ES2883131T3 - Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN - Google Patents

Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN Download PDF

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ES2883131T3
ES2883131T3 ES17183472T ES17183472T ES2883131T3 ES 2883131 T3 ES2883131 T3 ES 2883131T3 ES 17183472 T ES17183472 T ES 17183472T ES 17183472 T ES17183472 T ES 17183472T ES 2883131 T3 ES2883131 T3 ES 2883131T3
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cells
cell
rna
cas9
target
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Philippe Duchateau
ANDRé CHOULIKA
Laurent Poirot
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Cellectis SA
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/32—T-cell receptors [TCR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/4211—CD19 or B4
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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ES17183472T 2013-05-29 2014-04-01 Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN Active ES2883131T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DKPA201370297 2013-05-29
US201361888259P 2013-10-08 2013-10-08
US201361907858P 2013-11-22 2013-11-22
US201361907874P 2013-11-22 2013-11-22
DKPA201370771 2013-12-13
EP2014051458 2014-01-24

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ES2883131T3 true ES2883131T3 (es) 2021-12-07

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ES17183472T Active ES2883131T3 (es) 2013-05-29 2014-04-01 Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
ES14714278.0T Active ES2645393T3 (es) 2013-05-29 2014-04-01 Métodos de manipulación de linfocitos T para inmunoterapia usando el sistema de nucleasa Cas guiada por ARN

Family Applications After (1)

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ES14714278.0T Active ES2645393T3 (es) 2013-05-29 2014-04-01 Métodos de manipulación de linfocitos T para inmunoterapia usando el sistema de nucleasa Cas guiada por ARN

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US (6) US9890393B2 (enExample)
EP (2) EP3309248B1 (enExample)
JP (1) JP6608807B2 (enExample)
AU (1) AU2014273490B2 (enExample)
CA (1) CA2913830C (enExample)
DK (2) DK3004337T3 (enExample)
ES (2) ES2883131T3 (enExample)
WO (1) WO2014191128A1 (enExample)

Cited By (1)

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US20250066825A1 (en) * 2021-12-22 2025-02-27 Technische Universität München A method for genetic modification for high gc content microorganisms

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