ZA838572B - Benzazepine derivatives,processes for their preparation,and pharmaceutical compositions thereof - Google Patents

Benzazepine derivatives,processes for their preparation,and pharmaceutical compositions thereof

Info

Publication number
ZA838572B
ZA838572B ZA838572A ZA838572A ZA838572B ZA 838572 B ZA838572 B ZA 838572B ZA 838572 A ZA838572 A ZA 838572A ZA 838572 A ZA838572 A ZA 838572A ZA 838572 B ZA838572 B ZA 838572B
Authority
ZA
South Africa
Prior art keywords
processes
pharmaceutical compositions
preparation
benzazepine derivatives
new compounds
Prior art date
Application number
ZA838572A
Inventor
Manfred Dr Reiffen
Norbert Dr Hauel
Joachim Dr Heider
Walter Prof Dr Kobinger
Volkhard Dr Austel
Christian Dr Lillie
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of ZA838572B publication Critical patent/ZA838572B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Luminescent Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compound of general formula I <IMAGE> (wherein R1 to R6, A, B, E and G are as defined in claim 1) and acid addition salts thereof. The new compounds have valuable pharmacological properties, in particular a heart-rate lowering effect. Processes for preparing the new compounds and pharmaceutical compositions containing them are also described.
ZA838572A 1982-11-18 1983-11-17 Benzazepine derivatives,processes for their preparation,and pharmaceutical compositions thereof ZA838572B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823242599 DE3242599A1 (en) 1982-11-18 1982-11-18 NEW BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
ZA838572B true ZA838572B (en) 1985-07-31

Family

ID=6178417

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA838572A ZA838572B (en) 1982-11-18 1983-11-17 Benzazepine derivatives,processes for their preparation,and pharmaceutical compositions thereof

Country Status (23)

Country Link
EP (1) EP0109636B1 (en)
JP (1) JPS59106466A (en)
KR (1) KR840006628A (en)
AT (1) ATE40118T1 (en)
AU (1) AU568101B2 (en)
CA (1) CA1211107A (en)
CS (1) CS239947B2 (en)
DD (1) DD215540A5 (en)
DE (2) DE3242599A1 (en)
DK (1) DK527483A (en)
ES (2) ES527308A0 (en)
FI (1) FI834174A (en)
GB (1) GB2130213B (en)
GR (1) GR81253B (en)
HU (1) HU193189B (en)
IE (1) IE56261B1 (en)
IL (1) IL70258A (en)
NO (1) NO834222L (en)
NZ (1) NZ206305A (en)
PL (1) PL139449B1 (en)
PT (1) PT77683B (en)
YU (1) YU226283A (en)
ZA (1) ZA838572B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3418271A1 (en) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach NEW BENZAZEPINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3631013A1 (en) * 1986-09-12 1988-03-24 Thomae Gmbh Dr K NEW NAPHTHYL DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
JP2699511B2 (en) * 1988-01-29 1998-01-19 武田薬品工業株式会社 Substituted amines
FR2868776B1 (en) * 2004-04-13 2008-04-18 Servier Lab NOVEL PROCESS FOR THE SYNTHESIS OF 1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE DERIVATIVES AND THE APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474090A (en) * 1966-12-22 1969-10-21 American Cyanamid Co 3-aminoalkyl-1,3-benzodiazepin-2-ones
US3780023A (en) * 1972-06-30 1973-12-18 J Suh 2-aralkylamino-4,5-dihydro-3h-1,3-benzodiazepines
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
DE2639718A1 (en) * 1976-09-03 1978-03-16 Thomae Gmbh Dr K NEW PHENYLAETHYLAMINE
IN156096B (en) * 1981-03-19 1985-05-11 Usv Pharma Corp
DE3119874A1 (en) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS"
DE3269625D1 (en) * 1981-08-11 1986-04-10 Ciba Geigy Ag Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use
JPS6436829A (en) * 1987-07-31 1989-02-07 Shinko Kinzoku Kogyo Kk Evacuation part washing apparatus

Also Published As

Publication number Publication date
PT77683B (en) 1986-05-12
EP0109636A3 (en) 1985-11-21
JPS59106466A (en) 1984-06-20
YU226283A (en) 1986-04-30
AU568101B2 (en) 1987-12-17
DK527483A (en) 1984-05-19
PL244610A1 (en) 1985-07-16
HU193189B (en) 1987-08-28
GB2130213B (en) 1986-03-26
JPH0441144B2 (en) 1992-07-07
IE56261B1 (en) 1991-06-05
IE832692L (en) 1984-05-18
ES8502424A1 (en) 1985-01-01
DK527483D0 (en) 1983-11-17
AU2146183A (en) 1984-05-24
DE3378980D1 (en) 1989-02-23
PT77683A (en) 1983-12-01
DE3242599A1 (en) 1984-05-24
DD215540A5 (en) 1984-11-14
CA1211107A (en) 1986-09-09
KR840006628A (en) 1984-12-01
PL139449B1 (en) 1987-01-31
FI834174A0 (en) 1983-11-15
ATE40118T1 (en) 1989-02-15
IL70258A (en) 1987-08-31
CS239947B2 (en) 1986-01-16
NZ206305A (en) 1986-10-08
NO834222L (en) 1984-05-21
IL70258A0 (en) 1984-02-29
ES532662A0 (en) 1985-01-16
EP0109636B1 (en) 1989-01-18
ES8502689A1 (en) 1985-01-16
GB2130213A (en) 1984-05-31
ES527308A0 (en) 1985-01-01
GB8330731D0 (en) 1983-12-29
GR81253B (en) 1984-12-11
EP0109636A2 (en) 1984-05-30
FI834174A (en) 1984-05-19

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