DK527483A - PROCEDURE FOR THE PREPARATION OF BENZAZEPINE DERIVATIVES - Google Patents

PROCEDURE FOR THE PREPARATION OF BENZAZEPINE DERIVATIVES Download PDF

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Publication number
DK527483A
DK527483A DK527483A DK527483A DK527483A DK 527483 A DK527483 A DK 527483A DK 527483 A DK527483 A DK 527483A DK 527483 A DK527483 A DK 527483A DK 527483 A DK527483 A DK 527483A
Authority
DK
Denmark
Prior art keywords
procedure
preparation
benzazepine derivatives
new compounds
heart
Prior art date
Application number
DK527483A
Other languages
Danish (da)
Other versions
DK527483D0 (en
Inventor
Manfred Reiffen
Joachim Heider
Volkhard Austel
Norbert Hauel
Walter Kobinger
Christian Lillie
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of DK527483D0 publication Critical patent/DK527483D0/en
Publication of DK527483A publication Critical patent/DK527483A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Luminescent Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compound of general formula I <IMAGE> (wherein R1 to R6, A, B, E and G are as defined in claim 1) and acid addition salts thereof. The new compounds have valuable pharmacological properties, in particular a heart-rate lowering effect. Processes for preparing the new compounds and pharmaceutical compositions containing them are also described.
DK527483A 1982-11-18 1983-11-17 PROCEDURE FOR THE PREPARATION OF BENZAZEPINE DERIVATIVES DK527483A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823242599 DE3242599A1 (en) 1982-11-18 1982-11-18 NEW BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS

Publications (2)

Publication Number Publication Date
DK527483D0 DK527483D0 (en) 1983-11-17
DK527483A true DK527483A (en) 1984-05-19

Family

ID=6178417

Family Applications (1)

Application Number Title Priority Date Filing Date
DK527483A DK527483A (en) 1982-11-18 1983-11-17 PROCEDURE FOR THE PREPARATION OF BENZAZEPINE DERIVATIVES

Country Status (23)

Country Link
EP (1) EP0109636B1 (en)
JP (1) JPS59106466A (en)
KR (1) KR840006628A (en)
AT (1) ATE40118T1 (en)
AU (1) AU568101B2 (en)
CA (1) CA1211107A (en)
CS (1) CS239947B2 (en)
DD (1) DD215540A5 (en)
DE (2) DE3242599A1 (en)
DK (1) DK527483A (en)
ES (2) ES527308A0 (en)
FI (1) FI834174A (en)
GB (1) GB2130213B (en)
GR (1) GR81253B (en)
HU (1) HU193189B (en)
IE (1) IE56261B1 (en)
IL (1) IL70258A (en)
NO (1) NO834222L (en)
NZ (1) NZ206305A (en)
PL (1) PL139449B1 (en)
PT (1) PT77683B (en)
YU (1) YU226283A (en)
ZA (1) ZA838572B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3418271A1 (en) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach NEW BENZAZEPINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3631013A1 (en) * 1986-09-12 1988-03-24 Thomae Gmbh Dr K NEW NAPHTHYL DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
JP2699511B2 (en) * 1988-01-29 1998-01-19 武田薬品工業株式会社 Substituted amines
FR2868776B1 (en) * 2004-04-13 2008-04-18 Servier Lab NOVEL PROCESS FOR THE SYNTHESIS OF 1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE DERIVATIVES AND THE APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474090A (en) * 1966-12-22 1969-10-21 American Cyanamid Co 3-aminoalkyl-1,3-benzodiazepin-2-ones
US3780023A (en) * 1972-06-30 1973-12-18 J Suh 2-aralkylamino-4,5-dihydro-3h-1,3-benzodiazepines
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
DE2639718A1 (en) * 1976-09-03 1978-03-16 Thomae Gmbh Dr K NEW PHENYLAETHYLAMINE
IN156096B (en) * 1981-03-19 1985-05-11 Usv Pharma Corp
DE3119874A1 (en) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS"
EP0072352B1 (en) * 1981-08-11 1986-03-05 Ciba-Geigy Ag Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use
JPS6436829A (en) * 1987-07-31 1989-02-07 Shinko Kinzoku Kogyo Kk Evacuation part washing apparatus

Also Published As

Publication number Publication date
EP0109636A2 (en) 1984-05-30
ES532662A0 (en) 1985-01-16
YU226283A (en) 1986-04-30
ATE40118T1 (en) 1989-02-15
IE56261B1 (en) 1991-06-05
GB2130213B (en) 1986-03-26
CS239947B2 (en) 1986-01-16
JPH0441144B2 (en) 1992-07-07
ES8502689A1 (en) 1985-01-16
FI834174A0 (en) 1983-11-15
HU193189B (en) 1987-08-28
GR81253B (en) 1984-12-11
PL139449B1 (en) 1987-01-31
GB2130213A (en) 1984-05-31
DK527483D0 (en) 1983-11-17
ES8502424A1 (en) 1985-01-01
GB8330731D0 (en) 1983-12-29
IE832692L (en) 1984-05-18
FI834174A (en) 1984-05-19
IL70258A (en) 1987-08-31
AU568101B2 (en) 1987-12-17
IL70258A0 (en) 1984-02-29
PT77683A (en) 1983-12-01
ZA838572B (en) 1985-07-31
KR840006628A (en) 1984-12-01
EP0109636B1 (en) 1989-01-18
CA1211107A (en) 1986-09-09
AU2146183A (en) 1984-05-24
DD215540A5 (en) 1984-11-14
DE3242599A1 (en) 1984-05-24
PL244610A1 (en) 1985-07-16
PT77683B (en) 1986-05-12
JPS59106466A (en) 1984-06-20
EP0109636A3 (en) 1985-11-21
DE3378980D1 (en) 1989-02-23
ES527308A0 (en) 1985-01-01
NZ206305A (en) 1986-10-08
NO834222L (en) 1984-05-21

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment