ES8103049A1 - Un procedimiento de preparacion de nuevas fenoxiaminas hete-rociclicas - Google Patents
Un procedimiento de preparacion de nuevas fenoxiaminas hete-rociclicasInfo
- Publication number
- ES8103049A1 ES8103049A1 ES493111A ES493111A ES8103049A1 ES 8103049 A1 ES8103049 A1 ES 8103049A1 ES 493111 A ES493111 A ES 493111A ES 493111 A ES493111 A ES 493111A ES 8103049 A1 ES8103049 A1 ES 8103049A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- substituted heterocyclic
- alkyl
- local anaesthetics
- amines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 heterocyclic phenoxy amines Chemical class 0.000 title abstract 2
- 229960005015 local anesthetics Drugs 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE FENOXIAMINAS HETEROCICLICAS SUSTITUIDAS, DE FORMULA (I) EN DONDE <M> Y <N> VALEN 0 O 2, CON LA CONDICION DE QUE LA SUMA DE <M> Y <N> SEA IGUAL A 2. LOS SIMBOLOS DE LOS RADICALES DE LA FORMULA (I) TIENEN EL SIGUIENTE SIGNIFICADO: A ES HIDROGENO O UN ALCOHILOXI APROPIADO; X PUEDE SER FLUOR, CLORO O BROMO Y R REPRESENTA HIDROGENO UN GRUPO ALCOHILO INFERIROR, UN GRUPO CICLOALCOILO O UN CICLOALQUNILO. SE BASA DICHO PROCEDIMIENTO EN LA REACCION DE UN FENOL SUSTITUIDO DE FORMULA (II) CON UNA AMINA DE FORMULA (III) DONDE A,X Y R TIENEN LOS SIGNIFICADOS ANTERIORMENTE INDICADOS E Y ES UN RESTO ANIONICO ELIMINABLE, CON LO QUE SE OBTIENEN COMPUESTOS DE FORMULA I QUE PUEDEN TRANSFORMARSE, OPCIONALMENTE, EN SUS SALES DE ADICION DE ACIDO O EN OTRAS SUSTANCIAS DERIVADAS. LOS COMPUESTOS OBTENIDOS PRESENTAN ACTIVIDAD DOBRE EL SISTEMA NERVIOSO CENTRAL Y SON DE EMPLEO COMO ANESTESICOS LOCALES. *FORMULA*
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7917610A FR2460935A1 (fr) | 1979-07-06 | 1979-07-06 | Nouvelles phenoxyamines heterocycliques substituees, leur methode de preparation et leur application comme anesthetiques locaux |
| FR8007352A FR2479218A2 (fr) | 1980-04-01 | 1980-04-01 | Nouvelles phenoxyamines heterocycliques substituees, leur methode de preparation et leur application comme anesthesiques locaux |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES493111A0 ES493111A0 (es) | 1981-02-16 |
| ES8103049A1 true ES8103049A1 (es) | 1981-02-16 |
Family
ID=26221244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES493111A Expired ES8103049A1 (es) | 1979-07-06 | 1980-07-04 | Un procedimiento de preparacion de nuevas fenoxiaminas hete-rociclicas |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US4379161A (es) |
| EP (2) | EP0094102B1 (es) |
| JP (2) | JPS5639065A (es) |
| AR (1) | AR224012A1 (es) |
| AT (2) | ATE10739T1 (es) |
| AU (2) | AU536482B2 (es) |
| BE (1) | BE884124A (es) |
| BG (2) | BG35746A3 (es) |
| CA (1) | CA1163273A (es) |
| CH (2) | CH655100A5 (es) |
| CS (1) | CS216933B2 (es) |
| DD (2) | DD153206A5 (es) |
| DE (2) | DE3071314D1 (es) |
| DK (1) | DK157538C (es) |
| ES (1) | ES8103049A1 (es) |
| FI (2) | FI74274C (es) |
| GR (1) | GR69638B (es) |
| HK (2) | HK55689A (es) |
| HU (2) | HU186539B (es) |
| IE (2) | IE50061B1 (es) |
| IL (2) | IL60472A (es) |
| IN (2) | IN153037B (es) |
| IT (1) | IT1188985B (es) |
| JO (1) | JO1077B1 (es) |
| LU (1) | LU82584A1 (es) |
| MA (1) | MA18893A1 (es) |
| MX (2) | MX7642E (es) |
| NO (2) | NO156086C (es) |
| NZ (1) | NZ194230A (es) |
| OA (1) | OA06561A (es) |
| PH (1) | PH16449A (es) |
| PL (1) | PL127393B1 (es) |
| PT (1) | PT71482A (es) |
| RO (2) | RO81532B (es) |
| SU (1) | SU1085507A3 (es) |
| YU (2) | YU42344B (es) |
| ZW (1) | ZW15280A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2586018B1 (fr) * | 1985-08-12 | 1988-03-25 | Ile De France | Nouveau benzodioxepanne, son procede de synthese et ses applications en therapeutique |
| AU5358490A (en) * | 1989-04-07 | 1990-11-05 | Fujisawa Pharmaceutical Co., Ltd. | New naphthalene compounds and method of producing the same |
| EP0471941A3 (en) * | 1990-08-16 | 1992-10-14 | American Cyanamid Company | An improved process for the preparation of 5-bromo-2-methoxyresorcinol |
| US5472958A (en) * | 1994-08-29 | 1995-12-05 | Abbott Laboratories | 2-((nitro)phenoxymethyl) heterocyclic compounds that enhance cognitive function |
| US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
| DE69817214T2 (de) * | 1997-11-05 | 2004-06-09 | Neurosearch A/S | Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren |
| US8473062B2 (en) * | 2008-05-01 | 2013-06-25 | Autonomic Technologies, Inc. | Method and device for the treatment of headache |
| US8412336B2 (en) | 2008-12-29 | 2013-04-02 | Autonomic Technologies, Inc. | Integrated delivery and visualization tool for a neuromodulation system |
| US9320908B2 (en) * | 2009-01-15 | 2016-04-26 | Autonomic Technologies, Inc. | Approval per use implanted neurostimulator |
| US8494641B2 (en) | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
| US20100185249A1 (en) * | 2009-01-22 | 2010-07-22 | Wingeier Brett M | Method and Devices for Adrenal Stimulation |
| CN111205015B (zh) * | 2020-01-20 | 2021-11-26 | 东南大学 | 一种高稳定泡沫混凝土发泡剂的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE543876C (de) * | 1928-04-25 | 1932-02-11 | C H Boehringer Sohn Akt Ges | Verfahren zur Darstellung von Piperidinalkinen |
| US3117976A (en) * | 1958-11-12 | 1964-01-14 | Beecham Res Lab | Nu-alkyl-pyrrolidine-2-methanol, alpha cyclohexyl mandelates |
| FR1342756A (fr) * | 1958-11-21 | 1963-11-15 | Beecham Res Lab | Esters basiques et leur procédé de préparation, notamment le phényl-cyclohexyl-glycolate de (1-méthyl-2-pyrrolidyl) méthyle et ses sels d'addition |
| GB1096441A (en) * | 1964-01-15 | 1967-12-29 | Bristol Myers Co | Ethers of benzyl phenols and a process for the preparation thereof |
| US3904622A (en) * | 1968-02-16 | 1975-09-09 | Ile De France | Dialkylaminoalkyl ethers of 2-alkoxy-3,5-dihalobenzene |
| GB1268951A (en) * | 1969-06-12 | 1972-03-29 | Pfizer Ltd | Phenoxy-amines |
| FR2155927A1 (en) * | 1971-10-15 | 1973-05-25 | Synthelabo | 1-phenylcyclo hexane carboxylic acid esters - with antispasmodic and anticholinergic activity |
| JPS5139661A (en) * | 1974-09-27 | 1976-04-02 | Nippon Kayaku Kk | Kogakukatsusei 11 mechiru 22 * beetaaa hidorokishechiru * pirorijin oyobisono chukantaino seizoho |
| JPS5251362A (en) * | 1975-10-20 | 1977-04-25 | Teijin Ltd | Preparation of optically active pyrrolidine derivatives |
| LU78625A1 (de) * | 1977-12-02 | 1979-06-13 | Byk Gulden Lomberg Chem Fab | Substituierte 1-phenyl-2-pyrrolidin-2-yl-ethanole,verfahren zu ihrer herstellung,ihre verwendung und sie enthaltende arzneimittel |
| DE2811952A1 (de) * | 1978-03-18 | 1979-10-31 | Merck Patent Gmbh | Phenoxyalkylamine und verfahren zu ihrer herstellung |
-
1980
- 1980-06-25 US US06/162,796 patent/US4379161A/en not_active Expired - Lifetime
- 1980-07-01 DE DE8383105420T patent/DE3071314D1/de not_active Expired
- 1980-07-01 EP EP83105420A patent/EP0094102B1/fr not_active Expired
- 1980-07-01 EP EP80400999A patent/EP0024960B1/fr not_active Expired
- 1980-07-01 AT AT80400999T patent/ATE10739T1/de not_active IP Right Cessation
- 1980-07-01 DE DE8080400999T patent/DE3069789D1/de not_active Expired
- 1980-07-01 BG BG8362115A patent/BG35746A3/xx unknown
- 1980-07-01 OA OA57149A patent/OA06561A/xx unknown
- 1980-07-01 CS CS804693A patent/CS216933B2/cs unknown
- 1980-07-01 YU YU1710/80A patent/YU42344B/xx unknown
- 1980-07-01 BG BG8048341A patent/BG35039A3/xx unknown
- 1980-07-01 AT AT83105420T patent/ATE17119T1/de not_active IP Right Cessation
- 1980-07-01 SU SU802938255A patent/SU1085507A3/ru active
- 1980-07-02 PT PT71482A patent/PT71482A/pt unknown
- 1980-07-02 AU AU60028/80A patent/AU536482B2/en not_active Ceased
- 1980-07-02 IL IL60472A patent/IL60472A/xx unknown
- 1980-07-02 BE BE1/9873A patent/BE884124A/fr not_active IP Right Cessation
- 1980-07-03 HU HU822217A patent/HU186539B/hu not_active IP Right Cessation
- 1980-07-03 HU HU80801658A patent/HU181147B/hu not_active IP Right Cessation
- 1980-07-03 RO RO101590A patent/RO81532B/ro unknown
- 1980-07-03 AR AR281635A patent/AR224012A1/es active
- 1980-07-03 RO RO110029A patent/RO85323B/ro unknown
- 1980-07-03 NZ NZ194230A patent/NZ194230A/xx unknown
- 1980-07-04 MX MX8011334U patent/MX7642E/es unknown
- 1980-07-04 MX MX80100439U patent/MX6366E/es unknown
- 1980-07-04 ZW ZW152/80A patent/ZW15280A1/xx unknown
- 1980-07-04 FI FI802156A patent/FI74274C/fi not_active IP Right Cessation
- 1980-07-04 PL PL1980225473A patent/PL127393B1/pl unknown
- 1980-07-04 NO NO802027A patent/NO156086C/no unknown
- 1980-07-04 GR GR62381A patent/GR69638B/el unknown
- 1980-07-04 CH CH5684/84A patent/CH655100A5/fr not_active IP Right Cessation
- 1980-07-04 LU LU82584A patent/LU82584A1/fr unknown
- 1980-07-04 MA MA19091A patent/MA18893A1/fr unknown
- 1980-07-04 DK DK289580A patent/DK157538C/da not_active IP Right Cessation
- 1980-07-04 CH CH5169/80A patent/CH648827A5/fr not_active IP Right Cessation
- 1980-07-04 ES ES493111A patent/ES8103049A1/es not_active Expired
- 1980-07-04 IE IE1653/85A patent/IE50061B1/en not_active IP Right Cessation
- 1980-07-04 IT IT49163/80A patent/IT1188985B/it active
- 1980-07-04 IE IE1392/80A patent/IE50060B1/en not_active IP Right Cessation
- 1980-07-05 JO JO19801077A patent/JO1077B1/en active
- 1980-07-05 IN IN779/CAL/80A patent/IN153037B/en unknown
- 1980-07-07 DD DD222455A patent/DD153206A5/de unknown
- 1980-07-07 DD DD80234984A patent/DD201141A5/de not_active IP Right Cessation
- 1980-07-07 PH PH24248A patent/PH16449A/en unknown
- 1980-07-07 JP JP9321680A patent/JPS5639065A/ja active Granted
- 1980-09-30 JP JP13751280A patent/JPS5649351A/ja active Granted
-
1982
- 1982-12-16 CA CA000417963A patent/CA1163273A/fr not_active Expired
- 1982-12-17 YU YU2801/82A patent/YU42824B/xx unknown
-
1983
- 1983-06-01 IL IL68854A patent/IL68854A0/xx not_active IP Right Cessation
- 1983-10-10 IN IN1246/CAL/83A patent/IN158706B/en unknown
-
1984
- 1984-03-02 AU AU25260/84A patent/AU563009B2/en not_active Ceased
-
1986
- 1986-05-20 NO NO861988A patent/NO861988L/no unknown
-
1987
- 1987-07-03 FI FI872955A patent/FI872955A0/fi not_active Application Discontinuation
-
1989
- 1989-07-13 HK HK556/89A patent/HK55689A/xx unknown
- 1989-07-13 HK HK558/89A patent/HK55889A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19960603 |