ES8401760A1 - Un procedimiento para la preparacion de derivados de ciclohepteno. - Google Patents

Un procedimiento para la preparacion de derivados de ciclohepteno.

Info

Publication number
ES8401760A1
ES8401760A1 ES517501A ES517501A ES8401760A1 ES 8401760 A1 ES8401760 A1 ES 8401760A1 ES 517501 A ES517501 A ES 517501A ES 517501 A ES517501 A ES 517501A ES 8401760 A1 ES8401760 A1 ES 8401760A1
Authority
ES
Spain
Prior art keywords
intermediates
pharmceuticals
preparation
cycloheptene derivatives
cycloheptene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517501A
Other languages
English (en)
Other versions
ES517501A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8401760A1 publication Critical patent/ES8401760A1/es
Publication of ES517501A0 publication Critical patent/ES517501A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CICLOHEPTENO.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON PIRROLIDINA, EN UN DISOLVENTE ORGANICO INERTE, TAL COMO ETER DIETILICO, TETRAHIDROFURANO, ETANOL, ETILENGLICOL, Y SIMILARES, Y PIRROLIDINA EN EXCESO, EN PRESENCIA DE UN AGENTE ACEPTOR DE ACIDO, TAL COMO CARBONATO POTASICO Y SODICO Y SIMILARES, O PIRROLIDINA EN EXCESO OBTENIENDOSE EL 1-2-(4,5,10,11-TETRAHIDRO-1H-DIBEN ZO (A,D) CICLOHEPTEN-5-IL)ETILPIRROLIDINA DE FORMULA (I) QUE SE AISLA COMO LA BASE LIBRE O COMO UNA SAL DE ADICION DE ACIDOFARMACEUTICAMENTE ACEPTABLE. EL RADICAL X PUEDE SER CLORO, BROMO, YODO, METANSULFONILOXILO, P-TOLUENSULFONILOXILO, BENCEN SULFONILOXILO Y SIMILARES.DE APLICACION FARMACOLOGICA PARA EL CONTROL O PREVENCION DE REACCIONES ALERGICAS, COMO URTICARIA, FIEBRE DEL HENO, ANAFILAXIS E HIPERSENSIBILIDAD A LOS MEDICAMENTOS.
ES517501A 1981-01-16 1982-11-19 Un procedimiento para la preparacion de derivados de ciclohepteno. Granted ES517501A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH27381 1981-01-16

Publications (2)

Publication Number Publication Date
ES8401760A1 true ES8401760A1 (es) 1984-01-01
ES517501A0 ES517501A0 (es) 1984-01-01

Family

ID=4183246

Family Applications (2)

Application Number Title Priority Date Filing Date
ES508775A Expired ES8304557A1 (es) 1981-01-16 1982-01-15 Un procedimiento para la preparacion de derivados de ciclo- hepteno.
ES517501A Granted ES517501A0 (es) 1981-01-16 1982-11-19 Un procedimiento para la preparacion de derivados de ciclohepteno.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES508775A Expired ES8304557A1 (es) 1981-01-16 1982-01-15 Un procedimiento para la preparacion de derivados de ciclo- hepteno.

Country Status (23)

Country Link
US (2) US4513002A (es)
EP (1) EP0056617B1 (es)
JP (1) JPS57139021A (es)
KR (1) KR880001863B1 (es)
AR (1) AR229877A1 (es)
AT (1) ATE16484T1 (es)
AU (1) AU550523B2 (es)
CA (1) CA1157853A (es)
DE (1) DE3267334D1 (es)
DK (1) DK17982A (es)
ES (2) ES8304557A1 (es)
FI (1) FI76572C (es)
GR (1) GR75161B (es)
HU (1) HU184981B (es)
IE (1) IE51955B1 (es)
IL (1) IL64755A (es)
MC (1) MC1439A1 (es)
NO (1) NO157374C (es)
NZ (1) NZ199451A (es)
PH (1) PH17091A (es)
PT (1) PT74287A (es)
YU (1) YU6782A (es)
ZA (1) ZA82136B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513002A (en) * 1981-01-16 1985-04-23 Hoffmann-La Roche Inc. Cycloheptene derivatives
US5049673A (en) * 1987-10-30 1991-09-17 The Regents Of The University Of California Fluorescent indicator dyes for calcium working at long wavelengths
US4920025A (en) * 1988-04-08 1990-04-24 Xerox Corporation Control of selenium alloy fractionation
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
NZ568694A (en) 2005-11-09 2011-09-30 Zalicus Inc Method, compositions, and kits for the treatment of medical conditions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3409640A (en) * 1959-07-22 1968-11-05 Schering Corp 5-(3'-dimethylamino-2'-methyl-propyl)dibenzocycloheptenes
GB1017696A (en) * 1961-09-25 1966-01-19 Merck & Co Inc Substituted 5h-dibenzo[a, d]cycloheptenes and 10,11-dihydro-5h-dibenzo[a, d]cycloheptenes
US3922305A (en) * 1962-08-09 1975-11-25 Merck & Co Inc Chemical compounds
US4136116A (en) * 1968-05-03 1979-01-23 Hoffmann-La Roche Inc. Tricyclic compounds
US4127717A (en) * 1978-03-20 1978-11-28 E. R. Squibb & Sons, Inc. Benzo-cyclitolamines
US4513002A (en) * 1981-01-16 1985-04-23 Hoffmann-La Roche Inc. Cycloheptene derivatives
US4337260A (en) * 1981-09-10 1982-06-29 Yoshitomi Pharmaceutical Industries, Ltd. Imidazopyridine-spiro-piperidine compounds

Also Published As

Publication number Publication date
MC1439A1 (fr) 1982-12-06
DE3267334D1 (en) 1985-12-19
KR830009021A (ko) 1983-12-17
EP0056617A3 (en) 1982-11-17
NO157374C (no) 1988-03-09
YU6782A (en) 1985-03-20
ZA82136B (en) 1982-11-24
NO157374B (no) 1987-11-30
IL64755A (en) 1985-04-30
IL64755A0 (en) 1982-03-31
FI820106L (fi) 1982-07-17
PT74287A (en) 1982-02-01
ATE16484T1 (de) 1985-11-15
ES508775A0 (es) 1983-03-16
AU7941882A (en) 1982-07-22
DK17982A (da) 1982-07-17
ES8304557A1 (es) 1983-03-16
PH17091A (en) 1984-05-29
EP0056617B1 (de) 1985-11-13
HU184981B (en) 1984-11-28
NO820125L (no) 1982-07-19
JPS57139021A (en) 1982-08-27
AR229877A1 (es) 1983-12-30
US4691040A (en) 1987-09-01
GR75161B (es) 1984-07-13
AU550523B2 (en) 1986-03-27
FI76572C (fi) 1988-11-10
KR880001863B1 (ko) 1988-09-23
FI76572B (fi) 1988-07-29
IE820072L (en) 1982-07-16
IE51955B1 (en) 1987-04-29
NZ199451A (en) 1984-12-14
EP0056617A2 (de) 1982-07-28
CA1157853A (en) 1983-11-29
US4513002A (en) 1985-04-23
ES517501A0 (es) 1984-01-01

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