ES2072193A1 - Nuevos derivados del1-fenilmetil bencimidazol piperacinas. - Google Patents

Nuevos derivados del1-fenilmetil bencimidazol piperacinas.

Info

Publication number
ES2072193A1
ES2072193A1 ES09301104A ES9301104A ES2072193A1 ES 2072193 A1 ES2072193 A1 ES 2072193A1 ES 09301104 A ES09301104 A ES 09301104A ES 9301104 A ES9301104 A ES 9301104A ES 2072193 A1 ES2072193 A1 ES 2072193A1
Authority
ES
Spain
Prior art keywords
phenylmethyl
new
piperazine derivatives
benzimidazole
benzimidazole piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09301104A
Other languages
English (en)
Other versions
ES2072193B1 (es
Inventor
Aurelio Orjales-Venero
Rosa Rodes-Solanes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Original Assignee
Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA filed Critical Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Priority to ES09301104A priority Critical patent/ES2072193B1/es
Priority to DE69426372T priority patent/DE69426372T2/de
Priority to AT94500089T priority patent/ATE197952T1/de
Priority to EP94500089A priority patent/EP0628549B1/en
Publication of ES2072193A1 publication Critical patent/ES2072193A1/es
Priority to US08/589,651 priority patent/US5672604A/en
Application granted granted Critical
Publication of ES2072193B1 publication Critical patent/ES2072193B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Abstract

SE DESCRIBEN NUEVOS DERIVADOS DE 1-FENILMETIL BENCIMIDAZOL PIPERACINAS DE FORMULA GENERAL: *FIG* EN DONDE R1 Y R2 PUEDEN SER UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO ALQUILO DE CADENA CORTA, UN GRUPO NITRO, Y UN GRUPO HIDROXI, ASI COMO DE SUS SALES DE ADICION CON ACIDOS FARMACEUTICAMENTE ACEPTABLES. ESTOS COMPUESTOS PRESENTAN ACTIVIDAD FARMACOLOGICA COMO ANTAGONISTAS DE LOS RECEPTORES 5HT3 DE LA SEROTONINA.
ES09301104A 1993-05-21 1993-05-21 Nuevos derivados del1-fenilmetil bencimidazol piperacinas. Expired - Fee Related ES2072193B1 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES09301104A ES2072193B1 (es) 1993-05-21 1993-05-21 Nuevos derivados del1-fenilmetil bencimidazol piperacinas.
DE69426372T DE69426372T2 (de) 1993-05-21 1994-05-19 Neue 1-Phenylmethyl-benzimidazol-piperazinderivate
AT94500089T ATE197952T1 (de) 1993-05-21 1994-05-19 Neue 1-phenylmethyl-benzimidazol- piperazinderivate
EP94500089A EP0628549B1 (en) 1993-05-21 1994-05-19 New 1-phenylmethyl benzimidazole piperazine derivatives
US08/589,651 US5672604A (en) 1993-05-21 1996-01-22 1-phenylmethyl benzimidazole piperazine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09301104A ES2072193B1 (es) 1993-05-21 1993-05-21 Nuevos derivados del1-fenilmetil bencimidazol piperacinas.

Publications (2)

Publication Number Publication Date
ES2072193A1 true ES2072193A1 (es) 1995-07-01
ES2072193B1 ES2072193B1 (es) 1996-02-16

Family

ID=8281908

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09301104A Expired - Fee Related ES2072193B1 (es) 1993-05-21 1993-05-21 Nuevos derivados del1-fenilmetil bencimidazol piperacinas.

Country Status (5)

Country Link
US (1) US5672604A (es)
EP (1) EP0628549B1 (es)
AT (1) ATE197952T1 (es)
DE (1) DE69426372T2 (es)
ES (1) ES2072193B1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2731707B1 (fr) * 1995-03-13 1997-04-30 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
AU707139B2 (en) * 1996-04-03 1999-07-01 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6136807A (en) * 1998-11-10 2000-10-24 3M Innovative Properties Company Composition for the transdermal delivery of lerisetron
ES2154605B1 (es) * 1999-09-14 2001-11-16 Univ Madrid Complutense Nuevos derivados mixtos de bencimidazol-arilpiperazina con afinidad por los receptores serotoninergicos 5-ht1a y 5-ht3
US10501421B1 (en) 2017-01-27 2019-12-10 Vanderbilt University Substituted benzimidazoles as modulators of Ras signaling

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093726A (en) * 1976-12-02 1978-06-06 Abbott Laboratories N-(2-benzimidazolyl)-piperazines
EP0079545A1 (en) * 1981-11-06 1983-05-25 Kanebo, Ltd. Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
WO1991018904A1 (en) * 1990-05-30 1991-12-12 American Home Products Corporation Substituted arylsulfonamides and benzamides
WO1992006977A1 (fr) * 1990-10-17 1992-04-30 Laboratoire Theramex S.A. NOUVEAUX DERIVES p-SUBSTITUES DE PHENYL 4-OXYBUTANE AMINE, LEURS PROCEDES DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES EN RENFERMANT
ES2038532A1 (es) * 1991-05-10 1993-07-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4941198A (es) * 1972-09-11 1974-04-17
JPS50126682A (es) * 1974-03-25 1975-10-04
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
US5106857A (en) * 1991-05-09 1992-04-21 A. H. Robins Company, Incorporated N-(1-methyl-3-pyrrolidinyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine and analogs as antiarrhythmic and muscle relaxing agents
US5256665A (en) * 1991-05-10 1993-10-26 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. Process for preparing new 2-piperazinylbenzimidazole

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093726A (en) * 1976-12-02 1978-06-06 Abbott Laboratories N-(2-benzimidazolyl)-piperazines
EP0079545A1 (en) * 1981-11-06 1983-05-25 Kanebo, Ltd. Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
WO1991018904A1 (en) * 1990-05-30 1991-12-12 American Home Products Corporation Substituted arylsulfonamides and benzamides
WO1992006977A1 (fr) * 1990-10-17 1992-04-30 Laboratoire Theramex S.A. NOUVEAUX DERIVES p-SUBSTITUES DE PHENYL 4-OXYBUTANE AMINE, LEURS PROCEDES DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES EN RENFERMANT
ES2038532A1 (es) * 1991-05-10 1993-07-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol.

Also Published As

Publication number Publication date
ATE197952T1 (de) 2000-12-15
US5672604A (en) 1997-09-30
DE69426372D1 (de) 2001-01-11
EP0628549A1 (en) 1994-12-14
EP0628549B1 (en) 2000-12-06
ES2072193B1 (es) 1996-02-16
DE69426372T2 (de) 2001-05-10

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Legal Events

Date Code Title Description
GC2A Exploitation certificate registered application with search report

Effective date: 19990628

FD1A Patent lapsed

Effective date: 20010522