SG11201803156TA - Sustained release formulations of local anesthetics - Google Patents

Sustained release formulations of local anesthetics

Info

Publication number
SG11201803156TA
SG11201803156TA SG11201803156TA SG11201803156TA SG11201803156TA SG 11201803156T A SG11201803156T A SG 11201803156TA SG 11201803156T A SG11201803156T A SG 11201803156TA SG 11201803156T A SG11201803156T A SG 11201803156TA SG 11201803156T A SG11201803156T A SG 11201803156TA
Authority
SG
Singapore
Prior art keywords
sustained release
release formulations
local anesthetics
anesthetics
local
Prior art date
Application number
SG11201803156TA
Inventor
James Helliwell
Amanda Malone
Rafi Chapanian
Richard Liggins
Original Assignee
Eupraxia Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eupraxia Pharmaceuticals Inc filed Critical Eupraxia Pharmaceuticals Inc
Publication of SG11201803156TA publication Critical patent/SG11201803156TA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201803156TA 2015-10-27 2016-10-27 Sustained release formulations of local anesthetics SG11201803156TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562247159P 2015-10-27 2015-10-27
PCT/US2016/059141 WO2017075232A1 (en) 2015-10-27 2016-10-27 Sustained release formulations of local anesthetics

Publications (1)

Publication Number Publication Date
SG11201803156TA true SG11201803156TA (en) 2018-05-30

Family

ID=57249923

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201803156TA SG11201803156TA (en) 2015-10-27 2016-10-27 Sustained release formulations of local anesthetics

Country Status (20)

Country Link
US (2) US11351124B2 (en)
EP (1) EP3206672B1 (en)
JP (1) JP2018531951A (en)
KR (1) KR20180069055A (en)
CN (1) CN108289857A (en)
AU (1) AU2016343952A1 (en)
BR (1) BR112018008415A2 (en)
CA (1) CA3003159A1 (en)
CL (1) CL2018001098A1 (en)
DK (1) DK3206672T3 (en)
ES (1) ES2672993T3 (en)
IL (1) IL258852A (en)
MX (1) MX2018005035A (en)
PL (1) PL3206672T3 (en)
PT (1) PT3206672T (en)
RU (1) RU2018119121A (en)
SG (1) SG11201803156TA (en)
TR (1) TR201808237T4 (en)
TW (1) TW201720427A (en)
WO (1) WO2017075232A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
CN108289857A (en) * 2015-10-27 2018-07-17 优普顺药物公司 The extended release preparation of local anesthetic
EP3691618A1 (en) 2017-10-06 2020-08-12 Foundry Therapeutics, Inc. Implantable depots for the controlled release of therapeutic agents
BR112021020319A2 (en) * 2019-04-10 2021-12-14 Eupraxia Pharmaceuticals Inc Process for fabricating drug crystals of desired size distribution and morphology

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2515898A (en) 1947-09-15 1950-07-18 Lilly Co Eli Procaine penicillin and therapeutic compositions
US2627491A (en) 1950-07-15 1953-02-03 Wyeth Corp Penicillin salts of substituted alkylene diamines
US3993073A (en) 1969-04-01 1976-11-23 Alza Corporation Novel drug delivery device
US3867519A (en) 1972-04-27 1975-02-18 Alza Corp Bioerodible drug delivery device
US4105776A (en) 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
GB1523965A (en) 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids
DE2805106A1 (en) * 1978-02-07 1979-08-16 Hoechst Ag MICROCAPSULES MADE OF POLYVINYL ALCOHOL WITH LIQUID, WATER-INSOLUBLE FILLING MATERIAL AND PROCESS FOR THEIR PRODUCTION
IT1205604B (en) 1981-06-23 1989-03-23 Pierrel Spa PROCEDURE FOR THE TOTAL OR PARTIAL ELIMINATION OF ASPARTIC ACID AND GLUTAMIC ACID FROM PROTEIN HYDROLYSATES AND AMINO ACID MICELS WITH CONSEQUENT OBTAINING OF HIGH NUTRITIONAL AMINO ACID MIXTURES
US4316906A (en) 1978-08-11 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of substituted prolines
IL58849A (en) 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4508729A (en) 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
US4444784A (en) 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
MX7065E (en) 1980-06-06 1987-04-10 Sankyo Co A MICROBIOLOGICAL PROCEDURE FOR PREPARING DERIVATIVES OF ML-236B
US4344949A (en) 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
ZA817261B (en) 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4337201A (en) 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4410520A (en) 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
GB2128984B (en) 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4542025A (en) 1982-07-29 1985-09-17 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US4739073A (en) 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
US4888176A (en) 1984-05-21 1989-12-19 Massachusetts Institute Of Technology Controlled drug delivery high molecular weight polyanhydrides
US4757128A (en) 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
JPS60100516A (en) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd Preparation of sustained release microcapsule
US4568559A (en) 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
US4623588A (en) 1984-02-06 1986-11-18 Biotek, Inc. Controlled release composite core coated microparticles
JPS61191609U (en) 1985-05-20 1986-11-28
US5116870A (en) 1986-06-23 1992-05-26 Merck & Co., Inc. HMG-CoA reductase inhibitors
US4940727A (en) 1986-06-23 1990-07-10 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4789724A (en) 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
JPS63122620A (en) 1986-11-12 1988-05-26 Sanraku Inc Polylactic acid microsphere and production thereof
US5310572A (en) 1987-02-03 1994-05-10 Dow Corning Corporation Process for forming a coated active agent-containing article
US5091378A (en) 1987-05-22 1992-02-25 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method
US5017716A (en) 1987-05-22 1991-05-21 E.R. Squibb & Sons, Inc. Phosphorous-containing HMG-CoA reductase inhibitors, new intermediates and method
US4904646A (en) 1987-05-22 1990-02-27 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-COA reductase inhibitors
US4857311A (en) 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
US4906624A (en) 1987-09-08 1990-03-06 Warner-Lambert Company 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4997837A (en) 1987-09-08 1991-03-05 Warner-Lambert Company 6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4929620A (en) 1987-12-10 1990-05-29 Warner-Lambert Company 5-pyrimidinyl-3,5-dihydroxy-6-heptenoic acid compounds useful as inhibitors of cholesterol biosynthesis
US5001144A (en) 1987-12-21 1991-03-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
US4939143A (en) 1987-12-21 1990-07-03 Rorer Pharmaceutical Corporation Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
US4900754A (en) 1987-12-21 1990-02-13 Rorer Pharmaceutical Corp. HMG-COA reductase inhibitors
US5001128A (en) 1987-12-21 1991-03-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. HMG-COA reductase inhibitors
US4994494A (en) 1987-12-21 1991-02-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. HMG-COA reductase inhibitors
US4946864A (en) 1988-02-01 1990-08-07 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US5021453A (en) 1988-03-02 1991-06-04 Merck & Co., Inc. 3-keto HMG-CoA reductase inhibitors
DE68914495T2 (en) 1988-03-02 1994-10-27 Merck & Co Inc Antihypercholesterolemic agent.
US4920109A (en) 1988-04-18 1990-04-24 Merck & Co., Inc. Antifungal compositions and method of controlling mycotic infections
MC2025A1 (en) 1988-04-20 1990-04-25 Asta Pharma Ag MEDICINAL PRODUCT CONTAINING AZELASTINE AND CAPABLE OF RELEASING IT IN A CONTROLLED WAY
US5271946A (en) 1988-04-20 1993-12-21 Asta Pharma Aktiengesellschaft Controlled release azelastine-containing pharmaceutical compositions
US5166171A (en) 1988-05-13 1992-11-24 Hoechst Aktiengesellschaft 6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, and in treating hypercholesterolemia
US4897402A (en) 1988-06-29 1990-01-30 Merck & Co., Inc. 5-oxa, 5-thia, 5-aza HmG-CoA reductase inhibitors
US4963538A (en) 1988-06-29 1990-10-16 Merck & Co., Inc. 5-oxygenated HMG-CoA reductase inhibitors
IT1226726B (en) 1988-07-29 1991-02-05 Zambon Spa ACTIVE COMPOUNDS AS CHOLESTEROL BIOSYNTHESIS INHIBITORS.
US5196440A (en) 1988-07-29 1993-03-23 Zambon Group S.P.A. Compounds active as inhibitors of the cholesterol biosynthesis
DE3832570A1 (en) 1988-09-24 1990-03-29 Hoechst Ag 7-SUBSTITUTED DERIVATIVES OF 3,5-DIHYDROXYHEPT-6-ACID, METHODS FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND INTERMEDIATE PRODUCTS
US4957940A (en) 1988-12-21 1990-09-18 Warner-Lambert Company Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis
US4906657A (en) 1988-12-21 1990-03-06 Warner-Lambert Company Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis
US4950675A (en) 1988-12-21 1990-08-21 Warner-Lambert Company Pyridine di-mevalono-lactones as inhibitors of cholesterol biosynthesis
US4923861A (en) 1989-02-07 1990-05-08 Warner-Lambert Company 6-(2-(2-(Substituted amino)-3-quinolinyl) ethenyl and ethyl) tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US5130306A (en) 1989-03-13 1992-07-14 Merck & Co., Inc. 5-Oxygenated HMG-COA reductase inhibitors
US5132312A (en) 1989-03-27 1992-07-21 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US4970231A (en) 1989-06-09 1990-11-13 Merck & Co., Inc. 4-substituted HMG-CoA reductase inhibitors
US5102911A (en) 1989-06-09 1992-04-07 Merck & Co, Inc. 4-Substituted HMG-CoA reductase inhibitors
PH30995A (en) 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
FI94339C (en) 1989-07-21 1995-08-25 Warner Lambert Co Process for the preparation of pharmaceutically acceptable [R- (R *, R *)] - 2- (4-fluorophenyl) -, - dihydroxy-5- (1-methylethyl) -3-phenyl-4 - [(phenylamino) carbonyl] -1H- for the preparation of pyrrole-1-heptanoic acid and its pharmaceutically acceptable salts
US4992429A (en) 1989-08-24 1991-02-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel HMG-COA reductase inhibitors
US5098931A (en) 1989-08-31 1992-03-24 Merck & Co., Inc. 7-substituted HMG-CoA reductase inhibitors
US4946860A (en) 1989-11-03 1990-08-07 Rorer Pharmaceutical Corporation Benzothiopyranyl derivatives as HMG-CoA reductase inhibitors
IT1237793B (en) 1989-12-21 1993-06-17 Zambon Spa ACTIVE COMPOUNDS AS INHIBITORS OF THE HMG-COA REDUCTASE ENZYME
US5133947A (en) 1990-03-02 1992-07-28 Occidental Chemical Corporation Hydrous trivalent chromium oxide/carbon particles and method of making the same
US5025000A (en) 1990-03-02 1991-06-18 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-CoA reductase inhibitor compounds
US5084287A (en) 1990-03-15 1992-01-28 Warner-Lambert Company Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat
US5622985A (en) 1990-06-11 1997-04-22 Bristol-Myers Squibb Company Method for preventing a second heart attack employing an HMG CoA reductase inhibitor
US5091185A (en) 1990-06-20 1992-02-25 Monsanto Company Coated veterinary implants
US5112857A (en) 1990-09-04 1992-05-12 Merck & Co., Inc. Hmg-coa reductase inhibitor metabolites
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5182298A (en) 1991-03-18 1993-01-26 Merck & Co., Inc. Cholesterol lowering agents
US5654009A (en) 1991-03-25 1997-08-05 Fujisawa Pharmaceutical Co., Ltd. Delayed action preparation
US5256689A (en) 1991-05-10 1993-10-26 Merck & Co., Inc. Cholesterol lowering compounds
US5135935A (en) 1991-05-17 1992-08-04 Merck & Co., Inc. Squalene synthetase inhibitors
US5286497A (en) 1991-05-20 1994-02-15 Carderm Capital L.P. Diltiazem formulation
US5250435A (en) 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)
US5202327A (en) 1991-07-10 1993-04-13 E. R. Squibb & Sons, Inc. Phosphorus-containing hmg-coa reductase inhibitors
DE69223601T2 (en) * 1991-08-19 1998-06-18 Eastman Kodak Co PHOTOGRAPHIC PAPER WITH LOW OXYGEN PERMEABILITY
DE69220317T2 (en) 1991-10-01 1997-10-16 Takeda Chemical Industries Ltd Microparticle summary for extended release and manufacture of the same
HU9203780D0 (en) 1991-12-12 1993-03-29 Sandoz Ag Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
US5260332A (en) 1992-02-07 1993-11-09 Merci & Co., Inc. Cholesterol lowering compounds
US5262435A (en) 1992-02-10 1993-11-16 Merck & Co., Inc. Cholesterol lowering compounds
US5286895A (en) 1992-02-19 1994-02-15 Merck & Co., Inc. Cholesterol lowering compounds
US5302604A (en) 1992-03-09 1994-04-12 Merck & Co., Inc. Cholesterol lowering compounds produced by directed biosynthesis
US5369125A (en) 1992-07-17 1994-11-29 Merck & Co., Inc. Cholesterol-lowering agents
US5283256A (en) 1992-07-22 1994-02-01 Merck & Co., Inc. Cholesterol-lowering agents
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
ES2170074T3 (en) 1992-09-10 2002-08-01 Childrens Medical Center BIODEGRADABLE POLYMER MATRICES FOR THE PROLONGED RELEASE OF LOCAL ANESTHETIC AGENTS.
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5317031A (en) 1992-10-19 1994-05-31 Merck & Co., Inc. Cholesterol lowering compounds
KR100201352B1 (en) 1995-03-16 1999-06-15 성재갑 Single shot vaccine formulation
SE505146C2 (en) 1995-10-19 1997-06-30 Biogram Ab Particles for delayed release
US6046187A (en) 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
BR9713215A (en) 1996-09-24 2000-04-04 Lilly Co Eli Coated particle formulation
WO1998051290A2 (en) 1997-05-16 1998-11-19 Children's Medical Center Corporation Local anesthetic formulations comprising a site 1 sodium channel blocker combined with a second active agent
DE60128910T2 (en) 2000-04-27 2008-02-28 Verion Inc. ZERO-ORDER RELEASE AND TEMPERATURE-CONTROLLED MICRO-CAPSULES AND MANUFACTURING METHOD
AU2001294458B2 (en) 2000-10-06 2004-03-11 Jagotec Ag Biodegradable microparticles for controlled release administration, with purified amylopectin-based starch of reduced molecular weight
FR2816411B1 (en) 2000-11-03 2003-07-04 Inst Nat Sante Rech Med MEANS FOR DETECTING THE PATHOLOGICAL TRANSFORMATION OF THE APP PROTEIN AND THEIR APPLICATIONS
IL155479A0 (en) 2000-11-03 2003-11-23 Control Delivery Sys Inc Improved device and method for treating conditions of a joint
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
WO2002058670A1 (en) 2001-01-25 2002-08-01 Euroceltique S.A. Local anesthetic, and method of use
CA2451187C (en) 2001-06-22 2012-08-14 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
DE10140597A1 (en) * 2001-08-18 2003-03-06 Kuraray Specialities Europe Partially cross-linked polyvinyl alcohol
US20070218139A1 (en) 2002-12-20 2007-09-20 Smith Thomas J High Pressure Compaction For Pharmaceutical Formulations
EP1583519A1 (en) 2002-12-20 2005-10-12 St. James Associates Llc/Faber Research Series High pressure compaction for pharmaceutical formulations
US20040208833A1 (en) 2003-02-04 2004-10-21 Elan Pharma International Ltd. Novel fluticasone formulations
US20040191326A1 (en) 2003-03-31 2004-09-30 Reo Joseph P. Taste-masking vehicle for coated oxazolidinone particles
US7063862B2 (en) 2003-06-03 2006-06-20 Biokey, Inc. Pharmaceutical composition and method for treating
CA2533406C (en) 2003-07-31 2013-01-22 Sol-Gel Technologies Ltd. Microcapsules loaded with active ingredients and a method for their preparation
BRPI0414907A (en) 2003-09-30 2006-11-07 Acusphere Inc injectable, oral or topical sustained release pharmaceutical formulations
US20070224278A1 (en) 2003-11-12 2007-09-27 Lyons Robert T Low immunogenicity corticosteroid compositions
RU2262355C1 (en) 2004-02-09 2005-10-20 Уракова Наталья Александровна Method for treating arthritis due to intra-articular injection of medicinal suspension
CN1679515A (en) 2004-04-06 2005-10-12 孙永海 Slow-releasing polymer microglobe of analgesic and preparation thereof
US20090082321A1 (en) 2007-09-21 2009-03-26 Allergan, Inc. Steroid containing drug delivery systems
AU2007313077B2 (en) 2006-10-17 2011-06-02 Neothetics, Inc. Methods, compositions, and formulations for the treatment of thyroid eye disease
SE0700404L (en) 2007-02-19 2008-08-20 Xylophane Ab Polymeric film or coating comprising hemicellulose
US8962022B2 (en) 2007-03-27 2015-02-24 Aptalis Pharmatech, Inc. Pharmaceutical compositions comprising an active substance from the substituted benzhydrylpiperazine family
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
US20080317805A1 (en) 2007-06-19 2008-12-25 Mckay William F Locally administrated low doses of corticosteroids
MX2009014115A (en) 2007-06-25 2010-04-21 Otsuka Pharma Co Ltd Microspheres having core/shell structure.
US8846068B2 (en) 2008-04-18 2014-09-30 Warsaw Orthopedic, Inc. Methods and compositions for treating post-operative pain comprising a local anesthetic
MX2011000405A (en) 2008-07-18 2011-03-04 Prosonix Ltd Process for improving crystallinity.
WO2010017265A2 (en) 2008-08-07 2010-02-11 Calosyn Pharma Injectable extended release compositions and methods of treating arthritis using same
JP2010111592A (en) 2008-11-04 2010-05-20 Aska Pharmaceutical Co Ltd Agent for local administration containing fluticasone propionate
US20110081420A1 (en) 2009-10-07 2011-04-07 Zyga Technology, Inc. Method of forming prolonged-release injectable steroids
EP2515864A4 (en) 2009-12-23 2013-09-11 Psivida Inc Sustained release delivery devices
KR101423237B1 (en) 2010-05-04 2014-07-30 주식회사 삼양바이오팜 Release controlled pharmaceutical composition comprising tamsulosin or pharmaceutically acceptable salts thereof, and oral dosage form comprising the composition
UA111162C2 (en) 2010-08-04 2016-04-11 Флекшен Терап'Ютікс, Інк. INJECTION COMPOSITION OF TRIAMCINOLONE ACETONIDE FOR TREATMENT OF PAIN
CN102070895B (en) 2010-11-17 2013-03-27 无锡中科光远生物材料有限公司 Core-shell microcapsule and preparation method thereof
JP6083936B2 (en) 2011-03-11 2017-02-22 大阪ガスケミカル株式会社 Method for producing sustained release particles
WO2013067170A1 (en) 2011-11-03 2013-05-10 Gtx, Inc. Pharmaceutical compositions of selective androgen receptor modulators and methods of use thereof
EP2819741B1 (en) 2012-02-27 2018-03-28 O-Ray Pharma, Inc. Solid drug implants for intracochlear delivery of therapeutics for the treatment of otic disorders
KR102373259B1 (en) 2012-05-03 2022-03-17 칼라 파마슈티컬스, 인크. Pharmaceutical nanoparticles showing improved mucosal transport
EP2844227B1 (en) 2012-05-03 2020-11-18 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
EP2976062B1 (en) 2013-03-21 2021-11-03 Eupraxia Pharmaceuticals USA LLC Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith
BR112017005666A2 (en) 2014-09-19 2017-12-19 Eupraxia Pharmaceuticals Inc injectable microparticles for hyper-localized release of therapeutic agents
CN108289857A (en) * 2015-10-27 2018-07-17 优普顺药物公司 The extended release preparation of local anesthetic
US9957233B1 (en) 2016-08-05 2018-05-01 Calitor Sciences, Llc Process for preparing substituted quinolin-4-ol compounds

Also Published As

Publication number Publication date
AU2016343952A1 (en) 2018-05-10
MX2018005035A (en) 2018-09-06
TW201720427A (en) 2017-06-16
KR20180069055A (en) 2018-06-22
US20230089355A1 (en) 2023-03-23
ES2672993T3 (en) 2018-06-19
US20180311173A1 (en) 2018-11-01
PL3206672T3 (en) 2018-09-28
WO2017075232A1 (en) 2017-05-04
EP3206672A1 (en) 2017-08-23
PT3206672T (en) 2018-06-20
RU2018119121A (en) 2019-11-28
CA3003159A1 (en) 2017-05-04
JP2018531951A (en) 2018-11-01
RU2018119121A3 (en) 2020-03-10
BR112018008415A2 (en) 2018-10-30
DK3206672T3 (en) 2018-06-18
EP3206672B1 (en) 2018-03-14
CL2018001098A1 (en) 2018-06-15
CN108289857A (en) 2018-07-17
IL258852A (en) 2018-06-28
US11351124B2 (en) 2022-06-07
TR201808237T4 (en) 2018-07-23

Similar Documents

Publication Publication Date Title
IL280485A (en) Modified release formulations of pridopidine
ZA201608209B (en) Stable cannabinoid formulations
HK1225334A1 (en) Extended release fragrance compositions
EP2991639A4 (en) Controlled release pharmaceutical formulations
GB201404139D0 (en) Sustained release buprenorphine solution formulations
ZA201704263B (en) Controlled-release formulations
GB201419261D0 (en) Formulations
GB201419091D0 (en) Formulations
HK1249068A1 (en) Therapeutic uses of berberine formulations
IL258852A (en) Sustained release formulations of local anesthetics
IL272857A (en) Formulations of copanlisib
IL275735A (en) Sustained release olanzapine formulations
HK1213770A1 (en) Sustained release formulations of lorazepam
GB201417589D0 (en) Pharmaceutical Formulations
PT3678644T (en) Formulations of copanlisib
IL253125A0 (en) Tetracaine-based formulations for use as an anesthetic
TWI561205B (en) Quick release structure of electrosurgical unit
GB201507784D0 (en) Formulations
GB201505532D0 (en) Formulations
GB201501153D0 (en) Immunogenic formulations
GB201405857D0 (en) Immunogenic formulations
PL2848259T3 (en) Sustained release pharmaceutical formulations of Thiocolchicoside