ES8400667A1 - "procedimiento para la preparacion de una forma retardada debroxhexina, consistente en particulas esferoidales o tabletas dotadas de un recubrimiento". - Google Patents

"procedimiento para la preparacion de una forma retardada debroxhexina, consistente en particulas esferoidales o tabletas dotadas de un recubrimiento".

Info

Publication number
ES8400667A1
ES8400667A1 ES513754A ES513754A ES8400667A1 ES 8400667 A1 ES8400667 A1 ES 8400667A1 ES 513754 A ES513754 A ES 513754A ES 513754 A ES513754 A ES 513754A ES 8400667 A1 ES8400667 A1 ES 8400667A1
Authority
ES
Spain
Prior art keywords
acid
bromhexine
weight
percent
tablets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513754A
Other languages
English (en)
Other versions
ES513754A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8400667A1 publication Critical patent/ES8400667A1/es
Publication of ES513754A0 publication Critical patent/ES513754A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PREPARACION DE UNA FORMA RETARDADA DE BROMHEXINA, CONSISTENTE EN PARTICULAS ESFEROIDALES O TABLETAS DOTADAS DE UN RECUBRIMIENTO. SE VENCE LA INSOLUBILIDAD DE LA BROMHEXINA AL PH MAS ELEVADO DEL TRACTO INTESTINAL MEDIANTE LA ADICION DE SUSTANCIAS DE ACCION ACIDA. LAS DIVERSAS FORMAS DE ESTE PREPARADO FARMACEUTICO SE REVISTEN CON UNA MEMBRANA QUE MUESTRA, POR UNA PARTE, UNA CARACTERISTICA DE LIBERACION ESPECIALMENTE ADAPTADA PARA LA BROMHEXINA PERO, POR OTRA PARTE, RETIENE DURANTE UN TIEMPO SUFICIENTEMENTE LARGO DENTRO DE LA FORMA FARMACEUTICA TAMBIEN LAS SUSTANCIAS ACIDAS QUE NORMALMENTE SE DISUELVEN MUCHO MAS RAPIDAMENTE. LA MEMBRANA ESTA CONSTITUIDA ESENCIALMENTE POR BARNICES INSOLUBLES EN ACIDOS PERO SOLUBLES EN EL JUGO INTESTINAL.
ES513754A 1981-07-07 1982-07-06 "procedimiento para la preparacion de una forma retardada debroxhexina, consistente en particulas esferoidales o tabletas dotadas de un recubrimiento". Granted ES513754A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813126703 DE3126703A1 (de) 1981-07-07 1981-07-07 Bromhexin-retardform und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8400667A1 true ES8400667A1 (es) 1983-11-01
ES513754A0 ES513754A0 (es) 1983-11-01

Family

ID=6136275

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513754A Granted ES513754A0 (es) 1981-07-07 1982-07-06 "procedimiento para la preparacion de una forma retardada debroxhexina, consistente en particulas esferoidales o tabletas dotadas de un recubrimiento".

Country Status (24)

Country Link
US (1) US4438091A (es)
EP (1) EP0069259B1 (es)
JP (1) JPS5859916A (es)
KR (1) KR880001753B1 (es)
AR (1) AR229183A1 (es)
AT (1) ATE11106T1 (es)
AU (1) AU556917B2 (es)
CA (1) CA1205384A (es)
CS (1) CS244909B2 (es)
DE (2) DE3126703A1 (es)
DK (1) DK163171C (es)
ES (1) ES513754A0 (es)
FI (1) FI822375L (es)
GB (1) GB2101485B (es)
GR (1) GR76850B (es)
HU (1) HU186538B (es)
IE (1) IE53803B1 (es)
IL (1) IL66224A (es)
NO (1) NO159061C (es)
NZ (1) NZ201182A (es)
PH (1) PH20651A (es)
PL (1) PL142312B1 (es)
PT (1) PT75198B (es)
ZA (1) ZA824786B (es)

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DE3237575A1 (de) * 1982-10-09 1984-04-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue orale mopidamolformen
DE3317558A1 (de) * 1983-05-13 1984-11-15 Dietrich Dr.med. Sta. Eulalia Ibiza Reichert Orales antischnarchmittel
AU574360B2 (en) * 1983-05-13 1988-07-07 Reichert, D. Antisnoring agent
DE3320582A1 (de) * 1983-06-08 1984-12-13 Dr. Karl Thomae Gmbh, 7950 Biberach Gliquidonhaltige zubereitungsformen und verfahren zu ihrer herstellung
DE3320583A1 (de) * 1983-06-08 1984-12-13 Dr. Karl Thomae Gmbh, 7950 Biberach Neue galenische zubereitungsformen von oralen antidiabetika und verfahren zu ihrer herstellung
JPS6051106A (ja) * 1983-08-31 1985-03-22 Yamanouchi Pharmaceut Co Ltd 塩酸アモスラロ−ル持続性製剤
IE56459B1 (en) * 1983-12-21 1991-08-14 Elan Corp Ltd Controlled absorption pharmaceutical formulation
GB8414221D0 (en) * 1984-06-04 1984-07-11 Sterwin Ag Unit dosage form
GB8414220D0 (en) * 1984-06-04 1984-07-11 Sterwin Ag Medicaments in unit dose form
US4867984A (en) * 1984-11-06 1989-09-19 Nagin K. Patel Drug in bead form and process for preparing same
DE3524003A1 (de) 1985-07-04 1987-01-08 Heumann Ludwig & Co Gmbh Arzneimittelgranulat mit verzoegerter wirkstofffreisetzung und verfahren zu seiner herstellung
GB8707421D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
ATE120089T1 (de) * 1991-05-20 1995-04-15 Marion Laboratories Inc Mehrschichtige zubereitung mit kontrollierter freisetzung.
US5266331A (en) * 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
US20080075781A1 (en) * 1992-11-25 2008-03-27 Purdue Pharma Lp Controlled release oxycodone compositions
US5332727A (en) * 1993-04-29 1994-07-26 Birkmayer U.S.A. Stable, ingestable and absorbable NADH and NADPH therapeutic compositions
US20070275062A1 (en) * 1993-06-18 2007-11-29 Benjamin Oshlack Controlled release oxycodone compositions
JP3149125B2 (ja) * 1995-05-01 2001-03-26 信越化学工業株式会社 固形腸溶製剤のコーティング用基剤
AU5758799A (en) * 1998-09-25 2000-04-17 Sankyo Company Limited Hmg-coa reductase inhibitor-containing preparations
JP2000159692A (ja) * 1998-09-25 2000-06-13 Sankyo Co Ltd ＨＭＧ―ＣｏＡレダクタ―ゼ阻害薬含有製剤
US6319332B1 (en) 1999-06-11 2001-11-20 James Albert Gavney, Jr. Squeegee device and system
PT1207860E (pt) 1999-09-02 2008-01-24 Nostrum Pharmaceuticals Inc Formulação de peletes de libertação controlada
UA81224C2 (uk) * 2001-05-02 2007-12-25 Euro Celtic S A Дозована форма оксикодону та її застосування
DE10149674A1 (de) 2001-10-09 2003-04-24 Apogepha Arzneimittel Gmbh Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung
UA78974C2 (en) 2001-10-20 2007-05-10 Boehringer Ingelheim Pharma Use of flibanserin for treating disorders of sexual desire
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
PT1870100E (pt) * 2002-03-07 2012-04-17 Boehringer Ingelheim Int Metanossulfonato de 3-[(2-{[4-(hexiloxicarbonilamino-iminometil)- fenilamino]-metil}-1-metil-1h-benzimidazol-5-carbonil)- piridin-2-il-amino]-propionato de etilo
DE10209982A1 (de) * 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Oral zu applizierende Darreichungsform für schwerlösliche basische Wirkstoffe
US20030181488A1 (en) * 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
DE10337697A1 (de) * 2003-08-16 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tablette enthaltend 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenyl-amino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester oder dessen Salze
DE10339862A1 (de) * 2003-08-29 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel
DE10341414A1 (de) * 2003-09-05 2005-03-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Oral zu applizierende Darreichungsform für schwerlösliche saure und amphotere Wirkstoffe
US20050053669A1 (en) * 2003-09-05 2005-03-10 Boehringer Ingelheim International Gmbh Administration form for the oral application of poorly soluble acidic and amphorteric drugs
DE102004023930A1 (de) * 2004-05-12 2005-12-08 Boehringer Ingelheim Vetmedica Gmbh Schnell lösliches Granulat von Bromhexin/Bromhexinhydrochlorid, Verfahren zu dessen Herstellung und dessen Verwendung
ES2546258T3 (es) 2005-03-22 2015-09-22 Stada Arzneimittel Ag Ibuprofeno solubilizado
US8227476B2 (en) 2005-08-03 2012-07-24 Sprout Pharmaceuticals, Inc. Use of flibanserin in the treatment of obesity
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US8133506B2 (en) * 2008-03-12 2012-03-13 Aptalis Pharmatech, Inc. Drug delivery systems comprising weakly basic drugs and organic acids
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US10987313B2 (en) 2013-10-07 2021-04-27 Impax Laboratories, Llc Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
EP3054929B1 (en) 2013-10-07 2020-08-05 Impax Laboratories, LLC Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
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US2928770A (en) 1958-11-28 1960-03-15 Frank M Bardani Sustained action pill
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US3538214A (en) 1969-04-22 1970-11-03 Merck & Co Inc Controlled release medicinal tablets
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Also Published As

Publication number Publication date
IL66224A0 (en) 1982-11-30
HU186538B (en) 1985-08-28
US4438091A (en) 1984-03-20
ATE11106T1 (de) 1985-01-15
PL237305A1 (en) 1985-05-07
CS244909B2 (en) 1986-08-14
DK303682A (da) 1983-01-08
FI822375L (fi) 1983-01-08
PT75198B (de) 1985-10-04
GB2101485B (en) 1984-10-03
EP0069259A3 (en) 1983-06-15
PH20651A (en) 1987-03-16
NZ201182A (en) 1985-09-13
DE3261839D1 (en) 1985-02-21
KR840000230A (ko) 1984-02-18
NO159061B (no) 1988-08-22
CA1205384A (en) 1986-06-03
AR229183A1 (es) 1983-06-30
ZA824786B (en) 1984-03-28
IE53803B1 (en) 1989-03-01
DK163171B (da) 1992-02-03
EP0069259A2 (de) 1983-01-12
KR880001753B1 (ko) 1988-09-12
IE821626L (en) 1983-01-07
ES513754A0 (es) 1983-11-01
CS516382A2 (en) 1985-09-17
JPS5859916A (ja) 1983-04-09
PT75198A (de) 1982-08-01
GB2101485A (en) 1983-01-19
PL142312B1 (en) 1987-10-31
IL66224A (en) 1986-02-28
GR76850B (es) 1984-09-04
NO159061C (no) 1988-11-30
AU556917B2 (en) 1986-11-27
DE3126703A1 (de) 1983-01-27
DK163171C (da) 1992-06-22
AU8564682A (en) 1983-01-13
EP0069259B1 (de) 1985-01-09
NO822216L (no) 1983-01-10
FI822375A0 (fi) 1982-07-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519