SG55492G - Phenylacetic-acid derivatives,medicines containing these compounds and process for their preparation - Google Patents
Phenylacetic-acid derivatives,medicines containing these compounds and process for their preparationInfo
- Publication number
- SG55492G SG55492G SG554/92A SG55492A SG55492G SG 55492 G SG55492 G SG 55492G SG 554/92 A SG554/92 A SG 554/92A SG 55492 A SG55492 A SG 55492A SG 55492 G SG55492 G SG 55492G
- Authority
- SG
- Singapore
- Prior art keywords
- phenylacetic
- compounds
- preparation
- acid derivatives
- medicines containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Glass Compositions (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Lubricants (AREA)
Abstract
1. Two new solid forms of 2-ethoxy-4-[N-(1-(2-piperidino- phenyl)-3-methyl-1-butyl)-aminocarbonylmethyl]-benzoic acid, the form designated (B) being characterised by the melting point of 140-142 degrees C and by the IR(KBr) spectrum according to Figure B' and the form designated (C) being characterised by a melting point of 75-85 degrees C and by the IR(KBr) spectrum according to Figure C'.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833347565 DE3347565A1 (en) | 1983-12-30 | 1983-12-30 | NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
| DE19853522604 DE3522604A1 (en) | 1983-12-30 | 1985-06-25 | NEW SOLID FORMS OF 2- (GAMMA) THOXY-4- (N- (1- (2- (2-PIPERIDINO-PHENYL) -3-METHYL-1-BUTYL) -AMINOCARBONYLMETHYL) -BENZOESIC ACID, MEDICINAL PRODUCTS CONTAINING THESE FORMS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG55492G true SG55492G (en) | 1992-10-02 |
Family
ID=37847099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG554/92A SG55492G (en) | 1983-12-30 | 1992-05-25 | Phenylacetic-acid derivatives,medicines containing these compounds and process for their preparation |
Country Status (26)
| Country | Link |
|---|---|
| EP (2) | EP0147850B1 (en) |
| JP (2) | JPH0623200B2 (en) |
| KR (1) | KR900005320B1 (en) |
| AT (1) | ATE44027T1 (en) |
| AU (2) | AU577815B2 (en) |
| BG (1) | BG61519B2 (en) |
| CA (2) | CA1225398A (en) |
| CS (1) | CS409791A3 (en) |
| DD (1) | DD231348A5 (en) |
| DE (4) | DE3347565A1 (en) |
| DK (2) | DK167439B1 (en) |
| ES (7) | ES8605500A1 (en) |
| FI (2) | FI80447C (en) |
| GR (2) | GR82614B (en) |
| HK (1) | HK87492A (en) |
| HU (1) | HU194548B (en) |
| IE (1) | IE57700B1 (en) |
| IL (2) | IL73963A (en) |
| LU (1) | LU90301I2 (en) |
| MX (1) | MX9202772A (en) |
| NL (1) | NL980034I1 (en) |
| NO (3) | NO162819C (en) |
| NZ (2) | NZ210657A (en) |
| PT (2) | PT79772B (en) |
| SG (1) | SG55492G (en) |
| ZA (2) | ZA8410103B (en) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3347565A1 (en) * | 1983-12-30 | 1985-07-11 | Thomae Gmbh Dr K | NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
| DE3523466A1 (en) * | 1985-07-01 | 1987-01-08 | Thomae Gmbh Dr K | NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
| PL170210B1 (en) * | 1991-06-21 | 1996-11-29 | Thomae Gmbh Dr K | Method of obtaining a novel (s)(+)-2-ethoxy-4-(n-)1-(2-pieridynophenyl)-3-methyl-1-butyloamino carbonylomethyl)benzoic acid and its salts |
| ATE184279T1 (en) * | 1991-06-21 | 1999-09-15 | Boehringer Ingelheim Pharma | USE OF (S)(+)-2-ETHOXY-4-(N-(1-(2-PIPERIDINO-PHENYL)-3-METHYL-1-BUTYL>AMINOCARBONYLMETHYL>-BENZOIC ACID FOR PRODUCING A LONG-TERM ANTIDIABETIC |
| FR2763590B1 (en) * | 1997-05-22 | 2000-03-24 | Synthelabo | ACID DERIVATIVES [[[(ARYLMETHYL) AMINO] CARBONYL] ALKYL] - AROMATICS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| ES2433476T3 (en) | 2000-01-21 | 2013-12-11 | Novartis Ag | Combinations containing dipeptidylpeptidase-IV inhibitors and antidiabetic agents |
| US20040102477A1 (en) * | 2002-08-23 | 2004-05-27 | Dr. Reddy's Laboratories Limited | Polymorphic forms of (S)-Repaglinide and the processes for preparation thereof |
| US7915421B2 (en) | 2003-05-14 | 2011-03-29 | Cilag Ltd. | Method for preparing phenyl acetic acid derivatives |
| WO2004103983A1 (en) * | 2003-05-26 | 2004-12-02 | Biocon Limited | Process for the preparation of s(+)-2-ethoxy-4-[n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl]benzoic acid derivatives |
| US7582766B2 (en) * | 2003-06-09 | 2009-09-01 | Boehringer Ingelheim International Gmbh | Inhibitors of papilloma virus |
| FR2875805B1 (en) * | 2004-09-27 | 2006-12-29 | Genfit S A | SUBSTITUTED N- (BENZYL) PHENYLACETAMIDE DERIVATIVE COMPOUNDS, PREPARATION AND USES |
| CN1305863C (en) * | 2004-12-27 | 2007-03-21 | 浙江大学 | Method for synthesizing (S)-isopropyl-(2-piperidine) phenyl-methylhistamine |
| GT200600381A (en) | 2005-08-25 | 2007-03-28 | ORGANIC COMPOUNDS | |
| PL1931350T5 (en) | 2005-09-14 | 2021-11-15 | Takeda Pharmaceutical Company Limited | Administration of dipeptidyl peptidase inhibitors |
| EP2177221A1 (en) | 2008-10-20 | 2010-04-21 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of substantially optically pure Repaglinide and precursors thereof |
| CA2761853A1 (en) | 2009-05-15 | 2010-11-18 | Novartis Ag | Benzoxazolone derivatives as aldosterone synthase inhibitors |
| PE20120403A1 (en) | 2009-05-15 | 2012-05-03 | Novartis Ag | ARYL-PYRIDINES AS INHIBITORS OF ALDOSTERONE SYNTHASE |
| AU2010251967B9 (en) | 2009-05-28 | 2014-04-03 | Novartis Ag | Substituted aminopropionic derivatives as neprilysin inhibitors |
| EA201101672A1 (en) | 2009-05-28 | 2012-06-29 | Новартис Аг | SUBSTITUTED DERIVATIVES OF AMINOISAL ACID AS NEPRILISIN INHIBITORS |
| WO2011041293A1 (en) | 2009-09-30 | 2011-04-07 | Takeda Pharmaceutical Company Limited | Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors |
| CN102712589B (en) | 2009-11-17 | 2015-05-13 | 诺华股份有限公司 | Aryl-pyridine derivatives as aldosterone synthase inhibitors |
| JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors |
| JP5575913B2 (en) | 2009-11-30 | 2014-08-20 | ノバルティス アーゲー | Imidazole derivatives as aldosterone synthase inhibitors |
| PT2531501E (en) | 2010-02-03 | 2014-02-17 | Takeda Pharmaceutical | Apoptosis signal-regulating kinase 1 inhibitors |
| US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
| US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
| WO2012095548A2 (en) | 2011-01-13 | 2012-07-19 | Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas (Ciberned) | Compounds for treating neurodegenerative disorders |
| UY35144A (en) | 2012-11-20 | 2014-06-30 | Novartis Ag | APELINE SYNTHETIC LINEAR MIMETICS FOR THE CARDIAC INSUFFICIENCY TREATMENT |
| PE20151666A1 (en) | 2013-02-14 | 2015-11-19 | Novartis Ag | SUBSTITUTE DERIVATIVES OF BISPHENYL BUTANOIC PHOSPHONE ACID AS INHIBITORS OF NEP |
| PE20160991A1 (en) | 2013-07-25 | 2016-10-15 | Novartis Ag | BIOCONJUGATES OF SYNTHETIC APELLIN POLYPEPTIDES |
| CN105612172A (en) | 2013-07-25 | 2016-05-25 | 诺华股份有限公司 | Cyclic polypeptides for the treatment of heart failure |
| BR112017014194A2 (en) | 2015-01-23 | 2018-01-09 | Novartis Ag | synthetic apelin fatty acid conjugates with improved half life |
| UY38072A (en) | 2018-02-07 | 2019-10-01 | Novartis Ag | COMPOSITIONS DERIVED FROM BUTANOIC ESTER SUBSTITUTED WITH BISPHENYL AS INHIBITORS OF NEP, COMPOSITIONS AND COMBINATIONS OF THE SAME |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3100575A1 (en) * | 1981-01-10 | 1982-09-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | "NEW BENZOESAEURS, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS" |
| DE3100535A1 (en) * | 1981-01-10 | 1982-08-12 | Dr. Karl Thomae Gmbh, 7950 Biberach | "NEW CARBONIC ACID DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS" |
| EP0099017B1 (en) * | 1982-07-06 | 1988-03-02 | Dr. Karl Thomae GmbH | Phenyl-acetic-acid derivatives, their preparation and pharmaceutical compostions containing them |
| FR2554875B1 (en) * | 1983-11-10 | 1986-02-28 | Dba | HYDRAULIC BRAKE AMPLIFIER |
| DE3347565A1 (en) * | 1983-12-30 | 1985-07-11 | Thomae Gmbh Dr K | NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
| DE3523466A1 (en) * | 1985-07-01 | 1987-01-08 | Thomae Gmbh Dr K | NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
-
1983
- 1983-12-30 DE DE19833347565 patent/DE3347565A1/en not_active Withdrawn
-
1984
- 1984-12-20 DK DK613184A patent/DK167439B1/en active Protection Beyond IP Right Term
- 1984-12-20 NZ NZ210657A patent/NZ210657A/en unknown
- 1984-12-24 JP JP59272685A patent/JPH0623200B2/en not_active Expired - Lifetime
- 1984-12-27 AT AT84116359T patent/ATE44027T1/en active
- 1984-12-27 DE DE1998175044 patent/DE19875044I2/en active Active
- 1984-12-27 DE DE8484116359T patent/DE3478682D1/en not_active Expired
- 1984-12-27 ES ES539078A patent/ES8605500A1/en not_active Expired
- 1984-12-27 EP EP84116359A patent/EP0147850B1/en not_active Expired
- 1984-12-28 KR KR1019840008504A patent/KR900005320B1/en not_active IP Right Cessation
- 1984-12-28 HU HU844870A patent/HU194548B/en unknown
- 1984-12-28 ZA ZA8410103A patent/ZA8410103B/en unknown
- 1984-12-28 IE IE3349/84A patent/IE57700B1/en not_active IP Right Cessation
- 1984-12-28 PT PT79772A patent/PT79772B/en unknown
- 1984-12-28 DD DD84272061A patent/DD231348A5/en not_active IP Right Cessation
- 1984-12-28 CA CA000471120A patent/CA1225398A/en not_active Expired
- 1984-12-28 IL IL73963A patent/IL73963A/en not_active IP Right Cessation
- 1984-12-28 GR GR82614A patent/GR82614B/en unknown
- 1984-12-28 NO NO845282A patent/NO162819C/en not_active IP Right Cessation
- 1984-12-28 FI FI845145A patent/FI80447C/en active IP Right Grant
- 1984-12-28 AU AU37210/84A patent/AU577815B2/en not_active Expired
-
1985
- 1985-06-25 DE DE19853522604 patent/DE3522604A1/en not_active Withdrawn
- 1985-08-05 ES ES545882A patent/ES8604547A1/en not_active Expired
- 1985-08-05 ES ES545881A patent/ES8604546A1/en not_active Expired
- 1985-08-05 ES ES545880A patent/ES8604545A1/en not_active Expired
- 1985-08-05 ES ES545879A patent/ES8604544A1/en not_active Expired
- 1985-08-05 ES ES545883A patent/ES8604548A1/en not_active Expired
-
1986
- 1986-06-10 EP EP86107890A patent/EP0207331B1/en not_active Expired - Lifetime
- 1986-06-16 GR GR861558A patent/GR861558B/en unknown
- 1986-06-23 FI FI862650A patent/FI82689C/en not_active IP Right Cessation
- 1986-06-24 AU AU59139/86A patent/AU583631B2/en not_active Expired
- 1986-06-24 CA CA000512269A patent/CA1292000C/en not_active Expired - Lifetime
- 1986-06-24 DK DK296686A patent/DK167573B1/en not_active IP Right Cessation
- 1986-06-24 NZ NZ216640A patent/NZ216640A/en unknown
- 1986-06-24 PT PT82832A patent/PT82832B/en unknown
- 1986-06-24 ZA ZA864695A patent/ZA864695B/en unknown
- 1986-06-24 IL IL79217A patent/IL79217A/en not_active IP Right Cessation
- 1986-06-24 NO NO862532A patent/NO168302C/en not_active IP Right Cessation
- 1986-06-24 ES ES556495A patent/ES8802145A1/en not_active Expired
- 1986-06-24 JP JP61148027A patent/JPH0739405B2/en not_active Expired - Lifetime
-
1991
- 1991-12-27 CS CS914097A patent/CS409791A3/en unknown
-
1992
- 1992-05-25 SG SG554/92A patent/SG55492G/en unknown
- 1992-06-10 MX MX9202772A patent/MX9202772A/en unknown
- 1992-11-05 HK HK874/92A patent/HK87492A/en not_active IP Right Cessation
-
1994
- 1994-01-24 BG BG098407A patent/BG61519B2/en unknown
-
1998
- 1998-10-21 LU LU90301C patent/LU90301I2/en unknown
- 1998-11-18 NL NL980034C patent/NL980034I1/en unknown
-
1999
- 1999-07-20 NO NO1999016C patent/NO1999016I1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3478682D1 (en) | Phenylacetic-acid derivatives, medicines containing these compounds and process for their preparation |