ES2812099T3 - Composiciones y métodos para modular la expresión del receptor de la hormona del crecimiento - Google Patents

Composiciones y métodos para modular la expresión del receptor de la hormona del crecimiento Download PDF

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Publication number
ES2812099T3
ES2812099T3 ES15786107T ES15786107T ES2812099T3 ES 2812099 T3 ES2812099 T3 ES 2812099T3 ES 15786107 T ES15786107 T ES 15786107T ES 15786107 T ES15786107 T ES 15786107T ES 2812099 T3 ES2812099 T3 ES 2812099T3
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antisense
oligonucleotides
oligonucleotide
compound
group
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Spanish (es)
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Thazha Prakash
Punit Seth
Eric Swayze
Sanjay Bhanot
Susan Freier
Huynh-Hoa Bui
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/3525—MOE, methoxyethoxy

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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ES15786107T 2014-05-01 2015-05-01 Composiciones y métodos para modular la expresión del receptor de la hormona del crecimiento Active ES2812099T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461987470P 2014-05-01 2014-05-01
US201462061071P 2014-10-07 2014-10-07
US201462082511P 2014-11-20 2014-11-20
PCT/US2015/028887 WO2015168618A2 (en) 2014-05-01 2015-05-01 Compositions and methods for modulating growth hormone receptor expression

Publications (1)

Publication Number Publication Date
ES2812099T3 true ES2812099T3 (es) 2021-03-16

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ES15786107T Active ES2812099T3 (es) 2014-05-01 2015-05-01 Composiciones y métodos para modular la expresión del receptor de la hormona del crecimiento

Country Status (14)

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US (5) US9994855B2 (https=)
EP (3) EP3757215A3 (https=)
JP (2) JP6667453B2 (https=)
KR (2) KR102149571B1 (https=)
CN (2) CN110903337A (https=)
AU (2) AU2015252841B2 (https=)
BR (2) BR122020024446B8 (https=)
CA (1) CA2942570A1 (https=)
DK (1) DK3137604T3 (https=)
ES (1) ES2812099T3 (https=)
IL (2) IL247716B (https=)
MX (2) MX373283B (https=)
RU (1) RU2724527C2 (https=)
WO (1) WO2015168618A2 (https=)

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EP3694530A4 (en) * 2017-10-12 2021-06-30 Wave Life Sciences Ltd. COMPOSITIONS OF OLIGONUCLEOTIDES AND RELATED PROCESSES
US11459564B2 (en) 2017-12-21 2022-10-04 Ionis Pharmaceuticals, Inc. Modulation of frataxin expression
EP4025252A4 (en) * 2019-09-03 2023-10-18 Arcturus Therapeutics, Inc. ASIALOGLYCOPROTEIN RECEPTOR-MEDIATED ADMINISTRATION OF THERAPEUTICALLY ACTIVE CONJUGATES
EP4048801A4 (en) * 2019-10-24 2023-11-22 Genevant Sciences Gmbh Conjugates and methods for treating acromegaly
KR20230011913A (ko) 2020-03-04 2023-01-25 버브 테라퓨틱스, 인크. 표적화된 rna 전달을 위한 조성물 및 방법
US20240335551A1 (en) * 2021-05-20 2024-10-10 Olix Us, Inc. Functional moieties and their uses and synthetic preparation
JP2024530647A (ja) * 2021-08-03 2024-08-23 ヴァーヴ・セラピューティクス，インコーポレーテッド 標的ｒｎａ送達のための組成物および方法
JP2024532271A (ja) 2021-08-30 2024-09-05 ホンジーン バイオテック コーポレイション 官能化ｎ－アセチルガラクトサミンアナログ
WO2023114746A1 (en) 2021-12-15 2023-06-22 Hongene Biotech Corporation Functionalized n-acetylgalactosamine analogs
WO2024001172A1 (en) * 2022-06-27 2024-01-04 Ractigen Therapeutics Oligonucleotide modulators activating complement factor h expression
WO2024118503A1 (en) 2022-11-28 2024-06-06 Hongene Biotech Corporation Functionalized n-acetylgalactosamine analogs
WO2026006415A1 (en) * 2024-06-27 2026-01-02 Veranova, L.P. Selectively soluble triamide-derived supports for liquid-phase peptide and oligonucleotide synthesis

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