ATE44035T1 - Derivate des neocarzinostatins und verfahren zu deren herstellung. - Google Patents
Derivate des neocarzinostatins und verfahren zu deren herstellung.Info
- Publication number
- ATE44035T1 ATE44035T1 AT84305414T AT84305414T ATE44035T1 AT E44035 T1 ATE44035 T1 AT E44035T1 AT 84305414 T AT84305414 T AT 84305414T AT 84305414 T AT84305414 T AT 84305414T AT E44035 T1 ATE44035 T1 AT E44035T1
- Authority
- AT
- Austria
- Prior art keywords
- residue
- neocarzinostatin
- maleic acid
- sma
- chem
- Prior art date
Links
- QZGIWPZCWHMVQL-UIYAJPBUSA-N neocarzinostatin chromophore Chemical class O1[C@H](C)[C@H](O)[C@H](O)[C@@H](NC)[C@H]1O[C@@H]1C/2=C/C#C[C@H]3O[C@@]3([C@@H]3OC(=O)OC3)C#CC\2=C[C@H]1OC(=O)C1=C(O)C=CC2=C(C)C=C(OC)C=C12 QZGIWPZCWHMVQL-UIYAJPBUSA-N 0.000 title abstract 5
- 101710204212 Neocarzinostatin Proteins 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid group Chemical group C(\C=C/C(=O)O)(=O)O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 229950009268 zinostatin Drugs 0.000 abstract 2
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 125000003011 styrenyl group Chemical group [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58145419A JPS6075499A (ja) | 1983-08-08 | 1983-08-08 | ネオカルチノスタチン誘導体及びその製造法 |
| EP84305414A EP0136792B1 (de) | 1983-08-08 | 1984-08-08 | Derivate des Neocarzinostatins und Verfahren zu deren Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE44035T1 true ATE44035T1 (de) | 1989-06-15 |
Family
ID=15384811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84305414T ATE44035T1 (de) | 1983-08-08 | 1984-08-08 | Derivate des neocarzinostatins und verfahren zu deren herstellung. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4762885A (de) |
| EP (1) | EP0136792B1 (de) |
| JP (1) | JPS6075499A (de) |
| AT (1) | ATE44035T1 (de) |
| CA (1) | CA1241640A (de) |
| DE (1) | DE3478689D1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5389366A (en) * | 1986-09-19 | 1995-02-14 | Yamanouchi Pharmaceutical Co., Ltd. | Neocarzinostatin derivative composition for oral administration |
| JP2556865B2 (ja) * | 1986-09-19 | 1996-11-27 | 山之内製薬株式会社 | ネオカルチノスタチン誘導体の非注射投与用組成物 |
| CA1327161C (en) * | 1987-09-01 | 1994-02-22 | Mitsugu Kobayashi | Lyophilized pharmaceutical composition of neocarzinostatin derivative |
| ES2642179T3 (es) * | 2003-05-26 | 2017-11-15 | Hiroshi Maeda | Agente antitumoral y proceso para producir el mismo |
| WO2006080171A1 (ja) | 2005-01-31 | 2006-08-03 | Effector Cell Institute, Inc. | 免疫増強剤 |
| WO2015076312A1 (ja) | 2013-11-19 | 2015-05-28 | 前田 浩 | スチレン-マレイン酸共重合体の誘導体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3085994A (en) * | 1959-10-30 | 1963-04-16 | Sinclair Research Inc | Chain terminated copolymer of styrene and maleic anhydride of low solution viscosity |
| US3121043A (en) * | 1960-05-11 | 1964-02-11 | Scient Associates Inc | Sustained release pharmaceutical preparation and methods for making same |
| US3245933A (en) * | 1960-05-19 | 1966-04-12 | Sinclair Research Inc | Styrene-maleic anhydride copolymers cross-linked with aliphatic polyhydroxy compounds |
| JPS6017206B2 (ja) * | 1977-03-24 | 1985-05-01 | 浩 前田 | ネオカルチノスタチン誘導体の製造法 |
| DE3367921D1 (en) * | 1982-02-27 | 1987-01-15 | Kuraray Co | Neocarzinostatin complexes, a method for producing the same, and an antitumor agent containing said complexes as an active component |
-
1983
- 1983-08-08 JP JP58145419A patent/JPS6075499A/ja active Granted
-
1984
- 1984-07-26 CA CA000459768A patent/CA1241640A/en not_active Expired
- 1984-08-08 DE DE8484305414T patent/DE3478689D1/de not_active Expired
- 1984-08-08 AT AT84305414T patent/ATE44035T1/de not_active IP Right Cessation
- 1984-08-08 EP EP84305414A patent/EP0136792B1/de not_active Expired
-
1986
- 1986-09-25 US US06/911,456 patent/US4762885A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE3478689D1 (en) | 1989-07-20 |
| EP0136792B1 (de) | 1989-06-14 |
| CA1241640A (en) | 1988-09-06 |
| EP0136792A2 (de) | 1985-04-10 |
| US4762885A (en) | 1988-08-09 |
| EP0136792A3 (en) | 1985-12-18 |
| JPS6075499A (ja) | 1985-04-27 |
| JPH0133120B2 (de) | 1989-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |