DK527483A - PROCEDURE FOR THE PREPARATION OF BENZAZEPINE DERIVATIVES - Google Patents
PROCEDURE FOR THE PREPARATION OF BENZAZEPINE DERIVATIVES Download PDFInfo
- Publication number
- DK527483A DK527483A DK527483A DK527483A DK527483A DK 527483 A DK527483 A DK 527483A DK 527483 A DK527483 A DK 527483A DK 527483 A DK527483 A DK 527483A DK 527483 A DK527483 A DK 527483A
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- preparation
- benzazepine derivatives
- new compounds
- heart
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Luminescent Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Compound of general formula I <IMAGE> (wherein R1 to R6, A, B, E and G are as defined in claim 1) and acid addition salts thereof. The new compounds have valuable pharmacological properties, in particular a heart-rate lowering effect. Processes for preparing the new compounds and pharmaceutical compositions containing them are also described.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823242599 DE3242599A1 (en) | 1982-11-18 | 1982-11-18 | NEW BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS |
Publications (2)
Publication Number | Publication Date |
---|---|
DK527483D0 DK527483D0 (en) | 1983-11-17 |
DK527483A true DK527483A (en) | 1984-05-19 |
Family
ID=6178417
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK527483A DK527483A (en) | 1982-11-18 | 1983-11-17 | PROCEDURE FOR THE PREPARATION OF BENZAZEPINE DERIVATIVES |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP0109636B1 (en) |
JP (1) | JPS59106466A (en) |
KR (1) | KR840006628A (en) |
AT (1) | ATE40118T1 (en) |
AU (1) | AU568101B2 (en) |
CA (1) | CA1211107A (en) |
CS (1) | CS239947B2 (en) |
DD (1) | DD215540A5 (en) |
DE (2) | DE3242599A1 (en) |
DK (1) | DK527483A (en) |
ES (2) | ES527308A0 (en) |
FI (1) | FI834174A (en) |
GB (1) | GB2130213B (en) |
GR (1) | GR81253B (en) |
HU (1) | HU193189B (en) |
IE (1) | IE56261B1 (en) |
IL (1) | IL70258A (en) |
NO (1) | NO834222L (en) |
NZ (1) | NZ206305A (en) |
PL (1) | PL139449B1 (en) |
PT (1) | PT77683B (en) |
YU (1) | YU226283A (en) |
ZA (1) | ZA838572B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3418271A1 (en) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW BENZAZEPINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
DE3631013A1 (en) * | 1986-09-12 | 1988-03-24 | Thomae Gmbh Dr K | NEW NAPHTHYL DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
JP2699511B2 (en) * | 1988-01-29 | 1998-01-19 | 武田薬品工業株式会社 | Substituted amines |
FR2868776B1 (en) | 2004-04-13 | 2008-04-18 | Servier Lab | NOVEL PROCESS FOR THE SYNTHESIS OF 1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE DERIVATIVES AND THE APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3474090A (en) * | 1966-12-22 | 1969-10-21 | American Cyanamid Co | 3-aminoalkyl-1,3-benzodiazepin-2-ones |
US3780023A (en) * | 1972-06-30 | 1973-12-18 | J Suh | 2-aralkylamino-4,5-dihydro-3h-1,3-benzodiazepines |
US4210749A (en) * | 1974-11-12 | 1980-07-01 | Pennwalt Corporation | Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines |
DE2639718A1 (en) * | 1976-09-03 | 1978-03-16 | Thomae Gmbh Dr K | NEW PHENYLAETHYLAMINE |
IN156096B (en) * | 1981-03-19 | 1985-05-11 | Usv Pharma Corp | |
DE3119874A1 (en) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS" |
ATE18397T1 (en) * | 1981-08-11 | 1986-03-15 | Ciba Geigy Ag | BENZAZEPINE-2-ONE, PROCESS FOR THEIR MANUFACTURE, PHARMACEUTICAL PREPARATIONS CONTAINING SUCH COMPOUNDS, AND COMPOUNDS FOR THERAPEUTIC USE. |
JPS6436829A (en) * | 1987-07-31 | 1989-02-07 | Shinko Kinzoku Kogyo Kk | Evacuation part washing apparatus |
-
1982
- 1982-11-18 DE DE19823242599 patent/DE3242599A1/en not_active Withdrawn
-
1983
- 1983-11-14 AT AT83111348T patent/ATE40118T1/en not_active IP Right Cessation
- 1983-11-14 DE DE8383111348T patent/DE3378980D1/en not_active Expired
- 1983-11-14 EP EP83111348A patent/EP0109636B1/en not_active Expired
- 1983-11-15 CS CS838456A patent/CS239947B2/en unknown
- 1983-11-15 FI FI834174A patent/FI834174A/en not_active Application Discontinuation
- 1983-11-16 GR GR73003A patent/GR81253B/el unknown
- 1983-11-16 ES ES527308A patent/ES527308A0/en active Granted
- 1983-11-16 DD DD83256756A patent/DD215540A5/en unknown
- 1983-11-17 PL PL1983244610A patent/PL139449B1/en unknown
- 1983-11-17 DK DK527483A patent/DK527483A/en not_active Application Discontinuation
- 1983-11-17 IE IE2692/83A patent/IE56261B1/en not_active IP Right Cessation
- 1983-11-17 AU AU21461/83A patent/AU568101B2/en not_active Ceased
- 1983-11-17 JP JP58217069A patent/JPS59106466A/en active Granted
- 1983-11-17 HU HU833968A patent/HU193189B/en unknown
- 1983-11-17 ZA ZA838572A patent/ZA838572B/en unknown
- 1983-11-17 YU YU02262/83A patent/YU226283A/en unknown
- 1983-11-17 NO NO834222A patent/NO834222L/en unknown
- 1983-11-17 NZ NZ206305A patent/NZ206305A/en unknown
- 1983-11-17 IL IL70258A patent/IL70258A/en not_active IP Right Cessation
- 1983-11-17 CA CA000441425A patent/CA1211107A/en not_active Expired
- 1983-11-17 GB GB08330731A patent/GB2130213B/en not_active Expired
- 1983-11-17 PT PT77683A patent/PT77683B/en unknown
- 1983-11-18 KR KR1019830005495A patent/KR840006628A/en not_active Application Discontinuation
-
1984
- 1984-05-21 ES ES532662A patent/ES8502689A1/en not_active Expired
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |