ES2974634T3 - Inhibidores de tienopiridinas de RIPK2 - Google Patents

Inhibidores de tienopiridinas de RIPK2 Download PDF

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Publication number
ES2974634T3
ES2974634T3 ES19899710T ES19899710T ES2974634T3 ES 2974634 T3 ES2974634 T3 ES 2974634T3 ES 19899710 T ES19899710 T ES 19899710T ES 19899710 T ES19899710 T ES 19899710T ES 2974634 T3 ES2974634 T3 ES 2974634T3
Authority
ES
Spain
Prior art keywords
thiazol
thieno
pyridin
amine
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES19899710T
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English (en)
Spanish (es)
Inventor
Kurt Armbrust
Michailidis Fedor Romanov
Karin Irmgard Worm
John Michael Ellis
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Celgene Corp
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Celgene Corp
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Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
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Publication of ES2974634T3 publication Critical patent/ES2974634T3/es
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES19899710T 2018-12-21 2019-12-20 Inhibidores de tienopiridinas de RIPK2 Active ES2974634T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862783742P 2018-12-21 2018-12-21
PCT/US2019/067724 WO2020132384A1 (en) 2018-12-21 2019-12-20 Thienopyridine inhibitors of ripk2

Publications (1)

Publication Number Publication Date
ES2974634T3 true ES2974634T3 (es) 2024-06-28

Family

ID=71098055

Family Applications (1)

Application Number Title Priority Date Filing Date
ES19899710T Active ES2974634T3 (es) 2018-12-21 2019-12-20 Inhibidores de tienopiridinas de RIPK2

Country Status (9)

Country Link
US (1) US11168093B2 (https=)
EP (1) EP3897630B1 (https=)
JP (1) JP7458406B2 (https=)
KR (1) KR102943035B1 (https=)
CN (1) CN113874015B (https=)
AR (1) AR117472A1 (https=)
ES (1) ES2974634T3 (https=)
TW (1) TW202039481A (https=)
WO (1) WO2020132384A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020132384A1 (en) 2018-12-21 2020-06-25 Celgene Corporation Thienopyridine inhibitors of ripk2
WO2021174024A1 (en) 2020-02-28 2021-09-02 First Wave Bio, Inc. Methods of treating iatrogenic autoimmune colitis
IT202000031778A1 (it) 2020-12-22 2022-06-22 Guala Closures Spa Chiusura con sigillo a strappo
CN114957280B (zh) * 2021-12-31 2024-09-17 成都赜灵生物医药科技有限公司 噻吩[2,3-d]嘧啶衍生物及其用途
WO2025085928A1 (en) 2023-10-20 2025-04-24 Odyssey Therapeutics, Inc. Methods of treating a patient with an inflammatory bowel disease
CN117843656B (zh) * 2023-11-13 2026-02-03 四川大学华西医院 一类噻吩[3,2-d]嘧啶衍生物及其制备方法和应用
CN119462516B (zh) * 2024-10-18 2025-10-14 广东莱佛士制药技术有限公司 一种式i化合物及其制备方法和应用、阿贝西利中间体化合物a的制备方法

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