JPS56123965A - Preparation of 3-substituted benzoylthio-2 s - methylpropionic acid - Google Patents
Preparation of 3-substituted benzoylthio-2 s - methylpropionic acidInfo
- Publication number
- JPS56123965A JPS56123965A JP2767680A JP2767680A JPS56123965A JP S56123965 A JPS56123965 A JP S56123965A JP 2767680 A JP2767680 A JP 2767680A JP 2767680 A JP2767680 A JP 2767680A JP S56123965 A JPS56123965 A JP S56123965A
- Authority
- JP
- Japan
- Prior art keywords
- methylpropionic acid
- diastereoisomeric salt
- optically active
- benzoylthio
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as a diuretic agent, a synthetic intermediate for a medicine, etc., by reacting a specific compound with an optically active amine, separating the resultant diastereoisomeric salt, and decomposing the separated diastereoisomeric salt.
CONSTITUTION: 3-( 4-Chloro-3-sulfamoylbenzoylthio )-2(R,S)-methylpropionic acid of formula I is reacted with an optically active amine, e.g. quinidine, as a resolving agent, in an inert solvent, e.g. water or methanol, to give a diastereoisomeric salt, which is then purified by the conventional method of fractional crystallization. The resultant purified diastereoisomeric salt is then decomposed with an acid or base by the conventional method to afford an optically active 3-(4-chloro-3-sulfamoylbenzoylthio)-2(S)-methylpropionic acid of formula II.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2767680A JPS56123965A (en) | 1980-03-04 | 1980-03-04 | Preparation of 3-substituted benzoylthio-2 s - methylpropionic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2767680A JPS56123965A (en) | 1980-03-04 | 1980-03-04 | Preparation of 3-substituted benzoylthio-2 s - methylpropionic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56123965A true JPS56123965A (en) | 1981-09-29 |
Family
ID=12227553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2767680A Pending JPS56123965A (en) | 1980-03-04 | 1980-03-04 | Preparation of 3-substituted benzoylthio-2 s - methylpropionic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56123965A (en) |
-
1980
- 1980-03-04 JP JP2767680A patent/JPS56123965A/en active Pending
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