ES2831416T3 - Terapia de combinación de un inhibidor de MET y un inhibidor de EGFR - Google Patents
Terapia de combinación de un inhibidor de MET y un inhibidor de EGFR Download PDFInfo
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- ES2831416T3 ES2831416T3 ES15747562T ES15747562T ES2831416T3 ES 2831416 T3 ES2831416 T3 ES 2831416T3 ES 15747562 T ES15747562 T ES 15747562T ES 15747562 T ES15747562 T ES 15747562T ES 2831416 T3 ES2831416 T3 ES 2831416T3
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| ES2894830T3 (es) | 2012-04-03 | 2022-02-16 | Novartis Ag | Productos combinados con inhibidores de tirosina·cinasa y su uso |
| UY38349A (es) | 2018-08-30 | 2020-03-31 | Array Biopharma Inc | Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met |
| CN113302188A (zh) | 2019-01-03 | 2021-08-24 | 阵列生物制药公司 | 作为tam及met激酶抑制剂的喹啉化合物 |
| KR20220148867A (ko) * | 2020-03-03 | 2022-11-07 | 어레이 바이오파마 인크. | (R)-N-(3-플루오로-4-((3-((1-히드록시프로판-2-일)아미노)-1H-피라졸로[3,4-b]피리딘-4-일)옥시)페닐)-3-(4-플루오로페닐)-1-이소프로필-2,4-디옥소-1,2,3,4-테트라히드로피리미딘-5-카르복스아미드를 사용하여 암을 치료하는 방법 |
| KR102522963B1 (ko) * | 2020-11-12 | 2023-04-19 | 중앙대학교 산학협력단 | 캡마티닙을 포함하는 항비만 조성물 |
| CN118159538A (zh) * | 2021-11-05 | 2024-06-07 | 上海海和药物研究开发股份有限公司 | 含met受体酪氨酸激酶抑制剂的药物组合及应用 |
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| GB1219606A (en) | 1968-07-15 | 1971-01-20 | Rech S Et D Applic Scient Soge | Quinuclidinol derivatives and preparation thereof |
| LU88769I2 (fr) | 1982-07-23 | 1996-11-05 | Zeneca Ltd | Bicalutamide et ses sels et esters pharmaceutiquement acceptables (Casodex (R)) |
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| GB8916480D0 (en) | 1989-07-19 | 1989-09-06 | Glaxo Group Ltd | Chemical process |
| GB8923590D0 (en) | 1989-10-19 | 1989-12-06 | Pfizer Ltd | Antimuscarinic bronchodilators |
| US5395855A (en) | 1990-05-07 | 1995-03-07 | Ciba-Geigy Corporation | Hydrazones |
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-
2015
- 2015-07-29 KR KR1020177005144A patent/KR20170036037A/ko not_active Ceased
- 2015-07-29 JP JP2017505465A patent/JP6526789B2/ja not_active Expired - Fee Related
- 2015-07-29 RU RU2017105827A patent/RU2695230C2/ru active
- 2015-07-29 CA CA2954862A patent/CA2954862A1/en not_active Abandoned
- 2015-07-29 WO PCT/IB2015/055737 patent/WO2016016822A1/en not_active Ceased
- 2015-07-29 ES ES15747562T patent/ES2831416T3/es active Active
- 2015-07-29 EP EP15747562.5A patent/EP3174869B1/en active Active
- 2015-07-29 BR BR112017001695A patent/BR112017001695A2/pt not_active Application Discontinuation
- 2015-07-29 AU AU2015294889A patent/AU2015294889B2/en not_active Ceased
- 2015-07-29 MX MX2017001461A patent/MX373272B/es active IP Right Grant
- 2015-07-29 US US15/328,710 patent/US10195208B2/en not_active Expired - Fee Related
- 2015-07-29 CN CN201580053665.1A patent/CN107207510B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN107207510A (zh) | 2017-09-26 |
| JP2017521474A (ja) | 2017-08-03 |
| US10195208B2 (en) | 2019-02-05 |
| AU2015294889A1 (en) | 2017-02-02 |
| AU2015294889B2 (en) | 2018-03-15 |
| CA2954862A1 (en) | 2016-02-04 |
| EP3174869A1 (en) | 2017-06-07 |
| MX2017001461A (es) | 2017-05-11 |
| WO2016016822A1 (en) | 2016-02-04 |
| KR20170036037A (ko) | 2017-03-31 |
| CN107207510B (zh) | 2019-11-29 |
| EP3174869B1 (en) | 2020-08-19 |
| MX373272B (es) | 2020-04-16 |
| BR112017001695A2 (pt) | 2017-11-21 |
| RU2017105827A3 (enExample) | 2019-03-04 |
| US20170209457A1 (en) | 2017-07-27 |
| RU2695230C2 (ru) | 2019-07-22 |
| RU2017105827A (ru) | 2018-08-30 |
| JP6526789B2 (ja) | 2019-06-05 |
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