JP4343228B2 - 生体液試料の採集および選択された成分の処置のための装置および方法 - Google Patents
生体液試料の採集および選択された成分の処置のための装置および方法 Download PDFInfo
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Description
図6Aから図6Eは、開口上端部および閉じた下端部を有し、ゲル分離部材101を収容する管100を示す。図6Aおよび図6Bは、遠心分離前に管閉塞部121の下面に懸架された伸縮式カップ120内に収容された試薬108を示す。図6Cは、試薬カップの上部即ち摺動カバー122が、遠心分離中に、Z方向に引き降ろされ圧縮ばね123によりかけられる力に打ち勝つことを示す。図6Dおよび図6Eは、遠心分離が完了する場合、2つのカップ部分120と122との間の摩擦により、ばね123がカップ120および122の両部分をA方向に押し上げることが可能になり、それによって、試薬108のための通路を開き、逃がし、分離された血漿112と混合することを示す。
(a)試薬解放機構を閉じた状態に保持する(ばね、または、ベルビルワッシャなどの)バイアス要素。分離プロセス(例えば遠心分離)が付勢力に打ち勝ち、分離後に試薬との接触が可能になる(受動式)。
(b)分離後に手動で開くことができる、破断可能または穿刺可能な小袋/仕切り(手動式)。
(c)管閉塞部に取り付けられ、この閉塞部に取り付けられたことにより、試薬解放機構が閉じた状態で保持される容器。分離プロセス(例えば遠心分離)が取付力に打ち勝ち、容器を解放し、分離後、試薬との接触が可能になる(受動式)。または、
(d)カバーに取り付けられた容器であって、そのカバーが試薬との接触を防ぐ。分離プロセス(例えば遠心分離)が取付力に打ち勝ち、カバーを解放し、分離後、試薬との接触が可能になる。
例えば、分離プロセスがロック機構を解放するが、容器または通路を開くように手動工程が必要とされる場合など、受動式と手動式のいくつかの組合せが可能であることに留意されたい。
(a)管閉塞部に直接的に取り付けられる。
(b)例えば、閉塞部付近に配置された構造部材上に載るように管閉塞部に隣接する。
(c)管の内壁と一体のリブなどの構造部材上に載っている分離部材の最終位置に隣接するがそれより上方の管の位置。
Claims (23)
- 生体試料を採集するための装置であって、
第1の開口端部および第2の開口端部を有し、該第1の開口端部内および前記第2の開口端部内に閉塞部を有する管と、
前記管内で前記第1の開口端部と前記第2の開口端部との間に配され、前記試料を別々の成分に分離することができるゲルと、
前記第1の開口端部と前記ゲルとの間の空間によって形成されたリザーバ部と、
前記ゲルと前記第2の開口端部との間に配置された少なくとも1つの試薬と、
を含む装置。 - 前記管は、大気圧より低い圧力に排気される請求項1に記載の装置。
- 前記試薬は、核酸安定剤である請求項1に記載の装置。
- 前記核酸安定剤は、全血試料から分離された血漿または血清成分と選択的に接触するように配置される請求項3に記載の装置。
- 前記ゲルは、前記試薬から物理的に分離される請求項1に記載の装置。
- 前記ゲルは、血漿と残存する細胞成分との中間、または血清と赤血球との中間の密度を有する請求項1に記載の装置。
- 前記試薬は、溶液、懸濁液またはその他の液体、小丸剤、錠剤、カプセル、スプレードライ物質、フリーズドライ物質、粉剤、粒状剤、ゲル剤、結晶および凍結乾燥物質からなる群から選択される形式である請求項1に記載の装置。
- 前記試薬は、タンパク質安定剤である請求項1に記載の装置。
- 前記リザーバ部分は、血液凝固阻害または血液凝固活性化のための試剤を含む請求項1に記載の装置。
- 前記血液凝固活性化剤は、シリカを基剤としたものである請求項9に記載の装置。
- 前記管は、さらに抗凝血剤を含む請求項1に記載の装置。
- 検体採集および調製のための方法であって、
閉塞部を有する開口上端部および閉塞部を有する開口下端部と、前記上端部と前記下端部との間に配置され、それによって前記上端部とゲルとの間にリザーバ部分を形成し、前記試料を別々の成分に分離することができるゲルと、該ゲルと前記下端部との間に配置された少なくとも1つの試薬とを含む管を設け、
前記採集された試料は前記試薬から分離されたまま、前記リザーバ部分に試料を採集し、
前記管を、前記試料を別々の成分に分離させる処理にかけ、
分離を引き起こす前記処理が混合を引き起こすことによって、または別個の混合工程によって、前記試料の前記所望の別々の成分を前記試薬と混合させることを含む方法。 - 前記試料は、全血である請求項12に記載の方法。
- 前記管を、前記試料を分離させる処理にかける前記工程、および前記試料の前記所望の別々の成分を前記試薬と混合させる前記工程は、
前記下端部を上に向けて前記管を遠心分離機内に配置し、
血漿または血清を前記残存する血液成分から分離させるために前記管を遠心分離機に配置し、
前記血漿または血清を前記試薬に接触させることを可能にし、または前記試薬との接触を開始させるために前記管を逆さまにすることを含む請求項13に記載の方法。 - 前記試薬と接触する前記別々の成分は、血漿である請求項14に記載の方法。
- 前記試薬は、核酸安定剤である請求項14に記載の方法。
- 前記混合する工程は、前記管を逆さまにすることを含む請求項14に記載の方法。
- 前記試料を分離させる前記処理は、遠心分離である請求項12に記載の方法。
- 前記ゲルは、前記試薬から物理的に分離される請求項12に記載の方法。
- 前記試薬は、溶液、懸濁液またはその他の液体、小丸剤、錠剤、カプセル、スプレードライ材料、フリーズドライ材料、粉剤、粒状剤、ゲル剤、結晶および凍結乾燥材料からなる群から選択される形式である請求項12に記載の方法。
- 前記混合する工程は、前記管を逆さまにすることを含む請求項12に記載の方法。
- 前記試薬は、核酸安定剤である請求項12に記載の方法。
- 前記試薬は、タンパク質安定剤である請求項12に記載の方法。
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US49231303P | 2003-08-05 | 2003-08-05 | |
PCT/US2004/025355 WO2005014173A1 (en) | 2003-08-05 | 2004-08-05 | Device and methods for collection of biological fluidsample and treatment of selected components |
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US6406671B1 (en) * | 1998-12-05 | 2002-06-18 | Becton, Dickinson And Company | Device and method for separating components of a fluid sample |
US7947236B2 (en) | 1999-12-03 | 2011-05-24 | Becton, Dickinson And Company | Device for separating components of a fluid sample |
US7700276B2 (en) | 2003-07-10 | 2010-04-20 | Universite Libre De Bruxelles | Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed |
US7947450B2 (en) | 2003-07-10 | 2011-05-24 | Universite Libre De Bruxelles | Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed |
US20070140915A1 (en) * | 2005-12-12 | 2007-06-21 | Cytyc Corporation | Method and Apparatus for Obtaining Aliquot from Liquid-Based Cytological Sample |
US7686771B2 (en) * | 2005-12-12 | 2010-03-30 | Cytyc Corporation | Method and apparatus for obtaining aliquot from liquid-based cytological sample |
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BRPI0413350A (pt) | 2006-10-10 |
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