ES522085A0 - Procedimiento para producir t-p-a humano activador de plasminogeno. - Google Patents

Procedimiento para producir t-p-a humano activador de plasminogeno.

Info

Publication number
ES522085A0
ES522085A0 ES522085A ES522085A ES522085A0 ES 522085 A0 ES522085 A0 ES 522085A0 ES 522085 A ES522085 A ES 522085A ES 522085 A ES522085 A ES 522085A ES 522085 A0 ES522085 A0 ES 522085A0
Authority
ES
Spain
Prior art keywords
procedure
plasminogen activator
produce human
human
produce
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES522085A
Other languages
English (en)
Spanish (es)
Other versions
ES8501629A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27409206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES522085(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/483,052 external-priority patent/US4766075A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ES8501629A1 publication Critical patent/ES8501629A1/es
Publication of ES522085A0 publication Critical patent/ES522085A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C12N9/003—Dihydrofolate reductase [DHFR] (1.5.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES522085A 1982-05-05 1983-05-04 Procedimiento para producir t-p-a humano activador de plasminogeno. Granted ES522085A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37486082A 1982-05-05 1982-05-05
US39800382A 1982-07-14 1982-07-14
US06/483,052 US4766075A (en) 1982-07-14 1983-04-07 Human tissue plasminogen activator

Publications (2)

Publication Number Publication Date
ES8501629A1 ES8501629A1 (es) 1984-12-16
ES522085A0 true ES522085A0 (es) 1984-12-16

Family

ID=27409206

Family Applications (1)

Application Number Title Priority Date Filing Date
ES522085A Granted ES522085A0 (es) 1982-05-05 1983-05-04 Procedimiento para producir t-p-a humano activador de plasminogeno.

Country Status (26)

Country Link
EP (1) EP0093619B2 (en22)
JP (2) JPH0216981A (en22)
AR (1) AR241654A1 (en22)
BG (1) BG60253B1 (en22)
BR (1) BR8302318A (en22)
CA (1) CA1293211C (en22)
CS (1) CS248705B2 (en22)
CY (1) CY1341A (en22)
DD (1) DD210303A5 (en22)
DE (3) DE3380567D1 (en22)
DK (1) DK174236B1 (en22)
ES (1) ES522085A0 (en22)
FR (1) FR2526443B1 (en22)
GB (1) GB2119804B (en22)
GR (1) GR79202B (en22)
HK (1) HK88586A (en22)
IE (1) IE54975B1 (en22)
IL (1) IL68561A (en22)
KE (1) KE3647A (en22)
MY (1) MY8700119A (en22)
NO (2) NO831575L (en22)
OA (1) OA07419A (en22)
PL (1) PL152438B1 (en22)
PT (1) PT76636B (en22)
RO (1) RO90639B (en22)
ZW (1) ZW10483A1 (en22)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4558010A (en) * 1980-04-03 1985-12-10 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator and method of making plasminogen activator protein therefrom
GR79202B (en22) * 1982-05-05 1984-10-22 Genentech Inc
AU2353384A (en) * 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US5011795A (en) * 1983-01-19 1991-04-30 Genentech, Inc. Human tPA production using vectors coding for DHFR protein
IE56716B1 (en) * 1983-01-19 1991-11-20 Genentech Inc Method for producing human tpa and expression vectors therefor
US5010002A (en) * 1983-01-19 1991-04-23 Genentech, Inc. Human t-PA production using vectors coding DHFR protein
US4713339A (en) * 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
US5169762A (en) * 1983-03-03 1992-12-08 Genentech, Inc. Human nerve growth factor by recombinant technology
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
DE3479520D1 (en) * 1983-11-21 1989-09-28 Ciba Geigy Ag Synthesis of tissue plasminogen activator(tpa) by yeast
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
KR850004274A (ko) * 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
JP2648301B2 (ja) * 1983-12-27 1997-08-27 ジエネテイツクス・インスチチユ−ト・インコ−ポレ−テツド 真核細胞の形質転換のための補助ｄｎａを含むベクター
EP0154272B1 (en) * 1984-02-27 1992-01-08 Green Cross Corporation Production of human urokinase
EP0156169B1 (en) * 1984-02-29 1991-12-18 Asahi Kasei Kogyo Kabushiki Kaisha An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method
US4758512A (en) * 1984-03-06 1988-07-19 President And Fellows Of Harvard College Hosts and methods for producing recombinant products in high yields
EP0173552B1 (en) * 1984-08-24 1991-10-09 The Upjohn Company Recombinant dna compounds and the expression of polypeptides such as tpa
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
EP0174835A1 (en) * 1984-09-11 1986-03-19 The Upjohn Company Human tissue plasminogen activator and recombinant DNA compounds
UA54363C2 (uk) 1984-09-28 2003-03-17 Кірін-Амген, Інк Виділена молекула днк, яка кодує людський еритропоетин (варіанти), біологічно функціональний кільцевий плазмідний або вірусний днк-вектор, штам еукаріотичних клітин-хазяїв (варіанти), спосіб одержання поліпептиду, фармацевтична композиція
IE81135B1 (en) * 1984-10-01 2000-03-22 Genzyme Corp Recombinant DNA techniques and the products thereof
FI90990C (fi) * 1984-12-18 1994-04-25 Boehringer Ingelheim Int Rekombinantti-DNA-molekyyli, transformoitu isäntäorganismi ja menetelmä interferonin valmistamiseksi
DE3500961A1 (de) * 1985-01-14 1986-07-17 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Escherichia-coli-staemme, dna-teilsequenzen dieser staemme und herstellungsverfahren
EP0211047B1 (en) 1985-01-28 1994-02-02 Xoma Corporation Arab promoters and method of producing polypeptides, includinn cecropins, by microbiological techniques
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
GB8508717D0 (en) * 1985-04-03 1985-05-09 Beecham Group Plc Composition
NZ215660A (en) * 1985-04-04 1990-03-27 Beecham Group Plc Tissue plasminogen activator modified in the growth factor domain
EP0199574B1 (en) * 1985-04-22 1991-10-23 Genentech, Inc. Human tissue plasminogen activator mutants, methods and intermediates therefor, and compositions using such mutants
US5736134A (en) * 1985-04-22 1998-04-07 Genentech, In.C Tissue plasminogen activator variants
US5756093A (en) * 1985-04-22 1998-05-26 Genentech, Inc. Tissue plasminogen activator variants
FI85334C (fi) * 1985-05-28 1992-04-10 Wellcome Found Foerfarande foer framstaellning av en vattenbaserad, vaevnadsplasminogenaktivator (t-pa) innehaollande, koncentrerad parenterad loesning.
AU593264B2 (en) * 1985-07-10 1990-02-08 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Chromosomal DNA sequence, expression vector for human tissue plasminogen activating factor, cultured cells transfected with same and method of producing said activating factor
US4916071A (en) 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
US5244806A (en) * 1985-08-26 1993-09-14 Eli Lilly And Company DNA encoding novel tissue plasminogen activator derivatives having kringles 1 and 2 deleted, vectors and host cells
USH2055H1 (en) 1985-09-20 2002-12-03 Zymogenetics, Inc. Expression of tissue-type plasminogen activator in bacteria
DE3537708A1 (de) 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
JP2581668B2 (ja) * 1985-11-27 1997-02-12 三井東圧化学株式会社 ヒト正常細胞由来のヒト組織プラスミノ−ゲン活性化因子をコ−ドする新しいｄｎａ配列とそれを含むベクタ−及び細胞
DE3682754D1 (de) * 1985-12-16 1992-01-16 Ethicon Inc Hemmung von post-chirurgischer adhaesionsbildung durch topische verabreichung von gewebeplasminogenaktivator.
EP0231624B1 (en) 1985-12-20 1993-01-27 The Upjohn Company Tissue plasminogen activator (tpa) analogs
US5106741A (en) * 1985-12-20 1992-04-21 The Upjohn Company Tissue plasminogen activator (TPA) analogs
ATE74379T1 (de) * 1985-12-23 1992-04-15 Chiron Corp Peptidplasminogenaktivatoren.
JPS62149625A (ja) * 1985-12-25 1987-07-03 Green Cross Corp:The 生理活性物質の製造方法
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
US5002887A (en) * 1986-01-31 1991-03-26 Genetics Institute, Inc. Truncated thrombolytic proteins
US5837518A (en) * 1986-01-31 1998-11-17 Genetics Institute, Inc. Thrombolytic proteins
US5258298A (en) * 1986-01-31 1993-11-02 Genetics Institute, Inc. Deletion and glycosylation mutant of human tissue plasminogen activator
US5204255A (en) * 1986-01-31 1993-04-20 Sagami Chemical Research Center Hybrid tissue plasminogen activator/urokinase polypeptides
EP0231883B1 (en) * 1986-01-31 1992-09-02 Sagami Chemical Research Center Hybrid plasminogen activator-like polypeptide
DE3682891D1 (de) * 1986-02-17 1992-01-23 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
FR2594845B1 (fr) * 1986-02-21 1989-12-01 Genetica Preparation par voie microbiologique de l'activateur tissulaire humain du plasminogene (t-pa) et conversion de l'enzyme ainsi obtenue en sa forme active
US4927630A (en) * 1986-02-26 1990-05-22 Monsanto Company Tissue plasminogen activator from normal human colon cells
US4751084A (en) * 1986-02-26 1988-06-14 Monsanto Company Tissue plasminogen activator from normal human colon cells
US4851517A (en) * 1986-02-26 1989-07-25 Monsanto Company Tissue plasminogen activator oligosaccharide from normal human colon cells
US5132214A (en) * 1986-04-09 1992-07-21 Monsanto Company Large scale production of plasminogen activator from normal human colon cells
US5589361A (en) * 1986-03-18 1996-12-31 Genentech, Inc. Human tissue-type plasminogen activator variant
ATE90967T1 (de) * 1986-03-28 1993-07-15 Creative Biomolecules Inc Proteinanaloge des gewebs-plasminogenaktivators.
JPH01500322A (ja) * 1986-03-28 1989-02-09 クリエイティブ　バイオモレクレス，インコーポレーテッド 組織プラスミノーゲンアクテイベーター類縁蛋白質
GB8608020D0 (en) * 1986-04-02 1986-05-08 Beecham Group Plc Compounds
PT84588B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
PT84587B (pt) * 1986-04-02 1989-11-30 Beecham Group Plc Processo para preparacao de uma enzima fibrinolitica
DE3643158A1 (de) * 1986-04-21 1987-11-19 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator(tpa) - derivat und seine herstellung
DE3613401A1 (de) * 1986-04-21 1987-12-17 Boehringer Mannheim Gmbh Verfahren zur herstellung von plasminogen-aktivatoren in prokaryonten
JP2585532B2 (ja) * 1986-05-10 1997-02-26 三井東圧化学株式会社 動物細胞の形質転換体及びそれを得る方法並びにその形質転換体を用いてｔ−ＰＡを生産する方法
IL82746A (en) * 1986-06-06 1994-10-07 Genentech Inc Process for producing biologically active tissue-type plasminogen activator
DK345087A (da) * 1986-07-11 1988-01-12 Novo Industri As Modificeret vaevsplasminogenaktivator
PT86162B (pt) * 1986-11-21 1990-11-20 Smithkline Beecham Corp Expressao de proteina recombinante
GB8628398D0 (en) * 1986-11-27 1986-12-31 Central Blood Lab Authority Pharmaceutically-active conjugates
ZA879286B (en) 1986-12-16 1988-10-26 Smith Kline Rit New plasminogen activators
NL8700013A (nl) * 1987-01-06 1988-08-01 Leuven Res & Dev Vzw Hybride plasminogeenactivatoren met verbeterde trombolytische eigenschappen en geneesmiddelen die deze plasminogeenactivatoren bevatten.
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
US5681713A (en) * 1987-05-08 1997-10-28 Smithkline Beecham Corporation Expression of heterologous proteins in Drosophila cells
CA1341345C (en) * 1987-05-08 2002-03-05 Hanne Ranch Johansen Expression of foreign genes in drosophila cells
DE3853100T2 (de) * 1987-06-04 1995-08-03 Eisai Co Ltd Gewebs-Plasminogen-Aktivator-Analoge mit modifizierten Wachstumsfaktordomänen.
US5266474A (en) * 1987-06-24 1993-11-30 Genentech, Inc. Balanced inducible transcription system
DE3853479T2 (de) * 1987-06-24 1995-09-28 Genentech Inc Ausgeglichenes, konstitutives, induzierbares transkriptionssystem.
US4935237A (en) * 1988-03-21 1990-06-19 Genentech, Inc. Processes for the preparation of t-PA mutants
WO1989000191A1 (en) * 1987-07-06 1989-01-12 Genetics Institute, Inc. Novel thrombolytic proteins
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same
US5504001A (en) * 1987-11-25 1996-04-02 Zymogenetics, Inc. Hybrid plasminogen activator
DE3741149A1 (de) * 1987-12-04 1989-06-15 Thomae Gmbh Dr K Zubereitungsformen zur verhinderung von adhaesionen von organen und organteilen
US5364622A (en) * 1987-12-04 1994-11-15 Dr. Karl Thomae Gmbh Methods for preventing adhesions to organs and parts of organs by application of tissue plasminogen activator and hydroxyethylcellulose hydrogel
US4929560A (en) * 1988-02-03 1990-05-29 Damon Biotech, Inc. Recovery of tissue plasminogen activator
JP2576200B2 (ja) * 1988-03-09 1997-01-29 味の素株式会社 生理活性タンパク質の製造法
US5210037A (en) * 1988-03-22 1993-05-11 Centocor Incorporated Method to enhance TPA production
WO1989009257A1 (en) * 1988-03-22 1989-10-05 Invitron Corporation METHOD TO ENHANCE tPA PRODUCTION
US5037646A (en) * 1988-04-29 1991-08-06 Genentech, Inc. Processes for the treatment of vascular disease
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
WO1990001332A1 (en) * 1988-08-10 1990-02-22 Cetus Corporation Plasminogen activator-heparin conjugates
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3831714A1 (de) * 1988-09-17 1990-03-22 Basf Ag Tpa-aehnliche polypeptide, ihre herstellung und verwendung
US5252713A (en) * 1988-09-23 1993-10-12 Neorx Corporation Polymeric carriers for non-covalent drug conjugation
US5550042A (en) * 1989-03-06 1996-08-27 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors and genes encoding the same and serine protease inhibitor mutants and genes encoding the same
US5866413A (en) * 1989-03-06 1999-02-02 Board Of Regents Of The University Of Texas System Pai-1 mutants
EP1029921B1 (en) * 1989-03-06 2002-10-23 The Board of Regents of The University of Texas System Serpin resistant t-PA; mutants; genes
DK0559795T3 (da) * 1990-11-30 1996-01-29 Monoclonetics Int Fremgangsmåder til diagnosticering af kroniske smerter i lænderegionen og halshvrivelsøjlen
EP0786257B1 (en) * 1992-06-03 2003-07-30 Genentech, Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
DE10153601A1 (de) 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
JP4595968B2 (ja) * 2007-07-12 2010-12-08 パナソニック電工株式会社 往復式電気かみそりの内刃

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL43343A (en) * 1972-10-24 1976-03-31 Lilly Co Eli Production of plasminogen activator
FR2252842B1 (en22) * 1973-12-03 1977-11-04 Fabre Sa Pierre
FR2310133A2 (fr) * 1975-05-05 1976-12-03 Fabre Sa Pierre Nouveau medicament comportant un activateur du plasminogene perfectionne
US4245051A (en) 1978-03-30 1981-01-13 Rockefeller University Human serum plasminogen activator
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
ES8106836A2 (es) * 1979-07-27 1981-10-01 Fabre Sa Pierre Procedimiento de obtencion de un activador del plasminogeno
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
JPS5852634B2 (ja) * 1980-12-05 1983-11-24 株式会社林原生物化学研究所 ウロキナ−ゼの製造法
MX197183A (es) * 1982-05-05 1994-02-28 Genentech Inc Activador de plasminogeno de tejido humano
GR79202B (en22) * 1982-05-05 1984-10-22 Genentech Inc

Also Published As

Publication number Publication date
PT76636B (en) 1986-01-10
CS248705B2 (en) 1987-02-12
KE3647A (en) 1986-07-25
GB2119804B (en) 1986-02-26
CA1293211C (en) 1991-12-17
ES8501629A1 (es) 1984-12-16
BG60253B2 (bg) 1994-03-24
IL68561A0 (en) 1983-09-30
JP2564444B2 (ja) 1996-12-18
DK174236B1 (da) 2002-10-07
GB2119804A (en) 1983-11-23
HK88586A (en) 1986-11-28
EP0093619B2 (en) 1996-09-18
BR8302318A (pt) 1984-01-10
EP0093619B1 (en) 1989-09-13
IE54975B1 (en) 1990-04-11
JPH0448440B2 (en22) 1992-08-06
AU1414283A (en) 1983-11-10
DK198883D0 (da) 1983-05-04
CY1341A (en) 1987-01-16
JPH0216981A (ja) 1990-01-19
AU563031B2 (en) 1987-06-25
EP0093619A1 (en) 1983-11-09
FR2526443B1 (fr) 1985-12-06
DD210303A5 (de) 1984-06-06
RO90639B (ro) 1987-01-31
FR2526443A1 (fr) 1983-11-10
NO852065L (no) 1983-11-07
RO90639A (ro) 1987-01-30
PL241805A1 (en) 1984-07-30
BG60253B1 (bg) 1994-03-24
JPH05137583A (ja) 1993-06-01
NO831575L (no) 1983-11-07
DE93619T1 (de) 1987-08-13
GR79202B (en22) 1984-10-22
DE3316297A1 (de) 1983-11-17
OA07419A (fr) 1984-11-30
PL152438B1 (en) 1990-12-31
IE831024L (en) 1983-11-05
DE3316297C2 (en22) 1989-09-21
ZW10483A1 (en) 1983-09-21
AR241654A1 (es) 1992-10-30
GB8312221D0 (en) 1983-06-08
DE3380567D1 (en) 1989-10-19
MY8700119A (en) 1987-12-31
DK198883A (da) 1983-12-20
PT76636A (en) 1983-06-01
IL68561A (en) 1991-01-31

Similar Documents

Publication Publication Date Title
ES522085A0 (es) Procedimiento para producir t-p-a humano activador de plasminogeno.
MX197183A (es) Activador de plasminogeno de tejido humano
MX7035E (es) Procedimiento para preparar 3-isoxazolidinona
ES543085A0 (es) Procedimiento para preparar nuevos 2-fenil-imidazoles.
FI832878L (fi) Laettoeppnat, foerpackat bandage
AR230995A1 (es) Procedimiento para producir n-fosfono-metilglicina
DE3382389D1 (de) Plasminogenaktivator.
IT8220097A0 (it) Tessuto.
FI831484A7 (fi) Ihmiskudoksen plasminogeenien aktivaattori.
FI842948L (fi) Bandningsanordning.
NO156515C (no) Hudpleiepreparat.
DK96787D0 (da) Human vaevs-plasminogenaktivator
ES521744A0 (es) Procedimiento para preparar ciclohexanol y ciclohexanona.
FI841510A7 (fi) Hierontalaite.
ES523497A0 (es) Procedimiento para preparar n-fosfonometilglicina.
FI843266A7 (fi) Terapeutiska aemnen.
DE3688625D1 (de) Therapeutische bandage.
ES557305A0 (es) Procedimiento para preparar n6 -benzopirano- y benzotiopirano-adenosinas.
ES518959A0 (es) Procedimiento para preparar fenilureas.
ES522046A0 (es) Procedimiento para preparar ureasssustituidas.
ES522166A0 (es) Procedimiento para la obtencion de sulfonil- y sulfonil-azacicloheptan-2-onas.
ES521460A0 (es) Procedimiento para preparar derivados de bencimidazol.
ES531586A0 (es) Procedimiento para preparar difenilazometinas
ES530320A0 (es) Procedimiento para preparar 4-alquilamino-quinazolinas.
SE8205451L (sv) Enterostomibandage