ES545883A0 - Procedimiento para preparar nuevos derivados de acidos feni-laceticos - Google Patents

Procedimiento para preparar nuevos derivados de acidos feni-laceticos

Info

Publication number
ES545883A0
ES545883A0 ES545883A ES545883A ES545883A0 ES 545883 A0 ES545883 A0 ES 545883A0 ES 545883 A ES545883 A ES 545883A ES 545883 A ES545883 A ES 545883A ES 545883 A0 ES545883 A0 ES 545883A0
Authority
ES
Spain
Prior art keywords
lacetic
pheni
acids
procedure
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES545883A
Other languages
English (en)
Other versions
ES8604548A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8604548A1 publication Critical patent/ES8604548A1/es
Publication of ES545883A0 publication Critical patent/ES545883A0/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Lubricants (AREA)
  • Glass Compositions (AREA)
ES545883A 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos Expired ES8604548A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833347565 DE3347565A1 (de) 1983-12-30 1983-12-30 Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE19853522604 DE3522604A1 (de) 1983-12-30 1985-06-25 Neue feste formen von 2-(gamma)thoxy-4-(n-(1-(2-piperidino-phenyl)-3-methyl-1-butyl)-aminocarbonylmethyl)-benzoesaeure, diese formen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8604548A1 ES8604548A1 (es) 1986-02-01
ES545883A0 true ES545883A0 (es) 1986-02-01

Family

ID=37847099

Family Applications (7)

Application Number Title Priority Date Filing Date
ES539078A Expired ES8605500A1 (es) 1983-12-30 1984-12-27 Procedimiento para preparar derivados de acidos fenilaceticos.
ES545879A Expired ES8604544A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES545882A Expired ES8604547A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES545881A Expired ES8604546A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES545880A Expired ES8604545A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES545883A Expired ES8604548A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES556495A Expired ES8802145A1 (es) 1983-12-30 1986-06-24 Procedimiento para preparar dos nuevas formas solidas de acido 2-etoxi-4-(n-(1-(2-piperidino-fenil)-3-metil-1-butil)-aminocarbonilmetil)-benzoico

Family Applications Before (5)

Application Number Title Priority Date Filing Date
ES539078A Expired ES8605500A1 (es) 1983-12-30 1984-12-27 Procedimiento para preparar derivados de acidos fenilaceticos.
ES545879A Expired ES8604544A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES545882A Expired ES8604547A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES545881A Expired ES8604546A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES545880A Expired ES8604545A1 (es) 1983-12-30 1985-08-05 Procedimiento para preparar nuevos derivados de acidos feni-laceticos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES556495A Expired ES8802145A1 (es) 1983-12-30 1986-06-24 Procedimiento para preparar dos nuevas formas solidas de acido 2-etoxi-4-(n-(1-(2-piperidino-fenil)-3-metil-1-butil)-aminocarbonilmetil)-benzoico

Country Status (26)

Country Link
EP (2) EP0147850B1 (es)
JP (2) JPH0623200B2 (es)
KR (1) KR900005320B1 (es)
AT (1) ATE44027T1 (es)
AU (2) AU577815B2 (es)
BG (1) BG61519B2 (es)
CA (2) CA1225398A (es)
CS (1) CS409791A3 (es)
DD (1) DD231348A5 (es)
DE (4) DE3347565A1 (es)
DK (2) DK167439B1 (es)
ES (7) ES8605500A1 (es)
FI (2) FI80447C (es)
GR (2) GR82614B (es)
HK (1) HK87492A (es)
HU (1) HU194548B (es)
IE (1) IE57700B1 (es)
IL (2) IL73963A (es)
LU (1) LU90301I2 (es)
MX (1) MX9202772A (es)
NL (1) NL980034I1 (es)
NO (3) NO162819C (es)
NZ (2) NZ210657A (es)
PT (2) PT79772B (es)
SG (1) SG55492G (es)
ZA (2) ZA8410103B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3347565A1 (de) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3523466A1 (de) * 1985-07-01 1987-01-08 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE59109151D1 (de) * 1991-06-21 1999-10-14 Boehringer Ingelheim Pharma Verwendung von (s)(+)-2-äthoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoesäure zur herstellung eines langzeitantidiabetikums
DE59109240D1 (de) * 1991-06-21 2002-10-10 Boehringer Ingelheim Pharma Verfahren zur Herstellung von (S)-3-Methyl-1-(2-piperidino-phenyl)-1-butylamin
FR2763590B1 (fr) * 1997-05-22 2000-03-24 Synthelabo Derives d'acides[[[(arylmethyl)amino]carbonyl] alkyl]- aromatiques, leur preparation et leur application en therapeutique
PT1741446E (pt) 2000-01-21 2008-05-09 Novartis Pharma Ag Combinações incluindo inibidores da dipeptidilpeptidase-iv e agentes anti-diabéticos
WO2004018442A1 (en) * 2002-08-23 2004-03-04 Dr. Reddy's Laboratories Limited Crystalline and amorphous forms of (s) -repaglinide and the processes for preparation thereof
US7915421B2 (en) 2003-05-14 2011-03-29 Cilag Ltd. Method for preparing phenyl acetic acid derivatives
AU2003237595A1 (en) * 2003-05-26 2004-12-13 Biocon Limited Process for the preparation of s(+)-2-ethoxy-4-(n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl)benzoic acid derivatives
JP4550811B2 (ja) * 2003-06-09 2010-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング パピローマウイルスのインヒビター
FR2875805B1 (fr) * 2004-09-27 2006-12-29 Genfit S A Composes derives de n-(benzyl) phenylacetamide substitues, preparation et utilisations
CN1305863C (zh) * 2004-12-27 2007-03-21 浙江大学 (s)-异丙基-(2-哌啶)苯基-甲基胺的合成方法
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
PL1931350T5 (pl) 2005-09-14 2021-11-15 Takeda Pharmaceutical Company Limited Podanie inhibitorów dipeptydylo-peptydazy
EP2177221A1 (en) 2008-10-20 2010-04-21 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of substantially optically pure Repaglinide and precursors thereof
HRP20140371T1 (hr) 2009-05-15 2014-05-23 Novartis Ag Arilpiridini kao inhibitori sinteze aldosterona
WO2010130773A2 (en) 2009-05-15 2010-11-18 Novartis Ag Benzoxazolone derivatives as aldosterone symthase inhibitors
EP2435402B1 (en) 2009-05-28 2016-04-13 Novartis AG Substituted aminobutyric derivatives as neprilysin inhibitors
CN103896796B (zh) 2009-05-28 2016-04-27 诺华股份有限公司 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
US8519134B2 (en) 2009-11-17 2013-08-27 Novartis Ag Aryl-pyridine derivatives as aldosterone synthase inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
ES2472446T3 (es) 2009-11-30 2014-07-01 Novartis Ag Derivados de imidazol como inhibidores de aldosterona sintasa
PL2531501T3 (pl) 2010-02-03 2014-05-30 Takeda Pharmaceuticals Co Inhibitory kinazy 1 regulującej sygnał apoptotyczny
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
WO2012095548A2 (es) 2011-01-13 2012-07-19 Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas (Ciberned) Compuestos para el tratamiento de enfermedades neurodegenerativas
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
CU24330B1 (es) 2013-02-14 2018-03-13 Novartis Ag Derivados del ácido 4-((1,1) bifenil-4-il)-3-(3-fosfonopropanamido) butanoico, activos como inhibidores de nep (endopeptidasa neutral)
CN105705167A (zh) 2013-07-25 2016-06-22 诺华股份有限公司 合成的apelin多肽的生物缀合物
MX2016001020A (es) 2013-07-25 2016-08-03 Novartis Ag Polipeptidos ciclicos para el tratamiento de insuficiencia cardiaca.
CR20170338A (es) 2015-01-23 2017-09-12 Novartis Ag Conjugados de ácidos grasos y apelina sintética con mayor vida media
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3100535A1 (de) * 1981-01-10 1982-08-12 Dr. Karl Thomae Gmbh, 7950 Biberach "neue carbonsaeure-derivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3100575A1 (de) * 1981-01-10 1982-09-02 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benzoesaeuren, ihre herstellung und ihre verwendung als arzneimittel"
SU1170969A3 (ru) * 1982-07-06 1985-07-30 Др.Карл Томэ,Гмбх (Фирма) Способ получени производных фенилуксусной кислоты или их солей
FR2554875B1 (fr) * 1983-11-10 1986-02-28 Dba Amplificateur hydraulique de freinage
DE3523466A1 (de) * 1985-07-01 1987-01-08 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3347565A1 (de) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
FI82689C (fi) 1991-04-10
EP0147850A3 (en) 1985-08-07
DE3478682D1 (en) 1989-07-20
CA1225398A (en) 1987-08-11
DE3522604A1 (de) 1987-01-08
ATE44027T1 (de) 1989-06-15
FI845145L (fi) 1985-07-01
GR861558B (en) 1986-10-17
DD231348A5 (de) 1985-12-24
ES545881A0 (es) 1986-02-01
ES8802145A1 (es) 1988-04-01
DK167573B1 (da) 1993-11-22
EP0147850B1 (de) 1989-06-14
ES545879A0 (es) 1986-02-01
NL980034I1 (nl) 1999-02-01
PT79772A (de) 1985-01-01
NO845282L (no) 1985-07-01
ES8604546A1 (es) 1986-02-01
DK296686A (da) 1986-12-26
NZ216640A (en) 1989-02-24
ES8604544A1 (es) 1986-02-01
AU3721084A (en) 1985-08-01
FI862650L (fi) 1986-12-26
KR900005320B1 (ko) 1990-07-27
AU577815B2 (en) 1988-10-06
LU90301I2 (fr) 1998-12-21
NO862532D0 (no) 1986-06-24
BG61519B2 (bg) 1997-10-31
AU5913986A (en) 1987-01-08
FI80447C (fi) 1990-06-11
FI862650A0 (fi) 1986-06-23
IE57700B1 (en) 1993-03-10
ES8604547A1 (es) 1986-02-01
DK613184A (da) 1985-07-01
EP0147850A2 (de) 1985-07-10
FI845145A0 (fi) 1984-12-28
NO168302B (no) 1991-10-28
FI82689B (fi) 1990-12-31
CS409791A3 (en) 1992-07-15
IL73963A0 (en) 1985-03-31
ES545882A0 (es) 1986-02-01
JPH0739405B2 (ja) 1995-05-01
DK296686D0 (da) 1986-06-24
ES8604548A1 (es) 1986-02-01
ZA864695B (en) 1988-02-24
NO162819C (no) 1990-02-21
JPH0623200B2 (ja) 1994-03-30
CA1292000C (en) 1991-11-12
SG55492G (en) 1992-10-02
NO168302C (no) 1992-02-05
HK87492A (en) 1992-11-13
PT82832B (pt) 1988-12-15
IL79217A0 (en) 1986-09-30
EP0207331A1 (de) 1987-01-07
JPS60158171A (ja) 1985-08-19
JPS62474A (ja) 1987-01-06
NZ210657A (en) 1988-10-28
PT79772B (de) 1987-01-05
GR82614B (en) 1985-05-02
ES545880A0 (es) 1986-02-01
ES556495A0 (es) 1988-04-01
NO862532L (no) 1986-12-29
DK613184D0 (da) 1984-12-20
ES8604545A1 (es) 1986-02-01
DK167439B1 (da) 1993-11-01
FI80447B (fi) 1990-02-28
ES539078A0 (es) 1986-03-16
IL79217A (en) 1991-01-31
HU194548B (en) 1988-02-29
ES8605500A1 (es) 1986-03-16
NO1999016I1 (no) 1999-07-20
PT82832A (de) 1986-07-01
NO162819B (no) 1989-11-13
KR850004590A (ko) 1985-07-25
ZA8410103B (en) 1986-09-24
IL73963A (en) 1989-01-31
EP0207331B1 (de) 1990-05-23
MX9202772A (es) 1992-06-30
AU583631B2 (en) 1989-05-04
DE3347565A1 (de) 1985-07-11
HUT37773A (en) 1986-02-28
DE19875044I2 (de) 2002-07-18
IE843349L (en) 1985-06-30

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