ES2818569T3 - Métodos para la recopilación, estabilización y conservación de muestras - Google Patents
Métodos para la recopilación, estabilización y conservación de muestras Download PDFInfo
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- ES2818569T3 ES2818569T3 ES16845220T ES16845220T ES2818569T3 ES 2818569 T3 ES2818569 T3 ES 2818569T3 ES 16845220 T ES16845220 T ES 16845220T ES 16845220 T ES16845220 T ES 16845220T ES 2818569 T3 ES2818569 T3 ES 2818569T3
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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| PCT/US2016/051157 WO2017044887A1 (en) | 2015-09-09 | 2016-09-09 | Systems, methods, and devices for sample collection, stabilization and preservation |
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Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012018486A2 (en) | 2010-07-26 | 2012-02-09 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
| US9295417B2 (en) | 2011-04-29 | 2016-03-29 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
| CN102405018B (zh) | 2009-03-02 | 2014-11-19 | 第七感生物系统有限公司 | 与血液取样相关联的技术和装置 |
| EP2954916A3 (en) * | 2010-08-13 | 2016-04-20 | Seventh Sense Biosystems, Inc. | Clinical and/or consumer techniques and devices |
| WO2012021801A2 (en) | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Systems and techniques for monitoring subjects |
| EP2992827B1 (en) | 2010-11-09 | 2017-04-19 | Seventh Sense Biosystems, Inc. | Systems and interfaces for blood sampling |
| KR20140034200A (ko) | 2011-04-29 | 2014-03-19 | 세븐쓰 센스 바이오시스템즈, 인크. | 혈액 스폿들 또는 다른 신체 유체들을 수집 및/또는 조작하기 위한 시스템들 및 방법들 |
| US20130158468A1 (en) | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
| CN103874460B (zh) | 2011-04-29 | 2016-06-22 | 第七感生物系统有限公司 | 一种用于从受验者的皮肤接收血液或其它物质的装置 |
| CN108473932B (zh) * | 2015-09-09 | 2022-07-15 | 集联健康有限公司 | 用于样品收集、稳定化和保存的系统、方法和装置 |
| WO2018081161A1 (en) * | 2016-10-24 | 2018-05-03 | Biomatrica, Inc. | Stabilization of nucleic acids on paper |
| TWI882519B (zh) | 2017-01-10 | 2025-05-01 | 美商集聯健康有限公司 | 用於收集和儲存來自受試者之血液的裝置 |
| US11168323B2 (en) | 2017-06-01 | 2021-11-09 | Nantomics Llc | DNA stabilization of RNA |
| KR20200083461A (ko) * | 2017-09-26 | 2020-07-08 | 주노 다이어그노스틱스, 인크. | 바이오마커 분석을 위한 디바이스, 시스템 및 방법 |
| AU2018355575A1 (en) * | 2017-10-27 | 2020-05-21 | Juno Diagnostics, Inc. | Devices, systems and methods for ultra-low volume liquid biopsy |
| US10758867B2 (en) | 2017-11-30 | 2020-09-01 | Wellsim Biomedical Technologies, Inc | Isolation device and isolation method |
| GB201819134D0 (en) * | 2018-11-23 | 2019-01-09 | Cancer Research Tech Ltd | Improvements in variant detection |
| US12462935B2 (en) | 2018-03-30 | 2025-11-04 | Nucleix Ltd. | Deep learning-based methods, devices, and systems for prenatal testing |
| EP3923808B1 (en) * | 2019-02-14 | 2023-06-07 | Becton, Dickinson and Company | Capillary collector with rotatable connection |
| WO2021046343A1 (en) * | 2019-09-06 | 2021-03-11 | Teleflex Medical Incorporated | Lysing solution for real-time determining the identification and antibiotic resistance of pathogenic microorganisms |
| US20220251650A1 (en) * | 2019-09-23 | 2022-08-11 | Gateway Genomics, Llc | Methods, compositions, and kits for determining the sex of a fetus |
| US20230203586A1 (en) * | 2020-05-29 | 2023-06-29 | The Rockefeller University | Method and system for rna isolation from self-collected and small volume samples |
| KR20230069096A (ko) * | 2020-09-18 | 2023-05-18 | 프로콤큐어 바이오테크 게엠베하 | 타액 샘플 수집용 키트 |
| CN112280661A (zh) * | 2020-10-15 | 2021-01-29 | 西咸新区国睿一诺药物安全评价研究有限公司 | 一种胚胎卵黄囊吸收毒性试验用的流水式测试系统 |
| US20220133191A1 (en) * | 2020-11-04 | 2022-05-05 | Verily Life Sciences Llc | Optical methods to modulate local blood perfusion at the skin |
| WO2022192295A1 (en) * | 2021-03-08 | 2022-09-15 | Michael Wohl | Kits and methods for collecting and transporting a pathogen |
| CN112760360B (zh) * | 2021-03-22 | 2023-12-19 | 洛阳赛奥生物工程技术有限公司 | 一种rna保护剂及其应用 |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| US11452474B1 (en) | 2021-04-14 | 2022-09-27 | Satio, Inc. | Dual lever dermal patch system |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12214346B2 (en) | 2021-10-13 | 2025-02-04 | Satio, Inc. | Dermal patch with a diagnostic test strip |
| US12178979B2 (en) | 2021-10-13 | 2024-12-31 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| CN113349774B (zh) * | 2021-06-07 | 2022-06-24 | 孟斯琴 | 一种心内科临床检验采血用固定装置 |
| CN113462750B (zh) * | 2021-06-29 | 2024-08-27 | 浙江峻山生物科技有限公司 | 一种提高病毒核酸检测灵敏度的样本保存液及其制备方法 |
| EP4405655A4 (en) * | 2021-09-23 | 2025-11-19 | Drawbridge Health Inc | SAMPLE COLLECTION SYSTEMS AND METHODS |
| MX2024004522A (es) * | 2021-10-15 | 2024-05-08 | Becton Dickinson Co | Mezcla con aditivos para la recogida de muestras de sangre. |
| CN114426924B (zh) * | 2022-01-26 | 2024-06-04 | 天宫精准医疗技术(上海)有限公司 | 一种多功能干细胞组织采集装置 |
| US11957465B2 (en) | 2022-08-23 | 2024-04-16 | Reddrop Dx, Inc. | Accelerated ergonomic collection of capillary blood |
| KR20250056189A (ko) | 2022-08-24 | 2025-04-25 | 가부시끼가이샤아사히폴리슬라이더 | 채혈 디바이스 및 채혈 저류 디바이스 |
| CN115628951A (zh) * | 2022-10-18 | 2023-01-20 | 南京火眼金睛安全科技有限公司 | 一种用于痕量毒品检测的人体毛发裂解液及其应用 |
| CN117169519B (zh) * | 2023-10-26 | 2024-01-30 | 艾康生物技术(杭州)有限公司 | 用于检测样本中tt3和/或tt4的解离剂和试剂盒 |
| SE548123C2 (en) * | 2023-11-08 | 2026-03-31 | Sequrna Ab | Device for dry storage of biological samples, conserving RNA from degradation and use of such devices |
| CN120591257B (zh) * | 2025-08-07 | 2025-12-12 | 上海金福康制药工程技术有限公司 | 一种cfDNA提取试剂盒及提取方法 |
Family Cites Families (431)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE542544A (https=) | 1954-11-04 | |||
| US3070486A (en) | 1958-12-15 | 1962-12-25 | Ohio Commw Eng Co | Cigarette paper products comprising water insoluble dextran |
| US3227075A (en) | 1961-04-04 | 1966-01-04 | Fitchburg Paper | Planographic printing plates |
| US3300474A (en) | 1964-02-12 | 1967-01-24 | Pharmacia Ab | Sucrose ether copolymerizates |
| CA928198A (en) | 1968-07-15 | 1973-06-12 | Boehringer Mannheim G.M.B.H. | Storable blood and serum samples and a process for their preparation |
| CH522395A (fr) | 1968-07-26 | 1972-05-15 | Micromedic Systems Inc | Eprouvette destinée à la prise de sang percutanée et digitale |
| AU2919171A (en) | 1970-05-27 | 1972-11-30 | Pharmacia Ab | A method for carrying out tests, a reagent andan additive for carrying out the method |
| JPS5319092A (en) | 1976-11-08 | 1978-02-21 | Shionogi Seiyaku Kk | Composite for liver desease detection |
| CH620300A5 (en) | 1977-04-29 | 1980-11-14 | Miles Lab | Reactive strip for analysis |
| US4257426A (en) | 1979-06-22 | 1981-03-24 | Marquest Medical Products, Inc. | Vacuum assisted anti-coagulant syringe device for taking blood samples |
| US4540506A (en) | 1983-04-15 | 1985-09-10 | Genex Corporation | Composition for cleaning drains clogged with deposits containing hair |
| CA1255197A (en) | 1984-09-24 | 1989-06-06 | Joseph L. Orlik | Leukocyte differentiation composition and method |
| US5173422A (en) | 1986-08-22 | 1992-12-22 | Miles Inc. | Monoclonal antibodies specific for human glycoalbumin |
| SE462464B (sv) | 1987-01-14 | 1990-07-02 | Broden Bengt Inge | Utrustning foer provtagning paa patienter |
| JP2728757B2 (ja) | 1988-02-11 | 1998-03-18 | キューノ,インコーポレーテッド | 変性多糖支持体の親和性マトリックス |
| JPH01291164A (ja) | 1988-05-19 | 1989-11-22 | Fujirebio Inc | 標準瀘紙用組成物 |
| US5807527A (en) | 1991-05-29 | 1998-09-15 | Flinders Technologies Pty. Ltd. | Solid medium and method for DNA storage |
| US5972386A (en) | 1995-12-19 | 1999-10-26 | Flinders Technologies Pty, Ltd. | Dry solid medium for storage and analysis of genetic material |
| US5756126A (en) | 1991-05-29 | 1998-05-26 | Flinders Technologies Pty. Ltd. | Dry solid medium for storage and analysis of genetic material |
| US6627226B2 (en) | 1988-10-05 | 2003-09-30 | Whatman, Inc. | Dry solid medium for storage and analysis of genetic material |
| US5496562A (en) | 1988-10-05 | 1996-03-05 | Flinders Technologies Pty Ltd | Solid medium and method for DNA storage |
| US5985327A (en) | 1988-10-05 | 1999-11-16 | Flinders Technologies Pty. Ltd. | Solid medium and method for DNA storage |
| US5252489A (en) | 1989-01-17 | 1993-10-12 | Macri James N | Down syndrome screening method utilizing dried blood samples |
| US5234809A (en) | 1989-03-23 | 1993-08-10 | Akzo N.V. | Process for isolating nucleic acid |
| US5054499A (en) | 1989-03-27 | 1991-10-08 | Swierczek Remi D | Disposable skin perforator and blood testing device |
| ATE118615T1 (de) | 1989-04-07 | 1995-03-15 | Abbott Lab | Verfahren und vorrichtung zur trennung von plasma oder von serum aus blut. |
| US5141850A (en) | 1990-02-07 | 1992-08-25 | Hygeia Sciences, Inc. | Porous strip form assay device method |
| GB9010742D0 (en) | 1990-05-14 | 1990-07-04 | Quadrant Bioresources Ltd | Stabilization of biological macromolecular substances |
| JP2572823Y2 (ja) | 1992-02-13 | 1998-05-25 | 株式会社アドバンス | 簡易採血器 |
| US5494646A (en) | 1993-04-14 | 1996-02-27 | Seymour; Eugene H. | Sampling device and sample adequacy system |
| JP3494183B2 (ja) | 1993-08-10 | 2004-02-03 | 株式会社アドバンス | 簡易採血装置 |
| US5756362A (en) | 1993-10-12 | 1998-05-26 | Cornell Research Foundation, Inc. | Liposome-enhanced immunoaggregation assay and test device |
| CA2127605A1 (en) | 1993-12-23 | 1995-06-24 | Peter J. Degen | Affinity separation method |
| ATE295223T1 (de) | 1994-03-04 | 2005-05-15 | Pall Corp | Gross-porige membranen aus synthetischen polymeren |
| US6277281B1 (en) | 1994-03-04 | 2001-08-21 | Usf Filtration And Separations Group Inc. | Large pore synthetic polymer membranes |
| US5593824A (en) | 1994-09-02 | 1997-01-14 | Pharmacia Biotech, Inc. | Biological reagent spheres |
| SE9404468D0 (sv) | 1994-12-22 | 1994-12-22 | Astra Ab | Powder formulations |
| US5636640A (en) | 1995-02-06 | 1997-06-10 | Volunteers For Medical Engineering | Liquid sampling and test apparatus |
| US5725774A (en) | 1995-04-07 | 1998-03-10 | Lxn Corp. | Whole blood separation method and devices using the same |
| AU706447B2 (en) | 1995-04-13 | 1999-06-17 | Advanced Cytometrix, Inc. | Aspiration needle apparatus incorporating its own vacuum and method and adapter for use therewith |
| CA2222641C (en) | 1995-06-07 | 2006-10-17 | Memtec America Corporation | Microfiltration membranes having high pore density and mixed isotropic and anisotropic structure |
| WO1996039813A1 (en) | 1995-06-07 | 1996-12-19 | Flinders Technologies Pty. Ltd. | Dry solid medium for storage and analysis of genetic material |
| DE69628007T2 (de) * | 1995-06-07 | 2003-11-27 | Elan Drug Delivery Ltd., Ruddington | Verfahren zur stabilen einarbeitung von substanzen in trockene geschäumte glasmatrizen und auf diese weise hergestellte zusammensetzungen |
| US5906742A (en) | 1995-07-05 | 1999-05-25 | Usf Filtration And Separations Group Inc. | Microfiltration membranes having high pore density and mixed isotropic and anisotropic structure |
| US5981218A (en) | 1995-08-09 | 1999-11-09 | Bristol-Myers Squibb Company | Isolated nucleic acid molecules useful as leukemia markers and in breast cancer prognosis and encoded polypeptides |
| US5804684A (en) | 1995-08-24 | 1998-09-08 | The Theobald Smith Research Institute, Inc. | Method for isolating nucleic acids |
| DE29514084U1 (de) | 1995-09-01 | 1995-11-02 | Biosafe Diagnostics Corp., Lincolnshire, Ill. | Blutentnahme- und -testvorrichtung |
| US5662127A (en) | 1996-01-17 | 1997-09-02 | Bio-Plas, Inc. | Self-contained blood withdrawal apparatus and method |
| US7235056B2 (en) | 1996-05-17 | 2007-06-26 | Amira Medical | Body fluid sampling device and methods of use |
| US6340354B1 (en) | 1996-05-17 | 2002-01-22 | Christopher L Rambin | Automated compulsory blood extraction system |
| US7828749B2 (en) | 1996-05-17 | 2010-11-09 | Roche Diagnostics Operations, Inc. | Blood and interstitial fluid sampling device |
| US6332871B1 (en) | 1996-05-17 | 2001-12-25 | Amira Medical | Blood and interstitial fluid sampling device |
| US7666150B2 (en) | 1996-05-17 | 2010-02-23 | Roche Diagnostics Operations, Inc. | Blood and interstitial fluid sampling device |
| US6004278A (en) | 1996-12-05 | 1999-12-21 | Mdc Investment Holdings, Inc. | Fluid collection device with retractable needle |
| WO1998024493A1 (en) | 1996-12-05 | 1998-06-11 | Mdc Investment Holdings, Inc. | Fluid collection device with retractable needle |
| US6071251A (en) | 1996-12-06 | 2000-06-06 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
| US6063039A (en) | 1996-12-06 | 2000-05-16 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
| US6045899A (en) | 1996-12-12 | 2000-04-04 | Usf Filtration & Separations Group, Inc. | Highly assymetric, hydrophilic, microfiltration membranes having large pore diameters |
| JPH10179722A (ja) | 1996-12-25 | 1998-07-07 | Sumitomo Bakelite Co Ltd | 表面処理 |
| US5939259A (en) | 1997-04-09 | 1999-08-17 | Schleicher & Schuell, Inc. | Methods and devices for collecting and storing clinical samples for genetic analysis |
| US6129710A (en) | 1997-05-12 | 2000-10-10 | Spectrum Biotech Inc. | Needle cannula attachment device for a disposable syringe |
| US5984940A (en) | 1997-05-29 | 1999-11-16 | Atrion Medical Products, Inc. | Lancet device |
| US5938679A (en) | 1997-10-14 | 1999-08-17 | Hewlett-Packard Company | Apparatus and method for minimally invasive blood sampling |
| US6155992A (en) | 1997-12-02 | 2000-12-05 | Abbott Laboratories | Method and apparatus for obtaining interstitial fluid for diagnostic tests |
| US5971941A (en) | 1997-12-04 | 1999-10-26 | Hewlett-Packard Company | Integrated system and method for sampling blood and analysis |
| US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
| JP2000014662A (ja) | 1998-01-22 | 2000-01-18 | Terumo Corp | 体液検査装置 |
| US6309887B1 (en) | 1998-01-27 | 2001-10-30 | Flexsite Diagnostics, Inc. | Filter paper treatment for improved diagnostic assays |
| US7056306B1 (en) | 1998-02-05 | 2006-06-06 | Mdc Investment Holdings, Inc. | Fluid sampling device with retractable needle |
| US6086545A (en) | 1998-04-28 | 2000-07-11 | Amira Medical | Methods and apparatus for suctioning and pumping body fluid from an incision |
| US5951582A (en) | 1998-05-22 | 1999-09-14 | Specialized Health Products, Inc. | Lancet apparatus and methods |
| US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| US7344499B1 (en) | 1998-06-10 | 2008-03-18 | Georgia Tech Research Corporation | Microneedle device for extraction and sensing of bodily fluids |
| US6204375B1 (en) | 1998-07-31 | 2001-03-20 | Ambion, Inc. | Methods and reagents for preserving RNA in cell and tissue samples |
| DE19836559A1 (de) | 1998-08-12 | 2000-03-23 | Antigen Gmbh | Gefäß zur Entnahme von Blut |
| GB9817662D0 (en) | 1998-08-13 | 1998-10-07 | Crocker Peter J | Substance delivery |
| US20010039010A1 (en) | 1998-09-03 | 2001-11-08 | Leigh Alexander Burgoyne | Sample collection medium incorporating material for sample visualization |
| US6036659A (en) | 1998-10-09 | 2000-03-14 | Flexsite Diagnostics, Inc. | Collection device for biological samples and methods of use |
| US6746841B1 (en) | 1999-04-14 | 2004-06-08 | Whatman Inc. | FTA- coated media for use as a molecular diagnostic tool |
| DE19909602A1 (de) | 1999-03-05 | 2000-09-07 | Roche Diagnostics Gmbh | Gerät zur Entnahme von Blut für Diagnosezwecke |
| US7077828B2 (en) | 1999-03-05 | 2006-07-18 | Roche Diagnostics Gmbh | Device for withdrawing blood for diagnostic applications |
| US6132449A (en) | 1999-03-08 | 2000-10-17 | Agilent Technologies, Inc. | Extraction and transportation of blood for analysis |
| AU6048199A (en) | 1999-03-11 | 2000-09-28 | Whatman, Inc. | Solid medium and process for the storage and rapid purification of nucleic acid |
| AU4353500A (en) | 1999-04-30 | 2000-11-17 | Whatman, Inc. | Substrate including anionic detergent for purifying nucleic acid |
| AU4588000A (en) | 1999-04-30 | 2000-12-28 | Cyclops Genome Sciences Limited | Polynucleotides |
| US6818185B1 (en) * | 1999-05-28 | 2004-11-16 | Cepheid | Cartridge for conducting a chemical reaction |
| EP1187653B1 (en) | 1999-06-04 | 2010-03-31 | Georgia Tech Research Corporation | Devices for enhanced microneedle penetration of biological barriers |
| US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| US6152942A (en) | 1999-06-14 | 2000-11-28 | Bayer Corporation | Vacuum assisted lancing device |
| GB9914355D0 (en) | 1999-06-19 | 1999-08-18 | Owen Mumford Ltd | Improvements relating to blood sampling devices |
| US6531061B1 (en) * | 1999-07-21 | 2003-03-11 | Olivia M. Cholewa | Disposable dialysis cassette |
| WO2001021830A1 (en) | 1999-09-24 | 2001-03-29 | Ambion, Inc. | Nuclease inhibitor cocktail |
| WO2001043643A1 (en) | 1999-12-16 | 2001-06-21 | Alza Corporation | Device for enhancing transdermal flux of sampled agents |
| DE10006662A1 (de) | 2000-02-15 | 2001-08-23 | Antigen Produktions Gmbh | Gefäß zur Nukleinsäureanalytik |
| US6558361B1 (en) | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| US6612111B1 (en) | 2000-03-27 | 2003-09-02 | Lifescan, Inc. | Method and device for sampling and analyzing interstitial fluid and whole blood samples |
| WO2003026506A1 (en) | 2001-09-19 | 2003-04-03 | Terumo Kabushiki Kaisha | Apparatus for measuring component and chip |
| DE10026172A1 (de) | 2000-05-26 | 2001-11-29 | Roche Diagnostics Gmbh | System zur Entnahme von Körperflüssigkeit |
| US6506168B1 (en) | 2000-05-26 | 2003-01-14 | Abbott Laboratories | Apparatus and method for obtaining blood for diagnostic tests |
| US6540675B2 (en) | 2000-06-27 | 2003-04-01 | Rosedale Medical, Inc. | Analyte monitor |
| DE10036907B4 (de) | 2000-07-28 | 2012-03-22 | Xantec Bioanalytics Gmbh | Verfahren zur Herstellung einer Beschichtung auf einem mit Gold bedampften Glassubstrat, Beschichtung hergestellt nach diesem Verfahren und deren Verwendung |
| JP4536890B2 (ja) | 2000-09-12 | 2010-09-01 | テルモ株式会社 | 成分測定装置用チップおよび成分測定システム |
| US20080027368A1 (en) | 2000-09-27 | 2008-01-31 | Sorin Group Usa, Inc. | Disposable cartridge for a blood perfusion system |
| US20100261159A1 (en) * | 2000-10-10 | 2010-10-14 | Robert Hess | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
| US6602718B1 (en) | 2000-11-08 | 2003-08-05 | Becton, Dickinson And Company | Method and device for collecting and stabilizing a biological sample |
| US7001724B1 (en) | 2000-11-28 | 2006-02-21 | Applera Corporation | Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases |
| US7993839B2 (en) | 2001-01-19 | 2011-08-09 | General Electric Company | Methods and kits for reducing non-specific nucleic acid amplification |
| BR0206604A (pt) | 2001-01-22 | 2004-02-17 | Hoffmann La Roche | Dispositivo de lanceta que tem ação capilar |
| US6752817B2 (en) | 2001-03-26 | 2004-06-22 | Bayer Corporation | Split pressure ring for lancing device and method of operation |
| US6591124B2 (en) | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
| US7531362B2 (en) | 2001-06-07 | 2009-05-12 | Medmira Inc. | Rapid diagnostic assay |
| WO2002100274A1 (en) | 2001-06-08 | 2002-12-19 | Hoffmann-La Roche Ag | Bodily fluid sampling device and test media cassette to be used with such a device |
| US20020188223A1 (en) | 2001-06-08 | 2002-12-12 | Edward Perez | Devices and methods for the expression of bodily fluids from an incision |
| US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
| WO2002100252A2 (en) | 2001-06-12 | 2002-12-19 | Pelikan Technologies, Inc. | Blood sampling apparatus and method |
| CA2484062A1 (en) | 2001-08-20 | 2003-02-27 | James C. Davis | Dna purification and recovery from high particulate and solids samples |
| WO2003020924A2 (en) | 2001-09-05 | 2003-03-13 | Whatman Plc | Stable storage of proteins |
| US20040267160A9 (en) | 2001-09-26 | 2004-12-30 | Edward Perez | Method and apparatus for sampling bodily fluid |
| ES2337665T3 (es) | 2001-11-15 | 2010-04-28 | Whatman, Inc. | Procedimientos y materiales para detectar material genetico. |
| GB0129816D0 (en) | 2001-12-13 | 2002-01-30 | The Technology Partnership Plc | Testing device for chemical or biochemical analysis |
| US20030215358A1 (en) | 2002-01-15 | 2003-11-20 | Schulman Lloyd S. | Liquid permeable composition in dry reagent devices |
| US7047070B2 (en) | 2002-04-02 | 2006-05-16 | Becton, Dickinson And Company | Valved intradermal delivery device and method of intradermally delivering a substance to a patient |
| WO2003086443A1 (en) | 2002-04-11 | 2003-10-23 | Medimmune Vaccines, Inc. | Spray freeze dry of compositions for intranasal administration |
| US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
| WO2004054455A1 (en) | 2002-12-13 | 2004-07-01 | Pelikan Technologies, Inc. | Method and apparatus for measuring analytes |
| US7198606B2 (en) | 2002-04-19 | 2007-04-03 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with analyte sensing |
| US7892185B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
| US7258693B2 (en) | 2002-04-19 | 2007-08-21 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
| US6984485B2 (en) | 2002-04-23 | 2006-01-10 | Beckman Coulter, Inc. | Polymer-coated substrates for immobilization of biomolecules and cells |
| US7156945B2 (en) | 2002-04-24 | 2007-01-02 | Sipix Imaging, Inc. | Process for forming a patterned thin film structure for in-mold decoration |
| US6755802B2 (en) | 2002-05-06 | 2004-06-29 | Beckman Coulter, Inc. | Whole blood sampling device |
| US7303726B2 (en) | 2002-05-09 | 2007-12-04 | Lifescan, Inc. | Minimal procedure analyte test system |
| WO2003099123A1 (en) | 2002-05-22 | 2003-12-04 | Spectrx, Inc. | System and method for the extraction and monitoring of a biological fluid |
| US7482116B2 (en) | 2002-06-07 | 2009-01-27 | Dna Genotek Inc. | Compositions and methods for obtaining nucleic acids from sputum |
| WO2004005553A1 (en) | 2002-07-10 | 2004-01-15 | Massachusetts Institute Of Technology | Apparatus and method for isolating a nucleic acid from a sample |
| DE10231659B4 (de) | 2002-07-12 | 2006-01-19 | Preanalytix Gmbh | Zusammensetzung zum Binden von Nukleinsäure an eine Festphase |
| GB0217963D0 (en) | 2002-08-02 | 2002-09-11 | Cyclops Genome Sciences Ltd | Purification of nucleic acids |
| US7740600B2 (en) | 2002-08-02 | 2010-06-22 | Candela Corporation | Apparatus and method for inhibiting pain signals transmitted during a skin related medical treatment |
| US7163515B2 (en) | 2002-09-03 | 2007-01-16 | Mcnenny James H | Projectile blood collection device |
| US20040096914A1 (en) | 2002-11-20 | 2004-05-20 | Ye Fang | Substrates with stable surface chemistry for biological membrane arrays and methods for fabricating thereof |
| EP1570783A4 (en) | 2002-12-13 | 2009-09-09 | Arkray Inc | NADELEINFÜHRVORRICHTUNG |
| EP1581114B1 (en) | 2002-12-30 | 2014-04-30 | Roche Diagnostics GmbH | Flexible test strip lancet device |
| EP1589873B1 (en) | 2003-01-29 | 2011-12-21 | Roche Diagnostics GmbH | Integrated lancing test strip |
| US7267950B2 (en) | 2003-05-01 | 2007-09-11 | Veridex, Lcc | Rapid extraction of RNA from cells and tissues |
| JP4241183B2 (ja) | 2003-05-19 | 2009-03-18 | 株式会社日立ハイテクノロジーズ | 核酸回収方法及び核酸回収キット |
| JP2007502428A (ja) | 2003-05-23 | 2007-02-08 | ユィロス・パテント・アクチボラグ | 非湿潤性表面に基づく流体機能 |
| WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
| US7250270B2 (en) | 2003-06-13 | 2007-07-31 | Ambion, Inc. | Methods and compositions for preparing tissue samples for RNA extraction |
| ATE514791T1 (de) | 2003-07-09 | 2011-07-15 | Genvault Corp | Raumtemperatur-eluierung der nukleinsäuren |
| CN101554601A (zh) | 2003-08-05 | 2009-10-14 | 贝克顿·迪金森公司 | 收集生物流体样品及处理选定成分的装置和方法 |
| MXPA06001373A (es) | 2003-08-12 | 2006-05-15 | Becton Dickinson Co | Dispositivo de infusion similar a un parche. |
| CA2538038C (en) | 2003-09-11 | 2015-10-27 | Theranos, Inc. | Medical device for analyte monitoring and drug delivery |
| JP3714940B2 (ja) | 2003-11-07 | 2005-11-09 | 株式会社日立ハイテクノロジーズ | Rna抽出方法、および生体材料の分析方法 |
| US20110059441A1 (en) | 2007-04-16 | 2011-03-10 | Mcmaster University | Methof of producing bioactive paper |
| US7521021B2 (en) | 2003-11-26 | 2009-04-21 | Leica Biosvstems St. Louis Llc | System for in situ processing of a tissue specimen |
| CN1902492A (zh) | 2003-12-30 | 2007-01-24 | 3M创新有限公司 | 基底及结合到该基底上的化合物 |
| US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
| US7354515B2 (en) | 2004-02-23 | 2008-04-08 | Millennium Medical Technologies, Inc. | Fluid concentrator |
| US20050222539A1 (en) | 2004-03-30 | 2005-10-06 | Pediamed Pharmaceuticals, Inc. | Automatic injection device |
| WO2005094920A1 (en) | 2004-03-30 | 2005-10-13 | Novo Nordisk A/S | Actuator system comprising lever mechanism |
| US7045295B2 (en) | 2004-04-02 | 2006-05-16 | Hematologics, Inc. | Method for collecting purified cells |
| US20080176209A1 (en) | 2004-04-08 | 2008-07-24 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| CA2560513A1 (en) | 2004-04-08 | 2005-12-01 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| US20060099567A1 (en) | 2004-04-08 | 2006-05-11 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| CN1980738A (zh) | 2004-04-09 | 2007-06-13 | 科研智囊团有限公司 | 用于收集、储存和运输生物样本的设备和方法 |
| DE102004021780B4 (de) | 2004-04-30 | 2008-10-02 | Siemens Ag | Verfahren und Anordnung zur DNA-Isolierung mit Trockenreagenzien |
| EP1746419A1 (en) | 2004-04-30 | 2007-01-24 | Arkray, Inc. | Sample analyzing tool |
| US9101302B2 (en) | 2004-05-03 | 2015-08-11 | Abbott Diabetes Care Inc. | Analyte test device |
| US8142723B2 (en) | 2004-05-03 | 2012-03-27 | Chromologic, LLC | Tag free bio sensing micro strip |
| CN1968651A (zh) | 2004-05-07 | 2007-05-23 | 贝克顿·迪金森公司 | 凸轮致动的医疗穿刺装置及方法 |
| WO2005116651A2 (en) | 2004-05-24 | 2005-12-08 | Diasys Corporation | Method and device for testing for bence-jones protein |
| EP1758937B1 (en) | 2004-05-24 | 2009-09-02 | Genvault Corporation | Stable protein storage and stable nucleic acid storage in recoverable form |
| EP1765195B1 (en) | 2004-06-25 | 2014-07-30 | Facet Technologies, LLC | Low cost safety lancet |
| US7776530B2 (en) | 2004-06-29 | 2010-08-17 | Wallac Oy | Integrated nucleic acid analysis |
| US20060030790A1 (en) | 2004-08-06 | 2006-02-09 | Braig James R | Sample element with barrier material and vacuum |
| US20060068399A1 (en) * | 2004-09-24 | 2006-03-30 | Cepheid | Multiple bead reagent system for protein based assays with optimized matrices |
| WO2006047787A2 (en) | 2004-10-27 | 2006-05-04 | Exact Sciences Corporation | Method for monitoring disease progression or recurrence |
| ATE464381T1 (de) | 2004-12-23 | 2010-04-15 | Ge Healthcare Bio Sciences | Rna-amplifikation auf ligationsbasis |
| US20090208919A1 (en) | 2005-01-21 | 2009-08-20 | Argylla Technologies, Llp | Particle matrix for storage of biomolecules |
| US20060240451A1 (en) | 2005-02-09 | 2006-10-26 | Epicentre Technologies | Compositions and methods employing 5' phosphate-dependent nucleic acid exonucleases |
| US7695442B2 (en) | 2005-04-12 | 2010-04-13 | Roche Diagnostics Operations, Inc. | Integrated lancing test strip with retractable lancet |
| CN101175853A (zh) | 2005-03-16 | 2008-05-07 | Dna吉诺特克股份有限公司 | 用于保存来自体液的核酸的组合物和方法 |
| GB0505909D0 (en) | 2005-03-23 | 2005-04-27 | Univ Leeds | Formulations |
| US20060234251A1 (en) * | 2005-04-19 | 2006-10-19 | Lumigen, Inc. | Methods of enhancing isolation of RNA from biological samples |
| US7858384B2 (en) | 2005-04-29 | 2010-12-28 | Kimberly-Clark Worldwide, Inc. | Flow control technique for assay devices |
| US7803319B2 (en) | 2005-04-29 | 2010-09-28 | Kimberly-Clark Worldwide, Inc. | Metering technique for lateral flow assay devices |
| KR100716015B1 (ko) | 2005-06-08 | 2007-05-08 | 유재천 | 란셋 장치 및 이를 이용한 혈액의 채취 및 주입 방법 |
| US20070015165A1 (en) | 2005-07-13 | 2007-01-18 | Sigma-Aldrich Co. | Method for the isolation of RNA from biological sources |
| USD548339S1 (en) | 2005-08-09 | 2007-08-07 | Recuperatio Limited | Skin treatment device |
| CA2620943A1 (en) | 2005-09-02 | 2007-03-08 | Iomai Corporation | Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof |
| EP1931800A4 (en) | 2005-09-15 | 2011-06-15 | Artemis Health Inc | SYSTEMS AND METHOD FOR ENRICHING ANALYTES |
| USD546440S1 (en) | 2005-09-27 | 2007-07-10 | C.R. Bard, Inc. | Injectable power port |
| US8057404B2 (en) | 2005-10-12 | 2011-11-15 | Panasonic Corporation | Blood sensor, blood testing apparatus, and method for controlling blood testing apparatus |
| US7816122B2 (en) | 2005-10-18 | 2010-10-19 | Idexx Laboratories, Inc. | Lateral flow device with onboard reagents |
| JP4699868B2 (ja) | 2005-11-04 | 2011-06-15 | 株式会社日立ハイテクノロジーズ | 核酸精製方法及び核酸精製器具 |
| CA2625638C (en) | 2005-11-08 | 2014-03-11 | Surmodics, Inc. | Ultra-thin photo-polymer coatings and uses thereof |
| US8030034B2 (en) | 2005-12-09 | 2011-10-04 | Promega Corporation | Nucleic acid purification with a binding matrix |
| US8333712B2 (en) | 2006-01-11 | 2012-12-18 | Canon Kabushiki Kaisha | Body fluid sampling device |
| EP1983889A4 (en) | 2006-01-31 | 2009-09-16 | Univ Chicago | METHOD AND DEVICE FOR ANALYZING BLOOD COAGULATION |
| WO2007100986A2 (en) * | 2006-02-24 | 2007-09-07 | Rosetta Inpharmatics Llc | Extraction and diagnostic fluid devices, systems and methods of use |
| WO2007108515A1 (ja) | 2006-03-22 | 2007-09-27 | Matsushita Electric Industrial Co., Ltd. | 血液検査装置 |
| US8741230B2 (en) | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
| EP1852069B1 (de) | 2006-05-04 | 2015-06-17 | Roche Diagnostics GmbH | Blutentnahmesystem zur Entnahme von Blut aus einem Körperteil für Diagnosezwecke |
| GB0610553D0 (en) | 2006-05-26 | 2006-07-05 | Bakhtyari Nejad Esfahani Arash | Dressing |
| EP3260556B1 (en) | 2006-05-31 | 2019-07-31 | Sequenom, Inc. | Methods for the extraction of nucleic acid from a sample |
| US8163535B2 (en) | 2006-06-26 | 2012-04-24 | Blood Cell Storage, Inc. | Devices and processes for nucleic acid extraction |
| JP2008022988A (ja) | 2006-07-19 | 2008-02-07 | Ritsumeikan | 採血装置 |
| ATE540663T1 (de) | 2006-08-18 | 2012-01-15 | Medingo Ltd | Verfahren und vorrichtungen zur abgabe einer flüssigkeit an ein reservoir einer flüssigkeitsabgabevorrichtung |
| US7736338B2 (en) | 2006-08-23 | 2010-06-15 | Medtronic Minimed, Inc. | Infusion medium delivery system, device and method with needle inserter and needle inserter device and method |
| US8080645B2 (en) | 2007-10-01 | 2011-12-20 | Longhorn Vaccines & Diagnostics Llc | Biological specimen collection/transport compositions and methods |
| US20100099149A1 (en) | 2006-10-06 | 2010-04-22 | Dna Genotek Inc. | Stabilizing compositions and methods for extraction of ribonucleic acid |
| DE102006047519A1 (de) | 2006-10-07 | 2008-05-21 | Fresenius Kabi Deutschland Gmbh | Port für einen Katheter |
| US9163229B2 (en) | 2006-10-10 | 2015-10-20 | Trovagene, Inc. | Compositions, methods and kits for isolating nucleic acids from body fluids using anion exchange media |
| JP2008099991A (ja) | 2006-10-20 | 2008-05-01 | Olympus Corp | 採血装置 |
| JP2008099992A (ja) | 2006-10-20 | 2008-05-01 | Olympus Corp | 採血装置 |
| JP2008099988A (ja) | 2006-10-20 | 2008-05-01 | Olympus Corp | 採血装置 |
| US7521213B2 (en) | 2006-12-01 | 2009-04-21 | Quest Diagnostics Investments Incorporated | Sample processing for nucleic acid amplification |
| US8377379B2 (en) | 2006-12-15 | 2013-02-19 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay device |
| GB0700374D0 (en) | 2007-01-09 | 2007-02-14 | Oncomethylome Sciences S A | NDRG family methylation markers |
| EP2118260A2 (en) | 2007-01-16 | 2009-11-18 | Genvault Corporation | Nanoparticles useful for biomolecule storage |
| US7748283B2 (en) | 2007-02-16 | 2010-07-06 | Whatman, Inc. | Controlled transfer biological sample collection devices and methods of using such devices |
| US8469986B2 (en) | 2007-03-30 | 2013-06-25 | Stat Medical Devices, Inc. | Lancet device with combined trigger and cocking mechanism and method |
| EP2545854B1 (en) | 2007-04-30 | 2014-06-04 | Roche Diagnostics GmbH | Instrument and system for producing a sample of a body liquid and for analysis thereof |
| EP2164799B1 (en) | 2007-05-16 | 2018-12-26 | Mystic Pharmaceuticals, Inc. | Combination unit dose dispensing containers |
| CA2922219C (en) | 2007-05-17 | 2018-11-13 | Advance Dx, Inc. | Fluid separator collection card |
| CA2754884C (en) | 2007-06-21 | 2013-04-30 | Gen-Probe Incorporated | Methods of concentrating an analyte |
| MX2010000703A (es) | 2007-07-19 | 2010-07-29 | Medical Components Inc | Ensamble de puerto de acceso venoso con indicaciones que se distinguen para rayos x. |
| US20090053704A1 (en) | 2007-08-24 | 2009-02-26 | Natalia Novoradovskaya | Stabilization of nucleic acids on solid supports |
| EP2195050B1 (en) | 2007-08-29 | 2011-05-04 | Brighter AB | A portable medical apparatus comprising sampling means, determining means and injecting means |
| JP2009092651A (ja) | 2007-09-20 | 2009-04-30 | Fujifilm Corp | 担体およびその製造方法 |
| FR2923151B1 (fr) | 2007-11-02 | 2010-09-03 | Commissariat Energie Atomique | Dispositif de prelevement sanguin comportant au moins un filtre . |
| US20090155838A1 (en) * | 2007-11-28 | 2009-06-18 | Smart Tube, Inc. | Devices, systems and methods for the collection, stimulation, stabilization, and analysis of a biological sample |
| US20090143570A1 (en) | 2007-11-30 | 2009-06-04 | Ge Healthcare Bio-Sciences Corp. | Method for isolation of genomic dna, rna and proteins from a single sample |
| WO2009081405A2 (en) | 2007-12-25 | 2009-07-02 | Rapidx Ltd. | Devices and methods for reduced-pain blood sampling |
| WO2009090174A1 (en) | 2008-01-17 | 2009-07-23 | Whatman Inc | Composite membrane blends comprising ionic branch polymers and methods of use |
| US7766846B2 (en) | 2008-01-28 | 2010-08-03 | Roche Diagnostics Operations, Inc. | Rapid blood expression and sampling |
| CA2713545A1 (en) | 2008-01-30 | 2009-08-06 | Novartis Ag | Two stage enrichment of cell-free fetal dna in maternal plasma |
| PL2252349T3 (pl) | 2008-02-13 | 2012-01-31 | Unomedical As | Uszczelnienie między częścią kaniulową a drogą przepływu płynu |
| AU2009219375B2 (en) | 2008-02-29 | 2014-10-02 | Medical Components, Inc. | Venous access port assembly with push surfaces |
| EP2128169A1 (de) | 2008-05-30 | 2009-12-02 | Qiagen GmbH | Verfahren zur Isolierung von kurzkettigen Nukleinsäuren |
| WO2009145920A1 (en) | 2008-05-30 | 2009-12-03 | Intuity Medical, Inc. | Body fluid sampling device -- sampling site interface |
| JP5642066B2 (ja) | 2008-06-06 | 2014-12-17 | インテュイティ メディカル インコーポレイテッド | 体液の試料内に含まれている検体の存在または濃度を決定する検定を行う方法および装置 |
| US20100209957A1 (en) | 2008-06-20 | 2010-08-19 | Genvault Corporation | Biosample storage devices and methods of use thereof |
| US20100099074A1 (en) | 2008-07-25 | 2010-04-22 | Garry Nolan | Collection device and method for stimulating and stabilizing a biological sample |
| EP3206009B1 (en) | 2008-08-21 | 2025-05-14 | DNA Genotek Inc. | Sample receiving device |
| EP2334792B1 (en) | 2008-09-12 | 2020-09-09 | GenTegra LLC | Matrices and media for storage and stabilization of biomolecules |
| GB0818609D0 (en) | 2008-10-10 | 2008-11-19 | Univ Hull | apparatus and method |
| US8932271B2 (en) | 2008-11-13 | 2015-01-13 | C. R. Bard, Inc. | Implantable medical devices including septum-based indicators |
| US8961787B2 (en) | 2008-12-01 | 2015-02-24 | General Electric Company | Systems and methods for processing complex biological materials |
| EP2376689B1 (en) | 2008-12-23 | 2023-09-13 | 3M Innovative Properties Co. | Functionalized nonwoven article |
| US8337464B2 (en) | 2009-01-29 | 2012-12-25 | Vital Access Corporation | Vascular access ports and related methods |
| US8807169B2 (en) | 2009-02-12 | 2014-08-19 | Picolife Technologies, Llc | Flow control system for a micropump |
| CA2751470C (en) | 2009-02-16 | 2016-07-26 | Epicentre Technologies Corporation | Template-independent ligation of single-stranded dna |
| DE202010018569U1 (de) | 2009-02-18 | 2017-09-26 | Streck Inc. | Konservierung zellfreier Nukleinsäuren |
| US20120149128A1 (en) | 2009-02-23 | 2012-06-14 | Victor Manneh | Assays and assay devices |
| US20110105951A1 (en) | 2009-10-30 | 2011-05-05 | Seventh Sense Biosystems, Inc. | Systems and methods for treating, sanitizing, and/or shielding the skin or devices applied to the skin |
| US9041541B2 (en) | 2010-01-28 | 2015-05-26 | Seventh Sense Biosystems, Inc. | Monitoring or feedback systems and methods |
| WO2012018486A2 (en) | 2010-07-26 | 2012-02-09 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
| US9295417B2 (en) | 2011-04-29 | 2016-03-29 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
| US20110105952A1 (en) | 2009-10-30 | 2011-05-05 | Seventh Sense Biosystems, Inc. | Relatively small devices applied to the skin, modular systems, and methods of use thereof |
| WO2010101625A2 (en) | 2009-03-02 | 2010-09-10 | Seventh Sense Biosystems, Inc. | Oxygen sensor |
| CN102405018B (zh) | 2009-03-02 | 2014-11-19 | 第七感生物系统有限公司 | 与血液取样相关联的技术和装置 |
| US20110105872A1 (en) | 2009-10-30 | 2011-05-05 | Seventh Sense Biosystems, Inc. | Systems and methods for application to skin and control of actuation, delivery, and/or perception thereof |
| EP2241252A1 (de) | 2009-03-17 | 2010-10-20 | F. Hoffmann-La Roche AG | Testvorrichtung insbesondere für Blutzuckertests |
| US20120100538A1 (en) | 2009-03-24 | 2012-04-26 | Biocept, Inc. | Devices and methods of cell capture and analysis |
| US9415392B2 (en) | 2009-03-24 | 2016-08-16 | The University Of Chicago | Slip chip device and methods |
| JP2012523888A (ja) | 2009-04-15 | 2012-10-11 | シー・アール・バード・インコーポレーテッド | 統合された流体管理システムを有する生検機器 |
| WO2010132453A2 (en) | 2009-05-11 | 2010-11-18 | Nexus Dx, Inc. | Methods and compositions for analyte detection |
| EP2430195B1 (en) | 2009-05-11 | 2019-01-23 | Biomatrica, INC. | Compositions and methods for biological sample storage |
| WO2010144682A1 (en) | 2009-06-12 | 2010-12-16 | Micronics, Inc. | Rehydratable matrices for dry storage of taq polymerase in a microfluidic device |
| CN102497814B (zh) | 2009-07-30 | 2015-01-28 | 贝克顿·迪金森公司 | 具有鞍状尖端的采血设备 |
| WO2011014741A1 (en) | 2009-07-31 | 2011-02-03 | Artemis Health, Inc. | Methods and compositions for cell stabilization |
| US20110040208A1 (en) | 2009-08-11 | 2011-02-17 | Abbott Diabetes Care Inc. | Integrated lancet and test strip and methods of making and using same |
| US8222397B2 (en) | 2009-08-28 | 2012-07-17 | Promega Corporation | Methods of optimal purification of nucleic acids and kit for use in performing such methods |
| US20130018279A1 (en) | 2009-09-01 | 2013-01-17 | Pathway Genomics | "blood sample collection apparatus and kits" |
| US20120165697A1 (en) | 2009-09-04 | 2012-06-28 | Atomo Diagnostics Pty Ltd | Sample collecting device |
| JP5784031B2 (ja) | 2009-10-30 | 2015-09-24 | セブンス センス バイオシステムズ,インコーポレーテッド | 皮膚に適用される比較的小型のデバイス、モジュラーシステム、およびその使用方法 |
| CN102612343B (zh) | 2009-11-17 | 2015-11-25 | C·R·巴德股份有限公司 | 包括锚定装置和标识部分的包覆模制的进入端口 |
| WO2011065972A2 (en) | 2009-11-24 | 2011-06-03 | Seventh Sense Biosystems, Inc. | Patient-enacted sampling technique |
| EP2519631B1 (en) | 2009-12-29 | 2017-02-15 | GE Healthcare Bio-Sciences Corp. | Improvements to nucleic acid elution |
| JP5826766B2 (ja) | 2010-01-13 | 2015-12-02 | セブンス センス バイオシステムズ,インコーポレーテッド | 試料採取デバイスインタフェース |
| EP3243435A1 (en) | 2010-01-13 | 2017-11-15 | Seventh Sense Biosystems, Inc. | Sampling device interfaces |
| CN102811754B (zh) | 2010-01-13 | 2017-05-17 | 第七感生物系统有限公司 | 流体的快速输送和/或抽出 |
| US8657763B2 (en) | 2010-01-19 | 2014-02-25 | Christopher A. Jacobs | Vacuum assisted lancing system with elective vacuum release and method for blood extraction with minimal pain |
| US8426151B2 (en) | 2010-02-10 | 2013-04-23 | Companion Diagnostics Inc. | Systems and methods for the detection of biomarkers |
| US20110224106A1 (en) | 2010-03-10 | 2011-09-15 | Ibis Biosciences, Inc. | Production Of Single-Stranded Circular Nucleic Acid |
| US20110306853A1 (en) | 2010-03-19 | 2011-12-15 | Michael Darryl Black | Body fluid sampling/fluid delivery device |
| EP2555918A1 (en) | 2010-04-06 | 2013-02-13 | Genvault Corporation | Stabilized chemical dehydration of biological material |
| US20130102501A1 (en) | 2010-04-14 | 2013-04-25 | Cornell University | Device for recovery and isolation of biomolecules |
| AU2011244348B2 (en) | 2010-04-20 | 2015-02-12 | Octapharma Ag | New stabilizing agent for pharmaceutical proteins |
| EP2388312A1 (en) | 2010-05-17 | 2011-11-23 | Curetis AG | Universally applicable lysis buffer and processing methods for the lysis of bodily samples |
| US20120158100A1 (en) | 2010-06-21 | 2012-06-21 | Kevin Schomacker | Driving Microneedle Arrays into Skin and Delivering RF Energy |
| JP5514008B2 (ja) | 2010-06-22 | 2014-06-04 | ニプロ株式会社 | ディスポーザブル型穿刺器具 |
| WO2011163347A2 (en) | 2010-06-23 | 2011-12-29 | Seventh Sense Biosystems, Inc. | Sampling devices and methods involving relatively little pain |
| WO2012009613A1 (en) | 2010-07-16 | 2012-01-19 | Seventh Sense Biosystems, Inc. | Low-pressure environment for fluid transfer devices |
| US9845489B2 (en) | 2010-07-26 | 2017-12-19 | Biomatrica, Inc. | Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| CA2806670A1 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| WO2012015926A2 (en) | 2010-07-27 | 2012-02-02 | Northwestern University | Devices and methods for filtering blood plasma |
| WO2012021801A2 (en) | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Systems and techniques for monitoring subjects |
| EP2954916A3 (en) | 2010-08-13 | 2016-04-20 | Seventh Sense Biosystems, Inc. | Clinical and/or consumer techniques and devices |
| AU2011293832B2 (en) | 2010-08-26 | 2014-07-17 | Spot Bioscience, Llc | Biological fluid sampling and storage apparatus for remote use |
| PL2627255T3 (pl) | 2010-10-15 | 2016-10-31 | Zespół do pobierania próbek | |
| US8474332B2 (en) | 2010-10-20 | 2013-07-02 | Medtronic Minimed, Inc. | Sensor assembly and medical device incorporating same |
| EP2992827B1 (en) | 2010-11-09 | 2017-04-19 | Seventh Sense Biosystems, Inc. | Systems and interfaces for blood sampling |
| CN103370412B (zh) | 2010-12-04 | 2015-07-22 | 万芬 | 核糖核酸稳定性增强剂 |
| US20120152743A1 (en) | 2010-12-17 | 2012-06-21 | General Electric Company | Method for electroeluting genetic material from dried samples |
| WO2012092260A1 (en) | 2010-12-27 | 2012-07-05 | Ibis Biosciences, Inc. | Compositions and methods for producing single-stranded circular dna |
| US8852123B2 (en) | 2010-12-30 | 2014-10-07 | Roche Diagnostics Operations, Inc. | Handheld medical diagnostic devices housing with sample transfer |
| EP2673031B1 (en) | 2011-02-09 | 2020-07-15 | Becton, Dickinson and Company | Medical infusion device comprising a self-contained torsion spring inserter |
| SG192270A1 (en) * | 2011-02-17 | 2013-08-30 | Nestec Sa | Apparatus and method for isolating leukocytes and tumor cells by filtration |
| GB201103258D0 (en) | 2011-02-25 | 2011-04-13 | Ge Healthcare Uk Ltd | Solid support and method of enhancing the recovery of biological material therefrom |
| GB201103256D0 (en) | 2011-02-25 | 2011-04-13 | Ge Healthcare Uk Ltd | Solid support and method of recovering biological material therefrom |
| GB201103257D0 (en) | 2011-02-25 | 2011-04-13 | Ge Healthcare Uk Ltd | Paper support and method of recovering biological material therefrom |
| AU2012236109A1 (en) | 2011-04-01 | 2013-11-21 | Occam Biolabs, Inc. | Methods and kits for detecting cell-free pathogen-specific nucleic acids |
| US20120271125A1 (en) | 2011-04-11 | 2012-10-25 | Seventh Sense Biosystems, Inc. | Devices and methods for delivery and/or withdrawal of fluids and preservation of withdrawn fluids |
| KR20140034200A (ko) | 2011-04-29 | 2014-03-19 | 세븐쓰 센스 바이오시스템즈, 인크. | 혈액 스폿들 또는 다른 신체 유체들을 수집 및/또는 조작하기 위한 시스템들 및 방법들 |
| US20130158468A1 (en) | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
| CN103874460B (zh) | 2011-04-29 | 2016-06-22 | 第七感生物系统有限公司 | 一种用于从受验者的皮肤接收血液或其它物质的装置 |
| JP5559096B2 (ja) | 2011-05-10 | 2014-07-23 | 株式会社堀場製作所 | 血球計数用試薬、及び血液検査方法 |
| CA2843945C (en) | 2011-08-03 | 2022-06-21 | Intuity Medical, Inc. | Devices and methods for body fluid sampling and analysis |
| CN103827303B (zh) | 2011-09-26 | 2021-10-22 | 普瑞阿那利提克斯有限公司 | 细胞外核酸的稳定化和分离 |
| GB2496122A (en) | 2011-10-31 | 2013-05-08 | Ge Healthcare Bio Sciences Ab | Biological sample preservation on paper |
| US9554736B2 (en) | 2011-11-29 | 2017-01-31 | Teleflex Medical Incorporated | Device with integrated allergy testing |
| WO2013082273A1 (en) * | 2011-11-30 | 2013-06-06 | Wellstat Diagnostics, Llc. | Filtration module |
| US20130150811A1 (en) | 2011-12-12 | 2013-06-13 | Angiodynamics, Inc. | High-Flow Port Stem |
| CN103173432B (zh) | 2011-12-22 | 2020-08-04 | 通用电气公司 | 分离核酸的方法及装置 |
| US20130211289A1 (en) | 2012-01-25 | 2013-08-15 | Tasso, Inc. | Handheld Device for Drawing, Collecting, and Analyzing Bodily Fluid |
| PT2814981T (pt) | 2012-02-13 | 2017-10-03 | Streck Inc | Dispositivo de colheita de sangue para estabilizar adn plasmático livre de célula |
| US9353393B2 (en) | 2012-02-15 | 2016-05-31 | General Electric Company | Methods and kits for reducing non-specific nucleic acid amplification |
| JP6008940B2 (ja) | 2012-03-13 | 2016-10-19 | シチズンホールディングス株式会社 | 半導体発光装置及びその製造方法 |
| US9933343B2 (en) | 2012-03-14 | 2018-04-03 | Chromologic Llc | Integrated membrane for preservation of biomolecules |
| US9795960B2 (en) | 2012-03-31 | 2017-10-24 | Dbs System Sa | Device and method for dried fluid spot analysis |
| EP2839260B1 (en) | 2012-04-20 | 2018-07-18 | Talis Biomedical Corporation | Fluidic devices and systems for sample preparation or autonomous analysis |
| US9808798B2 (en) | 2012-04-20 | 2017-11-07 | California Institute Of Technology | Fluidic devices for biospecimen preservation |
| US10076630B2 (en) | 2012-04-24 | 2018-09-18 | The Queen Elizabeth Hospital King's Lynn Nhs Foundation Trust | Device for performing regional anesthesia |
| US9044738B2 (en) | 2012-04-30 | 2015-06-02 | General Electric Company | Methods and compositions for extraction and storage of nucleic acids |
| US9040675B2 (en) | 2012-04-30 | 2015-05-26 | General Electric Company | Formulations for nucleic acid stabilization on solid substrates |
| US9480966B2 (en) * | 2012-04-30 | 2016-11-01 | General Electric Company | Substrates and methods for collection, stabilization and elution of biomolecules |
| US9040679B2 (en) | 2012-04-30 | 2015-05-26 | General Electric Company | Methods and compositions for extraction and storage of nucleic acids |
| ES2385079B1 (es) | 2012-05-08 | 2013-05-24 | Leventon S.A.U. | Reductor de presión para el suministro de medicamentos a un paciente y procedimiento de fabricación correspondiente |
| US9081001B2 (en) | 2012-05-15 | 2015-07-14 | Wellstat Diagnostics, Llc | Diagnostic systems and instruments |
| US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
| US8777170B2 (en) | 2012-06-05 | 2014-07-15 | Lenmark Holdings, Llc | Display article support systems |
| WO2014018558A1 (en) | 2012-07-23 | 2014-01-30 | Tasso, Inc. | Methods, systems, and devices relating to open microfluidic channels |
| US9399986B2 (en) | 2012-07-31 | 2016-07-26 | General Electric Company | Devices and systems for isolating biomolecules and associated methods thereof |
| US20150259671A1 (en) | 2012-07-31 | 2015-09-17 | General Electric Company | Devices and systems for isolating biomolecules and associated methods thereof |
| US20140038172A1 (en) | 2012-08-06 | 2014-02-06 | Vivebio, Llc | Matrix and System for Preserving Biological Specimens for Qualitative and Quantitative Analysis |
| US9427184B2 (en) | 2012-09-06 | 2016-08-30 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample collection |
| US9636062B2 (en) | 2012-09-06 | 2017-05-02 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample collection |
| DE102012019400A1 (de) | 2012-10-04 | 2014-04-10 | Gerresheimer Regensburg Gmbh | Stechhilfevorrichtung zur Blutprobenentnahme |
| US20140358036A1 (en) | 2012-12-05 | 2014-12-04 | Theranos, Inc. | Bodily Fluid Sample Collection and Transport |
| AU2013356680A1 (en) | 2012-12-05 | 2015-05-28 | Theranos Ip Company, Llc | Systems, devices, and methods for bodily fluid sample collection and transport |
| US20140342371A1 (en) | 2012-12-05 | 2014-11-20 | Theranos, Inc. | Bodily Fluid Sample Collection and Transport |
| ES2692726T3 (es) | 2012-12-20 | 2018-12-04 | General Electric Company | Formulaciones para la estabilización de ácidos nucleicos en sustratos sólidos |
| EP2948121B1 (en) | 2013-01-23 | 2017-11-29 | C.R. Bard Inc. | Low-profile access port |
| US11420033B2 (en) | 2013-01-23 | 2022-08-23 | C. R. Bard, Inc. | Low-profile single and dual vascular access device |
| US9623409B2 (en) | 2013-03-11 | 2017-04-18 | Cue Inc. | Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes |
| US20140272925A1 (en) | 2013-03-14 | 2014-09-18 | Chromologic Llc | Plasma Separation Apparatus, Method and System |
| WO2014153181A1 (en) | 2013-03-14 | 2014-09-25 | Spot On Sciences, Inc. | Biological sample collection and preservation |
| US20140323911A1 (en) | 2013-03-15 | 2014-10-30 | Theranos, Inc. | Methods and devices for sample collection and sample separation |
| US20150273467A1 (en) | 2013-03-15 | 2015-10-01 | Theranos, Inc. | Methods and devices for sample collection and sample separation |
| US9795929B2 (en) | 2013-03-15 | 2017-10-24 | Theranos, Inc. | Systems, devices, and methods for bodily fluid separation materials |
| US10238812B2 (en) | 2013-03-15 | 2019-03-26 | Edge Systems Llc | Skin treatment systems and methods using needles |
| US9380973B2 (en) | 2013-04-15 | 2016-07-05 | Becton, Dickinson And Company | Biological fluid sampling transfer device and biological fluid separation and testing system |
| EP3135377A1 (en) | 2013-04-15 | 2017-03-01 | Becton, Dickinson and Company | Biological fluid collection device and biological fluid separation and testing system |
| BR112015026252B1 (pt) | 2013-04-15 | 2022-03-22 | Becton, Dickinson And Company | Dispositivo de coleta de fluido biológico e sistema de coleta e teste de fluido biológico |
| WO2014172233A1 (en) | 2013-04-15 | 2014-10-23 | Becton, Dickinson And Company | Biological fluid transfer device and biological fluid sampling system |
| US9408568B2 (en) | 2013-04-15 | 2016-08-09 | Becton, Dickinson And Company | Biological fluid sampling device |
| EP2986383B1 (en) | 2013-04-15 | 2020-08-26 | Becton, Dickinson and Company | Biological fluid separation device and biological fluid separation and testing system |
| MX369605B (es) | 2013-04-15 | 2019-11-13 | Becton Dickinson Co | Dispositivo de transferencia de muestreo de fluidos biologicos y sistema de separacion y analisis de fluidos biologicos. |
| WO2014172247A1 (en) | 2013-04-15 | 2014-10-23 | Becton, Dickinson And Company | Blood sampling transfer device |
| CN105491883B (zh) | 2013-06-13 | 2018-11-02 | 生物马特里卡公司 | 细胞稳定化 |
| JP6523263B2 (ja) | 2013-06-13 | 2019-05-29 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 分析デバイス |
| ES2676697T3 (es) | 2013-07-16 | 2018-07-24 | Rene La Fontaine | Módulo de aguja e instrumento para perforar la piel |
| US9938568B2 (en) | 2013-07-26 | 2018-04-10 | General Electric Company | Ligase-assisted nucleic acid circularization and amplification |
| US10655167B2 (en) | 2013-07-26 | 2020-05-19 | General Electric Company | Ligase-assisted nucleic acid circularization and amplification |
| US9217167B2 (en) | 2013-07-26 | 2015-12-22 | General Electric Company | Ligase-assisted nucleic acid circularization and amplification |
| US9644232B2 (en) | 2013-07-26 | 2017-05-09 | General Electric Company | Method and device for collection and amplification of circulating nucleic acids |
| WO2015022410A1 (en) | 2013-08-16 | 2015-02-19 | General Electric Company | Methods and compositions for extraction and storage of nucleic acids |
| CA2922806A1 (en) * | 2013-08-28 | 2015-03-05 | Cytonics Corporation | Systems, compositions, and methods for transplantation and treating conditions utilizing a composition comprising a wild-type or a variant a2m polypeptide or portion thereof |
| WO2015061743A1 (en) | 2013-10-24 | 2015-04-30 | Theranos, Inc. | Systems and methods for ordering laboratory tests and providing results thereof |
| US9719082B2 (en) | 2013-10-31 | 2017-08-01 | General Electric Company | Substrates and associated methods for elution of nucleic acids |
| US9534214B2 (en) | 2013-10-31 | 2017-01-03 | General Electric Company | Substrates and associated methods for elution of nucleic acids |
| CN113477149B (zh) | 2013-11-06 | 2023-09-12 | 贝克顿·迪金森公司 | 微流体性装置和制造和使用其的方法 |
| US20150164398A1 (en) | 2013-11-11 | 2015-06-18 | Theranos, Inc. | Methods and systems for a sample collection device with a novelty exterior |
| US20150166956A1 (en) | 2013-12-16 | 2015-06-18 | General Electric Company | Devices for separation of particulates, associated methods and systems |
| EP3083056B1 (en) | 2013-12-20 | 2023-04-05 | Spot Bioscience, LLC | Whole blood separation sampling apparatus |
| EP3082901B1 (en) | 2013-12-20 | 2019-05-15 | Sanofi-Aventis Deutschland GmbH | Drug delivery device with disposable cartridge and disposable injector |
| GB201401133D0 (en) | 2014-01-23 | 2014-03-12 | Renephra Ltd | Fluid extraction device, applicator device and associated methods |
| US20150211967A1 (en) | 2014-01-29 | 2015-07-30 | Trajan Scientific Australia Pty Ltd | Preparation of samples for analysis and sampling device therefor |
| HK1232291A1 (zh) * | 2014-04-25 | 2018-01-05 | Global Life Sciences Solutions Operations UK Ltd | 用於生物分子的收集、稳定和洗脱的基材和方法 |
| JP6669672B2 (ja) | 2014-06-10 | 2020-03-18 | バイオマトリカ,インク. | 周囲温度における血液サンプル中の変性されていないポリペプチド、核酸、およびエキソソームの安定化 |
| ES2864412T3 (es) | 2014-07-18 | 2021-10-13 | Becton Dickinson Co | Dispositivo de lanceta con retirada de la primera gota |
| US9901922B2 (en) | 2014-07-25 | 2018-02-27 | General Electric Company | Sample collection and transfer device |
| US9480981B2 (en) | 2014-07-25 | 2016-11-01 | General Electric Company | Sample collection and transfer device |
| CN113440134A (zh) | 2014-08-01 | 2021-09-28 | 塔索公司 | 用于重力增强的微流体采集、液体的处理和输送的装置、系统和方法 |
| US10779757B2 (en) | 2014-08-01 | 2020-09-22 | Tasso, Inc. | Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids |
| US9950321B2 (en) | 2014-08-04 | 2018-04-24 | General Electric Company | Device for separation and collection of plasma |
| US10335078B2 (en) | 2014-08-04 | 2019-07-02 | General Electric Company | Device for separation and collection of plasma |
| EP3201350B1 (en) | 2014-09-30 | 2020-12-02 | Global Life Sciences Solutions USA LLC | Method for nucleic acid analysis directly from an unpurified biological sample |
| US10111610B2 (en) * | 2014-11-04 | 2018-10-30 | Wainamics, Inc. | Microscale plasma separator |
| US10287570B2 (en) * | 2014-11-21 | 2019-05-14 | Occam Biolabs, Inc. | System and method for collecting a sample of nucleic acid |
| US20180008183A1 (en) | 2015-01-28 | 2018-01-11 | Seventh Sense Biosystems, Inc. | Devices and methods for delivering and/or receiving fluid |
| US10597697B2 (en) | 2015-02-05 | 2020-03-24 | Ge Healthcare Bio-Sciences Corp. | Method of determining a nucleotide sequence of a nucleic acid segment from a region of interest in a biological sample |
| WO2016134324A1 (en) | 2015-02-20 | 2016-08-25 | Neoteryx, Llc | Method and apparatus for acquiring blood for testing |
| US9730625B2 (en) | 2015-03-02 | 2017-08-15 | Verily Life Sciences Llc | Automated blood sampling device |
| ES2903175T3 (es) | 2015-03-31 | 2022-03-31 | Hoffmann La Roche | Tarjeta de separación de plasma |
| CN107567306B (zh) | 2015-05-14 | 2020-06-26 | 通用电气公司 | 用于血浆的分离和收集的装置 |
| PL3097933T3 (pl) | 2015-05-26 | 2020-03-31 | F. Hoffmann-La Roche Ag | Kaseta i urządzenie wprowadzające dla układu medycznego |
| JP6558971B2 (ja) | 2015-06-17 | 2019-08-14 | 株式会社日立ハイテクノロジーズ | 採血装置 |
| KR102604091B1 (ko) | 2015-07-17 | 2023-11-22 | 큐 헬스 인코퍼레이티드 | 분석물질의 증진된 검출 및 정량을 위한 시스템 및 방법 |
| MX2018001352A (es) | 2015-08-06 | 2018-05-22 | Becton Dickinson Co | Dispositivo de recoleccion de fluido biologico y sistema de recoleccion de fluido biologico. |
| JP6940485B2 (ja) | 2015-08-28 | 2021-09-29 | クリシー メディカル システムズ インコーポレイテッド | 吸収体を備える流量センサシステム |
| WO2017044888A1 (en) | 2015-09-09 | 2017-03-16 | Theranos, Inc. | Methods and devices for sample collection and sample separation |
| CN108473932B (zh) | 2015-09-09 | 2022-07-15 | 集联健康有限公司 | 用于样品收集、稳定化和保存的系统、方法和装置 |
| EP3371326B1 (en) | 2015-11-05 | 2023-11-01 | Global Life Sciences Solutions Operations UK Ltd | Ligase-assisted nucleic acid circularization and amplification |
| US20170128934A1 (en) | 2015-11-10 | 2017-05-11 | Neoteryx, Llc | Plasma extraction device |
| EP3393342B1 (en) | 2015-12-21 | 2020-07-08 | Tasso, Inc. | Devices for actuation and retraction in fluid collection |
| WO2017139723A1 (en) | 2016-02-12 | 2017-08-17 | Perqflo, Llc | Ambulatory infusion pumps and assemblies for use with same |
| US10610862B2 (en) | 2016-04-04 | 2020-04-07 | Advance Dx, Inc. | Multiple path sample collection card |
| WO2017214338A1 (en) | 2016-06-07 | 2017-12-14 | Drawbridge Health, Inc. | Metods and devices for strong or stabilizing molecules |
| EP3490453B1 (en) | 2016-07-29 | 2021-12-01 | YourBio Health, Inc. | Device for receiving bodily fluid from a subject |
| US11523805B2 (en) | 2016-09-21 | 2022-12-13 | Tasso, Inc. | Methods for delivery of bodily fluids onto a fibrous substrate |
| TWI882519B (zh) | 2017-01-10 | 2025-05-01 | 美商集聯健康有限公司 | 用於收集和儲存來自受試者之血液的裝置 |
| CN107260186A (zh) | 2017-07-07 | 2017-10-20 | 深圳鹏博威投资控股有限公司 | 负压式采血针头 |
| USD870264S1 (en) | 2017-09-06 | 2019-12-17 | C. R. Bard, Inc. | Implantable apheresis port |
| JP7438137B2 (ja) | 2018-05-14 | 2024-02-26 | ループ メディカル エスアー | ユーザーの流体のサンプルを抽出および採取するためのサンプル採取デバイス、システム、および方法 |
| EP4278983A3 (en) | 2018-09-14 | 2023-12-20 | Tasso, Inc. | Bodily fluid collection device |
| ES2940212T3 (es) | 2019-11-13 | 2023-05-04 | Loop Medical Sa | Dispositivo de recogida de muestras para extraer y recoger una muestra de un fluido de un usuario |
| EP4121733A4 (en) | 2020-03-18 | 2024-05-22 | Drawbridge Health, Inc. | SAMPLE COLLECTION SYSTEMS AND METHODS |
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2016
- 2016-09-09 CN CN201680065140.4A patent/CN108473932B/zh active Active
- 2016-09-09 CN CN202210755091.4A patent/CN115161178A/zh active Pending
- 2016-09-09 GB GB1615387.6A patent/GB2547062B/en active Active
- 2016-09-09 ES ES16845220T patent/ES2818569T3/es active Active
- 2016-09-09 FI FIEP22150560.5T patent/FI4035762T3/fi active
- 2016-09-09 EP EP16845220.9A patent/EP3347448B1/en active Active
- 2016-09-09 HK HK19100804.5A patent/HK1258397A1/zh unknown
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- 2016-09-09 EP EP20175443.9A patent/EP3754011B1/en active Active
- 2016-09-09 ES ES20175443T patent/ES2912965T3/es active Active
- 2016-09-09 US US15/261,707 patent/US11266337B2/en not_active Expired - Fee Related
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- 2016-09-09 WO PCT/US2016/051157 patent/WO2017044887A1/en not_active Ceased
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2022
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2023
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