RU2695230C2 - Сочетанная терапия - Google Patents

Сочетанная терапия Download PDF

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Publication number
RU2695230C2
RU2695230C2 RU2017105827A RU2017105827A RU2695230C2 RU 2695230 C2 RU2695230 C2 RU 2695230C2 RU 2017105827 A RU2017105827 A RU 2017105827A RU 2017105827 A RU2017105827 A RU 2017105827A RU 2695230 C2 RU2695230 C2 RU 2695230C2
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Russia
Prior art keywords
cancer
compound
tyrosine kinase
combination
inc280
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RU2017105827A
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English (en)
Russian (ru)
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RU2017105827A (ru
RU2017105827A3 (enExample
Inventor
Хуайсян ХАО
Сичжун Хуан
Энджела ТАМ
Схайладжа КАСИБХАТЛА
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Новартис Аг
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Publication of RU2017105827A publication Critical patent/RU2017105827A/ru
Publication of RU2017105827A3 publication Critical patent/RU2017105827A3/ru
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2017105827A 2014-07-31 2015-07-29 Сочетанная терапия RU2695230C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462031583P 2014-07-31 2014-07-31
US62/031,583 2014-07-31
PCT/IB2015/055737 WO2016016822A1 (en) 2014-07-31 2015-07-29 Combination therapy

Publications (3)

Publication Number Publication Date
RU2017105827A RU2017105827A (ru) 2018-08-30
RU2017105827A3 RU2017105827A3 (enExample) 2019-03-04
RU2695230C2 true RU2695230C2 (ru) 2019-07-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017105827A RU2695230C2 (ru) 2014-07-31 2015-07-29 Сочетанная терапия

Country Status (12)

Country Link
US (1) US10195208B2 (enExample)
EP (1) EP3174869B1 (enExample)
JP (1) JP6526789B2 (enExample)
KR (1) KR20170036037A (enExample)
CN (1) CN107207510B (enExample)
AU (1) AU2015294889B2 (enExample)
BR (1) BR112017001695A2 (enExample)
CA (1) CA2954862A1 (enExample)
ES (1) ES2831416T3 (enExample)
MX (1) MX373272B (enExample)
RU (1) RU2695230C2 (enExample)
WO (1) WO2016016822A1 (enExample)

Families Citing this family (6)

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CN110507654A (zh) 2012-04-03 2019-11-29 诺华有限公司 有酪氨酸激酶抑制剂的组合产品和其应用
UY38349A (es) 2018-08-30 2020-03-31 Array Biopharma Inc Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met
CA3125559A1 (en) 2019-01-03 2020-07-09 Array Biopharma Inc. Quinoline compounds as inhibitors of tam and met kinases
BR112022017267A2 (pt) * 2020-03-03 2022-12-13 Array Biopharma Inc Métodos para tratar o câncer usando (r)-n-(3-fluoro-4-((3-((1-hidroxipropan-2-il) amino)-1h-pirazolo[3,4-b]piridin-4-il)óxi)fenil)-3-(4-fluorofenil)-1-isopropil-2,4-dioxo-1,2,3,4-tetra-hidropirimidina-5-carboxamida
KR102522963B1 (ko) * 2020-11-12 2023-04-19 중앙대학교 산학협력단 캡마티닙을 포함하는 항비만 조성물
WO2023078408A1 (zh) * 2021-11-05 2023-05-11 上海海和药物研究开发股份有限公司 含met受体酪氨酸激酶抑制剂的药物组合及应用

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WO2013151913A1 (en) * 2012-04-03 2013-10-10 Novartis Ag Tyrosine kinase inhibitor combinations and their use
WO2013149581A1 (en) * 2012-04-03 2013-10-10 Novartis Ag Combination products with tyrosine kinase inhibitors and their use
WO2013184757A1 (en) * 2012-06-06 2013-12-12 Irm Llc Compounds and compositions for modulating egfr activity
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EA019961B1 (ru) * 2006-04-04 2014-07-30 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Антагонисты киназы

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