NO845282L - Analogifremgangsmaate for fremstilling av terapeutisk aktive fenyleddiksyrederivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive fenyleddiksyrederivater

Info

Publication number
NO845282L
NO845282L NO845282A NO845282A NO845282L NO 845282 L NO845282 L NO 845282L NO 845282 A NO845282 A NO 845282A NO 845282 A NO845282 A NO 845282A NO 845282 L NO845282 L NO 845282L
Authority
NO
Norway
Prior art keywords
phenyledic
preparation
acetic acid
acid derivatives
therapeutic active
Prior art date
Application number
NO845282A
Other languages
English (en)
Other versions
NO162819B (no
NO162819C (no
Inventor
Wolfgang Grell
Rudolf Hurnaus
Gerhart Griss
Robert Sauter
Eckhard Rupprecht
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO845282L publication Critical patent/NO845282L/no
Publication of NO162819B publication Critical patent/NO162819B/no
Publication of NO162819C publication Critical patent/NO162819C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Lubricants (AREA)
  • Glass Compositions (AREA)
NO845282A 1983-12-30 1984-12-28 Analogifremgangsmaate for fremstilling av terapeutisk aktive fenyleddiksyrederivater. NO162819C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833347565 DE3347565A1 (de) 1983-12-30 1983-12-30 Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE19853522604 DE3522604A1 (de) 1983-12-30 1985-06-25 Neue feste formen von 2-(gamma)thoxy-4-(n-(1-(2-piperidino-phenyl)-3-methyl-1-butyl)-aminocarbonylmethyl)-benzoesaeure, diese formen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (3)

Publication Number Publication Date
NO845282L true NO845282L (no) 1985-07-01
NO162819B NO162819B (no) 1989-11-13
NO162819C NO162819C (no) 1990-02-21

Family

ID=37847099

Family Applications (3)

Application Number Title Priority Date Filing Date
NO845282A NO162819C (no) 1983-12-30 1984-12-28 Analogifremgangsmaate for fremstilling av terapeutisk aktive fenyleddiksyrederivater.
NO862532A NO168302C (no) 1983-12-30 1986-06-24 Fremgangsmaate for fremstilling av krystallform (b) av 2-etoksy-4-(n-(1-(2-piperidino-fenyl)-3-metyl-1-butyl)-aminokarbonylmetyl)-benzoesyre
NO1999016C NO1999016I1 (no) 1983-12-30 1999-07-20 Repaglinid

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO862532A NO168302C (no) 1983-12-30 1986-06-24 Fremgangsmaate for fremstilling av krystallform (b) av 2-etoksy-4-(n-(1-(2-piperidino-fenyl)-3-metyl-1-butyl)-aminokarbonylmetyl)-benzoesyre
NO1999016C NO1999016I1 (no) 1983-12-30 1999-07-20 Repaglinid

Country Status (26)

Country Link
EP (2) EP0147850B1 (no)
JP (2) JPH0623200B2 (no)
KR (1) KR900005320B1 (no)
AT (1) ATE44027T1 (no)
AU (2) AU577815B2 (no)
BG (1) BG61519B2 (no)
CA (2) CA1225398A (no)
CS (1) CS409791A3 (no)
DD (1) DD231348A5 (no)
DE (4) DE3347565A1 (no)
DK (2) DK167439B1 (no)
ES (7) ES8605500A1 (no)
FI (2) FI80447C (no)
GR (2) GR82614B (no)
HK (1) HK87492A (no)
HU (1) HU194548B (no)
IE (1) IE57700B1 (no)
IL (2) IL73963A (no)
LU (1) LU90301I2 (no)
MX (1) MX9202772A (no)
NL (1) NL980034I1 (no)
NO (3) NO162819C (no)
NZ (2) NZ210657A (no)
PT (2) PT79772B (no)
SG (1) SG55492G (no)
ZA (2) ZA8410103B (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3347565A1 (de) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3523466A1 (de) * 1985-07-01 1987-01-08 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0589874B1 (de) * 1991-06-21 1999-09-08 Boehringer Ingelheim Pharma KG Verwendung von (s)(+)-2-äthoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoesäure zur herstellung eines langzeitantidiabetikums
ATE184279T1 (de) * 1991-06-21 1999-09-15 Boehringer Ingelheim Pharma Verwendung von (s)(+)-2-äthoxy-4-(n-(1-(2- piperidino-phenyl)-3-methyl-1- butyl>aminocarbonylmethyl>-benzoesäure zur herstellung eines langzeitantidiabetikums
FR2763590B1 (fr) * 1997-05-22 2000-03-24 Synthelabo Derives d'acides[[[(arylmethyl)amino]carbonyl] alkyl]- aromatiques, leur preparation et leur application en therapeutique
BRPI0107715B8 (pt) 2000-01-21 2021-05-25 Novartis Ag produto farmacêutico compreendendo um inibidor de dipeptidilpeptidase-iv e metformina, bem como usos do dito produto farmacêutico e do inibidor de dipeptidilpeptidase-iv
WO2004018442A1 (en) * 2002-08-23 2004-03-04 Dr. Reddy's Laboratories Limited Crystalline and amorphous forms of (s) -repaglinide and the processes for preparation thereof
US7915421B2 (en) 2003-05-14 2011-03-29 Cilag Ltd. Method for preparing phenyl acetic acid derivatives
AU2003237595A1 (en) * 2003-05-26 2004-12-13 Biocon Limited Process for the preparation of s(+)-2-ethoxy-4-(n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl)benzoic acid derivatives
JP4550811B2 (ja) * 2003-06-09 2010-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング パピローマウイルスのインヒビター
FR2875805B1 (fr) * 2004-09-27 2006-12-29 Genfit S A Composes derives de n-(benzyl) phenylacetamide substitues, preparation et utilisations
CN1305863C (zh) * 2004-12-27 2007-03-21 浙江大学 (s)－异丙基－(2－哌啶)苯基－甲基胺的合成方法
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
CN102908351B (zh) 2005-09-14 2014-07-23 武田药品工业株式会社 用于治疗糖尿病的二肽基肽酶抑制剂
EP2177221A1 (en) 2008-10-20 2010-04-21 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of substantially optically pure Repaglinide and precursors thereof
CN102459247B (zh) 2009-05-15 2014-09-17 诺华股份有限公司 作为醛固酮合酶抑制剂的苯并噁唑酮衍生物
BRPI1010600A2 (pt) 2009-05-15 2016-03-15 Novartis Ag aril piridina como inibidores de aldosterona sintase
KR101442897B1 (ko) 2009-05-28 2014-09-23 노파르티스 아게 네프릴리신 억제제로서의 치환된 아미노프로피온산 유도체
SG176010A1 (en) 2009-05-28 2011-12-29 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
US8519134B2 (en) 2009-11-17 2013-08-27 Novartis Ag Aryl-pyridine derivatives as aldosterone synthase inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
WO2011064376A1 (en) 2009-11-30 2011-06-03 Novartis Ag Imidazole derivatives as aldosterone synthase inhibitors
RS53176B (en) 2010-02-03 2014-06-30 Takeda Pharmaceutical Company Limited KINASE INHIBITORS 1 REGULATING SIGNALS IN APOPTOSIS
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
WO2012095548A2 (es) 2011-01-13 2012-07-19 Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas (Ciberned) Compuestos para el tratamiento de enfermedades neurodegenerativas
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
NZ710574A (en) 2013-02-14 2017-11-24 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
US9340582B2 (en) 2013-07-25 2016-05-17 Novartis Ag Bioconjugates of synthetic apelin polypeptides
WO2015013168A1 (en) 2013-07-25 2015-01-29 Novartis Ag Cyclic polypeptides for the treatment of heart failure
CA2972871A1 (en) 2015-01-23 2016-07-28 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3100535A1 (de) * 1981-01-10 1982-08-12 Dr. Karl Thomae Gmbh, 7950 Biberach "neue carbonsaeure-derivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3100575A1 (de) * 1981-01-10 1982-09-02 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benzoesaeuren, ihre herstellung und ihre verwendung als arzneimittel"
DE3375783D1 (en) * 1982-07-06 1988-04-07 Thomae Gmbh Dr K Phenyl-acetic-acid derivatives, their preparation and pharmaceutical compostions containing them
FR2554875B1 (fr) * 1983-11-10 1986-02-28 Dba Amplificateur hydraulique de freinage
DE3347565A1 (de) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3523466A1 (de) * 1985-07-01 1987-01-08 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
PT82832B (pt) 1988-12-15
ES539078A0 (es) 1986-03-16
IL79217A (en) 1991-01-31
DE3478682D1 (en) 1989-07-20
DK613184D0 (da) 1984-12-20
AU5913986A (en) 1987-01-08
DE3347565A1 (de) 1985-07-11
JPH0623200B2 (ja) 1994-03-30
AU577815B2 (en) 1988-10-06
LU90301I2 (fr) 1998-12-21
DE3522604A1 (de) 1987-01-08
KR900005320B1 (ko) 1990-07-27
EP0147850A3 (en) 1985-08-07
ES545883A0 (es) 1986-02-01
ES545880A0 (es) 1986-02-01
NO862532L (no) 1986-12-29
ZA864695B (en) 1988-02-24
CA1225398A (en) 1987-08-11
IL79217A0 (en) 1986-09-30
GR82614B (en) 1985-05-02
ZA8410103B (en) 1986-09-24
JPS62474A (ja) 1987-01-06
DD231348A5 (de) 1985-12-24
ES8802145A1 (es) 1988-04-01
JPS60158171A (ja) 1985-08-19
ES8604546A1 (es) 1986-02-01
IL73963A (en) 1989-01-31
JPH0739405B2 (ja) 1995-05-01
AU583631B2 (en) 1989-05-04
HU194548B (en) 1988-02-29
FI845145L (fi) 1985-07-01
ES8605500A1 (es) 1986-03-16
BG61519B2 (bg) 1997-10-31
DE19875044I2 (de) 2002-07-18
FI80447B (fi) 1990-02-28
ES545882A0 (es) 1986-02-01
EP0147850A2 (de) 1985-07-10
ATE44027T1 (de) 1989-06-15
NO862532D0 (no) 1986-06-24
PT82832A (de) 1986-07-01
ES545881A0 (es) 1986-02-01
FI82689C (fi) 1991-04-10
NZ216640A (en) 1989-02-24
IE57700B1 (en) 1993-03-10
GR861558B (en) 1986-10-17
DK296686A (da) 1986-12-26
EP0207331A1 (de) 1987-01-07
ES545879A0 (es) 1986-02-01
DK167439B1 (da) 1993-11-01
IE843349L (en) 1985-06-30
DK296686D0 (da) 1986-06-24
FI845145A0 (fi) 1984-12-28
AU3721084A (en) 1985-08-01
IL73963A0 (en) 1985-03-31
NO1999016I1 (no) 1999-07-20
NO168302B (no) 1991-10-28
DK167573B1 (da) 1993-11-22
NO162819B (no) 1989-11-13
KR850004590A (ko) 1985-07-25
NZ210657A (en) 1988-10-28
SG55492G (en) 1992-10-02
FI80447C (fi) 1990-06-11
CA1292000C (en) 1991-11-12
ES8604548A1 (es) 1986-02-01
MX9202772A (es) 1992-06-30
ES8604547A1 (es) 1986-02-01
NO162819C (no) 1990-02-21
HUT37773A (en) 1986-02-28
FI82689B (fi) 1990-12-31
HK87492A (en) 1992-11-13
DK613184A (da) 1985-07-01
NL980034I1 (nl) 1999-02-01
CS409791A3 (en) 1992-07-15
ES556495A0 (es) 1988-04-01
ES8604544A1 (es) 1986-02-01
ES8604545A1 (es) 1986-02-01
NO168302C (no) 1992-02-05
FI862650A0 (fi) 1986-06-23
EP0207331B1 (de) 1990-05-23
EP0147850B1 (de) 1989-06-14
FI862650A (fi) 1986-12-26
PT79772A (de) 1985-01-01
PT79772B (de) 1987-01-05

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Legal Events

Date Code Title Description
SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: REPAGLINID; NAT. REG. NO/DATE: NO , 97-2543, NO , 97-2544, NO , 97-2545 19990301; FIRST REG. NO/DATE: EP , 1/98/076/- 19980817

Spc suppl protection certif: 1999016

Filing date: 19990720

Extension date: 20091228

MK1K Patent expired