * 1988-06-17 1991-06-07 한국과학기술원 벤조일 아세틱 에스테르 유도체 및 그 제조방법
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
WO1990002123A1 (en) * 1988-08-23 1990-03-08 Pfizer Inc. Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
FR2649106A2 (fr) * 1989-06-29 1991-01-04 Esteve Labor Dr Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament
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IL69601A (en) 1987-08-31
ES8506309A1 (es) 1985-07-01
ES529935A0 (es) 1985-07-01
AU562286B2 (en) 1987-06-04
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NZ205529A (en) 1986-05-09
FI833151A0 (fi) 1983-09-05
EP0106489B1 (en) 1988-07-27
DK70094A (da) 1994-06-16
ES8506021A1 (es) 1985-06-16
ES529934A0 (es) 1985-06-01
ES8502687A1 (es) 1985-01-16
OA07527A (en) 1985-03-31
HU196986B (en) 1989-02-28
DK171098B1 (da) 1996-06-03
ES529933A0 (es) 1985-10-16
IE55898B1 (en) 1991-02-14
EP0106489A2 (en) 1984-04-25
ZA836357B (en) 1984-04-25
DK170471B1 (da) 1995-09-11
JPS5967269A (ja) 1984-04-16
CA1340721C (en) 1999-09-07
PT77308A (en) 1983-10-01
JPH04210961A (ja) 1992-08-03
FI83513C (fi) 1991-07-25
IE831961L (en) 1984-03-09
JPH0780770B2 (ja) 1995-08-30
DD216010A5 (de) 1984-11-28
AU1869883A (en) 1984-03-15
PH21530A (en) 1987-11-16
KR840006241A (ko) 1984-11-22
DK407483A (da) 1984-03-10
JPH08311061A (ja) 1996-11-26
DK407483D0 (da) 1983-09-08
NO164418B (no) 1990-06-25
JPH0742284B2 (ja) 1995-05-10
KR890001424B1 (ko) 1989-05-03
NO164418C (no) 1990-10-03
IL69601A0 (en) 1983-11-30
CS246065B2 (en) 1986-10-16
JPH01146880A (ja) 1989-06-08
EP0106489A3 (en) 1985-04-24
DE3377493D1 (en) 1988-09-01
FI83513B (fi) 1991-04-15
ES8506020A1 (es) 1985-06-16
GR79059B (es) 1984-10-02
ES529936A0 (es) 1985-06-16
ES8505673A1 (es) 1985-06-01
NO833206L (no) 1984-03-12
ES525493A0 (es) 1985-01-16
JPH0662561B2 (ja) 1994-08-17
PT77308B (en) 1986-04-09
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ES529937A0 (es) 1985-06-16
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