ES8100261A1 - Un procedimiento para la preparacion de un indol - Google Patents

Un procedimiento para la preparacion de un indol

Info

Publication number
ES8100261A1
ES8100261A1 ES484980A ES484980A ES8100261A1 ES 8100261 A1 ES8100261 A1 ES 8100261A1 ES 484980 A ES484980 A ES 484980A ES 484980 A ES484980 A ES 484980A ES 8100261 A1 ES8100261 A1 ES 8100261A1
Authority
ES
Spain
Prior art keywords
group
alkyl
hydrogen atom
aryl
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES484980A
Other languages
English (en)
Spanish (es)
Other versions
ES484980A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES484980A0 publication Critical patent/ES484980A0/es
Publication of ES8100261A1 publication Critical patent/ES8100261A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES484980A 1978-10-12 1979-10-11 Un procedimiento para la preparacion de un indol Expired ES8100261A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7840279 1978-10-12

Publications (2)

Publication Number Publication Date
ES484980A0 ES484980A0 (es) 1980-11-01
ES8100261A1 true ES8100261A1 (es) 1980-11-01

Family

ID=10500283

Family Applications (2)

Application Number Title Priority Date Filing Date
ES484980A Expired ES8100261A1 (es) 1978-10-12 1979-10-11 Un procedimiento para la preparacion de un indol
ES492114A Granted ES492114A0 (es) 1978-10-12 1980-06-03 Un procedimiento para la preparacion de un indol

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES492114A Granted ES492114A0 (es) 1978-10-12 1980-06-03 Un procedimiento para la preparacion de un indol

Country Status (18)

Country Link
US (1) US4252803A (en:Method)
JP (1) JPS5562063A (en:Method)
AU (1) AU531783B2 (en:Method)
BE (1) BE879381A (en:Method)
CA (1) CA1146550A (en:Method)
CH (1) CH646151A5 (en:Method)
DE (1) DE2940687A1 (en:Method)
DK (1) DK425579A (en:Method)
ES (2) ES8100261A1 (en:Method)
FI (1) FI793071A7 (en:Method)
FR (1) FR2438651A1 (en:Method)
GB (1) GB2035310B (en:Method)
IE (1) IE49304B1 (en:Method)
IT (1) IT1142170B (en:Method)
NL (1) NL7907583A (en:Method)
NZ (1) NZ191802A (en:Method)
SE (1) SE448628B (en:Method)
ZA (1) ZA795239B (en:Method)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES504694A0 (es) * 1980-08-12 1982-11-01 Glaxo Group Ltd Procedimiento para la preparacion de derivados del indol.
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
AT381491B (de) * 1980-08-12 1986-10-27 Glaxo Group Ltd Verfahren zur herstellung von neuen indolverbindungen und ihren salzen
NZ197996A (en) * 1980-08-12 1985-08-16 Glaxo Group Ltd 1-(3-(omega-aminoalkyl)-1h-indol-5-yl)alkanamides
ZA815541B (en) * 1980-08-12 1983-03-30 Glaxo Group Ltd Heterocyclic compounds
US4428962A (en) 1981-10-30 1984-01-31 Schering Corporation Indoles in treatment of peptic ulcers
GR79215B (en:Method) * 1982-06-07 1984-10-22 Glaxo Group Ltd
US4582848A (en) * 1982-06-10 1986-04-15 Sandoz, Inc. 2-substituted-3-indolamines and use thereof as anti-diabetics
US4803218A (en) * 1982-09-29 1989-02-07 Mcneilab, Inc. 3-aminoalkyl-1H-indole-5-urea and amide derivatives
US4521606A (en) * 1983-06-30 1985-06-04 American Home Products Corp. 5-Indolyl substituted aminoethanols
US4622399A (en) * 1983-06-30 1986-11-11 American Home Products Corporation Bicyclo-heterocyclic nitrogen substituted aminoethanol derivatives
US4562200A (en) * 1983-06-30 1985-12-31 American Home Products Corporation 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
AU571922B2 (en) * 1984-01-26 1988-04-28 Schering Agrochemicals Limited Veterinary implants comprising melatonin and derivatives thereof
US5026869A (en) * 1984-02-06 1991-06-25 Eli Lilly And Company 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
GB8431426D0 (en) * 1984-12-13 1985-01-23 Glaxo Group Ltd Chemical compounds
DE3537289A1 (de) * 1985-10-19 1987-04-23 Hoechst Ag 2-(3-brompropyl)-5,5-dimethyl-1,3-dioxan, sowie verfahren zur herstellung desselben und des 2-(4-brombutyl)-5,5-dimethyl-1,3-dioxans
US4833153A (en) * 1985-11-08 1989-05-23 Glaxo Group Limited Indole derivatives
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
AU601736B2 (en) * 1986-05-23 1990-09-20 Sanofi Sante Nutrition Animale Sa Coated veterinary implants
GB8614287D0 (en) * 1986-06-12 1986-07-16 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
US5276045A (en) * 1989-06-16 1994-01-04 Rhone-Poulenc Sante Thioformamide derivative, process for its preparation, pharmaceutical composition thereof and treatment method
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
AU646871B2 (en) * 1990-06-07 1994-03-10 Astrazeneca Uk Limited Therapeutic heterocyclic compounds
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
US5244912A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
EP0619805B1 (en) * 1991-11-25 2000-03-15 Pfizer Inc. 5-(hetero- or carbocyclylamino)-indole derivatives, their preparation and their use as 5-ht1 agonists
TW288010B (en:Method) * 1992-03-05 1996-10-11 Pfizer
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
CZ281763B6 (cs) 1992-04-07 1997-01-15 Pfizer Inc. Indolové deriváty představující 5-HT1 agonisty, způsob jejich přípravy, farmaceutické prostředky obsahující tyto látky, jejich použití a meziprodukty postupu přípravy
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
SK278182B6 (en) * 1992-04-10 1996-03-06 Pfizer Acylaminoindole derivatives as 5-ht1 agonists, method of their preparation and pharmaceutical compositions containing these matters their use and semifinished products of preparation proces
TW251284B (en:Method) * 1992-11-02 1995-07-11 Pfizer
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
EP0716649B1 (en) * 1993-08-31 1998-09-09 Pfizer Inc. 5-arylindole derivatives
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
AU707277B2 (en) 1995-12-14 1999-07-08 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
IL124613A0 (en) * 1995-12-14 1998-12-06 Merck & Co Inc Antagonists of gonadotropin releasing hormone
IL124459A0 (en) * 1995-12-14 1998-12-06 Merck & Co Inc Antagonists of gonadotropin releasing hormone
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6200957B1 (en) 1995-12-14 2001-03-13 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5780437A (en) * 1995-12-14 1998-07-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5849764A (en) * 1995-12-14 1998-12-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists
US6156767A (en) * 1997-06-05 2000-12-05 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6156772A (en) * 1997-06-05 2000-12-05 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
AU728988B2 (en) * 1997-06-05 2001-01-25 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
JP2002502428A (ja) * 1997-06-05 2002-01-22 メルク エンド カンパニー インコーポレーテッド ゴナドトロピン放出ホルモンの拮抗薬
US6004984A (en) * 1997-06-05 1999-12-21 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5981550A (en) * 1997-06-05 1999-11-09 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5985901A (en) * 1997-06-05 1999-11-16 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
CA2308454A1 (en) * 1997-10-28 1999-05-06 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6017944A (en) * 1997-10-28 2000-01-25 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6159975A (en) * 1998-02-11 2000-12-12 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6228867B1 (en) 1998-04-02 2001-05-08 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6025366A (en) * 1998-04-02 2000-02-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6077847A (en) * 1998-04-02 2000-06-20 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5998432A (en) * 1998-04-02 1999-12-07 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
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JP2002538205A (ja) 1999-03-10 2002-11-12 メルク エンド カムパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモン拮抗薬としての６−アザインドール化合物
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US6620824B2 (en) 2001-04-11 2003-09-16 Merck & Co., Inc. Process for the synthesis of gonadotropin releasing hormone antagonists
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
WO2004000845A1 (en) 2002-06-21 2003-12-31 Suven Life Sciences Limited Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
WO2004000849A2 (en) 2002-06-21 2003-12-31 Suven Life Sciences Limited Tetracyclic arylsulfonyl indoles having serotonin receptor affinity
SI1567492T1 (sl) 2002-11-28 2013-07-31 Suven Life Sciences Limited N-arilsulfonil-3-aminoalkoksiindoli
CN101544592B (zh) 2002-11-28 2013-08-21 苏文生命科学有限公司 N-芳基磺酰-3-取代吲哚制备的替代方法
EP2666772B1 (en) * 2002-12-20 2017-03-01 Basf Se Synthesis of amines and intermediates for the synthesis thereof
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
EP1718608B1 (en) * 2004-02-20 2013-07-17 Boehringer Ingelheim International GmbH Viral polymerase inhibitors
JP5015154B2 (ja) * 2005-08-12 2012-08-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルスポリメラーゼインヒビター
WO2011124704A1 (en) * 2010-04-09 2011-10-13 Ratiopharm Gmbh Process for preparing an intermediate for silodosin
JP7655943B2 (ja) 2020-05-08 2025-04-02 サイレラ インコーポレイテッド 新規な組成物および医薬組成物
WO2022104475A1 (en) * 2020-11-19 2022-05-27 Magicmed Industries Inc. Nitrilated psilocybin derivatives and methods of using
JP2024540030A (ja) * 2021-10-29 2024-10-31 サイレラ インコーポレイテッド 修飾インドール化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives
NL7316677A (en:Method) * 1972-12-21 1974-06-25
DE2314489A1 (de) * 1973-03-23 1974-10-03 Thomae Gmbh Dr K (+)-3-(2-dimethylamino-1-propyl)-2methyl-3-phenyl-3h-indol, dessen saeureadditionssalze und verfahren zu deren herstellung
US3997539A (en) * 1974-05-31 1976-12-14 American Hoechst Corporation 3-(4-Acylaminopiperazin-1-yl alkyl)indoles, precursors and processes for the preparation thereof

Also Published As

Publication number Publication date
ES8106142A1 (es) 1981-07-16
JPS5562063A (en) 1980-05-10
ZA795239B (en) 1980-11-26
CA1146550A (en) 1983-05-17
AU5165779A (en) 1980-04-17
SE7908443L (sv) 1980-04-13
JPS6358817B2 (en:Method) 1988-11-17
FI793071A7 (fi) 1981-01-01
FR2438651B1 (en:Method) 1983-03-04
DK425579A (da) 1980-04-13
ES492114A0 (es) 1981-07-16
GB2035310A (en) 1980-06-18
GB2035310B (en) 1982-12-22
NZ191802A (en) 1983-02-15
IT7950537A0 (it) 1979-10-11
IT1142170B (it) 1986-10-08
ES484980A0 (es) 1980-11-01
NL7907583A (nl) 1980-04-15
SE448628B (sv) 1987-03-09
IE49304B1 (en) 1985-09-18
AU531783B2 (en) 1983-09-08
DE2940687C2 (en:Method) 1991-08-01
US4252803A (en) 1981-02-24
BE879381A (fr) 1980-02-01
DE2940687A1 (de) 1980-04-30
CH646151A5 (de) 1984-11-15
IE791945L (en) 1980-04-12
FR2438651A1 (fr) 1980-05-09

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001204