ES400851A1 - Optically active benzodiazepines - Google Patents

Optically active benzodiazepines

Info

Publication number
ES400851A1
ES400851A1 ES72400851A ES400851A ES400851A1 ES 400851 A1 ES400851 A1 ES 400851A1 ES 72400851 A ES72400851 A ES 72400851A ES 400851 A ES400851 A ES 400851A ES 400851 A1 ES400851 A1 ES 400851A1
Authority
ES
Spain
Prior art keywords
general formula
formula
optically active
compound
same meaning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES72400851A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CRC Compagnie di Ricerca Chimica SpA
Original Assignee
CRC Compagnie di Ricerca Chimica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CRC Compagnie di Ricerca Chimica SpA filed Critical CRC Compagnie di Ricerca Chimica SpA
Publication of ES400851A1 publication Critical patent/ES400851A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A procedure for obtaining optically active compounds of the general formula which in position 3 contain an asymmetric carbon atom, and in which R1 means hydrogen, halogen or a nitro group, R2 hydrogen or a lower alcohol radical, and R3 a lower alcohol radical, phenyl or a substituted phenyl radical, characterized by than a compound of the general formula **(See formula)** wherein R1 and R2 have the same meaning as defined in formula I, is reacted with a compound of the general formula **(See formula)** wherein R3 has the same meaning as defined for compounds of the general formula I, and A represents the following groups: -H.HCl, tertiary butoxycarbonyl, phthalimide or other protecting group. (Machine-translation by Google Translate, not legally binding)
ES72400851A 1971-03-17 1972-03-16 Optically active benzodiazepines Expired ES400851A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH386871A CH554349A (en) 1971-03-17 1971-03-17 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 1,3-DIHYDRO-2H-1,4-BENZODIAZEPINE-2-ONES.

Publications (1)

Publication Number Publication Date
ES400851A1 true ES400851A1 (en) 1975-01-16

Family

ID=4265209

Family Applications (1)

Application Number Title Priority Date Filing Date
ES72400851A Expired ES400851A1 (en) 1971-03-17 1972-03-16 Optically active benzodiazepines

Country Status (16)

Country Link
AT (1) AT327909B (en)
BE (1) BE780892A (en)
CA (1) CA992079A (en)
CH (1) CH554349A (en)
DE (1) DE2212526A1 (en)
ES (1) ES400851A1 (en)
FR (1) FR2130342B1 (en)
GB (2) GB1391081A (en)
HU (1) HU165496B (en)
IL (2) IL38991A (en)
NL (1) NL7203536A (en)
NO (1) NO137896C (en)
SE (1) SE399887B (en)
SU (1) SU453842A3 (en)
YU (1) YU34882B (en)
ZA (1) ZA721845B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH602672A5 (en) * 1974-06-28 1978-07-31 Hoffmann La Roche
CH603655A5 (en) * 1974-10-21 1978-08-31 Hoffmann La Roche
AU6420700A (en) * 1999-08-05 2001-03-05 Prescient Neuropharma Inc. Novel 1,4-benzodiazepine compounds and derivatives thereof

Also Published As

Publication number Publication date
DE2212526A1 (en) 1972-09-21
YU34882B (en) 1980-04-30
BE780892A (en) 1972-07-17
IL38991A (en) 1976-09-30
YU69772A (en) 1979-10-31
SE399887B (en) 1978-03-06
HU165496B (en) 1974-09-28
GB1391081A (en) 1975-04-16
FR2130342B1 (en) 1977-01-14
CH554349A (en) 1974-09-30
CA992079A (en) 1976-06-29
FR2130342A1 (en) 1972-11-03
NL7203536A (en) 1972-09-19
IL38991A0 (en) 1972-05-30
ZA721845B (en) 1972-12-27
IL47123A (en) 1976-09-30
AT327909B (en) 1976-02-25
SU453842A3 (en) 1974-12-15
NO137896B (en) 1978-02-06
ATA214972A (en) 1975-05-15
NO137896C (en) 1978-05-16
GB1391082A (en) 1975-04-16

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