ES8206435A1 - Procedimiento para la obtencion de un nuevo compuesto deri- vado del acido p-clorofenoxiacetico - Google Patents

Procedimiento para la obtencion de un nuevo compuesto deri- vado del acido p-clorofenoxiacetico

Info

Publication number
ES8206435A1
ES8206435A1 ES506669A ES506669A ES8206435A1 ES 8206435 A1 ES8206435 A1 ES 8206435A1 ES 506669 A ES506669 A ES 506669A ES 506669 A ES506669 A ES 506669A ES 8206435 A1 ES8206435 A1 ES 8206435A1
Authority
ES
Spain
Prior art keywords
preparation
chlorophenoxyacetic acid
new
pharmaceutical composition
acid derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506669A
Other languages
English (en)
Other versions
ES506669A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Original Assignee
Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sociedad Espanola de Especialidades Farmaco Terapeuticas SA filed Critical Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Priority to ES506669A priority Critical patent/ES8206435A1/es
Publication of ES506669A0 publication Critical patent/ES506669A0/es
Publication of ES8206435A1 publication Critical patent/ES8206435A1/es
Priority to JP57188907A priority patent/JPS5883662A/ja
Priority to US06/436,960 priority patent/US4476319A/en
Priority to EP82109995A priority patent/EP0078518B1/en
Priority to DE8282109995T priority patent/DE3262166D1/de
Priority to AT82109995T priority patent/ATE11530T1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/06—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE P-CLOROFENOXIACETATO DE 1-AMINOADAMANSANO-2-ETANOL Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES. CONSISTE EN LA REACCION DE ESTERIFICACION DEL COMPUESTO ACILICO DE FORMULA (I), EN LA QUE X ES HIDROXILO O UN ATOMO DE HALOGENO, CON 1-AMINOADAMANSANO-2-ETANOL EN UN DISOLVENTE INERTE, A LA TEMPERATURA AMBIENTE. EL PRODUCTO OBTENIDO SE SEPARA Y PURIFICA SIGUIENDO METODOS CONVENCIONALES. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD SOBRE EL SISTEMA NERVIOSO CENTRAL.
ES506669A 1981-10-29 1981-10-29 Procedimiento para la obtencion de un nuevo compuesto deri- vado del acido p-clorofenoxiacetico Expired ES8206435A1 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES506669A ES8206435A1 (es) 1981-10-29 1981-10-29 Procedimiento para la obtencion de un nuevo compuesto deri- vado del acido p-clorofenoxiacetico
JP57188907A JPS5883662A (ja) 1981-10-29 1982-10-26 ｐ−クロロフエノキシ酢酸誘導体、その製法ならびに中枢神経機能障害改善剤
US06/436,960 US4476319A (en) 1981-10-29 1982-10-27 P-Chlorophenoxyacetic acid derivative, its method of preparation, the pharmaceutical compositions containing it and its use in medicine
EP82109995A EP0078518B1 (en) 1981-10-29 1982-10-28 A new p-chlorophenoxyacetic acid derivative, its method of preparation and pharmaceutical composition
DE8282109995T DE3262166D1 (en) 1981-10-29 1982-10-28 A new p-chlorophenoxyacetic acid derivative, its method of preparation and pharmaceutical composition
AT82109995T ATE11530T1 (de) 1981-10-29 1982-10-28 P-chlorophenoxyessigsaeure-derivat, verfahren zu dessen herstellung und pharmazeutische zusammenstellung.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES506669A ES8206435A1 (es) 1981-10-29 1981-10-29 Procedimiento para la obtencion de un nuevo compuesto deri- vado del acido p-clorofenoxiacetico

Publications (2)

Publication Number Publication Date
ES506669A0 ES506669A0 (es) 1982-08-16
ES8206435A1 true ES8206435A1 (es) 1982-08-16

Family

ID=8483149

Family Applications (1)

Application Number Title Priority Date Filing Date
ES506669A Expired ES8206435A1 (es) 1981-10-29 1981-10-29 Procedimiento para la obtencion de un nuevo compuesto deri- vado del acido p-clorofenoxiacetico

Country Status (6)

Country Link
US (1) US4476319A (es)
EP (1) EP0078518B1 (es)
JP (1) JPS5883662A (es)
AT (1) ATE11530T1 (es)
DE (1) DE3262166D1 (es)
ES (1) ES8206435A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0870757B1 (en) * 1997-04-10 2002-06-12 Pfizer Inc. Fluoro-substituted adamantane derivatives
CN117956988A (zh) * 2021-07-08 2024-04-30 Nls制药股份公司 用于治疗具有或不具有神经退行性疾病的昼夜节律睡眠障碍的Melafenoxate及其衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2628973A (en) * 1951-02-24 1953-02-17 Searle & Co Aryloxyacetates of basically substituted arylakanols and derivatives thereof
NL6410363A (es) * 1964-09-05 1966-03-07
US3546273A (en) * 1967-06-01 1970-12-08 Merck & Co Inc Ester derivatives of 2-(4-halophenoxy)alkanoic acids
JPS5135896B2 (es) * 1973-06-20 1976-10-05
JPS5019542A (es) * 1973-06-20 1975-03-01

Also Published As

Publication number Publication date
ES506669A0 (es) 1982-08-16
US4476319A (en) 1984-10-09
JPS632542B2 (es) 1988-01-19
JPS5883662A (ja) 1983-05-19
DE3262166D1 (en) 1985-03-14
ATE11530T1 (de) 1985-02-15
EP0078518A1 (en) 1983-05-11
EP0078518B1 (en) 1985-01-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519