MX9202772A - Derivados de acidos fenilaceticos y procedimiento para su preparacion. - Google Patents

Derivados de acidos fenilaceticos y procedimiento para su preparacion.

Info

Publication number
MX9202772A
MX9202772A MX9202772A MX9202772A MX9202772A MX 9202772 A MX9202772 A MX 9202772A MX 9202772 A MX9202772 A MX 9202772A MX 9202772 A MX9202772 A MX 9202772A MX 9202772 A MX9202772 A MX 9202772A
Authority
MX
Mexico
Prior art keywords
derivatives
procedure
preparation
phenylacetic acids
kbr
Prior art date
Application number
MX9202772A
Other languages
English (en)
Inventor
Wolfgang Grell
Rudolf Hernaus
Gehart Criss
Robert Sauter
Eckhard Ruprecht
Original Assignee
Thomae Gmbg Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbg Dr K filed Critical Thomae Gmbg Dr K
Publication of MX9202772A publication Critical patent/MX9202772A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Lubricants (AREA)
  • Glass Compositions (AREA)
MX9202772A 1983-12-30 1992-06-10 Derivados de acidos fenilaceticos y procedimiento para su preparacion. MX9202772A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833347565 DE3347565A1 (de) 1983-12-30 1983-12-30 Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE19853522604 DE3522604A1 (de) 1983-12-30 1985-06-25 Neue feste formen von 2-(gamma)thoxy-4-(n-(1-(2-piperidino-phenyl)-3-methyl-1-butyl)-aminocarbonylmethyl)-benzoesaeure, diese formen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
MX9202772A true MX9202772A (es) 1992-06-30

Family

ID=37847099

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9202772A MX9202772A (es) 1983-12-30 1992-06-10 Derivados de acidos fenilaceticos y procedimiento para su preparacion.

Country Status (26)

Country Link
EP (2) EP0147850B1 (es)
JP (2) JPH0623200B2 (es)
KR (1) KR900005320B1 (es)
AT (1) ATE44027T1 (es)
AU (2) AU577815B2 (es)
BG (1) BG61519B2 (es)
CA (2) CA1225398A (es)
CS (1) CS409791A3 (es)
DD (1) DD231348A5 (es)
DE (4) DE3347565A1 (es)
DK (2) DK167439B1 (es)
ES (7) ES8605500A1 (es)
FI (2) FI80447C (es)
GR (2) GR82614B (es)
HK (1) HK87492A (es)
HU (1) HU194548B (es)
IE (1) IE57700B1 (es)
IL (2) IL73963A (es)
LU (1) LU90301I2 (es)
MX (1) MX9202772A (es)
NL (1) NL980034I1 (es)
NO (3) NO162819C (es)
NZ (2) NZ210657A (es)
PT (2) PT79772B (es)
SG (1) SG55492G (es)
ZA (2) ZA8410103B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3347565A1 (de) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3523466A1 (de) * 1985-07-01 1987-01-08 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
AU660930B2 (en) * 1991-06-21 1995-07-13 Novo Nordisk A/S (S)(+)-2-ethoxy-4-(N-(1-(2-piperidinophenyl)-3-methyl-1- butyl)aminocarbonylmethyl)benzoic acid
ES2179558T3 (es) * 1991-06-21 2003-01-16 Boehringer Ingelheim Pharma Procedimiento para preparar (s)-3-metil-1-(2-piperidino-fenil)-1-butilamina.
FR2763590B1 (fr) * 1997-05-22 2000-03-24 Synthelabo Derives d'acides[[[(arylmethyl)amino]carbonyl] alkyl]- aromatiques, leur preparation et leur application en therapeutique
DE122008000018I1 (de) 2000-01-21 2008-08-14 Novartis Pharma Ag Zusammensetzungen bestehend aus Dipeptidylpeptidase-IV Inhibitoren und Antidiabetica
US20040102477A1 (en) * 2002-08-23 2004-05-27 Dr. Reddy's Laboratories Limited Polymorphic forms of (S)-Repaglinide and the processes for preparation thereof
WO2004101540A2 (de) * 2003-05-14 2004-11-25 Cilag Ag Verfahren zur herstellung von phenylessigsäurederivaten
AU2003237595A1 (en) * 2003-05-26 2004-12-13 Biocon Limited Process for the preparation of s(+)-2-ethoxy-4-(n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl)benzoic acid derivatives
EP1636200A2 (en) * 2003-06-09 2006-03-22 Boehringer Ingelheim International GmbH Inhibitors of papilloma virus
FR2875805B1 (fr) * 2004-09-27 2006-12-29 Genfit S A Composes derives de n-(benzyl) phenylacetamide substitues, preparation et utilisations
CN1305863C (zh) * 2004-12-27 2007-03-21 浙江大学 (s)－异丙基－(2－哌啶)苯基－甲基胺的合成方法
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
CA2622608C (en) 2005-09-14 2014-08-19 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors for treating diabetes
EP2177221A1 (en) 2008-10-20 2010-04-21 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of substantially optically pure Repaglinide and precursors thereof
BRPI1010600A2 (pt) 2009-05-15 2016-03-15 Novartis Ag aril piridina como inibidores de aldosterona sintase
AU2010247391A1 (en) 2009-05-15 2011-12-01 Novartis Ag Benzoxazolone derivatives as aldosterone synthase inhibitors
MA33364B1 (fr) 2009-05-28 2012-06-01 Novartis Ag Dérivés aminobutyriques substitués en tant qu'inhibiteurs de néprilysine
EA019511B1 (ru) 2009-05-28 2014-04-30 Новартис Аг Замещенные производные аминопропионовой кислоты в качестве ингибиторов неприлизина
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
EP2993169B1 (en) 2009-11-17 2017-12-20 Novartis AG Aryl-pyridine derivatives as aldosterone synthase inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
EP2507234B1 (en) 2009-11-30 2014-03-12 Novartis AG Imidazole derivatives as aldosterone synthase inhibitors
CN102834393B (zh) 2010-02-03 2015-07-22 武田药品工业株式会社 细胞凋亡信号调节激酶1抑制剂
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
WO2012095548A2 (es) 2011-01-13 2012-07-19 Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas (Ciberned) Compuestos para el tratamiento de enfermedades neurodegenerativas
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
SI2956464T1 (en) 2013-02-14 2018-08-31 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors (neutral endopeptidases)
SG11201600211XA (en) 2013-07-25 2016-02-26 Novartis Ag Cyclic polypeptides for the treatment of heart failure
UY35671A (es) 2013-07-25 2015-02-27 Novartis Ag Bioconjugados de polipéptidos de apelina sintética
MA41580A (fr) 2015-01-23 2017-11-29 Novartis Ag Conjugués d'acides gras de l'apeline synthétique présentant une demi-vie améliorée
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3100575A1 (de) * 1981-01-10 1982-09-02 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benzoesaeuren, ihre herstellung und ihre verwendung als arzneimittel"
DE3100535A1 (de) * 1981-01-10 1982-08-12 Dr. Karl Thomae Gmbh, 7950 Biberach "neue carbonsaeure-derivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3375783D1 (en) * 1982-07-06 1988-04-07 Thomae Gmbh Dr K Phenyl-acetic-acid derivatives, their preparation and pharmaceutical compostions containing them
FR2554875B1 (fr) * 1983-11-10 1986-02-28 Dba Amplificateur hydraulique de freinage
DE3523466A1 (de) * 1985-07-01 1987-01-08 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3347565A1 (de) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0207331A1 (de) 1987-01-07
KR850004590A (ko) 1985-07-25
AU3721084A (en) 1985-08-01
GR82614B (en) 1985-05-02
ES545880A0 (es) 1986-02-01
SG55492G (en) 1992-10-02
DE3478682D1 (en) 1989-07-20
IE843349L (en) 1985-06-30
HU194548B (en) 1988-02-29
DE3347565A1 (de) 1985-07-11
ZA8410103B (en) 1986-09-24
AU5913986A (en) 1987-01-08
ES8605500A1 (es) 1986-03-16
BG61519B2 (bg) 1997-10-31
DK613184A (da) 1985-07-01
EP0147850B1 (de) 1989-06-14
DK167439B1 (da) 1993-11-01
DK613184D0 (da) 1984-12-20
NO862532D0 (no) 1986-06-24
FI80447B (fi) 1990-02-28
FI82689C (fi) 1991-04-10
NO1999016I1 (no) 1999-07-20
LU90301I2 (fr) 1998-12-21
IL79217A0 (en) 1986-09-30
ES545882A0 (es) 1986-02-01
JPS60158171A (ja) 1985-08-19
PT82832B (pt) 1988-12-15
ES8604544A1 (es) 1986-02-01
IL79217A (en) 1991-01-31
ES545879A0 (es) 1986-02-01
ATE44027T1 (de) 1989-06-15
KR900005320B1 (ko) 1990-07-27
NO168302B (no) 1991-10-28
FI80447C (fi) 1990-06-11
IE57700B1 (en) 1993-03-10
ES539078A0 (es) 1986-03-16
FI862650A0 (fi) 1986-06-23
NZ210657A (en) 1988-10-28
HK87492A (en) 1992-11-13
ES545881A0 (es) 1986-02-01
NO162819B (no) 1989-11-13
NO862532L (no) 1986-12-29
DE3522604A1 (de) 1987-01-08
FI845145A0 (fi) 1984-12-28
DE19875044I2 (de) 2002-07-18
EP0147850A3 (en) 1985-08-07
NO168302C (no) 1992-02-05
NO162819C (no) 1990-02-21
FI845145L (fi) 1985-07-01
HUT37773A (en) 1986-02-28
ES545883A0 (es) 1986-02-01
ES8604547A1 (es) 1986-02-01
DK296686D0 (da) 1986-06-24
ES8604545A1 (es) 1986-02-01
EP0207331B1 (de) 1990-05-23
AU583631B2 (en) 1989-05-04
CS409791A3 (en) 1992-07-15
ES8604548A1 (es) 1986-02-01
ES556495A0 (es) 1988-04-01
ES8604546A1 (es) 1986-02-01
ES8802145A1 (es) 1988-04-01
DK296686A (da) 1986-12-26
PT82832A (de) 1986-07-01
DD231348A5 (de) 1985-12-24
JPS62474A (ja) 1987-01-06
JPH0739405B2 (ja) 1995-05-01
ZA864695B (en) 1988-02-24
JPH0623200B2 (ja) 1994-03-30
PT79772A (de) 1985-01-01
IL73963A0 (en) 1985-03-31
NZ216640A (en) 1989-02-24
AU577815B2 (en) 1988-10-06
EP0147850A2 (de) 1985-07-10
FI862650A (fi) 1986-12-26
NO845282L (no) 1985-07-01
FI82689B (fi) 1990-12-31
PT79772B (de) 1987-01-05
NL980034I1 (nl) 1999-02-01
DK167573B1 (da) 1993-11-22
GR861558B (en) 1986-10-17
IL73963A (en) 1989-01-31
CA1292000C (en) 1991-11-12
CA1225398A (en) 1987-08-11

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Publication Publication Date Title
MX9202772A (es) Derivados de acidos fenilaceticos y procedimiento para su preparacion.