NO162819C - ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PHENYLEDIC ACETIC ACID DERIVATIVES. - Google Patents

ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PHENYLEDIC ACETIC ACID DERIVATIVES.

Info

Publication number
NO162819C
NO162819C NO845282A NO845282A NO162819C NO 162819 C NO162819 C NO 162819C NO 845282 A NO845282 A NO 845282A NO 845282 A NO845282 A NO 845282A NO 162819 C NO162819 C NO 162819C
Authority
NO
Norway
Prior art keywords
phenyledic
preparation
acetic acid
acid derivatives
therapeutic active
Prior art date
Application number
NO845282A
Other languages
Norwegian (no)
Other versions
NO845282L (en
NO162819B (en
Inventor
Wolfgang Grell
Rudolf Hurnaus
Gerhart Griss
Robert Sauter
Eckhard Rupprecht
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO845282L publication Critical patent/NO845282L/en
Publication of NO162819B publication Critical patent/NO162819B/en
Publication of NO162819C publication Critical patent/NO162819C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

1. Two new solid forms of 2-ethoxy-4-[N-(1-(2-piperidino- phenyl)-3-methyl-1-butyl)-aminocarbonylmethyl]-benzoic acid, the form designated (B) being characterised by the melting point of 140-142 degrees C and by the IR(KBr) spectrum according to Figure B' and the form designated (C) being characterised by a melting point of 75-85 degrees C and by the IR(KBr) spectrum according to Figure C'.
NO845282A 1983-12-30 1984-12-28 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PHENYLEDIC ACETIC ACID DERIVATIVES. NO162819C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833347565 DE3347565A1 (en) 1983-12-30 1983-12-30 NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE19853522604 DE3522604A1 (en) 1983-12-30 1985-06-25 NEW SOLID FORMS OF 2- (GAMMA) THOXY-4- (N- (1- (2- (2-PIPERIDINO-PHENYL) -3-METHYL-1-BUTYL) -AMINOCARBONYLMETHYL) -BENZOESIC ACID, MEDICINAL PRODUCTS CONTAINING THESE FORMS

Publications (3)

Publication Number Publication Date
NO845282L NO845282L (en) 1985-07-01
NO162819B NO162819B (en) 1989-11-13
NO162819C true NO162819C (en) 1990-02-21

Family

ID=37847099

Family Applications (3)

Application Number Title Priority Date Filing Date
NO845282A NO162819C (en) 1983-12-30 1984-12-28 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PHENYLEDIC ACETIC ACID DERIVATIVES.
NO862532A NO168302C (en) 1983-12-30 1986-06-24 PROCEDURE FOR PREPARING CRYSTAL FORM (B) OF 2-ETHOXY-4- (N- (1- (2-PIPERIDINO-PHENYL) -3-METHYL-1-BUTYL) -AMINOCARBONYLMETHYL) -BENZOIC ACID
NO1999016C NO1999016I1 (en) 1983-12-30 1999-07-20 Repaglinide

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO862532A NO168302C (en) 1983-12-30 1986-06-24 PROCEDURE FOR PREPARING CRYSTAL FORM (B) OF 2-ETHOXY-4- (N- (1- (2-PIPERIDINO-PHENYL) -3-METHYL-1-BUTYL) -AMINOCARBONYLMETHYL) -BENZOIC ACID
NO1999016C NO1999016I1 (en) 1983-12-30 1999-07-20 Repaglinide

Country Status (26)

Country Link
EP (2) EP0147850B1 (en)
JP (2) JPH0623200B2 (en)
KR (1) KR900005320B1 (en)
AT (1) ATE44027T1 (en)
AU (2) AU577815B2 (en)
BG (1) BG61519B2 (en)
CA (2) CA1225398A (en)
CS (1) CS409791A3 (en)
DD (1) DD231348A5 (en)
DE (4) DE3347565A1 (en)
DK (2) DK167439B1 (en)
ES (7) ES8605500A1 (en)
FI (2) FI80447C (en)
GR (2) GR82614B (en)
HK (1) HK87492A (en)
HU (1) HU194548B (en)
IE (1) IE57700B1 (en)
IL (2) IL73963A (en)
LU (1) LU90301I2 (en)
MX (1) MX9202772A (en)
NL (1) NL980034I1 (en)
NO (3) NO162819C (en)
NZ (2) NZ210657A (en)
PT (2) PT79772B (en)
SG (1) SG55492G (en)
ZA (2) ZA8410103B (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3523466A1 (en) * 1985-07-01 1987-01-08 Thomae Gmbh Dr K NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3347565A1 (en) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE59109240D1 (en) * 1991-06-21 2002-10-10 Boehringer Ingelheim Pharma Process for the preparation of (S) -3-methyl-1- (2-piperidino-phenyl) -1-butylamine
SG43036A1 (en) * 1991-06-21 1997-10-17 Thomae Gmbh Dr K (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid
FR2763590B1 (en) * 1997-05-22 2000-03-24 Synthelabo ACID DERIVATIVES [[[(ARYLMETHYL) AMINO] CARBONYL] ALKYL] - AROMATICS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
JP2003520226A (en) 2000-01-21 2003-07-02 ノバルティス アクチエンゲゼルシャフト Combination comprising a dipeptidyl peptidase-IV inhibitor and an antidiabetic agent
AU2003260078A1 (en) * 2002-08-23 2004-03-11 Dr. Reddy's Laboratories Limited Crystalline and amorphous forms of (s) -repaglinide and the processes for preparation thereof
US7915421B2 (en) 2003-05-14 2011-03-29 Cilag Ltd. Method for preparing phenyl acetic acid derivatives
AU2003237595A1 (en) * 2003-05-26 2004-12-13 Biocon Limited Process for the preparation of s(+)-2-ethoxy-4-(n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl)benzoic acid derivatives
EP1636200A2 (en) * 2003-06-09 2006-03-22 Boehringer Ingelheim International GmbH Inhibitors of papilloma virus
FR2875805B1 (en) * 2004-09-27 2006-12-29 Genfit S A SUBSTITUTED N- (BENZYL) PHENYLACETAMIDE DERIVATIVE COMPOUNDS, PREPARATION AND USES
CN1305863C (en) * 2004-12-27 2007-03-21 浙江大学 Method for synthesizing (S)-isopropyl-(2-piperidine) phenyl-methylhistamine
GT200600381A (en) 2005-08-25 2007-03-28 ORGANIC COMPOUNDS
PE20070458A1 (en) 2005-09-14 2007-07-05 Takeda Pharmaceutical PHARMACEUTICAL COMPOSITION INCLUDING 2 - [[6- (3R) -3-AMINO-1-PIPERIDINYL] -3,4-DIHYDRO-3-METHYL-2,4-DIOXO-1 (2H) -PYRIMIDINYL] METHYL] -BENZONITRILE AS A DIPEPTIDYL PEPTIDASE INHIBITOR
EP2177221A1 (en) 2008-10-20 2010-04-21 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of substantially optically pure Repaglinide and precursors thereof
ES2459468T3 (en) 2009-05-15 2014-05-09 Novartis Ag Arylpyridines as aldosterone synthase inhibitors
EP2430018B1 (en) 2009-05-15 2013-07-03 Novartis AG Benzoxazolone derivatives as aldosterone symthase inhibitors
JP5466759B2 (en) 2009-05-28 2014-04-09 ノバルティス アーゲー Substituted aminobutyric acid derivatives as neprilysin inhibitors
CN103896796B (en) 2009-05-28 2016-04-27 诺华股份有限公司 As the alanine derivatives of the replacement of enkephalinase inhibitor
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
EP2501678B1 (en) 2009-11-17 2015-09-23 Novartis AG Aryl-pyridine derivatives as aldosterone synthase inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
WO2011064376A1 (en) 2009-11-30 2011-06-03 Novartis Ag Imidazole derivatives as aldosterone synthase inhibitors
WO2011097079A1 (en) 2010-02-03 2011-08-11 Takeda Pharmaceutical Company Limited Apoptosis signal-regulating kinase 1 inhibitors
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
WO2012095548A2 (en) 2011-01-13 2012-07-19 Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas (Ciberned) Compounds for treating neurodegenerative disorders
UY35144A (en) 2012-11-20 2014-06-30 Novartis Ag APELINE SYNTHETIC LINEAR MIMETICS FOR THE CARDIAC INSUFFICIENCY TREATMENT
NZ710574A (en) 2013-02-14 2017-11-24 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
EA201690278A1 (en) 2013-07-25 2016-06-30 Новартис Аг CYCLIC POLYPEPTIDES FOR TREATMENT OF HEART FAILURE
CA2918077A1 (en) 2013-07-25 2015-01-29 Novartis Ag Bioconjugates of synthetic apelin polypeptides
MA41580A (en) 2015-01-23 2017-11-29 Novartis Ag SYNTHETIC APELIN FATTY ACID CONJUGATES WITH IMPROVED HALF-LIFE
UY38072A (en) 2018-02-07 2019-10-01 Novartis Ag COMPOSITIONS DERIVED FROM BUTANOIC ESTER SUBSTITUTED WITH BISPHENYL AS INHIBITORS OF NEP, COMPOSITIONS AND COMBINATIONS OF THE SAME

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3100575A1 (en) * 1981-01-10 1982-09-02 Dr. Karl Thomae Gmbh, 7950 Biberach "NEW BENZOESAEURS, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS"
DE3100535A1 (en) * 1981-01-10 1982-08-12 Dr. Karl Thomae Gmbh, 7950 Biberach "NEW CARBONIC ACID DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS"
DE3375783D1 (en) * 1982-07-06 1988-04-07 Thomae Gmbh Dr K Phenyl-acetic-acid derivatives, their preparation and pharmaceutical compostions containing them
FR2554875B1 (en) * 1983-11-10 1986-02-28 Dba HYDRAULIC BRAKE AMPLIFIER
DE3523466A1 (en) * 1985-07-01 1987-01-08 Thomae Gmbh Dr K NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3347565A1 (en) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
ES545883A0 (en) 1986-02-01
IL79217A0 (en) 1986-09-30
JPS62474A (en) 1987-01-06
EP0147850A3 (en) 1985-08-07
FI82689B (en) 1990-12-31
IL73963A0 (en) 1985-03-31
HUT37773A (en) 1986-02-28
EP0147850B1 (en) 1989-06-14
JPH0623200B2 (en) 1994-03-30
SG55492G (en) 1992-10-02
AU583631B2 (en) 1989-05-04
FI80447C (en) 1990-06-11
KR900005320B1 (en) 1990-07-27
ES8604545A1 (en) 1986-02-01
DK167439B1 (en) 1993-11-01
AU577815B2 (en) 1988-10-06
ES539078A0 (en) 1986-03-16
IL79217A (en) 1991-01-31
ATE44027T1 (en) 1989-06-15
IE843349L (en) 1985-06-30
DD231348A5 (en) 1985-12-24
ES545881A0 (en) 1986-02-01
ES8604546A1 (en) 1986-02-01
ES8604547A1 (en) 1986-02-01
ZA864695B (en) 1988-02-24
DK167573B1 (en) 1993-11-22
EP0207331B1 (en) 1990-05-23
BG61519B2 (en) 1997-10-31
PT82832A (en) 1986-07-01
NO862532L (en) 1986-12-29
CS409791A3 (en) 1992-07-15
FI862650A (en) 1986-12-26
JPH0739405B2 (en) 1995-05-01
NO845282L (en) 1985-07-01
HK87492A (en) 1992-11-13
FI845145A0 (en) 1984-12-28
ZA8410103B (en) 1986-09-24
NO168302B (en) 1991-10-28
FI862650A0 (en) 1986-06-23
ES545882A0 (en) 1986-02-01
DE3478682D1 (en) 1989-07-20
DK613184D0 (en) 1984-12-20
PT79772A (en) 1985-01-01
ES8802145A1 (en) 1988-04-01
DK613184A (en) 1985-07-01
DE3522604A1 (en) 1987-01-08
NO862532D0 (en) 1986-06-24
ES8604548A1 (en) 1986-02-01
NZ216640A (en) 1989-02-24
MX9202772A (en) 1992-06-30
JPS60158171A (en) 1985-08-19
GR82614B (en) 1985-05-02
AU5913986A (en) 1987-01-08
PT79772B (en) 1987-01-05
KR850004590A (en) 1985-07-25
IL73963A (en) 1989-01-31
ES8605500A1 (en) 1986-03-16
NZ210657A (en) 1988-10-28
DE19875044I2 (en) 2002-07-18
PT82832B (en) 1988-12-15
DE3347565A1 (en) 1985-07-11
IE57700B1 (en) 1993-03-10
GR861558B (en) 1986-10-17
FI80447B (en) 1990-02-28
FI845145L (en) 1985-07-01
DK296686A (en) 1986-12-26
ES545880A0 (en) 1986-02-01
CA1292000C (en) 1991-11-12
ES545879A0 (en) 1986-02-01
AU3721084A (en) 1985-08-01
DK296686D0 (en) 1986-06-24
NL980034I1 (en) 1999-02-01
ES556495A0 (en) 1988-04-01
ES8604544A1 (en) 1986-02-01
NO162819B (en) 1989-11-13
NO168302C (en) 1992-02-05
EP0147850A2 (en) 1985-07-10
EP0207331A1 (en) 1987-01-07
NO1999016I1 (en) 1999-07-20
HU194548B (en) 1988-02-29
LU90301I2 (en) 1998-12-21
FI82689C (en) 1991-04-10
CA1225398A (en) 1987-08-11

Similar Documents

Publication Publication Date Title
NO162819C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PHENYLEDIC ACETIC ACID DERIVATIVES.
DE3265110D1 (en) New compound having antiinflammatory, analgesic and mucoregulating activity, process for its production and relative pharmaceutical compositions

Legal Events

Date Code Title Description
SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: REPAGLINID; NAT. REG. NO/DATE: NO , 97-2543, NO , 97-2544, NO , 97-2545 19990301; FIRST REG. NO/DATE: EP , 1/98/076/- 19980817

Spc suppl protection certif: 1999016

Filing date: 19990720

Extension date: 20091228

MK1K Patent expired