ES8101048A1 - Procedimiento para la preparacion de nuevos derivados indo- licos - Google Patents
Procedimiento para la preparacion de nuevos derivados indo- licosInfo
- Publication number
- ES8101048A1 ES8101048A1 ES490380A ES490380A ES8101048A1 ES 8101048 A1 ES8101048 A1 ES 8101048A1 ES 490380 A ES490380 A ES 490380A ES 490380 A ES490380 A ES 490380A ES 8101048 A1 ES8101048 A1 ES 8101048A1
- Authority
- ES
- Spain
- Prior art keywords
- indole derivatives
- medicaments
- preparation
- compounds
- indole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
PROCEDIMIENTO DE OBTENCION DE DERIVADOS INDOLICOS. CONSISTE EN HIDROLIZAR UN DERIVADO INDOLICO DE FORMULA GENERAL (I) EN UN DISOLVENTE, EN PRESENCIA DE UN ACIDO O BASE Y A LA TEMPERATURA DE EBULLICION DE LA MEZCLA DE REACCION. SE OBTIENE UN COMPUESTO DE FORMULA GENERAL (II) EN QUE R4 REPRESENTA UN GRUPO CARBOXILO. OPTATIVAMENTE, SE TRANSFORMA EL COMPUESTO OBTENIDO MEDIANTE REDUCCION EN EL CORRESPONDIENTE DE FORMULA GENERAL II, EN QUE R4 REPRESENTA EL GRUPO HIDROXIMETILO. *FORMULA* ACTIVIDAD HIPOLIPIDEMICA Y ANTIATEROSCLEROTICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19792909779 DE2909779A1 (de) | 1979-03-13 | 1979-03-13 | Neue indolderivate, deren herstellung und deren verwendung als arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
ES490380A0 ES490380A0 (es) | 1980-12-01 |
ES8101048A1 true ES8101048A1 (es) | 1980-12-01 |
Family
ID=6065240
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES488446A Expired ES488446A1 (es) | 1979-03-13 | 1980-02-11 | Procedimiento para la preparacion de nuevos derivados indo- licos |
ES490379A Granted ES490379A0 (es) | 1979-03-13 | 1980-04-09 | Procedimiento para la preparacion de nuevos derivados indo- licos |
ES490380A Expired ES8101048A1 (es) | 1979-03-13 | 1980-04-09 | Procedimiento para la preparacion de nuevos derivados indo- licos |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES488446A Expired ES488446A1 (es) | 1979-03-13 | 1980-02-11 | Procedimiento para la preparacion de nuevos derivados indo- licos |
ES490379A Granted ES490379A0 (es) | 1979-03-13 | 1980-04-09 | Procedimiento para la preparacion de nuevos derivados indo- licos |
Country Status (21)
Country | Link |
---|---|
US (1) | US4343811A (es) |
EP (1) | EP0015523B1 (es) |
JP (1) | JPS55124758A (es) |
AT (1) | ATE1642T1 (es) |
AU (1) | AU5636880A (es) |
CA (1) | CA1142519A (es) |
CS (1) | CS208800B2 (es) |
DD (1) | DD149804A5 (es) |
DE (2) | DE2909779A1 (es) |
ES (3) | ES488446A1 (es) |
FI (1) | FI800770A (es) |
GR (1) | GR75241B (es) |
HU (1) | HU180126B (es) |
IL (1) | IL59598A0 (es) |
NO (1) | NO800709L (es) |
NZ (1) | NZ193111A (es) |
PL (1) | PL222634A1 (es) |
PT (1) | PT70921B (es) |
SU (1) | SU1028247A3 (es) |
YU (1) | YU68180A (es) |
ZA (1) | ZA801441B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3165998D1 (de) * | 1980-06-18 | 1984-10-18 | May & Baker Ltd | Indole and indoline derivatives |
DE3232968A1 (de) * | 1981-09-10 | 1983-06-09 | Degussa Ag, 6000 Frankfurt | Neue 2-(hydroxy-phenyl)-indole und verfahren zu deren herstellung |
US4543360A (en) * | 1981-09-10 | 1985-09-24 | Degussa Aktiengesellschaft | 2-(Hydroxy-phenyl)-indoles and process for their production |
GB2111050B (en) * | 1981-11-19 | 1985-09-11 | Ciba Geigy Ag | N-substituted-2-pyridylindoles |
US4478842A (en) * | 1981-11-19 | 1984-10-23 | Ciba-Geigy Corporation | N-Substituted-2-pyridylindoles |
US4460777A (en) * | 1981-11-19 | 1984-07-17 | Ciba-Geigy Corporation | N-Substituted-2-pyridylindoles |
US4647576A (en) * | 1984-09-24 | 1987-03-03 | Warner-Lambert Company | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis |
US4759923A (en) * | 1987-06-25 | 1988-07-26 | Hercules Incorporated | Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives |
DE69728688T2 (de) | 1996-11-19 | 2004-08-19 | Amgen Inc., Thousand Oaks | Aryl und heteroaryl substituierte kondensierte pyrrole als entzündunghemmende mittel |
US6103733A (en) * | 1998-09-09 | 2000-08-15 | Bachmann; Kenneth A. | Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
JP2008507518A (ja) | 2004-07-22 | 2008-03-13 | ピーティーシー セラピューティクス,インコーポレーテッド | C型肝炎を治療するためのチエノピリジン |
DE102006053064A1 (de) * | 2006-11-08 | 2008-05-21 | Universität Potsdam | Verfahren zur Herstellung aromatischer Diazoniumsalze |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2237361A1 (de) * | 1972-07-29 | 1974-02-14 | Boehringer Mannheim Gmbh | (5-indolyloxy)-essigsaeure-derivate und verfahren zur herstellung derselben |
FI59246C (fi) * | 1974-06-24 | 1981-07-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin |
-
1979
- 1979-03-13 DE DE19792909779 patent/DE2909779A1/de not_active Withdrawn
-
1980
- 1980-02-11 ES ES488446A patent/ES488446A1/es not_active Expired
- 1980-02-12 SU SU802879303A patent/SU1028247A3/ru active
- 1980-02-19 GR GR61231A patent/GR75241B/el unknown
- 1980-02-29 US US06/126,006 patent/US4343811A/en not_active Expired - Lifetime
- 1980-03-03 AT AT80101037T patent/ATE1642T1/de not_active IP Right Cessation
- 1980-03-03 EP EP80101037A patent/EP0015523B1/de not_active Expired
- 1980-03-03 DE DE8080101037T patent/DE3060932D1/de not_active Expired
- 1980-03-10 DD DD80219568A patent/DD149804A5/de unknown
- 1980-03-10 PT PT70921A patent/PT70921B/pt unknown
- 1980-03-11 JP JP3083480A patent/JPS55124758A/ja active Pending
- 1980-03-11 CS CS801663A patent/CS208800B2/cs unknown
- 1980-03-12 NO NO800709A patent/NO800709L/no unknown
- 1980-03-12 IL IL59598A patent/IL59598A0/xx unknown
- 1980-03-12 CA CA000347485A patent/CA1142519A/en not_active Expired
- 1980-03-12 YU YU00681/80A patent/YU68180A/xx unknown
- 1980-03-12 PL PL22263480A patent/PL222634A1/xx unknown
- 1980-03-12 ZA ZA00801441A patent/ZA801441B/xx unknown
- 1980-03-12 AU AU56368/80A patent/AU5636880A/en not_active Abandoned
- 1980-03-12 FI FI800770A patent/FI800770A/fi not_active Application Discontinuation
- 1980-03-12 HU HU8080591A patent/HU180126B/hu unknown
- 1980-03-12 NZ NZ193111A patent/NZ193111A/xx unknown
- 1980-04-09 ES ES490379A patent/ES490379A0/es active Granted
- 1980-04-09 ES ES490380A patent/ES8101048A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ZA801441B (en) | 1981-11-25 |
IL59598A0 (en) | 1980-06-30 |
FI800770A (fi) | 1980-09-14 |
DD149804A5 (de) | 1981-07-29 |
ATE1642T1 (de) | 1982-10-15 |
PT70921A (de) | 1980-04-01 |
PL222634A1 (es) | 1980-12-01 |
PT70921B (de) | 1981-06-24 |
ES8101047A1 (es) | 1980-12-01 |
ES488446A1 (es) | 1980-10-01 |
JPS55124758A (en) | 1980-09-26 |
DE3060932D1 (en) | 1982-11-18 |
ES490380A0 (es) | 1980-12-01 |
NO800709L (no) | 1980-09-15 |
CS208800B2 (en) | 1981-09-15 |
ES490379A0 (es) | 1980-12-01 |
NZ193111A (en) | 1983-04-12 |
EP0015523B1 (de) | 1982-10-13 |
US4343811A (en) | 1982-08-10 |
CA1142519A (en) | 1983-03-08 |
GR75241B (es) | 1984-07-13 |
DE2909779A1 (de) | 1980-09-18 |
SU1028247A3 (ru) | 1983-07-07 |
AU5636880A (en) | 1980-09-18 |
YU68180A (en) | 1983-04-30 |
HU180126B (en) | 1983-02-28 |
EP0015523A1 (de) | 1980-09-17 |
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