JPS56123965A - Preparation of 3-substituted benzoylthio-2 s - methylpropionic acid - Google Patents

Preparation of 3-substituted benzoylthio-2 s - methylpropionic acid

Info

Publication number
JPS56123965A
JPS56123965A JP2767680A JP2767680A JPS56123965A JP S56123965 A JPS56123965 A JP S56123965A JP 2767680 A JP2767680 A JP 2767680A JP 2767680 A JP2767680 A JP 2767680A JP S56123965 A JPS56123965 A JP S56123965A
Authority
JP
Japan
Prior art keywords
methylpropionic acid
diastereoisomeric salt
optically active
benzoylthio
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2767680A
Other languages
Japanese (ja)
Inventor
Katsuo Arimura
Osamu Murakami
Yukio Abe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to JP2767680A priority Critical patent/JPS56123965A/en
Publication of JPS56123965A publication Critical patent/JPS56123965A/en
Pending legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a diuretic agent, a synthetic intermediate for a medicine, etc., by reacting a specific compound with an optically active amine, separating the resultant diastereoisomeric salt, and decomposing the separated diastereoisomeric salt.
CONSTITUTION: 3-( 4-Chloro-3-sulfamoylbenzoylthio )-2(R,S)-methylpropionic acid of formula I is reacted with an optically active amine, e.g. quinidine, as a resolving agent, in an inert solvent, e.g. water or methanol, to give a diastereoisomeric salt, which is then purified by the conventional method of fractional crystallization. The resultant purified diastereoisomeric salt is then decomposed with an acid or base by the conventional method to afford an optically active 3-(4-chloro-3-sulfamoylbenzoylthio)-2(S)-methylpropionic acid of formula II.
COPYRIGHT: (C)1981,JPO&Japio
JP2767680A 1980-03-04 1980-03-04 Preparation of 3-substituted benzoylthio-2 s - methylpropionic acid Pending JPS56123965A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2767680A JPS56123965A (en) 1980-03-04 1980-03-04 Preparation of 3-substituted benzoylthio-2 s - methylpropionic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2767680A JPS56123965A (en) 1980-03-04 1980-03-04 Preparation of 3-substituted benzoylthio-2 s - methylpropionic acid

Publications (1)

Publication Number Publication Date
JPS56123965A true JPS56123965A (en) 1981-09-29

Family

ID=12227553

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2767680A Pending JPS56123965A (en) 1980-03-04 1980-03-04 Preparation of 3-substituted benzoylthio-2 s - methylpropionic acid

Country Status (1)

Country Link
JP (1) JPS56123965A (en)

Similar Documents

Publication Publication Date Title
ATE108440T1 (en) ARYLAR ALKYL ETHER, PROCESS FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THERE.
JPS56125347A (en) Preparation of dipeptide
JPS56123965A (en) Preparation of 3-substituted benzoylthio-2 s - methylpropionic acid
GB8330731D0 (en) Chemical compounds
JPS57188563A (en) Preparation of optically active 3-benzoylthio-2-methyl- propionic acid
JPS56154483A (en) Preparation or pyrrole derivative
ES481799A1 (en) Imidazo (1,2-a) imidazoles, their acid addition salts, medicaments containing them and process for their preparation.
JPS5533440A (en) Optically active benzyl(2-hydroxymethylcyclohexyl) amine, its preparation, and its optical resolution
JPS5432480A (en) Novel preparation of piperidine derivatives
JPS53124259A (en) Preparation of perfluoro (3-methyltetrahydrofran)
JPS5223037A (en) Process for preparation of optical active amino acid
JPS51115402A (en) Process for preparation of alpha-amino acid
JPS52136165A (en) Purification of pyrrolidine derivatives
JPS5553264A (en) 3-(n-substituted carbamoylthio)-2(s)-methylpropionic acid
IE820273L (en) Preparation of pirbuterol
ATE23528T1 (en) +/- 2-((3,4-METHYLENEDIOXY)PHENETHYL)-5-((3CARBOXAMIDO-4-HYDROXY)-ALPHA-HYDROXYBENZYL)PYRROLIDINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR MANUFACTURE AND THEIR INTERMEDIATE PRODUCTS.
JPS57108049A (en) Preparation of tripeptide
JPS5646889A (en) Gold compound and its preparation
JPS55162786A (en) Glyoxylic acid derivative and its preparation
JPS5223067A (en) Novel synthesis of 2-aminomethyl-1- ethylpyrrolidine
JPS56123992A (en) Thiazinoimidazole derivative and its preparation
JPS51113823A (en) Process for preparation of cis-epoxysuccinic acid salts
JPS536487A (en) Purification of hortimycin a
JPS549277A (en) Preparation of 2,4-dinitrothioxanthones
JPS57145857A (en) Preparation of substituted sulfonediimine compound