GB1391081A - Optically active benzodiazepines - Google Patents

Optically active benzodiazepines

Info

Publication number
GB1391081A
GB1391081A GB1256772A GB1256772A GB1391081A GB 1391081 A GB1391081 A GB 1391081A GB 1256772 A GB1256772 A GB 1256772A GB 1256772 A GB1256772 A GB 1256772A GB 1391081 A GB1391081 A GB 1391081A
Authority
GB
United Kingdom
Prior art keywords
optically active
benzodiazepines
march
alkyl
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1256772A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CRC Compagnie di Ricerca Chimica SpA
Original Assignee
CRC Compagnie di Ricerca Chimica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CRC Compagnie di Ricerca Chimica SpA filed Critical CRC Compagnie di Ricerca Chimica SpA
Publication of GB1391081A publication Critical patent/GB1391081A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

1391081 Benzodiazepines CRC COMPAGNIA DI RICERCA CHIMICA SA 17 March 1972 [17 March 1971] 12567/72 Heading C2C 38-Compounds of the general formula (R<SP>1</SP> = H, halogen, NO 2 ; R<SP>2</SP> = H, C 1-4 alkyl; R<SP>3</SP> = C 1-4 alkyl, benzyl, substituted benzyl) are prepared by cyclizing a compound of the formula (A = protecting group) by removing the protecting group. The above compounds are sedatives and tranquillizers, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
GB1256772A 1971-03-17 1972-03-17 Optically active benzodiazepines Expired GB1391081A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH386871A CH554349A (en) 1971-03-17 1971-03-17 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 1,3-DIHYDRO-2H-1,4-BENZODIAZEPINE-2-ONES.

Publications (1)

Publication Number Publication Date
GB1391081A true GB1391081A (en) 1975-04-16

Family

ID=4265209

Family Applications (2)

Application Number Title Priority Date Filing Date
GB4955674A Expired GB1391082A (en) 1971-03-17 1972-03-17 Optically active amino benzophenones
GB1256772A Expired GB1391081A (en) 1971-03-17 1972-03-17 Optically active benzodiazepines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB4955674A Expired GB1391082A (en) 1971-03-17 1972-03-17 Optically active amino benzophenones

Country Status (16)

Country Link
AT (1) AT327909B (en)
BE (1) BE780892A (en)
CA (1) CA992079A (en)
CH (1) CH554349A (en)
DE (1) DE2212526A1 (en)
ES (1) ES400851A1 (en)
FR (1) FR2130342B1 (en)
GB (2) GB1391082A (en)
HU (1) HU165496B (en)
IL (2) IL47123A (en)
NL (1) NL7203536A (en)
NO (1) NO137896C (en)
SE (1) SE399887B (en)
SU (1) SU453842A3 (en)
YU (1) YU34882B (en)
ZA (1) ZA721845B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001010846A2 (en) * 1999-08-05 2001-02-15 Igt Pharma Inc. 1,4-diazepine derivatives for the treatment of diseases related to the central nervous system

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH602672A5 (en) * 1974-06-28 1978-07-31 Hoffmann La Roche
CH603655A5 (en) * 1974-10-21 1978-08-31 Hoffmann La Roche

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001010846A2 (en) * 1999-08-05 2001-02-15 Igt Pharma Inc. 1,4-diazepine derivatives for the treatment of diseases related to the central nervous system
WO2001010846A3 (en) * 1999-08-05 2001-11-08 Igt Pharma Inc 1,4-diazepine derivatives for the treatment of diseases related to the central nervous system

Also Published As

Publication number Publication date
DE2212526A1 (en) 1972-09-21
SU453842A3 (en) 1974-12-15
YU69772A (en) 1979-10-31
IL38991A (en) 1976-09-30
NO137896C (en) 1978-05-16
HU165496B (en) 1974-09-28
IL47123A (en) 1976-09-30
NL7203536A (en) 1972-09-19
NO137896B (en) 1978-02-06
CH554349A (en) 1974-09-30
BE780892A (en) 1972-07-17
AT327909B (en) 1976-02-25
FR2130342A1 (en) 1972-11-03
GB1391082A (en) 1975-04-16
ES400851A1 (en) 1975-01-16
FR2130342B1 (en) 1977-01-14
ATA214972A (en) 1975-05-15
YU34882B (en) 1980-04-30
SE399887B (en) 1978-03-06
CA992079A (en) 1976-06-29
IL38991A0 (en) 1972-05-30
ZA721845B (en) 1972-12-27

Similar Documents

Publication Publication Date Title
GB1481219A (en) Preparation of benzodiazepines
GB1147379A (en) 4-alkyl-dialkoxy-ª‡-methylphenethylamines and pharmacologically acceptable salts
GB1268951A (en) Phenoxy-amines
GB1188846A (en) Thiazole Derivatives
GB1391081A (en) Optically active benzodiazepines
GB1505543A (en) Benzodiazepine derivatives and a process for the preparation thereof
GB1243953A (en) Benzdiazepine derivatives
GB1348449A (en) Benzodiazepine derivatives
GB1222294A (en) Oxazinobenzodiazepine derivatives
GB1327930A (en) 1,4-benzodiazepine derivatives
GB1340535A (en) Benzodiazepine derivatives
GB1444529A (en) Benzodiazepine derivatives
GB1468079A (en) Ethanolamine derivatives
ES8301866A1 (en) 2-Alkyl-5-hydroxy-1,4-naphthoquinones, process for their manufacture and pharmaceutical preparations containing these compounds.
GB1329130A (en) Isoindolo 1,2-b benzothiazol-11 -4bh- one 5-oxides
GB1395772A (en) 1-aryl-3h-1,4-benzodiazepin-2,5-1h,4h-diones
GB1373277A (en) Benzodiazepines
GB1373271A (en) Indoles
GB1470748A (en) 6-2-pyridyl-4h-s-triazolo-4,3-a-1,4-benzodiazepines
GB1309868A (en) Benzodiazepine derivativers and a aprocess for the manufacture thereof
GB1290468A (en)
GB1374529A (en) Benzodiazepines
GB1460679A (en) 1,4-benzodiazepines
GB1474305A (en) Benzodiazepine derivatives
GB1385766A (en) Benzodiazepines

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee