ES2831416T3 - Terapia de combinación de un inhibidor de MET y un inhibidor de EGFR - Google Patents
Terapia de combinación de un inhibidor de MET y un inhibidor de EGFR Download PDFInfo
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- ES2831416T3 ES2831416T3 ES15747562T ES15747562T ES2831416T3 ES 2831416 T3 ES2831416 T3 ES 2831416T3 ES 15747562 T ES15747562 T ES 15747562T ES 15747562 T ES15747562 T ES 15747562T ES 2831416 T3 ES2831416 T3 ES 2831416T3
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| CA2868202C (en) | 2012-04-03 | 2021-08-10 | Novartis Ag | Combination products with tyrosine kinase inhibitors and their use |
| UY38349A (es) | 2018-08-30 | 2020-03-31 | Array Biopharma Inc | Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met |
| US20200216416A1 (en) | 2019-01-03 | 2020-07-09 | Array Biopharma Inc. | Quinoline compounds as inhibitors of tam and met kinases |
| AU2021231435A1 (en) * | 2020-03-03 | 2022-09-22 | Array Biopharma Inc. | Methods to treat cancer using (R)-N-(3-fluoro-4-((3-((1-hydroxypropan-2-yl)amino)-1H-pyrazolo(3,4-b)pyridin-4-yl)oxy)phenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide |
| KR102522963B1 (ko) * | 2020-11-12 | 2023-04-19 | 중앙대학교 산학협력단 | 캡마티닙을 포함하는 항비만 조성물 |
| WO2023078408A1 (zh) * | 2021-11-05 | 2023-05-11 | 上海海和药物研究开发股份有限公司 | 含met受体酪氨酸激酶抑制剂的药物组合及应用 |
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| ATE28864T1 (de) | 1982-07-23 | 1987-08-15 | Ici Plc | Amide-derivate. |
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| PT100441A (pt) | 1991-05-02 | 1993-09-30 | Smithkline Beecham Corp | Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso |
| US5451700A (en) | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
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| NZ251092A (en) | 1992-04-02 | 1996-12-20 | Smithkline Beecham Corp | 4-cyano-cyclohexane derivatives; medicaments; used in treating asthma |
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-
2015
- 2015-07-29 EP EP15747562.5A patent/EP3174869B1/en active Active
- 2015-07-29 CN CN201580053665.1A patent/CN107207510B/zh not_active Expired - Fee Related
- 2015-07-29 BR BR112017001695A patent/BR112017001695A2/pt not_active Application Discontinuation
- 2015-07-29 JP JP2017505465A patent/JP6526789B2/ja not_active Expired - Fee Related
- 2015-07-29 CA CA2954862A patent/CA2954862A1/en not_active Abandoned
- 2015-07-29 RU RU2017105827A patent/RU2695230C2/ru active
- 2015-07-29 US US15/328,710 patent/US10195208B2/en not_active Expired - Fee Related
- 2015-07-29 WO PCT/IB2015/055737 patent/WO2016016822A1/en not_active Ceased
- 2015-07-29 AU AU2015294889A patent/AU2015294889B2/en not_active Ceased
- 2015-07-29 KR KR1020177005144A patent/KR20170036037A/ko not_active Ceased
- 2015-07-29 ES ES15747562T patent/ES2831416T3/es active Active
- 2015-07-29 MX MX2017001461A patent/MX373272B/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| RU2017105827A (ru) | 2018-08-30 |
| WO2016016822A1 (en) | 2016-02-04 |
| KR20170036037A (ko) | 2017-03-31 |
| CN107207510B (zh) | 2019-11-29 |
| EP3174869A1 (en) | 2017-06-07 |
| AU2015294889A1 (en) | 2017-02-02 |
| AU2015294889B2 (en) | 2018-03-15 |
| MX2017001461A (es) | 2017-05-11 |
| CA2954862A1 (en) | 2016-02-04 |
| JP6526789B2 (ja) | 2019-06-05 |
| MX373272B (es) | 2020-04-16 |
| JP2017521474A (ja) | 2017-08-03 |
| US20170209457A1 (en) | 2017-07-27 |
| BR112017001695A2 (pt) | 2017-11-21 |
| RU2017105827A3 (enExample) | 2019-03-04 |
| CN107207510A (zh) | 2017-09-26 |
| RU2695230C2 (ru) | 2019-07-22 |
| EP3174869B1 (en) | 2020-08-19 |
| US10195208B2 (en) | 2019-02-05 |
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