ES8101047A1 - Procedimiento para la preparacion de nuevos derivados indo- licos - Google Patents

Procedimiento para la preparacion de nuevos derivados indo- licos

Info

Publication number
ES8101047A1
ES8101047A1 ES490379A ES490379A ES8101047A1 ES 8101047 A1 ES8101047 A1 ES 8101047A1 ES 490379 A ES490379 A ES 490379A ES 490379 A ES490379 A ES 490379A ES 8101047 A1 ES8101047 A1 ES 8101047A1
Authority
ES
Spain
Prior art keywords
indole derivatives
medicaments
preparation
compounds
indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES490379A
Other languages
English (en)
Other versions
ES490379A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8101047A1 publication Critical patent/ES8101047A1/es
Publication of ES490379A0 publication Critical patent/ES490379A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

PROCEDIMIENTO DE OBTURACION DE DERIVADOS INDOLICOS. CONSISTE EN HACER REACCIONAR UN HIDROXI-INDOL DE FORMULA GENERAL (I) CON UN ALCOHOL DE FORMULA GENERAL (II), EN PRESENCIA DE UNA BASE INORGANICA. OPTATIVAMENTE SE PUEDE TRANSFORMAR EL COMPUESTO OBTENIDO (III) -DONDE R4 ES UN GRUPO CARBOXILO- MEDIANTE ESTERIFICACION O AMIDIFICACION EN UN COMPUESTO DE FORMULA GENERAL (III) EN QUE R4 ES UN GRUPO CARBALCOXI, UN GRUPO AMINOCARBOLINO, *FORMULA* UN GRUPO PIPERIDINO ARBONILO, MORFOLINO CARBONILO O TIOMORFOLINOCARBONILO. LA REACCION TIENE LUGAR EN UNA CETONA ANHIDRA. ACTIVIDAD HIPOLIPIDERNICA Y ANTIATEROSCLEROTICA. .
ES490379A 1979-03-13 1980-04-09 Procedimiento para la preparacion de nuevos derivados indo- licos Granted ES490379A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792909779 DE2909779A1 (de) 1979-03-13 1979-03-13 Neue indolderivate, deren herstellung und deren verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES8101047A1 true ES8101047A1 (es) 1980-12-01
ES490379A0 ES490379A0 (es) 1980-12-01

Family

ID=6065240

Family Applications (3)

Application Number Title Priority Date Filing Date
ES488446A Expired ES488446A1 (es) 1979-03-13 1980-02-11 Procedimiento para la preparacion de nuevos derivados indo- licos
ES490379A Granted ES490379A0 (es) 1979-03-13 1980-04-09 Procedimiento para la preparacion de nuevos derivados indo- licos
ES490380A Expired ES8101048A1 (es) 1979-03-13 1980-04-09 Procedimiento para la preparacion de nuevos derivados indo- licos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES488446A Expired ES488446A1 (es) 1979-03-13 1980-02-11 Procedimiento para la preparacion de nuevos derivados indo- licos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES490380A Expired ES8101048A1 (es) 1979-03-13 1980-04-09 Procedimiento para la preparacion de nuevos derivados indo- licos

Country Status (21)

Country Link
US (1) US4343811A (es)
EP (1) EP0015523B1 (es)
JP (1) JPS55124758A (es)
AT (1) ATE1642T1 (es)
AU (1) AU5636880A (es)
CA (1) CA1142519A (es)
CS (1) CS208800B2 (es)
DD (1) DD149804A5 (es)
DE (2) DE2909779A1 (es)
ES (3) ES488446A1 (es)
FI (1) FI800770A (es)
GR (1) GR75241B (es)
HU (1) HU180126B (es)
IL (1) IL59598A0 (es)
NO (1) NO800709L (es)
NZ (1) NZ193111A (es)
PL (1) PL222634A1 (es)
PT (1) PT70921B (es)
SU (1) SU1028247A3 (es)
YU (1) YU68180A (es)
ZA (1) ZA801441B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3165998D1 (de) * 1980-06-18 1984-10-18 May & Baker Ltd Indole and indoline derivatives
DE3232968A1 (de) * 1981-09-10 1983-06-09 Degussa Ag, 6000 Frankfurt Neue 2-(hydroxy-phenyl)-indole und verfahren zu deren herstellung
US4543360A (en) * 1981-09-10 1985-09-24 Degussa Aktiengesellschaft 2-(Hydroxy-phenyl)-indoles and process for their production
GB2111050B (en) * 1981-11-19 1985-09-11 Ciba Geigy Ag N-substituted-2-pyridylindoles
US4478842A (en) * 1981-11-19 1984-10-23 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4460777A (en) * 1981-11-19 1984-07-17 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
US4759923A (en) * 1987-06-25 1988-07-26 Hercules Incorporated Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
DE69728688T2 (de) 1996-11-19 2004-08-19 Amgen Inc., Thousand Oaks Aryl und heteroaryl substituierte kondensierte pyrrole als entzündunghemmende mittel
US6103733A (en) * 1998-09-09 2000-08-15 Bachmann; Kenneth A. Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
JP2008507518A (ja) 2004-07-22 2008-03-13 ピーティーシー セラピューティクス，インコーポレーテッド Ｃ型肝炎を治療するためのチエノピリジン
DE102006053064A1 (de) * 2006-11-08 2008-05-21 Universität Potsdam Verfahren zur Herstellung aromatischer Diazoniumsalze

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2237361A1 (de) * 1972-07-29 1974-02-14 Boehringer Mannheim Gmbh (5-indolyloxy)-essigsaeure-derivate und verfahren zur herstellung derselben
FI59246C (fi) * 1974-06-24 1981-07-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin

Also Published As

Publication number Publication date
ZA801441B (en) 1981-11-25
IL59598A0 (en) 1980-06-30
FI800770A (fi) 1980-09-14
DD149804A5 (de) 1981-07-29
ATE1642T1 (de) 1982-10-15
PT70921A (de) 1980-04-01
PL222634A1 (es) 1980-12-01
PT70921B (de) 1981-06-24
ES488446A1 (es) 1980-10-01
JPS55124758A (en) 1980-09-26
DE3060932D1 (en) 1982-11-18
ES490380A0 (es) 1980-12-01
NO800709L (no) 1980-09-15
CS208800B2 (en) 1981-09-15
ES490379A0 (es) 1980-12-01
NZ193111A (en) 1983-04-12
EP0015523B1 (de) 1982-10-13
US4343811A (en) 1982-08-10
CA1142519A (en) 1983-03-08
GR75241B (es) 1984-07-13
DE2909779A1 (de) 1980-09-18
SU1028247A3 (ru) 1983-07-07
AU5636880A (en) 1980-09-18
YU68180A (en) 1983-04-30
ES8101048A1 (es) 1980-12-01
HU180126B (en) 1983-02-28
EP0015523A1 (de) 1980-09-17

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