GB1268951A - Phenoxy-amines - Google Patents

Phenoxy-amines

Info

Publication number
GB1268951A
GB1268951A GB29780/69A GB2978069A GB1268951A GB 1268951 A GB1268951 A GB 1268951A GB 29780/69 A GB29780/69 A GB 29780/69A GB 2978069 A GB2978069 A GB 2978069A GB 1268951 A GB1268951 A GB 1268951A
Authority
GB
United Kingdom
Prior art keywords
alkyl
formula
carbon atoms
june
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29780/69A
Inventor
Joachim Augstein
David Alexander Cox
Peter Edward Cross
Peter Rodway Leeming
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Priority to GB29780/69A priority Critical patent/GB1268951A/en
Priority to DE19702026688 priority patent/DE2026688A1/en
Priority to FR7020199A priority patent/FR2052952B1/fr
Priority to US00044604A priority patent/US3709892A/en
Publication of GB1268951A publication Critical patent/GB1268951A/en
Priority to US00283396A priority patent/US3767819A/en
Priority to MY1973323A priority patent/MY7300323A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Abstract

1,268,951. Phenoxy-amines. PFIZER Ltd. 11 June, 1970 [12 June, 1969], No. 29780/69. Heading C2C. Compounds of the general formula (R<SP>2</SP>=C 7-9 alkyl or cycloalkyl - alkyl; Y= AlkNR<SP>2</SP>R<SP>3</SP> or C n H 2n -CHZ; R<SP>2,3</SP> = C 1-4 alkyl or NR<SP>2</SP>R<SP>3</SP> = saturated heterocyclic group; Alk= C 2-4 alkylene, the free valences being located on different carbon atoms; n = 0-3; Z = group which completes a saturated heterocyclic ring containing at least one nitrogen atom and at least four carbon atoms, any such nitrogen atom being separated from the oxygen atom to which the amino-cyclic group is attached by a chain of 2-4 carbon atoms; R<SP>4</SP> = H, halogen or C 1-4 alkyl, alkoxy, alkanoyl or α-oximinoalkyl) and their acid addition salts are prepared by standard methods from (a) the appropriate phenol of the formula (b) a salicylaldehyde derivative of the formula or (c) an o-acylphenol of the formula (R<SP>5</SP>=C 1-4 alkyl). The above compounds possess antihistamine activity, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
GB29780/69A 1969-06-12 1969-06-12 Phenoxy-amines Expired GB1268951A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB29780/69A GB1268951A (en) 1969-06-12 1969-06-12 Phenoxy-amines
DE19702026688 DE2026688A1 (en) 1969-06-12 1970-06-01 Orthosubstituted phenoxyamines with antihistaminic effects
FR7020199A FR2052952B1 (en) 1969-06-12 1970-06-02
US00044604A US3709892A (en) 1969-06-12 1970-06-08 Alkylphenoxy-alkylamines as gastric antisecretory agents
US00283396A US3767819A (en) 1969-06-12 1972-08-24 Alkylphenoxy alkylamines as gastric anti secretory agents
MY1973323A MY7300323A (en) 1969-06-12 1973-12-31 Phenoxy-amines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB29780/69A GB1268951A (en) 1969-06-12 1969-06-12 Phenoxy-amines

Publications (1)

Publication Number Publication Date
GB1268951A true GB1268951A (en) 1972-03-29

Family

ID=10297052

Family Applications (1)

Application Number Title Priority Date Filing Date
GB29780/69A Expired GB1268951A (en) 1969-06-12 1969-06-12 Phenoxy-amines

Country Status (5)

Country Link
US (2) US3709892A (en)
DE (1) DE2026688A1 (en)
FR (1) FR2052952B1 (en)
GB (1) GB1268951A (en)
MY (1) MY7300323A (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910896A (en) * 1970-03-13 1975-10-07 Pfizer Substituted phenoxyalkylamines as gastric anti-secretory agents
US4005084A (en) * 1975-07-10 1977-01-25 Yoshitomi Pharmaceutical Industries, Ltd. Thienylmethyl phenoxy morpholine compounds
DE2549999A1 (en) * 1975-11-07 1977-05-12 Boehringer Mannheim Gmbh PIPERIDINE DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION
DE2811952A1 (en) * 1978-03-18 1979-10-31 Merck Patent Gmbh PHENOXYALKYLAMINE AND METHOD FOR THE PRODUCTION THEREOF
FR2460935A1 (en) * 1979-07-06 1981-01-30 Ile De France 1-Heterocyclyl:oxy-3,5-di:halobenzene derivs. - useful as local anaesthetics
US4379161A (en) * 1979-06-07 1983-04-05 Michel Thominet Novel substituted heterocyclic phenoxyamines, the method of preparation thereof and the use thereof as local anaesthetics
FR2479218A2 (en) * 1980-04-01 1981-10-02 Ile De France 1-Heterocyclyl:oxy-3,5-di:halobenzene derivs. - useful as local anaesthetics
US4556664A (en) * 1984-03-13 1985-12-03 Gunnar A. K. Aberg Method and composition for the treatment of cardiac arrhythmias
US4795758A (en) * 1986-02-10 1989-01-03 Societe A Responsabilite Limitee: Institut De Recherches Chimiques Et Biologiques Appliquees (I.R.C.E.B.A.) 5-[2-(pyrrolidin-1-yl)ethoxy]-p-cymene derivatives, the process for the preparation of the said derivatives and drugs in which the said derivatives are present
US4822778A (en) * 1988-01-19 1989-04-18 Gunnar Aberg Membrane stabilizing phenoxy-piperidine compounds and pharmaceutical compositions employing such compounds
US6110937A (en) * 1997-04-03 2000-08-29 Syntex Usa, Inc. Phenoxymethyl piperidine derivatives for the treatment of neuropathic pain

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR829228A (en) * 1936-06-16 1938-06-16 Henkel & Cie Gmbh Manufacturing process of nitrogen containing compounds

Also Published As

Publication number Publication date
DE2026688A1 (en) 1970-12-17
US3709892A (en) 1973-01-09
FR2052952A1 (en) 1971-04-16
US3767819A (en) 1973-10-23
MY7300323A (en) 1973-12-31
FR2052952B1 (en) 1975-04-18

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