ES2136600T3 - Empleo de acido (s)(+)-2-etoxi-4-(n-(1-(2-piperidino-fenil)-3-metil-1-butil)aminocarbonilmetil)-benzoico para la preparacion de un antidiabetico de larga duracion. - Google Patents
Empleo de acido (s)(+)-2-etoxi-4-(n-(1-(2-piperidino-fenil)-3-metil-1-butil)aminocarbonilmetil)-benzoico para la preparacion de un antidiabetico de larga duracion.Info
- Publication number
- ES2136600T3 ES2136600T3 ES91911959T ES91911959T ES2136600T3 ES 2136600 T3 ES2136600 T3 ES 2136600T3 ES 91911959 T ES91911959 T ES 91911959T ES 91911959 T ES91911959 T ES 91911959T ES 2136600 T3 ES2136600 T3 ES 2136600T3
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- piperidino
- butyl
- benzoic
- etoxi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE AL NUEVO (S)(+) [N OCARBONILMETIL] EDADES FARMACOLOGICAS, VALIOSAS PRODUCIENDO UNA ACCION SOBRE EL METABOLISMO INTERMEDIO Y EN PARTICULAR SOBRE EL DESCENSO DE LOS NIVELES DE AZUCAR EN SANGRE. LA INVENCION SE REFIERE TAMBIEN A LOS NUEVOS PRODUCTOS INTERMEDIOS DE LAS FORMULAS (I), (III), (IV) Y (VI) ASI COMO A SUS SALES DE ADICION. LOS NUEVOS COMPUESTOS PUEDEN SER PREPARADOS DE ACUERDO CON LOS METODOS CONOCIDOS PARA LA PREPARACION DE COMPUESTOS ANALOGOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91911959A EP0589874B1 (de) | 1991-06-21 | 1991-06-21 | Verwendung von (s)(+)-2-äthoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoesäure zur herstellung eines langzeitantidiabetikums |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2136600T3 true ES2136600T3 (es) | 1999-12-01 |
Family
ID=8209133
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99101810T Expired - Lifetime ES2179558T3 (es) | 1991-06-21 | 1991-06-21 | Procedimiento para preparar (s)-3-metil-1-(2-piperidino-fenil)-1-butilamina. |
ES91911959T Expired - Lifetime ES2136600T3 (es) | 1991-06-21 | 1991-06-21 | Empleo de acido (s)(+)-2-etoxi-4-(n-(1-(2-piperidino-fenil)-3-metil-1-butil)aminocarbonilmetil)-benzoico para la preparacion de un antidiabetico de larga duracion. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99101810T Expired - Lifetime ES2179558T3 (es) | 1991-06-21 | 1991-06-21 | Procedimiento para preparar (s)-3-metil-1-(2-piperidino-fenil)-1-butilamina. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0965591B1 (es) |
AT (2) | ATE223391T1 (es) |
DE (1) | DE59109240D1 (es) |
ES (2) | ES2179558T3 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7915421B2 (en) | 2003-05-14 | 2011-03-29 | Cilag Ltd. | Method for preparing phenyl acetic acid derivatives |
EP2177221A1 (en) | 2008-10-20 | 2010-04-21 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of substantially optically pure Repaglinide and precursors thereof |
EP2364977A1 (en) | 2010-01-26 | 2011-09-14 | Reuter Chemische Apparatebau KG | Process for the enantiomeric enrichment of 3-methyl-1-(2-piperidinophenyl)-1-butylamine |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3320583A1 (de) * | 1983-06-08 | 1984-12-13 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue galenische zubereitungsformen von oralen antidiabetika und verfahren zu ihrer herstellung |
DE3347565A1 (de) * | 1983-12-30 | 1985-07-11 | Thomae Gmbh Dr K | Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
JPH01131143A (ja) * | 1987-11-16 | 1989-05-24 | Earth Chem Corp Ltd | d,l−カルニチンニトリルクロライドの光学分割法 |
-
1991
- 1991-06-21 DE DE59109240T patent/DE59109240D1/de not_active Expired - Lifetime
- 1991-06-21 EP EP99101810A patent/EP0965591B1/de not_active Expired - Lifetime
- 1991-06-21 AT AT99101810T patent/ATE223391T1/de not_active IP Right Cessation
- 1991-06-21 ES ES99101810T patent/ES2179558T3/es not_active Expired - Lifetime
- 1991-06-21 AT AT91911959T patent/ATE184279T1/de active
- 1991-06-21 ES ES91911959T patent/ES2136600T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0965591B1 (de) | 2002-09-04 |
EP0965591A1 (de) | 1999-12-22 |
ES2179558T3 (es) | 2003-01-16 |
ATE223391T1 (de) | 2002-09-15 |
DE59109240D1 (de) | 2002-10-10 |
ATE184279T1 (de) | 1999-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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