ES8502424A1 - Procedimiento para la preparacion de derivados de benzazepina - Google Patents
Procedimiento para la preparacion de derivados de benzazepinaInfo
- Publication number
- ES8502424A1 ES8502424A1 ES527308A ES527308A ES8502424A1 ES 8502424 A1 ES8502424 A1 ES 8502424A1 ES 527308 A ES527308 A ES 527308A ES 527308 A ES527308 A ES 527308A ES 8502424 A1 ES8502424 A1 ES 8502424A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pharmaceutical compounds
- benzazepine derivatives
- new compounds
- benzazepine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Luminescent Compositions (AREA)
- Photoreceptors In Electrophotography (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE BENZAZEPINA.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), CON ELIMINACION DE RADICALES PROTECTORES POR HIDROLISIS O HIDROGENOLISIS, PARA OBTENER LOS DERIVADOS DE BENZAZEPINA DE FORMULA (I) Y SUS SALES FISIOLOGICAMENTE COMPATIBLES. DONDE A ES -CH2-CH2-, -CHFCH- Y OTROS; B ES TIOCARBONILO O METILENO; G ES UN GRUPO N-ALCOHILENO DE C 3 A 5 EVENTUALMENTE SUSTITUIDO POR UN GRUPO ALCOHILO DE C 1 A 3; R1, R2, R3 Y R5 SON H, HAL Y OTROS; E ES UN GRUPO N-ALCOHILENO DE C 2 A 4, EVENTUALMENTE SUSTITUIDO CON UN GRUPO ALCOHILO DE C 1 A 3; R4 ES H O UN GRUPO METOXI; R6 ES H O UN GRUPO ALCOHILO; R1 Y R4 SON GRUPOS AMINO RADICALES PROTECTORES; U ES R6NH Y V ES HAL O UN GRUPO SULFONILOXI.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823242599 DE3242599A1 (de) | 1982-11-18 | 1982-11-18 | Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8502424A1 true ES8502424A1 (es) | 1985-01-01 |
ES527308A0 ES527308A0 (es) | 1985-01-01 |
Family
ID=6178417
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES527308A Granted ES527308A0 (es) | 1982-11-18 | 1983-11-16 | Procedimiento para la preparacion de derivados de benzazepina |
ES532662A Expired ES8502689A1 (es) | 1982-11-18 | 1984-05-21 | Procedimiento para la preparacion de derivados de benzazepina. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES532662A Expired ES8502689A1 (es) | 1982-11-18 | 1984-05-21 | Procedimiento para la preparacion de derivados de benzazepina. |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP0109636B1 (es) |
JP (1) | JPS59106466A (es) |
KR (1) | KR840006628A (es) |
AT (1) | ATE40118T1 (es) |
AU (1) | AU568101B2 (es) |
CA (1) | CA1211107A (es) |
CS (1) | CS239947B2 (es) |
DD (1) | DD215540A5 (es) |
DE (2) | DE3242599A1 (es) |
DK (1) | DK527483A (es) |
ES (2) | ES527308A0 (es) |
FI (1) | FI834174A (es) |
GB (1) | GB2130213B (es) |
GR (1) | GR81253B (es) |
HU (1) | HU193189B (es) |
IE (1) | IE56261B1 (es) |
IL (1) | IL70258A (es) |
NO (1) | NO834222L (es) |
NZ (1) | NZ206305A (es) |
PL (1) | PL139449B1 (es) |
PT (1) | PT77683B (es) |
YU (1) | YU226283A (es) |
ZA (1) | ZA838572B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3418271A1 (de) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE3631013A1 (de) * | 1986-09-12 | 1988-03-24 | Thomae Gmbh Dr K | Neue naphthylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
JP2699511B2 (ja) * | 1988-01-29 | 1998-01-19 | 武田薬品工業株式会社 | 置換アミン類 |
FR2868776B1 (fr) * | 2004-04-13 | 2008-04-18 | Servier Lab | Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3474090A (en) * | 1966-12-22 | 1969-10-21 | American Cyanamid Co | 3-aminoalkyl-1,3-benzodiazepin-2-ones |
US3780023A (en) * | 1972-06-30 | 1973-12-18 | J Suh | 2-aralkylamino-4,5-dihydro-3h-1,3-benzodiazepines |
US4210749A (en) * | 1974-11-12 | 1980-07-01 | Pennwalt Corporation | Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines |
DE2639718A1 (de) * | 1976-09-03 | 1978-03-16 | Thomae Gmbh Dr K | Neue phenylaethylamine |
IN156096B (es) * | 1981-03-19 | 1985-05-11 | Usv Pharma Corp | |
DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
DE3269625D1 (en) * | 1981-08-11 | 1986-04-10 | Ciba Geigy Ag | Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use |
JPS6436829A (en) * | 1987-07-31 | 1989-02-07 | Shinko Kinzoku Kogyo Kk | Evacuation part washing apparatus |
-
1982
- 1982-11-18 DE DE19823242599 patent/DE3242599A1/de not_active Withdrawn
-
1983
- 1983-11-14 EP EP83111348A patent/EP0109636B1/de not_active Expired
- 1983-11-14 DE DE8383111348T patent/DE3378980D1/de not_active Expired
- 1983-11-14 AT AT83111348T patent/ATE40118T1/de not_active IP Right Cessation
- 1983-11-15 CS CS838456A patent/CS239947B2/cs unknown
- 1983-11-15 FI FI834174A patent/FI834174A/fi not_active Application Discontinuation
- 1983-11-16 ES ES527308A patent/ES527308A0/es active Granted
- 1983-11-16 GR GR73003A patent/GR81253B/el unknown
- 1983-11-16 DD DD83256756A patent/DD215540A5/de unknown
- 1983-11-17 NO NO834222A patent/NO834222L/no unknown
- 1983-11-17 JP JP58217069A patent/JPS59106466A/ja active Granted
- 1983-11-17 GB GB08330731A patent/GB2130213B/en not_active Expired
- 1983-11-17 AU AU21461/83A patent/AU568101B2/en not_active Ceased
- 1983-11-17 IL IL70258A patent/IL70258A/xx not_active IP Right Cessation
- 1983-11-17 NZ NZ206305A patent/NZ206305A/en unknown
- 1983-11-17 YU YU02262/83A patent/YU226283A/xx unknown
- 1983-11-17 CA CA000441425A patent/CA1211107A/en not_active Expired
- 1983-11-17 PT PT77683A patent/PT77683B/pt unknown
- 1983-11-17 IE IE2692/83A patent/IE56261B1/en not_active IP Right Cessation
- 1983-11-17 PL PL1983244610A patent/PL139449B1/pl unknown
- 1983-11-17 DK DK527483A patent/DK527483A/da not_active Application Discontinuation
- 1983-11-17 HU HU833968A patent/HU193189B/hu unknown
- 1983-11-17 ZA ZA838572A patent/ZA838572B/xx unknown
- 1983-11-18 KR KR1019830005495A patent/KR840006628A/ko not_active Application Discontinuation
-
1984
- 1984-05-21 ES ES532662A patent/ES8502689A1/es not_active Expired
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8506677A1 (es) | Un procedimiento para la preparacion de nuevos derivados de 8-cloro71,5-benzotiazepina. | |
ES8203883A1 (es) | Un procedimiento para la preparacion de derivados de imida- zol | |
ES8401960A1 (es) | Procedimiento para la preparacion de imidazolilfenil-tetrahidropiridazinas. | |
IL78691A0 (en) | Quinolylglycinamide derivatives,their preparation and pharmaceutical compositions containing them | |
ES2001703A6 (es) | Procedimiento para la preparracion de derrrivados de acidos 2-(2-imidazolin -2-il)- piridin -3- carboxilicos. | |
ES8404852A1 (es) | Procedimiento para preparar derivados de acidos isoquinolein-4-carboxilicos | |
ES8505922A1 (es) | Procedimiento para preparar nuevos derivados del acido 4-fenil-4-oxo-buten-2-oico | |
ES8403125A1 (es) | Procedimiento para la preparacion de nuevas piridobenzodiazepinonas. | |
ES480111A1 (es) | Procedimiento para la preparacion de nuevos derivados de 2- iminoimidazolidina. | |
ES8502424A1 (es) | Procedimiento para la preparacion de derivados de benzazepina | |
EP0066909A3 (en) | Imidazole derivatives, pharmaceutical compositions containing them and processes for their production | |
ES8308833A1 (es) | "un metodo para la preparacion de 3-fenil-1-indanaminas". | |
ES2012559A6 (es) | Nuevos isopolipeptidos y procedimiento para su preparacion. | |
ES8308562A1 (es) | Procedimiento para preparar 3',4',5'-trimetoxibenzoato de 1718-dehidorapovincaminol, util como agente activo en preparaciones farmaceuticas | |
ES8704463A1 (es) | Procedimiento para preparar 2-(n-alquinil-n-fenilamino)-imidazolinas | |
ES484664A1 (es) | Un procedimiento para la preparacion de derivados octahidro-1h-benzo 4,5 furo,3,2-e isoquinolina. | |
EP0309262A3 (en) | Novel salicylates, their salts, pharmaceutical compositions containing them and process for preparing same | |
IL88639A0 (en) | 2-amino-tetrahydro-isoquinoline derivatives,process for the preparation thereof and pharmaceutical compositions containing same | |
CS321784A2 (en) | Zpusiob vyroby l,3 bis(dimethylamino) 2 propyl 4 chlor fenoxyacetatu |