ES8501978A1 - Un procedimiento para preparar un agente anti-inflamatorio - Google Patents

Un procedimiento para preparar un agente anti-inflamatorio

Info

Publication number
ES8501978A1
ES8501978A1 ES524518A ES524518A ES8501978A1 ES 8501978 A1 ES8501978 A1 ES 8501978A1 ES 524518 A ES524518 A ES 524518A ES 524518 A ES524518 A ES 524518A ES 8501978 A1 ES8501978 A1 ES 8501978A1
Authority
ES
Spain
Prior art keywords
solvent
injectable
acting
delivery
long
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524518A
Other languages
English (en)
Other versions
ES524518A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stolle Research and Development Corp
Original Assignee
Stolle Research and Development Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stolle Research and Development Corp filed Critical Stolle Research and Development Corp
Publication of ES8501978A1 publication Critical patent/ES8501978A1/es
Publication of ES524518A0 publication Critical patent/ES524518A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UNA COMPOSICION EN MICROPARTICULAS QUE CONTIENE UN AGENTE ANTI-INFLAMATORIO.COMPRENDE: A) DISOLVER O DISPERSAR UN AGENTE ANTI-INFLAMATORIO, EN UN DISOLVENTE, Y DISOLVER UN MATERIAL BIOCOMPATIBLE Y BIODEGRADABLE FORMADOR DE PARED EN EL DISOLVENTE; B) DISPERSAR EL DISOLVENTE QUE CONTIENE EL AGENTE ANTI-INFLAMATORIO Y AL MATERIAL FORMADOR DE PARED, EN UN MEDIO DE TRATAMIENTO DE FASE CONTINUA; C) EVAPORAR UNA PARTE DEL DISOLVENTE A PARTIR DE LA DISPERSION DE LA ETABA (B), PARA FORMAR EN LA SUSPENSION, MICROPARTICULAS QUE CONTENGAN AL AGENTE ANTI-INFLAMATORIO; Y D) EXTRAER EL RESTO DEL DISOLVENTE A PARTIR DE LAS MICROCAPSULAS. EL AGENTE ANTI-INFLAMATORIO ES UN COMPUESTO CORTICOSTEROIDE SELECCIONADO ENTRE COMPUESTOS DE PREDNISOLONA, TRIAMCINOLONAS Y DEXAMETASONAS. EL MATERIAL ES DE MATRIZ POLIMERICA Y SE ELIGE ENTRE POLIACIDO D,1-LACTICO, POLIACIDO GLICOLICO. EL DISOLVENTE SE ELIGE ENTRE ACETONAS, HIDROCARBUROS HALOGENADOS, COMPUESTOS DE HIDROCARBUROS AROMATICOS Y ETERES CICLICOS.
ES524518A 1982-07-29 1983-07-28 Un procedimiento para preparar un agente anti-inflamatorio Granted ES524518A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/402,857 US4530840A (en) 1982-07-29 1982-07-29 Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents

Publications (2)

Publication Number Publication Date
ES8501978A1 true ES8501978A1 (es) 1984-12-16
ES524518A0 ES524518A0 (es) 1984-12-16

Family

ID=23593552

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524518A Granted ES524518A0 (es) 1982-07-29 1983-07-28 Un procedimiento para preparar un agente anti-inflamatorio

Country Status (7)

Country Link
US (1) US4530840A (es)
EP (1) EP0102265B1 (es)
JP (1) JPS59161316A (es)
AT (1) ATE77946T1 (es)
CA (1) CA1218306A (es)
DE (1) DE3382587T2 (es)
ES (1) ES524518A0 (es)

Families Citing this family (294)

* Cited by examiner, † Cited by third party
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