ES8500253A1 - Procedimiento para la obtencion de derivados de la piridazina con accion psicotropa - Google Patents

Procedimiento para la obtencion de derivados de la piridazina con accion psicotropa

Info

Publication number
ES8500253A1
ES8500253A1 ES529108A ES529108A ES8500253A1 ES 8500253 A1 ES8500253 A1 ES 8500253A1 ES 529108 A ES529108 A ES 529108A ES 529108 A ES529108 A ES 529108A ES 8500253 A1 ES8500253 A1 ES 8500253A1
Authority
ES
Spain
Prior art keywords
preparation
activity
psychotrope
intermediates
pyridazine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529108A
Other languages
English (en)
Other versions
ES529108A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8301366A external-priority patent/FR2540115B1/fr
Priority claimed from FR8318433A external-priority patent/FR2555178B1/fr
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES529108A0 publication Critical patent/ES529108A0/es
Publication of ES8500253A1 publication Critical patent/ES8500253A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIDAZINA CON ACCION PSICOTROPA, ASI COMO SUS SALES FARMACEUTICAMENTE ACEPTABLES.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE TRATA UNA ETOXICARBONIL-4 PIRIDAZONA CON AMONIACO, PARA OBTENER LA CARBOXAMIDA-4 PIRIDAZONA; SEGUNDA, SE TRATA LA CARBOXAMIDA-4 PIRIDAZONA CON OXICLORURO DE FOSFORO, PARA OBTENER UN COMPUESTO DE FORMULA (II); Y POR ULTIMO, SE HACE REACCIONAR UN COMPUESTO DE FORMULA (II) CON UNA AMINA DE FORMULA (III), PARA OBTENER EL COMPUESTO DE FORMULA (I).DE APLICACION EN EL TRATAMIENTO DE DIVERSAS AFECCIONES NEUROLOGICAS.
ES529108A 1983-01-28 1984-01-24 Procedimiento para la obtencion de derivados de la piridazina con accion psicotropa Expired ES8500253A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8301366A FR2540115B1 (fr) 1983-01-28 1983-01-28 Derive de la pyridazine ayant une action psychotrope, son mode de preparation et les medicaments en contenant
FR8318433A FR2555178B1 (fr) 1983-11-18 1983-11-18 Derives cyanes de la pyridazine ayant une action psychotrope, leur mode de preparation et les medicaments en contenant

Publications (2)

Publication Number Publication Date
ES529108A0 ES529108A0 (es) 1984-10-01
ES8500253A1 true ES8500253A1 (es) 1984-10-01

Family

ID=26223263

Family Applications (1)

Application Number Title Priority Date Filing Date
ES529108A Expired ES8500253A1 (es) 1983-01-28 1984-01-24 Procedimiento para la obtencion de derivados de la piridazina con accion psicotropa

Country Status (25)

Country Link
US (2) US4565814A (es)
EP (1) EP0116494B1 (es)
KR (1) KR910000639B1 (es)
AU (1) AU566352B2 (es)
CA (1) CA1218655A (es)
CS (1) CS274405B2 (es)
DD (1) DD215542A5 (es)
DE (1) DE3469026D1 (es)
DK (3) DK159969C (es)
ES (1) ES8500253A1 (es)
FI (1) FI77453C (es)
GR (1) GR81682B (es)
HU (1) HU192975B (es)
IE (1) IE56750B1 (es)
IL (1) IL70755A (es)
MA (1) MA20019A1 (es)
NO (1) NO840329L (es)
NZ (1) NZ206957A (es)
OA (1) OA07645A (es)
PH (1) PH21476A (es)
PL (1) PL143994B1 (es)
PT (1) PT77994B (es)
SG (1) SG9389G (es)
SU (1) SU1274623A3 (es)
YU (1) YU14184A (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
ES8707201A1 (es) * 1985-06-14 1987-07-16 Lilly Co Eli Un procedimiento para la preparacion de una serie de piridazinas
US5106973A (en) * 1987-11-23 1992-04-21 Janssen Pharmaceutica N.V. Pyridzainamine derivatives
NZ509748A (en) * 1998-08-20 2003-01-31 Toyama Chemical Co Ltd Nitrogenous heterocyclic carboxamide derivatives or salts useful as antiviral agents
NZ529822A (en) * 1999-01-22 2005-11-25 Elan Pharm Inc Acyl derivatives which treat VLA-4 related disorders
TWI281470B (en) 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200307671A (en) 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
AU2005260102A1 (en) * 2004-05-08 2006-01-12 Novartis International Pharmaceutical Ltd. 3-aryl-5,6-disubstituted pyridazines
EP1741709A1 (en) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals
CN101273035A (zh) 2005-09-29 2008-09-24 伊兰制药公司 抑制由vla-4介导的白细胞粘附的氨基甲酸酯化合物
DK1940826T3 (da) 2005-09-29 2011-04-18 Elan Pharm Inc Pyrimidinylamidforbindelser, der inhiberer leukocytadhæsion medieret gennem BLA-4
MX2008010988A (es) 2006-02-27 2008-10-20 Elan Pharm Inc Compuestos de pirimidinil sulfonamida que inhiben la adhesion de los leucocitos mediada por vla-4.
CA2760151A1 (en) 2009-04-27 2010-11-04 Elan Pharmaceuticals, Inc. Pyridinone antagonists of alpha-4 integrins
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1345880A (en) * 1971-06-18 1974-02-06 Cepbepe Pyridazine derivatives
FR2510998B1 (fr) * 1981-08-07 1986-01-10 Sanofi Sa Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent
FR2510997A1 (fr) * 1981-08-10 1983-02-11 Sanofi Sa Nouveaux derives de la methyl-4 phenyl-6 pyridazine, procede pour leur preparation et medicaments actifs sur le systeme nerveux central en contenant
FR2539739B1 (fr) * 1983-01-24 1985-11-22 Sanofi Sa Nouveaux derives de la naphtyl pyridazine actifs sur le systeme nerveux central, procede de preparation de ces derives et medicaments en contenant

Also Published As

Publication number Publication date
DD215542A5 (de) 1984-11-14
OA07645A (fr) 1985-05-23
DK162219B (da) 1991-09-30
AU566352B2 (en) 1987-10-15
EP0116494A1 (fr) 1984-08-22
PL245932A1 (en) 1985-05-21
DK621589D0 (da) 1989-12-08
KR910000639B1 (ko) 1991-01-31
CA1218655A (en) 1987-03-03
FI840349A (fi) 1984-07-29
MA20019A1 (fr) 1984-10-01
DK25984A (da) 1984-07-29
HU192975B (en) 1987-08-28
SU1274623A3 (ru) 1986-11-30
FI840349A0 (fi) 1984-01-27
IL70755A (en) 1987-03-31
NO840329L (no) 1984-07-30
SG9389G (en) 1989-07-07
DK159969B (da) 1991-01-07
CS274405B2 (en) 1991-04-11
DK621689A (da) 1989-12-08
PT77994A (fr) 1984-02-01
CS61484A2 (en) 1990-09-12
YU14184A (en) 1986-10-31
ES529108A0 (es) 1984-10-01
DK162219C (da) 1992-03-02
KR840007587A (ko) 1984-12-08
FI77453C (fi) 1989-03-10
DK159969C (da) 1991-05-27
DK162218C (da) 1992-03-02
PH21476A (en) 1987-10-28
NZ206957A (en) 1987-06-30
DE3469026D1 (en) 1988-03-03
IE56750B1 (en) 1991-12-04
US4565814A (en) 1986-01-21
US4631280A (en) 1986-12-23
AU2372884A (en) 1984-08-02
FI77453B (fi) 1988-11-30
EP0116494B1 (fr) 1988-01-27
DK621689D0 (da) 1989-12-08
PL143994B1 (en) 1988-04-30
DK162218B (da) 1991-09-30
PT77994B (fr) 1986-04-10
IE840148L (en) 1984-07-28
GR81682B (es) 1984-12-12
DK621589A (da) 1989-12-08
IL70755A0 (en) 1984-04-30
DK25984D0 (da) 1984-01-20

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303